Jong Yun, PhD - Penn State Cancer Institute
Researcher Profile
Jong Yun, PhD
Associate Professor, Department of Pharmacology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Next-Generation Therapies
Recent Publications
2024
Hengst, JA, Nduwumwami, AJ, Sharma, A & Yun, JK 2024, 'Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?', Molecular pharmacology, vol. 105, no. 3, pp. 155-165. https://doi.org/10.1124/molpharm.123.000786
2023
Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060. https://doi.org/10.3390/ph16081060
2022
Hengst, JA, Nduwumwami, AJ, Raup-Konsavage, WM, Vrana, KE & Yun, JK 2022, 'Inhibition of Sphingosine Kinase Activity Enhances Immunogenic Cell Surface Exposure of Calreticulin Induced by the Synthetic Cannabinoid 5-epi-CP-55,940', Cannabis and Cannabinoid Research, vol. 7, no. 5, pp. 637-647. https://doi.org/10.1089/can.2021.0100
Hengst, JA, Nduwumwami, AJ & Yun, JK 2022, 'Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation', Cancers, vol. 14, no. 21, 5182. https://doi.org/10.3390/cancers14215182
2021
Nduwumwami, AJ, Hengst, JA & Yun, JK 2021, 'Sphingosine kinase inhibition enhances dimerization of calreticulin at the cell surface in mitoxantrone-induced immunogenic cell death', Journal of Pharmacology and Experimental Therapeutics, vol. 378, no. 3, pp. 300-310. https://doi.org/10.1124/jpet.121.000629
2020
Hengst, JA, Dick, TE, Smith, CD & Yun, JK 2020, 'Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)', Cancer Biology and Therapy, vol. 21, no. 9, pp. 841-852. https://doi.org/10.1080/15384047.2020.1798696
Hengst, JA, Hegde, S, Paulson, RF & Yun, JK 2020, 'Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization', Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 20, 127453. https://doi.org/10.1016/j.bmcl.2020.127453