Jay Raman, MD - Penn State Cancer Institute
Researcher Profile
Jay Raman, MD
Professor and Interim Chair, Department of Urology
Professor, Department of Surgery
Professor, Department of Surgery
Scientific Program:Cancer Control
Disease Teams:
Cancer Institute, Genitourinary Cancer Team
Research Interests
- Neoplasms
- Carcinoma
- Nephroureterectomy
- Kidney
- Survival
- Therapeutics
- Recurrence
- Nephrectomy
- Urinary Bladder Neoplasms
- Biopsy
- Renal Cell Carcinoma
- Prostate
Clinical Trials
Angelica Herbal Supplement AGN-CognI.Q Acute Dose Safety and Pharmacokinetics (PK) Dose-Response in Prostate Cancer Patients (PK Dose Trial)
Multicenter Phase 3 Pivotal Study to Evaluate the Safety and Efficacy of TOOKAD (padeliporfin) Vascular Targeted Photodynamic Therapy in the Treatment of Low Grade Upper Tract Urothelial Cancer
Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence
A Phase 1, Open-label, Dose-escalation Study to Investigate the Safety, Tolerability, and Pharmacokinetics of UGN-301 (zalifrelimab) Administered Intravesically as Monotherapy and in Combination with Other Agents in Patients with Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens
Multiparametric MRI (mpMRI) for Preoperative Staging and Treatment Planning for Newly-Diagnosed Prostate Cancer EA8171
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
A Phase II/III trial of Durvalumab and Chemotherapy for Patients with High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy EA8192
Recent Publications
2024
Marchetti, KA, Ferreri, CA, Bethel, EC, Lesser-Lee, B, Daignault-Newton, S, Merrill, S, Badalato, GM, Brown, ET, Guzzo, T, Houston Thompson, R, Klausner, A, Lee, R, Parekh, DJ, Raman, JD, Reese, A, Shenot, P, Williams, DH, Zaslau, S & Kraft, KH 2024, 'Gender-based Disparity Exists in the Surgical Experience of Female and Male Urology Residents', Urology. https://doi.org/10.1016/j.urology.2023.11.035
Corey, Z, Lehman, E, Lemack, GE, Clifton, MM, Klausner, AP, Mehta, A, Atiemo, H, Lee, R, Sorensen, M, Smith, R, Buckley, J, Thompson, H, Breyer, BN, Badalato, GM, Wallen, EM & Raman, JD 2024, 'Practice Readiness? Trends in Chief Resident Year Training Experience Across 13 Residency Programs', Urology Practice, vol. 11, no. 2, pp. 430-437. https://doi.org/10.1097/UPJ.0000000000000494
Abel, EJ, Master, VA, Spiess, PE, Raman, JD, Shapiro, DD, Sexton, WJ, Zemp, L, Patil, D, Lauer, K, Allen, GO, Matin, SF & Karam, JA 2024, 'Reply to Eduard Roussel, Riccardo Bertolo, Chiara Ciccarese, et al's Letter to the Editor re: E. Jason Abel, Viraj A. Master, Philippe E. Spiess, et al. The Selection for Cytoreductive Nephrectomy (SCREEN) Score: Improving Surgical Risk Stratification by Integrating Common Radiographic Features. Eur Urol Oncol. 2023;6:266-274', European Urology Oncology, vol. 7, no. 2, pp. 302-303. https://doi.org/10.1016/j.euo.2023.10.025
Abel, EJ, Master, VA, Spiess, PE, Raman, JD, Shapiro, DD, Sexton, WJ, Zemp, L, Patil, D, Lauer, K, Allen, GO, Matin, SF & Karam, JA 2024, 'The Selection for Cytoreductive Nephrectomy (SCREEN) Score: Improving Surgical Risk Stratification by Integrating Common Radiographic Features', European Urology Oncology, vol. 7, no. 2, pp. 266-274. https://doi.org/10.1016/j.euo.2023.06.008
2023
Lotan, Y, Barocas, DA, Chang, SS, Daneshmand, S, Konety, B, Meeks, JJ, Porten, S, Raman, JD, Rosser, CJ, Scarpato, KR, Sexton, WJ, Sfakianos, JP, Shore, ND & Svatek, RS 2023, 'Commentary on Novitas LCD', Bladder Cancer, vol. 9, no. 4, pp. 305-312. https://doi.org/10.3233/BLC-230057
Grossmann, NC, Soria, F, Juvet, T, Potretzke, AM, Djaladat, H, Ghoreifi, A, Kikuchi, E, Mari, A, Khene, ZE, Fujita, K, Raman, JD, Breda, A, Fontana, M, Sfakianos, JP, Pfail, JL, Laukhtina, E, Rajwa, P, Pallauf, M, Poyet, C, Cacciamani, GE, van Doeveren, T, Boormans, JL, Antonelli, A, Jamil, M, Abdollah, F, Ploussard, G, Heidenreich, A, Storz, E, Daneshmand, S, Boorjian, SA, Rouprêt, M, Rink, M, Shariat, SF & Pradere, B 2023, 'Comparing Oncological and Perioperative Outcomes of Open versus Laparoscopic versus Robotic Radical Nephroureterectomy for the Treatment of Upper Tract Urothelial Carcinoma: A Multicenter, Multinational, Propensity Score-Matched Analysis', Cancers, vol. 15, no. 5, 1409. https://doi.org/10.3390/cancers15051409
Esdaille, AR, Karam, JA, Master, VA, Spiess, PE, Raman, JD, Sharma, P, Shapiro, DD, Das, A, Sexton, WJ, Zemp, L, Patil, D, Allen, GO, Matin, SF, Wood, CG & Abel, JE 2023, 'Contemporary Patients Have Better Perioperative Outcomes Following Cytoreductive Nephrectomy: A Multi-institutional Analysis of 1272 Consecutive Patients', Urology, vol. 182, pp. 168-174. https://doi.org/10.1016/j.urology.2023.08.024
Coleman, JA, Clark, PE, Bixler, BR, Buckley, DI, Chang, SS, Chou, R, Hoffman-Censits, J, Kulkarni, GS, Matin, SF, Pierorazio, PM, Potretzke, AM, Psutka, SP, Raman, JD, Smith, AB & Smith, L 2023, 'Diagnosis and Management of Non-Metastatic Upper Tract Urothelial Carcinoma: AUA/SUO Guideline', Journal of Urology, vol. 209, no. 6, pp. 1071-1081. https://doi.org/10.1097/JU.0000000000003480
Pallauf, M, D'Andrea, D, König, F, Laukhtina, E, Yanagisawa, T, Rouprêt, M, Daneshmand, S, Djaladat, H, Ghoreifi, A, Soria, F, Fujita, K, Boorjian, SA, Potretzke, AM, Mari, A, Roumiguié, M, Antonelli, A, Bianchi, A, Khene, ZE, Sfakianos, JP, Jamil, M, Boormans, JL, Raman, JD, Grossmann, NC, Breda, A, Heidenreich, A, Del Giudice, F, Singla, N, Shariat, SF & Pradere, B 2023, 'Diagnostic Accuracy of Clinical Lymph Node Staging for Upper Tract Urothelial Cancer Patients: A Multicenter, Retrospective, Observational Study', Journal of Urology, vol. 209, no. 3, pp. 515-524. https://doi.org/10.1097/JU.0000000000003085
Taylor, JI, Souter, LH, Barocas, DA, Boorjian, SA, Raman, JD & Lotan, Y 2023, 'Diagnostic Imaging in the Evaluation of Asymptomatic Microhematuria: Systematic Review and Meta-analysis', Journal of Urology, vol. 209, no. 6, pp. 1099-1106. https://doi.org/10.1097/JU.0000000000003395
Mistry, NA, Sweis, J, Ofori, B, McKoy, JM, Langford, A, Psutka, SP, Perazza, E, Raman, JD & Murphy, AB 2023, 'Engaging disparities in prostate cancer: Piloting an interactive, virtual workshop to educate providers on shared decision-making for underserved populations', Urologic Oncology: Seminars and Original Investigations, vol. 41, no. 10, pp. 430.e1-430.e7. https://doi.org/10.1016/j.urolonc.2023.06.021
MacDonald, SM, Decter, RM, DeGraff, DJ, Raman, JD & Warrick, JI 2023, 'Histologic Analysis of Buccal Graft Quality Stratified by Tobacco Use in Patients Undergoing Substitution Urethroplasty', Urology, vol. 172, pp. 203-209. https://doi.org/10.1016/j.urology.2022.08.068
Margolin, EJ, Schoenfeld, D, Miles, CH, Merrill, SB, Raman, JD, Thompson, RH, Reese, AC, Parekh, DJ, Brown, ET, Klausner, A, Williams, DH, Lee, RK, Zaslau, S, Guzzo, TJ, Shenot, PJ, Anderson, CB & Badalato, GM 2023, 'Longitudinal Changes in the Operative Experience for Junior Urology Residents', Urology, vol. 179, pp. 32-38. https://doi.org/10.1016/j.urology.2023.03.064
Epstein, M, Syed, K, Danella, J, Ginzburg, S, Belkoff, L, Tomaszewski, J, Trabulsi, E, Singer, EA, Jacobs, BL, Raman, JD, Guzzo, TJ, Uzzo, R & Reese, AC 2023, 'Model risk scores may underestimate rate of biochemical recurrence in African American men with localized prostate cancer: a cohort analysis of over 3000 men', Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-023-00727-6
Chandrasekar, T, Denisenko, A, Mico, V, McPartland, C, Shah, Y, Mark, JR, Lallas, CD, Fonshell, C, Danella, J, Jacobs, B, Lanchoney, T, Raman, JD, Tomaszewski, J, Reese, A, Singer, EA, Ginzburg, S, Smaldone, M, Uzzo, R, Guzzo, TJ & Trabulsi, EJ 2023, 'Multiparametric MRI is not sufficient for prostate cancer staging: A single institutional experience validated by a multi-institutional regional collaborative', Urologic Oncology: Seminars and Original Investigations, vol. 41, no. 8, pp. 355.e1-355.e8. https://doi.org/10.1016/j.urolonc.2023.05.004
Johnson, BA, Raman, JD, Best, SL & Lotan, Y 2023, 'Prospective Randomized Trial of Single-Use vs Reusable Cystoscope for Ureteral Stent Removal', Journal of Endourology, vol. 37, no. 10, pp. 1139-1144. https://doi.org/10.1089/end.2023.0134
Fuletra, J, Rjepaj, C, Clark, JY, Knoedler, JJ, MacDonald, SM, Kaag, MG, Merrill, SB & Raman, JD 2023, 'Significant Bleeding Complications Following Transrectal Prostate Needle Biopsy: Incidence, Predictors, and Management', Urology Practice, vol. 10, no. 1, pp. 6-8. https://doi.org/10.1097/UPJ.0000000000000349
Lotan, Y, Raman, JD, Konety, B, Daneshmand, S, Schroeck, F, Shariat, SF, Black, P, De Lange, M, Asroff, S, Goldfischer, E, Efros, M, Chong, KT, Huang, E, Chua, HL, Wu, QH, Yeow, S, Lau, W, Yong, J & Eng, M 2023, 'Urinary Analysis of FGFR3 and TERT Gene Mutations Enhances Performance of Cxbladder Tests and Improves Patient Risk Stratification', Journal of Urology, vol. 209, no. 4, pp. 762-772. https://doi.org/10.1097/JU.0000000000003126
Strausser, SA, Mansfield, K, Zheng, A, Bhanja, D, Hoskins, M, Piper, M, Goss, M, McNutt, S, Raman, JD & Burns, AS 2024, 'Urology Match: Important Factors Women Consider When Choosing a Residency Training Program', Urology, vol. 183, pp. 288-300. https://doi.org/10.1016/j.urology.2023.09.056
Thavaseelan, S, Raman, JD & Pearle, M 2023, 'What can urology learn about sponsorship from business and medicine?', Nature Reviews Urology, vol. 20, no. 7, pp. 386-387. https://doi.org/10.1038/s41585-023-00732-3
2022
Warrick, JI, Knowles, MA, Hurst, CD, Shuman, L, Raman, JD, Walter, V, Putt, J, Dyrskjøt, L, Groeneveld, C, Castro, MAA, Robertson, AG & DeGraff, DJ 2022, 'A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma', Scientific reports, vol. 12, no. 1, 16538. https://doi.org/10.1038/s41598-022-20927-9
Lü, J, Jiang, C, Schell, TD, Joshi, M, Raman, JD & Xing, C 2022, 'Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges', American Journal of Chinese Medicine, vol. 50, no. 6, pp. 1475-1527. https://doi.org/10.1142/S0192415X2250063X
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation (Nature Communications, (2022), 13, 1, (6575), 10.1038/s41467-022-34251-3)', Nature communications, vol. 13, no. 1, 7920. https://doi.org/10.1038/s41467-022-35644-0
IDENTIFY Study group 2022, 'Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study', European Urology Focus, vol. 8, no. 6, pp. 1673-1682. https://doi.org/10.1016/j.euf.2022.06.001
Loloi, J, Eccles, JM, Owens, G, Lehman, E, Kaag, MG, Raman, JD & Merrill, SB 2022, 'Diagnostic Imaging in Low-Risk Prostate Cancer: More Harm Than Good?', Urology Practice, vol. 9, no. 2, pp. 135-139. https://doi.org/10.1097/UPJ.0000000000000288
Matin, SF, Pierorazio, PM, Kleinmann, N, Gore, JL, Shabsigh, A, Hu, B, Chamie, K, Godoy, G, Hubosky, SG, Rivera, M, O'Donnell, M, Quek, M, Raman, JD, Knoedler, JJ, Scherr, D, Weight, C, Weizer, A, Woods, M, Kaimakliotis, H, Smith, AB, Linehan, J, Coleman, J, Humphreys, MR, Pak, R, Lifshitz, D, Verni, M, Klein, I, Konorty, M, Strauss-Ayali, D, Hakim, G, Seltzer, E, Schoenberg, M & Lerner, SP 2022, 'Durability of Response to Primary Chemoablation of Low-Grade Upper Tract Urothelial Carcinoma Using UGN-101, a Mitomycin-Containing Reverse Thermal Gel: OLYMPUS Trial Final Report', Journal of Urology, vol. 207, no. 4, pp. 779-788. https://doi.org/10.1097/JU.0000000000002350
Abdel Raheem, A, Landi, I, Alowidah, I, Capitanio, U, Montorsi, F, Larcher, A, Derweesh, I, Ghali, F, Mottrie, A, Mazzone, E, De Naeyer, G, Campi, R, Sessa, F, Carini, M, Minervini, A, Raman, JD, Rjepaj, CJ, Kriegmair, MC, Autorino, R, Veccia, A, Mir, MC, Claps, F, Choi, YD, Ham, WS, Santok, GD, Tadifa, JP, Syling, J, Furlan, M, Simeone, C, Bada, M, Celia, A, Carrión, DM, Aguilera Bazan, A, Ruiz, CB, Malki, M, Barber, N, Hussain, M, Micali, S, Puliatti, S, Ghaith, A, Hagras, A, Ghoneem, AM, Eissa, A, Alqahtani, A, Rumaih, A, Alwahabi, A, Alenzi, MJ, Pavan, N, Traunero, F, Antonelli, A, Porcaro, AB, Illiano, E, Costantini, E & Rha, KH 2023, 'External validation of yonsei nomogram predicting chronic kidney disease development after partial nephrectomy: An international, multicenter study', International Journal of Urology, vol. 30, no. 3, pp. 308-317. https://doi.org/10.1111/iju.15108
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation', Nature communications, vol. 13, no. 1, 6575. https://doi.org/10.1038/s41467-022-34251-3
Hull, BP, Humphrey, MD, Lehman, KK, Kaag, MG, Merrill, SB & Raman, JD 2022, 'Impact of an inpatient advanced practice provider on hospital length of stay after major urologic oncology procedures', Urologic Oncology: Seminars and Original Investigations, vol. 40, no. 9, pp. 411.e19-411.e25. https://doi.org/10.1016/j.urolonc.2022.06.020
Ferraris, F, Raman, JD, Musso, CG & Rozanec, J 2022, 'Measuring renal function before kidney surgery — evolving towards precision in medicine', Nature Reviews Urology, vol. 19, no. 8, pp. 450-451. https://doi.org/10.1038/s41585-022-00613-1
Wu, Z, Li, M, Wang, L, Paul, A, Raman, JD, Necchi, A, Psutka, SP, Buonerba, C, Zargar, H, Black, PC, Derweesh, IH, Mir, MC, Uzzo, RG, Pandolfo, SD, Autorino, R & Di Lorenzo, G 2022, 'Neoadjuvant systemic therapy in patients undergoing nephroureterectomy for urothelial cancer: a multidisciplinary systematic review and critical analysis', Minerva Urology and Nephrology, vol. 74, no. 5, pp. 518-527. https://doi.org/10.23736/S2724-6051.22.04659-6
Sosenko, A, Owens, RG, Yang, AL, Alzubaidi, A, Guzzo, T, Trabulsi, E, Danella, J, Diorio, G, Reese, A, Tomaszewski, J, Ginzburg, S, Smaldone, M, Fonshell, C, Syed, K, Jacobs, B, Singer, EA & Raman, JD 2022, 'Non-infectious complications following transrectal prostate needle biopsy – Outcomes from over 8000 procedures', Prostate International, vol. 10, no. 3, pp. 158-161. https://doi.org/10.1016/j.prnil.2022.04.002
Strausser, SA, Owens, RG, Vu, T, Kwok, E, Schaefer, EW, Boltz, S, Aminsharifi, A, Kaag, M, Raman, JD & Merrill, SB 2022, 'Patient Perceptions Regarding Routine Oncologic Follow-Up for Urologic Malignancies', Clinical Genitourinary Cancer, vol. 20, no. 3, pp. 298-298.e11. https://doi.org/10.1016/j.clgc.2022.01.014
König, F, Grossmann, NC, Soria, F, D’andrea, D, Juvet, T, Potretzke, A, Djaladat, H, Ghoreifi, A, Kikuchi, E, Hayakawa, N, Mari, A, Khene, ZE, Fujita, K, Raman, JD, Breda, A, Fontana, M, Sfakianos, JP, Pfail, JL, Laukhtina, E, Rajwa, P, Pallauf, M, Cacciamani, GE, van Doeveren, T, Boormans, JL, Antonelli, A, Jamil, M, Abdollah, F, Budzyn, J, Ploussard, G, Heidenreich, A, Daneshmand, S, Boorjian, SA, Rouprêt, M, Rink, M, Shariat, SF & Pradere, B 2022, 'Pentafecta for Radical Nephroureterectomy in Patients with High-Risk Upper Tract Urothelial Carcinoma: A Proposal for Standardization of Quality Care Metrics', Cancers, vol. 14, no. 7, 1781. https://doi.org/10.3390/cancers14071781
Delto, JC, Fleishman, A, Chang, P, Da David, J, Hyde, S, McAnally, K, Crociani, C, Jamil, M, Patel, HD, Pavlinec, J, Budzyn, J, Durant, A, Eilender, B, Gordon, AO, Huang, MM, Pierorazio, PM, Raman, JD, Rogers, C, Su, LM & Wagner, AA 2022, 'Perioperative Aspirin Use Is Associated with Bleeding Complications during Robotic Partial Nephrectomy', Journal of Urology, vol. 207, no. 2, pp. 277-283. https://doi.org/10.1097/JU.0000000000002240
Pennsylvania Urologic Regional Collaborative and Michigan Urological Surgery Improvement Collaborative 2022, 'Perspectives on the Role of Biopsy for Management of T1 Renal Masses: Survey Results From Two Regional Quality Improvement Collaboratives', Urology, vol. 165, pp. 206-211. https://doi.org/10.1016/j.urology.2022.01.038
Chevli, KK, Shore, ND, Trainer, A, Smith, AB, Saltzstein, D, Ehrlich, Y, Raman, JD, Friedman, B, D'Anna, R, Morris, D, Hu, B, Tyson, M, Sankin, A, Kates, M, Linehan, J, Scherr, D, Kester, S, Verni, M, Chamie, K, Karsh, L, Cinman, A, Meads, A, Lahiri, S, Malinowski, M, Gabai, N, Raju, S, Schoenberg, M, Seltzer, E & Huang, WC 2022, 'Primary Chemoablation of Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer Using UGN-102, a Mitomycin-Containing Reverse Thermal Gel (Optima II): A Phase 2b, Open-Label, Single-Arm Trial', Journal of Urology, vol. 207, no. 1, pp. 61-68. https://doi.org/10.1097/JU.0000000000002186
Harrington, SA, Fialk, G & Raman, JD 2022, 'RE: “Transperineal Prostate Biopsy is Associated With Lower Tissue Core Pathogen Burden Relative to Transrectal Biopsy: Mechanistic Underpinnings for Lower Infection Risk in the Transperineal Approach”', Urology, vol. 166, pp. 297-298. https://doi.org/10.1016/j.urology.2022.05.024
Matin, SF, Pierorazio, PM, Kleinmann, N, Gore, JL, Shabsigh, A, Hu, B, Chamie, K, Godoy, G, Hubosky, SG, Rivera, M, O'Donnell, M, Quek, M, Raman, JD, Knoedler, JJ, Scherr, D, Weight, C, Weizer, A, Woods, M, Kaimakliotis, H, Smith, AB, Linehan, J, Coleman, J, Humphreys, MR, Pak, R, Lifshitz, D, Verni, M, Klein, I, Konorty, M, Strauss-Ayali, D, Hakim, G, Seltzer, E, Schoenberg, M & Lerner, SP 2022, 'Reply by Authors', Journal of Urology, vol. 207, no. 4, pp. 788. https://doi.org/10.1097/JU.0000000000002350.02
Eccles, JM, Michalak, NR, Raman, JD & Macdonald, SM 2022, 'Surgical Preparation by Urology Trainees in 2021: The Interplay of Video and Print Resources', Urology Practice, vol. 9, no. 5, pp. 512-518. https://doi.org/10.1097/UPJ.0000000000000321
Drevik, J, Dalimov, Z, Uzzo, R, Danella, J, Guzzo, T, Belkoff, L, Raman, J, Tomaszewski, J, Trabulsi, E, Reese, A, Singer, EA, Syed, K, Jacobs, B, Correa, A, Smaldone, M & Ginzburg, S 2022, 'Utility of PSA density in patients with PI-RADS 3 lesions across a large multi-institutional collaborative', Urologic Oncology: Seminars and Original Investigations, vol. 40, no. 11, pp. 490.e1-490.e6. https://doi.org/10.1016/j.urolonc.2022.08.003
Abdel Raheem, A, Alowidah, I, Capitanio, U, Montorsi, F, Larcher, A, Derweesh, I, Ghali, F, Mottrie, A, Mazzone, H, de Naeyer, G, Campi, R, Sessa, F, Carini, M, Minervini, A, Raman, JD, Rjepaj, CJ, Kriegmair, MC, Autorino, R, Veccia, A, Mir, MC, Claps, F, Choi, YD, Ham, WS, Tadifa, JP, Santok, GD, Furlan, M, Simeone, C, Bada, M, Celia, A, Carrion, DM, Aguilera Bazan, A, Ballesteros Ruiz, C, Malki, M, Barber, N, Hussain, M, Micali, S, Puliatti, S, Alwahabi, A, Alqahtani, A, Rumaih, A, Ghaith, A, Ghoneem, AM, Hagras, A, Eissa, A, Alenzi, MJ, Pavan, N, Traunero, F, Antonelli, A, Porcaro, AB, Illiano, E, Costantini, E & Rha, KH 2022, 'Warm ischemia time length during on-clamp partial nephrectomy: does it really matter?', Minerva Urology and Nephrology, vol. 74, no. 22, pp. 194-202. https://doi.org/10.23736/S2724-6051.21.04466-9
2021
Khene, ZE, Dosin, G, Peyronnet, B, Gasmi, A, Doumerc, N, Ouzaid, I, Pradere, B, Brassier, M, Roumiguié, M, Mathieu, R, Rioux-Leclercq, N, Raman, JD, Shariat, S & Bensalah, K 2021, 'Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis', International Journal of Clinical Oncology, vol. 26, no. 4, pp. 636-646. https://doi.org/10.1007/s10147-021-01871-6
Lindskrog, SV, Prip, F, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, JB, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, DG, Goel, A, Hurst, CD, Raman, JD, Warrick, JI, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, RT, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w
Bernstein, AN, Talwar, R, Handorf, E, Syed, K, Danella, J, Ginzburg, S, Belkoff, L, Reese, AC, Tomaszewski, J, Trabulsi, E, Singer, EA, Jacobs, B, Kutikov, A, Uzzo, R, Raman, JD, Guzzo, T, Smaldone, MC & Correa, A 2021, 'Assessment of Prostate Cancer Treatment Among Black and White Patients During the COVID-19 Pandemic', JAMA Oncology, vol. 7, no. 10, pp. 1467-1473. https://doi.org/10.1001/jamaoncol.2021.2755
Wu, H, Wang, M, Raman, JD & McDonald, AC 2021, 'Association between urinary arsenic, blood cadmium, blood lead, and blood mercury levels and serum prostate-specific antigen in a population-based cohort of men in the United States', PloS one, vol. 16, no. 4 April, e0250744. https://doi.org/10.1371/journal.pone.0250744
Ferraris, F, Raman, JD & Yaber, F 2022, 'Bladder Chemoprophylaxis Following Ureterorenoscopy in Patients with Upper Tract Urothelial Carcinoma', European Urology Focus, vol. 8, no. 5, pp. 1253-1255. https://doi.org/10.1016/j.euf.2021.07.007
Glick, L, Vincent, SA, Squadron, D, Han, TM, Syed, K, Danella, JF, Ginzburg, S, Guzzo, TJ, Lanchoney, T, Raman, JD, Smaldone, M, Uzzo, RG, Tomaszweski, JJ, Reese, A, Singer, EA, Jacobs, B, Trabulsi, EJ, Gomella, LG & Mann, MJ 2021, 'EDITORIAL COMMENT', Urology, vol. 155, pp. 18. https://doi.org/10.1016/j.urology.2021.02.044
Bernstein, AN, Talwar, R, Handorf, E, Syed, K, Danella, J, Ginzburg, S, Belkoff, L, Reese, AC, Tomaszewski, J, Trabulsi, E, Jacobs, B, Singer, EA, Raman, J, Smaldone, M, Uzzo, R, Guzzo, T & Correa, A 2021, 'Impact of COVID-19 on Initial Management and Evaluation of Prostate Cancer', Urology Practice, vol. 8, no. 6, pp. 668-675. https://doi.org/10.1097/UPJ.0000000000000261
Torab, P, Yan, Y, Ahmed, M, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2021, 'Intratumoral heterogeneity promotes collective cancer invasion through notch1 variation', Cells, vol. 10, no. 11, 3084. https://doi.org/10.3390/cells10113084
Grant Owens, R, Loloi, J, Lehman, EB, Kaag, MG, Raman, JD & Merrill, SB 2021, 'Is pelvic MRI imaging sufficient cross-sectional imaging for staging intermediate and high-risk prostate cancer?', Urologic Oncology: Seminars and Original Investigations, vol. 39, no. 7, pp. 433.e9-433.e15. https://doi.org/10.1016/j.urolonc.2021.01.029
Sternberg, KM, Awad, MA, Goldsmith, M, Hallgarth, LA & Raman, JD 2021, 'Laboratory Reporting Parameters of Microhematuria: Implications for Interpreting the 2020 AUA Guideline', Urology, vol. 154, pp. 24-27. https://doi.org/10.1016/j.urology.2021.04.014
Asghar, AM, McIntosh, AG, Smith, ZL, Kocher, NJ, Lee, Z, Barashi, NN, Li, T, Raman, JD, Eggener, SE, Uzzo, RG & Kutikov, A 2021, 'Pathological characteristics of the large renal mass: potential implication for clinical role of renal biopsy', The Canadian journal of urology, vol. 28, no. 2, pp. 10620-10624.
Segel, JE, Schaefer, EW, Zaorsky, NG, Hollenbeak, CS, Ramian, H & Raman, JD 2021, 'Potential Winners and Losers: Understanding How the Oncology Care Model May Differentially Affect Hospitals', JCO Oncology Practice, vol. 17, no. 8, pp. E1150-E1161. https://doi.org/10.1200/OP.21.00050
Ghandour, RA, Freifeld, Y, Cheaib, J, Singla, N, Meng, X, Kenigsberg, A, Bagrodia, A, Woldu, S, Hoffman-Censits, J, Enikeev, D, Rapoport, L, Petros, FG, Raman, JD, Pierorazio, PM, Matin, SF & Margulis, V 2021, 'Predictive model for systemic recurrence following cisplatin-based neoadjuvant chemotherapy and radical nephroureterectomy for high risk upper tract urothelial carcinoma', Urologic Oncology: Seminars and Original Investigations, vol. 39, no. 11, pp. 788.e15-788.e21. https://doi.org/10.1016/j.urolonc.2021.05.037
Raman, JD 2021, 'President's Message V28S3', The Canadian journal of urology, vol. 28, no. 5, pp. 1.
Glick, L, Vincent, SA, Squadron, D, Han, TM, Syed, K, Danella, JF, Ginzburg, S, Guzzo, TJ, Lanchoney, T, Raman, JD, Smaldone, M, Uzzo, RG, Tomaszweski, JJ, Reese, A, Singer, EA, Jacobs, B, Trabulsi, EJ, Gomella, LG & Mann, MJ 2021, 'Preventing Prostate Biopsy Complications: to Augment or to Swab?', Urology, vol. 155, pp. 12-19. https://doi.org/10.1016/j.urology.2021.02.043
Iyyanki, T, Zhang, B, Wang, Q, Hou, Y, Jin, Q, Xu, J, Yang, H, Liu, T, Wang, X, Song, F, Luan, Y, Yamashita, H, Chien, R, Lyu, H, Zhang, L, Wang, L, Warrick, J, Raman, JD, Meeks, JJ, DeGraff, DJ & Yue, F 2021, 'Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer', Genome biology, vol. 22, no. 1, 105. https://doi.org/10.1186/s13059-021-02325-y
Al Hussein Al Awamlh, B, Shoag, JE, Basourakos, SP, Lewicki, PJ, Posada, L, Ma, X, Raman, JD, Shariat, SF & Scherr, D 2021, 'The Consequences of Inadvertent Radical Nephrectomy in the Treatment of Upper Tract Urothelial Carcinoma', Urology, vol. 154, pp. 127-135. https://doi.org/10.1016/j.urology.2021.03.003
Raman, JD, Kavalieris, L, Konety, B, Porten, S, Daneshmand, S, Lotan, Y & Loo, R 2021, 'The Diagnostic Performance of Cxbladder Resolve, Alone and in Combination with Other Cxbladder Tests, in the Identification and Priority Evaluation of Patients at Risk for Urothelial Carcinoma', Journal of Urology, vol. 206, no. 6, pp. 1380-1388. https://doi.org/10.1097/JU.0000000000002135
IDENTIFY Study group 2021, 'The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer – a multicentre observational study', BJU International, vol. 128, no. 4, pp. 440-450. https://doi.org/10.1111/bju.15483
Ramedani, S, Clark, JY, Knoedler, JJ, MacDonald, S, Kaag, MG, Merrill, SB & Raman, JD 2021, 'Topical antiseptic at time of transrectal ultrasound prostate biopsy is associated with fewer severe clinical infections and improves antibiotic stewardship', Prostate International, vol. 9, no. 4, pp. 185-189. https://doi.org/10.1016/j.prnil.2021.05.003
Thacker, K, Raman, JD, McLean, T, Said, J, Oliver, L & Gore, JL 2021, 'Understanding the Economic Burden of Treating Low-Grade Upper Tract Urothelial Cancer in the United States', Urology Practice, vol. 8, no. 1, pp. 1-7. https://doi.org/10.1097/UPJ.0000000000000161
MacDonald, SM & Raman, JD 2021, 'Widely Variable Parental Leave Practices for Urology Residency Programs in the United States', Urology, vol. 153, pp. 81-86. https://doi.org/10.1016/j.urology.2020.12.049
2020
Loloi, J, Lin, YK, Camacho, F, Lengerich, E & Raman, JD 2020, '25-Year Trends in Stage-Specific Incidence Rates for Bladder Cancer in a Large Statewide Registry', Bladder Cancer, vol. 6, no. 4, pp. 445-451. https://doi.org/10.3233/BLC-200310
Raman, JD 2020, 'Adjuvant and ablative therapies for low-risk UTUC: avenues to enhance kidney preservation', Nature Reviews Urology, vol. 17, no. 8, pp. 433-434. https://doi.org/10.1038/s41585-020-0338-4
Knoedler, JJ & Raman, JD 2020, 'An editorial comment for the special series "upper-Tract Urothelial Carcinoma: Current State and Future Directions', Translational Andrology and Urology, vol. 9, no. 4, pp. 1778-1779. https://doi.org/10.21037/tau-2019-utuc-15
Xia, L, Sperling, CD, Taylor, BL, Talwar, R, Chelluri, RR, Raman, JD, Lee, DJ, Lee, DI & Guzzo, TJ 2020, 'Associations between Hospital Volume and Outcomes of Robot-Assisted Radical Prostatectomy', Journal of Urology, vol. 203, no. 5, pp. 926-932. https://doi.org/10.1097/JU.0000000000000698
Fuletra, JG, Watts, A, Kaag, MG, Lehman, E, Raman, JD & Merrill, SB 2020, 'Can preoperative imaging characteristics predict pT3 bladder cancer following cystectomy?', World Journal of Urology. https://doi.org/10.1007/s00345-020-03375-w
Geiger, S, Kocher, N, Illinsky, D, Xylinas, E, Chang, P, Dewey, L, Wagner, AA, Petros, F, Matin, SF, Tobert, C, Tracy, C, Patard, PM, Roumiguie, M, Monteiro, LL, Kassouf, W & Raman, JD 2020, 'Comparison of the Comprehensive Complication Index and Clavien-Dindo systems in predicting perioperative outcomes following radical nephroureterectomy', Translational Andrology and Urology, vol. 9, no. 4, pp. 1780-1785. https://doi.org/10.21037/tau.2020.01.16
Talwar, R, Friel, B, Mittal, S, Xia, L, Fonshell, C, Danella, J, Jacobs, B, Lanchoney, T, Raman, J, Tomaszewski, J, Trabulsi, E, Reese, A, Singer, EA, Ginzburg, S, Smaldone, M, Uzzo, R, Mucksavage, P, Guzzo, TJ & Lee, DJ 2020, 'Concordance of confirmatory prostate biopsy in active surveillance with national guidelines: An analysis from the multi-institutional PURC cohort', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 11, pp. 846.e17-846.e22. https://doi.org/10.1016/j.urolonc.2020.07.008
Agrawal, S, Johnstonbaugh, K, Clark, JY, Raman, JD, Wang, X & Kothapalli, SR 2020, 'Design, development, and multi-characterization of an integrated clinical transrectal ultrasound and photoacoustic device for human prostate imaging', Diagnostics, vol. 10, no. 8, 566. https://doi.org/10.3390/diagnostics10080566
Watts, A, Kocher, NJ, Pauli, E & Raman, JD 2020, 'Endoscopic Closure of a Large Rectovesical Fistula following Robotic Prostatectomy', Journal of Endourology Case Reports, vol. 6, no. 3, pp. 139-142. https://doi.org/10.1089/cren.2019.0132
Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Durant, AM, Lehman, E, Robyak, H, Merrill, SB, Kaag, MG & Raman, JD 2020, 'Hemostatic agent use during partial nephrectomy: trends, outcomes, and associated costs', International Urology and Nephrology, vol. 52, no. 11, pp. 2073-2078. https://doi.org/10.1007/s11255-020-02538-3
Kocher, NJ, Schilling, A, Hollenbeak, C & Raman, JD 2020, 'Impact of a Preoperative Safety Checklist on Perioperative Quality Outcomes and Operative Efficiency', Urology Practice, vol. 7, no. 6, pp. 502-506. https://doi.org/10.1097/UPJ.0000000000000131
Jeong, SH & Raman, JD 2021, 'Impact of the evolving United States Preventative Services Task Force policy statements on incidence and distribution of prostate cancer over 15 years in a statewide cancer registry', Prostate International, vol. 9, no. 1, pp. 12-17. https://doi.org/10.1016/j.prnil.2020.06.002
Loloi, J, Allen, JL, Schilling, A, Hollenbeak, C, Merrill, SB, Kaag, MG & Raman, JD 2020, 'In the World of Bladder Tumors: Size Does Matter', Bladder Cancer, vol. 6, no. 2, pp. 195-200. https://doi.org/10.3233/BLC-200273
Kocher, NJ, Canes, D, Bensalah, K, Roupret, M, Lallas, C, Margulis, V, Shariat, S, Colin, P, Matin, S, Tracy, C, Xylinas, E, Wagner, A, Roumiguie, M, Kassouf, W, Klatte, T & Raman, JD 2020, 'Incidence and preoperative predictors for major complications following radical nephroureterectomy', Translational Andrology and Urology, vol. 9, no. 4, pp. 1786-1793. https://doi.org/10.21037/tau.2020.01.22
Yeh, HC, Li, CC, Chien, TM, Li, CY, Cheng, YC, Woldu, SL, Robyak, H, Huang, CN, Ke, HL, Li, WM, Lee, HY, Yeh, BW, Yang, SF, Tu, HP, Sagalowsky, AI, Raman, JD, Singla, N, Margulis, V, Lotan, Y, Hsieh, JT & Wu, WJ 2021, 'Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy', World Journal of Urology, vol. 39, no. 2, pp. 491-500. https://doi.org/10.1007/s00345-020-03204-0
Freifeld, Y, Ghandour, R, Singla, N, Woldu, S, Bagrodia, A, Lotan, Y, Rapoport, LM, Gazimiev, M, Delafuente, K, Kulangara, R, Robyak, H, Petros, FG, Raman, JD, Matin, SF & Margulis, V 2020, 'Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 9, pp. 737.e11-737.e16. https://doi.org/10.1016/j.urolonc.2020.05.002
Moynihan, MJ, Sullivan, TB, Burks, E, Schober, J, Calabrese, M, Fredrick, A, Kalantzakos, T, Warrick, J, Canes, D, Raman, JD & Rieger-Christ, K 2020, 'MicroRNA profile in stage I clear cell renal cell carcinoma predicts progression to metastatic disease', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 10, pp. 799.e11-799.e22. https://doi.org/10.1016/j.urolonc.2020.05.006
Barocas, DA, Boorjian, SA, Alvarez, RD, Downs, TM, Gross, CP, Hamilton, BD, Kobashi, KC, Lipman, RR, Lotan, Y, Ng, CK, Nielsen, ME, Peterson, AC, Raman, JD, Smith-Bindman, R & Souter, LH 2020, 'Microhematuria: AUA/SUFU Guideline', Journal of Urology, vol. 204, no. 4, pp. 778-786. https://doi.org/10.1097/JU.0000000000001297
Singla, N, Christie, A, Freifeld, Y, Ghandour, RA, Woldu, SL, Clinton, TN, Petros, FG, Robyak, H, Yeh, HC, Fang, D, Enikeev, D, Bagrodia, A, Sagalowsky, AI, Lotan, Y, Raman, JD, Matin, SF & Margulis, V 2020, 'Pathologic stage as a surrogate for oncologic outcomes after receipt of neoadjuvant chemotherapy for high-grade upper tract urothelial carcinoma', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 12, pp. 933.e7-933.e12. https://doi.org/10.1016/j.urolonc.2020.04.025
Dreyfuss, LD, Master, VA, Raman, JD, Spiess, PE, Wells, SA, Merrill, SB, Peyton, CC, Sankar, D, Sohl, B, Patil, D, Shapiro, DD, Allen, GO & Abel, EJ 2020, 'Patterns of Initial Metastatic Recurrence After Surgery for High-Risk Nonmetastatic Renal Cell Carcinoma', Urology, vol. 146, pp. 152-157. https://doi.org/10.1016/j.urology.2020.07.045
Kleinmann, N, Matin, SF, Pierorazio, PM, Gore, JL, Shabsigh, A, Hu, B, Chamie, K, Godoy, G, Hubosky, S, Rivera, M, O'Donnell, M, Quek, M, Raman, JD, Knoedler, JJ, Scherr, D, Stern, J, Weight, C, Weizer, A, Woods, M, Kaimakliotis, H, Smith, AB, Linehan, J, Coleman, J, Humphreys, MR, Pak, R, Lifshitz, D, Verni, M, Adibi, M, Amin, MB, Seltzer, E, Klein, I, Konorty, M, Strauss-Ayali, D, Hakim, G, Schoenberg, M & Lerner, SP 2020, 'Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial', The Lancet Oncology, vol. 21, no. 6, pp. 776-785. https://doi.org/10.1016/S1470-2045(20)30147-9
McDonald, AC, Wasserman, E, Lengerich, EJ, Raman, JD, Geyer, NR, Hohl, RJ & Wang, M 2020, 'Prostate cancer incidence and aggressiveness in appalachia versus non-appalachia populations in Pennsylvania by urban-rural regions, 2004–2014', Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 7, pp. 1365-1373. https://doi.org/10.1158/1055-9965.EPI-19-1232
Raman, JD 2020, ROBOTIC SURGERY FOR UROLOGIC MALIGNANCIES. in Encyclopedia of Surgery: Volume 1: (22 Volume Set). vol. 1, Nova Science Publishers, Inc., pp. 4345-4366.
Lee, DJ, Talwar, R, Ding, J, Chandrasekar, T, Syed, K, Fonshell, C, Danella, J, Ginzburg, S, Lanchoney, T, Tomaszewski, J, Trabulsi, E, Reese, A, Smaldone, M, Uzzo, R, Raman, JD & Guzzo, TJ 2020, 'Stakeholder Perspective on Opioid Stewardship After Prostatectomy: Evaluating Barriers and Facilitators From the Pennsylvania Urology Regional Collaborative', Urology, vol. 145, pp. 120-126. https://doi.org/10.1016/j.urology.2020.05.096
Merrill, SB, Sohl, BS, Thompson, RH, Reese, AC, Parekh, DJ, Lynch, JH, Grob, BM, Williams, DH, Lee, RK, Zaslau, S, Guzzo, TJ, Shenot, PJ, Lehman, EB & Raman, JD 2020, 'The Balance between Open and Robotic Training among Graduating Urology Residents - Does Surgical Technique Need Monitoring?', Journal of Urology, vol. 203, no. 5, pp. 996-1001. https://doi.org/10.1097/JU.0000000000000689
Fang, D, Singla, N, Bao, Z, Jafri, SM, Su, X, Cao, Z, Xiong, G, Zhang, L, Woldu, S, Hutchinson, R, Sagalowsky, A, Lotan, Y, Li, X, Raman, JD, Margulis, V & Zhou, L 2020, 'The significance of preoperative serum sodium and hemoglobin in outcomes of upper tract urothelial carcinoma: Multi-center analysis between china and the united states', Cancer Management and Research, vol. 12, pp. 9825-9836. https://doi.org/10.2147/CMAR.S267969
Torab, P, Yan, Y, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2020, 'Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer', Analytical Chemistry, vol. 92, no. 13, pp. 8768-8775. https://doi.org/10.1021/acs.analchem.0c00057
Yeh, HC, Li, CC, Wen, SC, Singla, N, Woldu, SL, Robyak, H, Huang, CN, Ke, HL, Li, WM, Lee, HY, Li, CY, Yeh, BW, Yang, SF, Tu, HP, Shariat, SF, Sagalowsky, AI, Raman, JD, Lotan, Y, Hsieh, JT, Margulis, V & Wu, WJ 2020, 'Validation of hyponatremia as a prognostic predictor in multiregional upper tract urothelial carcinoma', Journal of Clinical Medicine, vol. 9, no. 4, 1218. https://doi.org/10.3390/jcm9041218