Researcher Profile

Researcher Profile

Jeffrey Neighbors, PhD

Jeffrey Neighbors, PhD

Associate Professor, Department of Pharmacology
Associate Professor, Department of Medicine
Scientific Program:Mechanisms of Carcinogenesis
jdn188@psu.edu

Research Interests

Dr. Jeffrey Neighbors’ lab is focused on drug development. One current research project is centered on the development of novel agents which inhibit steps in the mevalonate (cholesterol synthesis) pathway to reduce transcription of genes targeted by the Hippo pathway transcription factor TAZ as potential treatments for osteosarcoma.

Additionally, the lab is studying the potential for statin drugs that inhibit this same pathway as treatment for neuroblastoma and other cancers.

A completely different project looks at a family of natural products, pawhuskins, isolated from a prairie plant, that have antagonist activity at several opioid receptors and are under investigation for the potential to increase wound healing by inhibiting opioid growth factor activity.

Before coming to Penn State, Dr. Neighbors worked for a small biotech company driving the drug development efforts and has experience integrating development activity across disciplines from chemical synthesis to pharmacokinetics and ADME/DMPK studies.

  • Neoplasms
  • Biological Products
  • Cell Line
  • Stilbenes
  • Diphosphonates
  • Terpenes
  • Bone and Bones
  • Narcotic Antagonists
  • Glioblastoma
  • Prenylation
  • 3-deoxyschweinfurthin B
  • Growth

Recent Publications

2022

Ebetino, FH, Sun, S, Cherian, P, Roshandel, S, Neighbors, JD, Hu, E, Dunford, JE, Sedghizadeh, PP, McKenna, CE, Srinivasan, V, Boeckman, RK & Russell, RGG 2022, 'Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use', Bone, vol. 156, 116289. https://doi.org/10.1016/j.bone.2021.116289
Manfredi, B, Neighbors, JD & Hohl, RJ 2022, 'Cytotoxic Effects of the Schweinfurthin Analog 5'-Methylschweinfurthin G in Malignant Plasma Cells', Pharmacology, vol. 107, no. 9-10, pp. 510-523. https://doi.org/10.1159/000525299
Ren, Y, Xue, T, Rainbolt, J, Bentley, KLDM, Galloway, CA, Liu, Y, Cherian, P, Neighbors, J, Hofstee, MI, Ebetino, FH, Moriarty, TF, Sun, S, Schwarz, EM & Xie, C 2022, 'Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi', Frontiers in Cellular and Infection Microbiology, vol. 12, 910970. https://doi.org/10.3389/fcimb.2022.910970
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665. https://doi.org/10.1227/neu.0000000000002071
Weissenrieder, JS, Weissenkampen, JD, Reed, JL, Green, MV, Zheng, C, Neighbors, JD, Liu, DJ & Hohl, RJ 2022, 'RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins', Scientific reports, vol. 12, no. 1, 359. https://doi.org/10.1038/s41598-021-04117-7
Zhang, R, Neighbors, JD, Schell, TD & Hohl, RJ 2022, 'Schweinfurthin induces ICD without ER stress and caspase activation', OncoImmunology, vol. 11, no. 1, 2104551. https://doi.org/10.1080/2162402X.2022.2104551
Koubek, EJ, Weissenrieder, JS, Ortiz, LE, Nwogu, N, Pham, AM, Weissenkampen, JD, Reed, JL, Neighbors, JD, Hohl, RJ & Kwun, HJ 2022, 'Therapeutic Potential of 5′-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma', Viruses, vol. 14, no. 9, 1848. https://doi.org/10.3390/v14091848

2021

Weissenrieder, JS, Reed, JL, Moldovan, GL, Johnson, MT, Trebak, M, Neighbors, JD, Mailman, RB & Hohl, RJ 2021, 'Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner', Pharmacology Research and Perspectives, vol. 9, no. 3, e00689. https://doi.org/10.1002/prp2.689
Sun, S, Tao, J, Sedghizadeh, PP, Cherian, P, Junka, AF, Sodagar, E, Xing, L, Boeckman, RK, Srinivasan, V, Yao, Z, Boyce, BF, Lipe, B, Neighbors, JD, Russell, RGG, McKenna, CE & Ebetino, FH 2021, 'Bisphosphonates for delivering drugs to bone', British Journal of Pharmacology, vol. 178, no. 9, pp. 2008-2025. https://doi.org/10.1111/bph.15251
Sedghizadeh, PP, Sun, S, Jones, AC, Sodagar, E, Cherian, P, Chen, C, Junka, AF, Neighbors, JD, McKenna, CE, Russell, RGG & Ebetino, FH 2021, 'Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications', Bone, vol. 147, 115933. https://doi.org/10.1016/j.bone.2021.115933

2019

Huang, X, Sterling, NW, Du, G, Sun, D, Stetter, C, Kong, L, Zhu, Y, Neighbors, J, Lewis, MM, Chen, H, Hohl, RJ & Mailman, RB 2019, 'Brain cholesterol metabolism and Parkinson's disease', Movement Disorders, vol. 34, no. 3, pp. 386-395. https://doi.org/10.1002/mds.27609
Weissenrieder, JS, Neighbors, JD, Mailman, RB & Hohl, RJ 2019, 'Cancer and the dopamine D2 receptor: A pharmacological perspective', Journal of Pharmacology and Experimental Therapeutics, vol. 370, no. 1, pp. 111-126. https://doi.org/10.1124/jpet.119.256818
Larson-Casey, JL, Vaid, M, Gu, L, He, C, Cai, GQ, Ding, Q, Davis, D, Berryhill, TF, Wilson, LS, Barnes, S, Neighbors, JD, Hohl, RJ, Zimmerman, KA, Yoder, BK, Longhini, ALF, Hanumanthu, VS, Surolia, R, Antony, VB & Brent Carter, A 2019, 'Increased flux through the mevalonate pathway mediates fibrotic repair without injury', Journal of Clinical Investigation, vol. 129, no. 11, pp. 4962-4978. https://doi.org/10.1172/JCI127959
Weissenrieder, JS, Reed, JL, Green, MV, Moldovan, GL, Koubek, EJ, Neighbors, JD & Hohl, RJ 2020, 'The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells', Pharmacology, vol. 105, no. 1-2, pp. 19-27. https://doi.org/10.1159/000502562

Clinical Trials Search


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