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Jeffrey Neighbors, PhD

Jeffrey Neighbors, PhD

Associate Professor, Department of Pharmacology
Associate Professor, Department of Medicine
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Dr. Jeffrey Neighbors’ lab is focused on drug development. One current research project is centered on the development of novel agents which inhibit steps in the mevalonate (cholesterol synthesis) pathway to reduce transcription of genes targeted by the Hippo pathway transcription factor TAZ as potential treatments for osteosarcoma.

Additionally, the lab is studying the potential for statin drugs that inhibit this same pathway as treatment for neuroblastoma and other cancers.

A completely different project looks at a family of natural products, pawhuskins, isolated from a prairie plant, that have antagonist activity at several opioid receptors and are under investigation for the potential to increase wound healing by inhibiting opioid growth factor activity.

Before coming to Penn State, Dr. Neighbors worked for a small biotech company driving the drug development efforts and has experience integrating development activity across disciplines from chemical synthesis to pharmacokinetics and ADME/DMPK studies.

  • Neoplasms
  • Biological Products
  • Cell Line
  • Diphosphonates
  • Stilbenes
  • Terpenes
  • Growth
  • Bone and Bones
  • Narcotic Antagonists
  • Glioblastoma
  • Osteomyelitis
  • Prenylation

Recent Publications


Sedghizadeh, PP, Cherian, P, Roshandel, S, Tjokro, N, Chen, C, Junka, AF, Hu, E, Neighbors, J, Pawlak, J, Russell, RGG, McKenna, CE, Ebetino, FH, Sun, S & Sodagar, E 2023, 'Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates', International journal of molecular sciences, vol. 24, no. 3, 1985.


Ebetino, FH, Sun, S, Cherian, P, Roshandel, S, Neighbors, JD, Hu, E, Dunford, JE, Sedghizadeh, PP, McKenna, CE, Srinivasan, V, Boeckman, RK & Russell, RGG 2022, 'Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use', Bone, vol. 156, 116289.
Manfredi, B, Neighbors, JD & Hohl, RJ 2022, 'Cytotoxic Effects of the Schweinfurthin Analog 5'-Methylschweinfurthin G in Malignant Plasma Cells', Pharmacology, vol. 107, no. 9-10, pp. 510-523.
Ren, Y, Xue, T, Rainbolt, J, Bentley, KLDM, Galloway, CA, Liu, Y, Cherian, P, Neighbors, J, Hofstee, MI, Ebetino, FH, Moriarty, TF, Sun, S, Schwarz, EM & Xie, C 2022, 'Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi', Frontiers in Cellular and Infection Microbiology, vol. 12, 910970.
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665.
Weissenrieder, JS, Weissenkampen, JD, Reed, JL, Green, MV, Zheng, C, Neighbors, JD, Liu, DJ & Hohl, RJ 2022, 'RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins', Scientific reports, vol. 12, no. 1, 359.
Zhang, R, Neighbors, JD, Schell, TD & Hohl, RJ 2022, 'Schweinfurthin induces ICD without ER stress and caspase activation', OncoImmunology, vol. 11, no. 1, 2104551.
Koubek, EJ, Weissenrieder, JS, Ortiz, LE, Nwogu, N, Pham, AM, Weissenkampen, JD, Reed, JL, Neighbors, JD, Hohl, RJ & Kwun, HJ 2022, 'Therapeutic Potential of 5′-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma', Viruses, vol. 14, no. 9, 1848.


Weissenrieder, JS, Reed, JL, Moldovan, GL, Johnson, MT, Trebak, M, Neighbors, JD, Mailman, RB & Hohl, RJ 2021, 'Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner', Pharmacology Research and Perspectives, vol. 9, no. 3, e00689.
Sun, S, Tao, J, Sedghizadeh, PP, Cherian, P, Junka, AF, Sodagar, E, Xing, L, Boeckman, RK, Srinivasan, V, Yao, Z, Boyce, BF, Lipe, B, Neighbors, JD, Russell, RGG, McKenna, CE & Ebetino, FH 2021, 'Bisphosphonates for delivering drugs to bone', British Journal of Pharmacology, vol. 178, no. 9, pp. 2008-2025.
Sedghizadeh, PP, Sun, S, Jones, AC, Sodagar, E, Cherian, P, Chen, C, Junka, AF, Neighbors, JD, McKenna, CE, Russell, RGG & Ebetino, FH 2021, 'Bisphosphonates in dentistry: Historical perspectives, adverse effects, and novel applications', Bone, vol. 147, 115933.


Huang, X, Sterling, NW, Du, G, Sun, D, Stetter, C, Kong, L, Zhu, Y, Neighbors, J, Lewis, MM, Chen, H, Hohl, RJ & Mailman, RB 2019, 'Brain cholesterol metabolism and Parkinson's disease', Movement Disorders, vol. 34, no. 3, pp. 386-395.
Weissenrieder, JS, Neighbors, JD, Mailman, RB & Hohl, RJ 2019, 'Cancer and the dopamine D2 receptor: A pharmacological perspective', Journal of Pharmacology and Experimental Therapeutics, vol. 370, no. 1, pp. 111-126.
Larson-Casey, JL, Vaid, M, Gu, L, He, C, Cai, GQ, Ding, Q, Davis, D, Berryhill, TF, Wilson, LS, Barnes, S, Neighbors, JD, Hohl, RJ, Zimmerman, KA, Yoder, BK, Longhini, ALF, Hanumanthu, VS, Surolia, R, Antony, VB & Brent Carter, A 2019, 'Increased flux through the mevalonate pathway mediates fibrotic repair without injury', Journal of Clinical Investigation, vol. 129, no. 11, pp. 4962-4978.
Weissenrieder, JS, Reed, JL, Green, MV, Moldovan, GL, Koubek, EJ, Neighbors, JD & Hohl, RJ 2020, 'The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells', Pharmacology, vol. 105, no. 1-2, pp. 19-27.