Jeffrey Neighbors, PhD - Penn State Cancer Institute
Researcher Profile
Jeffrey Neighbors, PhD
Associate Professor, Department of Molecular and Precision Medicine
Associate Professor, Department of Medicine
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Associate Professor, Department of Medicine
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Blaha, LN, Derosia, NM, Neighbors, JD & Hohl, RJ 2026, 'Does Ras/Rho Have Skin in the Game: The Importance of the Isoprenoid Biosynthesis Pathway in Merkel Cell Carcinoma Cell Lines', Cancers, vol. 18, no. 10, 1579. https://doi.org/10.3390/cancers18101579
Wang, H, Lekkala, S, Ren, Y, Tay, AJH, Neighbors, J, Ebetino, FH, Sun, S, Joseph, NM, Schwarz, EM & Xie, C 2026, 'Effects of hydroxybisphosphonates-conjugated sitafloxacin on fracture healing and skeletal growth in mice', JBMR Plus, vol. 10, no. 3, ziaf195. https://doi.org/10.1093/jbmrpl/ziaf195
Blaha, LN, Neighbors, JD, Sandeep, R, Kondaka, A & Hohl, RJ 2026, 'Exploring the Isoprenoid Biosynthesis Pathway’s Role in Oncogenic Viruses', Viruses, vol. 18, no. 6, 637. https://doi.org/10.3390/v18060637
Green, MV, Reed, JL, Zielinski, CD & Neighbors, JD 2026, 'Inhibition of the Mevalonate Pathway Targets Neuroblastoma Stem Cells', Pharmacology, vol. 111, no. 1, pp. 10-32. https://doi.org/10.1159/000549949
2025
Vanvelk, N, Tapia-Dean, J, Zeiter, S, de Mesy Bentley, K, Xie, C, Ebetino, FH, Sun, S, Neighbors, J, Schwarz, EM & Moriarty, TF 2025, 'Bisphosphonate-Conjugated Sitafloxacin for Treatment of Staphylococcus aureus Infection Associated with Cortical Bone Screws: Case Series in Sheep Model', Pharmaceuticals, vol. 18, no. 5, 675. https://doi.org/10.3390/ph18050675
Depta, L, He, N, Madsen, ML, Nielsen, MLH, Bryce-Rogers, HP, Waterworth, SC, Neighbors, JD, Stockdale, DP, Callahan, MP, Mente, NR, Wiemer, DF, Beutler, JA & Laraia, L 2025, 'Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP)', MedChemComm, vol. 16, no. 12, pp. 6262-6274. https://doi.org/10.1039/d5md00625b
2024
Nachnani, R, Knehans, A, Neighbors, JD, Kocis, PT, Lee, T, Tegeler, K, Trite, T, Raup-Konsavage, WM & Vrana, KE 2024, 'Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis', Frontiers in Pharmacology, vol. 15, 1282831. https://doi.org/10.3389/fphar.2024.1282831
2023
Ren, Y, Weeks, J, Xue, T, Rainbolt, J, de Mesy Bentley, KL, Shu, Y, Liu, Y, Masters, E, Cherian, P, McKenna, CE, Neighbors, J, Ebetino, FH, Schwarz, EM, Sun, S & Xie, C 2023, 'Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis', Bone Research, vol. 11, no. 1, 51. https://doi.org/10.1038/s41413-023-00287-4
Sedghizadeh, PP, Cherian, P, Roshandel, S, Tjokro, N, Chen, C, Junka, AF, Hu, E, Neighbors, J, Pawlak, J, Russell, RGG, McKenna, CE, Ebetino, FH, Sun, S & Sodagar, E 2023, 'Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates', International journal of molecular sciences, vol. 24, no. 3, 1985. https://doi.org/10.3390/ijms24031985
2022
Ebetino, FH, Sun, S, Cherian, P, Roshandel, S, Neighbors, JD, Hu, E, Dunford, JE, Sedghizadeh, PP, McKenna, CE, Srinivasan, V, Boeckman, RK & Russell, RGG 2022, 'Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use', Bone, vol. 156, 116289. https://doi.org/10.1016/j.bone.2021.116289
Manfredi, B, Neighbors, JD & Hohl, RJ 2022, 'Cytotoxic Effects of the Schweinfurthin Analog 5'-Methylschweinfurthin G in Malignant Plasma Cells', Pharmacology, vol. 107, no. 9-10, pp. 510-523. https://doi.org/10.1159/000525299
Ren, Y, Xue, T, Rainbolt, J, Bentley, KLDM, Galloway, CA, Liu, Y, Cherian, P, Neighbors, J, Hofstee, MI, Ebetino, FH, Moriarty, TF, Sun, S, Schwarz, EM & Xie, C 2022, 'Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi', Frontiers in Cellular and Infection Microbiology, vol. 12, 910970. https://doi.org/10.3389/fcimb.2022.910970
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665. https://doi.org/10.1227/neu.0000000000002071
Weissenrieder, JS, Weissenkampen, JD, Reed, JL, Green, MV, Zheng, C, Neighbors, JD, Liu, DJ & Hohl, RJ 2022, 'RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins', Scientific reports, vol. 12, no. 1, 359. https://doi.org/10.1038/s41598-021-04117-7
Zhang, R, Neighbors, JD, Schell, TD & Hohl, RJ 2022, 'Schweinfurthin induces ICD without ER stress and caspase activation', OncoImmunology, vol. 11, no. 1, 2104551. https://doi.org/10.1080/2162402X.2022.2104551
Koubek, EJ, Weissenrieder, JS, Ortiz, LE, Nwogu, N, Pham, AM, Weissenkampen, JD, Reed, JL, Neighbors, JD, Hohl, RJ & Kwun, HJ 2022, 'Therapeutic Potential of 5′-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma', Viruses, vol. 14, no. 9, 1848. https://doi.org/10.3390/v14091848