Researcher Profile

Researcher Profile

Joshua D. Lambert, PhD

Joshua D. Lambert, PhD

Associate Professor, Food Science
Scientific Program:Cancer Control
jdl134@psu.edu

Research Interests

  • Tea
  • Polyphenols
  • epigallocatechin gallate
  • Neoplasms
  • Biological Availability
  • Catechin
  • Inflammation
  • Fats
  • Carcinogenesis
  • Liver
  • Reactive Oxygen Species
  • Obesity

Recent Publications

2020

Khoo, WY, Chrisfield, BJ, Sae-tan, S & Lambert, JD 2020, 'Mitigation of nonalcoholic fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise', Journal of Nutritional Biochemistry, vol. 76, 108262. https://doi.org/10.1016/j.jnutbio.2019.108262

2019

Racine, KC, Lee, AH, Wiersema, BD, Huang, H, Lambert, JD, Stewart, AC & Neilson, AP 2019, 'Development and characterization of a pilot-scale model cocoa fermentation system suitable for studying the impact of fermentation on putative bioactive compounds and bioactivity of cocoa', Foods, vol. 8, no. 3, 102. https://doi.org/10.3390/foods8030102
Racine, KC, Wiersema, BD, Griffin, LE, Essenmacher, LA, Lee, AH, Hopfer, H, Lambert, JD, Stewart, AC & Neilson, AP 2019, 'Flavanol polymerization is a superior predictor of α-glucosidase inhibitory activity compared to flavanol or total polyphenol concentrations in cocoas prepared by variations in controlled fermentation and roasting of the same raw cocoa beans', Antioxidants, vol. 8, no. 12, 635. https://doi.org/10.3390/antiox8120635
Cirillo, S, Urena, JF, Lambert, JD, Vivarelli, F, Canistro, D, Paolini, M, Cardenia, V, Rodriguez-Estrada, MT, Richie, JP & Elias, RJ 2019, 'Impact of electronic cigarette heating coil resistance on the production of reactive carbonyls, reactive oxygen species and induction of cytotoxicity in human lung cancer cells in vitro', Regulatory Toxicology and Pharmacology, vol. 109, 104500. https://doi.org/10.1016/j.yrtph.2019.104500
Dabas, D, Elias, RJ, Ziegler, GR & Lambert, JD 2019, 'In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract', International Journal of Food Science, vol. 2019, 6509421. https://doi.org/10.1155/2019/6509421
Hatzakis, E, Mazzola, EP, Shegog, RM, Ziegler, GR & Lambert, JD 2019, 'Perseorangin: A natural pigment from avocado (Persea americana) seed', Food Chemistry, vol. 293, pp. 15-22. https://doi.org/10.1016/j.foodchem.2019.04.064

2018

Lambert, JD, VanDusen, SR, Cockroft, JE, Smith, EC, Greenwood, DC & Cade, JE 2019, 'Bitter taste sensitivity, food intake, and risk of malignant cancer in the UK Women’s Cohort Study', European Journal of Nutrition, vol. 58, no. 5, pp. 2111-2121. https://doi.org/10.1007/s00394-018-1772-4
Van Buiten, CB, Lambert, JD & Elias, R 2018, 'Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro', Molecular Nutrition and Food Research, vol. 62, no. 12, 1700879. https://doi.org/10.1002/mnfr.201700879
Stanley, TH, Van Buiten, CB, Baker, SA, Elias, R, Anantheswaran, RC & Lambert, JD 2018, 'Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans', Food Chemistry, vol. 255, pp. 414-420. https://doi.org/10.1016/j.foodchem.2018.02.036
James, KD, Kennett, MJ & Lambert, JD 2018, 'Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice', Food and Chemical Toxicology, vol. 111, pp. 302-309. https://doi.org/10.1016/j.fct.2017.11.029
Khoo, WY, Chrisfield, BJ, Colantonio, AJ & Lambert, JD 2018, 'Vitamin-supplemented chewing gum can increase salivary and plasma levels of a panel of vitamins in healthy human participants', Journal of Functional Foods, vol. 50, pp. 37-44. https://doi.org/10.1016/j.jff.2018.09.026

2017

Ryan, CM, Khoo, W, Stewart, AC, O'Keefe, SF, Lambert, JD & Neilson, AP 2017, 'Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories', Food and Function, vol. 8, no. 2, pp. 746-756. https://doi.org/10.1039/c6fo01730d
Vernarelli, JA & Lambert, JD 2017, 'Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults', Nutrition and Diabetes, vol. 7, no. 5, e276. https://doi.org/10.1038/nutd.2017.22
Hao, X, Xiao, H, Ju, J, Lee, MJ, Lambert, JD & Yang, CS 2017, 'Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats', Nutrition and cancer, vol. 69, no. 4, pp. 623-631. https://doi.org/10.1080/01635581.2017.1295088
Richter, CK, Skulas-Ray, AC, Gaugler, TL, Lambert, JD, Proctor, DN & Kris-Etherton, PM 2017, 'Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: A randomized controlled trial', American Journal of Clinical Nutrition, vol. 105, no. 2, pp. 313-322. https://doi.org/10.3945/ajcn.116.141804
Glisan, SL, Grove, KA, Yennawar, NH & Lambert, JD 2017, 'Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies', Food Chemistry, vol. 216, pp. 296-300. https://doi.org/10.1016/j.foodchem.2016.08.052
Darvesh, AS, Mcclure, M, Sadana, P, Paxos, C, Geldenhuys, WJ, Lambert, JD, Haqqi, TM & Richardson, JR 2017, Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease. in Neuroprotective Effects of Phytochemicals in Neurological Disorders. wiley, pp. 243-263. https://doi.org/10.1002/9781119155195.ch11
Bitzer, ZT, Wopperer, AL, Chrisfield, BJ, Tao, L, Cooper, TK, Vanamala, J, Elias, RJ, Hayes, JE & Lambert, JD 2017, 'Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo', Journal of Nutritional Biochemistry, vol. 40, pp. 201-208. https://doi.org/10.1016/j.jnutbio.2016.11.012

2016

Bitzer, ZT, Elias, R, Kumar, MV & Lambert, JD 2016, '(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss', Molecular Nutrition and Food Research, vol. 60, no. 10, pp. 2267-2274. https://doi.org/10.1002/mnfr.201501042
Ziegler, GR, Hayes, JE & Lambert, JD 2016, 'Chocolate not necessarily healthier or tastier', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 42, pp. E6318. https://doi.org/10.1073/pnas.1614178113
Glisan, SL, Ryan, C, Neilson, AP & Lambert, JD 2016, 'Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice', Journal of Nutritional Biochemistry, vol. 37, pp. 60-66. https://doi.org/10.1016/j.jnutbio.2016.07.009
Yeoh, BS, Aguilera Olvera, R, Singh, V, Xiao, X, Kennett, MJ, Joe, B, Lambert, JD & Vijay-Kumar, M 2016, 'Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation', American Journal of Pathology, vol. 186, no. 4, pp. 912-926. https://doi.org/10.1016/j.ajpath.2015.12.004
Hao, L, Huang, KH, Ito, K, Sae-Tan, S, Lambert, JD & Ross, AC 2016, 'Fibroblast growth factor 21 (FGF21) gene expression is elevated in the liver of mice fed a high-carbohydrate liquid diet and attenuated by a lipid emulsion but is not upregulated in the liver of mice fed a high-fat obesogenic diet', Journal of Nutrition, vol. 146, no. 2, pp. 184-190. https://doi.org/10.3945/jn.115.216572
Reddivari, L, Charepalli, V, Radhakrishnan, S, Vadde, R, Elias, RJ, Lambert, JD & Vanamala, JKP 2016, 'Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis', BMC complementary and alternative medicine, vol. 16, no. 1, 278. https://doi.org/10.1186/s12906-016-1254-2
Ryan, CM, Khoo, W, Ye, L, Lambert, JD, Okeefe, SF & Neilson, AP 2016, 'Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa', Journal of agricultural and food chemistry, vol. 64, no. 18, pp. 3616-3625. https://doi.org/10.1021/acs.jafc.6b01725
O'Shea, D, Law, J, Egli, A, Douglas, D, Lund, G, Forester, S, Lambert, J, Law, M, Burton, DR, Tyrrell, DLJ, Houghton, M, Humar, A & Kneteman, N 2016, 'Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate', Liver Transplantation, vol. 22, no. 3, pp. 324-332. https://doi.org/10.1002/lt.24344

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)