Researcher Profile

Researcher Profile

Joshua D. Lambert, PhD

Joshua D. Lambert, PhD

Associate Professor, Food Science
Scientific Program:Cancer Control

Research Interests

  • Tea
  • Polyphenols
  • epigallocatechin gallate
  • Neoplasms
  • Catechin
  • Biological Availability
  • Inflammation
  • Carcinogenesis
  • Fats
  • Liver
  • Growth
  • Antioxidants

Recent Publications


Racine, KC, Lee, AH, Wiersema, BD, Huang, H, Lambert, JD, Stewart, AC & Neilson, AP 2019, 'Development and characterization of a pilot-scale model cocoa fermentation system suitable for studying the impact of fermentation on putative bioactive compounds and bioactivity of cocoa', Foods, vol. 8, no. 3, 102.
Dabas, D, Elias, R, Ziegler, GR & Lambert, JD 2019, 'In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract' International Journal of Food Science, vol. 2019, 6509421.
Hatzakis, E, Mazzola, EP, Shegog, RM, Ziegler, GR & Lambert, JD 2019, 'Perseorangin: A natural pigment from avocado (Persea americana) seed', Food Chemistry, vol. 293, pp. 15-22.


Lambert, JD, VanDusen, SR, Cockroft, JE, Smith, EC, Greenwood, DC & Cade, JE 2019, 'Bitter taste sensitivity, food intake, and risk of malignant cancer in the UK Women’s Cohort Study', European Journal of Nutrition, vol. 58, no. 5, pp. 2111-2121.
Van Buiten, CB, Lambert, JD & Elias, R 2018, 'Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro', Molecular Nutrition and Food Research, vol. 62, no. 12, 1700879.
Stanley, TH, Van Buiten, CB, Baker, SA, Elias, R, Anantheswaran, RC & Lambert, JD 2018, 'Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans', Food Chemistry, vol. 255, pp. 414-420.
James, KD, Kennett, MJ & Lambert, JD 2018, 'Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice', Food and Chemical Toxicology, vol. 111, pp. 302-309.
Khoo, WY, Chrisfield, BJ, Colantonio, AJ & Lambert, JD 2018, 'Vitamin-supplemented chewing gum can increase salivary and plasma levels of a panel of vitamins in healthy human participants' Journal of Functional Foods, vol. 50, pp. 37-44.


Ryan, CM, Khoo, W, Stewart, AC, O'Keefe, SF, Lambert, JD & Neilson, AP 2017, 'Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories', Food and Function, vol. 8, no. 2, pp. 746-756.
Vernarelli, JA & Lambert, JD 2017, 'Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults', Nutrition and Diabetes, vol. 7, no. 5, e276.
Hao, X, Xiao, H, Ju, J, Lee, MJ, Lambert, JD & Yang, CS 2017, 'Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats', Nutrition and Cancer, vol. 69, no. 4, pp. 623-631.
Richter, CK, Skulas-Ray, AC, Gaugler, TL, Lambert, JD, Proctor, DN & Kris-Etherton, PM 2017, 'Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: A randomized controlled trial', American Journal of Clinical Nutrition, vol. 105, no. 2, pp. 313-322.
Glisan, SL, Grove, KA, Yennawar, N & Lambert, JD 2017, 'Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies', Food Chemistry, vol. 216, pp. 296-300.
Darvesh, AS, Mcclure, M, Sadana, P, Paxos, C, Geldenhuys, WJ, Lambert, JD, Haqqi, TM & Richardson, JR 2017, Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease. in Neuroprotective Effects of Phytochemicals in Neurological Disorders. wiley, pp. 243-263.
Bitzer, ZT, Wopperer, AL, Chrisfield, BJ, Tao, L, Cooper, T, Vanamala, JKP, Elias, R, Hayes, JE & Lambert, JD 2017, 'Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo', Journal of Nutritional Biochemistry, vol. 40, pp. 201-208.


Bitzer, ZT, Elias, R, Kumar, MV & Lambert, JD 2016, '(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss', Molecular Nutrition and Food Research, vol. 60, no. 10, pp. 2267-2274.
Ziegler, GR, Hayes, JE & Lambert, JD 2016, 'Chocolate not necessarily healthier or tastier', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 42, pp. E6318.
Glisan, SL, Ryan, C, Neilson, AP & Lambert, JD 2016, 'Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice', Journal of Nutritional Biochemistry, vol. 37, pp. 60-66.
Yeoh, BS, Aguilera Olvera, R, Singh, V, Xiao, X, Kennett, MJ, Joe, B, Lambert, JD & Kumar, MV 2016, 'Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation', American Journal of Pathology, vol. 186, no. 4, pp. 912-926.
Hao, L, Huang, KH, Ito, K, Sae-Tan, S, Lambert, JD & Ross, AC 2016, 'Fibroblast growth factor 21 (FGF21) gene expression is elevated in the liver of mice fed a high-carbohydrate liquid diet and attenuated by a lipid emulsion but is not upregulated in the liver of mice fed a high-fat obesogenic diet', Journal of Nutrition, vol. 146, no. 2, pp. 184-190.
Reddivari, L, Charepalli, V, Radhakrishnan, S, Vadde, R, Elias, R, Lambert, JD & Vanamala, JKP 2016, 'Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis', BMC Complementary and Alternative Medicine, vol. 16, no. 1, 278.
Ryan, CM, Khoo, W, Ye, L, Lambert, JD, Okeefe, SF & Neilson, AP 2016, 'Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa', Journal of agricultural and food chemistry, vol. 64, no. 18, pp. 3616-3625.
O'Shea, D, Law, J, Egli, A, Douglas, D, Lund, G, Forester, S, Lambert, JD, Law, M, Burton, DR, Tyrrell, DLJ, Houghton, M, Humar, A & Kneteman, N 2016, 'Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate', Liver Transplantation, vol. 22, no. 3, pp. 324-332.


Stanley, TH, Smithson, AT, Neilson, AP, Anantheswaran, RC & Lambert, JD 2015, 'Analysis of Cocoa Proanthocyanidins Using Reversed Phase High-Performance Liquid Chromatography and Electrochemical Detection: Application to Studies on the Effect of Alkaline Processing', Journal of agricultural and food chemistry, vol. 63, no. 25, pp. 5970-5975.
Bitzer, ZT, Glisan, SL, Dorenkott, MR, Goodrich, KM, Ye, L, O'Keefe, SF, Lambert, JD & Neilson, AP 2015, 'Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation', Journal of Nutritional Biochemistry, vol. 26, no. 8, pp. 827-831.
Sae-tan, S, Rogers, CJ & Lambert, JD 2015, 'Decaffeinated green tea and voluntary exercise induce gene changes related to beige adipocyte formation in high fat-fed obese mice' Journal of Functional Foods, vol. 14, pp. 210-214.
James, KD, Forester, SC & Lambert, JD 2015, 'Dietary pretreatment with green tea polyphenol, (-)-epigallocatechin-3-gallate reduces the bioavailability and hepatotoxicity of subsequent oral bolus doses of (-)-epigallocatechin-3-gallate' Food and Chemical Toxicology, vol. 76, pp. 103-108.
Tao, L, Park, JY & Lambert, JD 2015, 'Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling', Molecular Nutrition and Food Research, vol. 59, no. 2, pp. 203-211.
McCrea, CE, West, SG, Kris-Etherton, PM, Lambert, JD, Gaugler, TL, Teeter, DL, Sauder, KA, Gu, Y, Glisan, SL & Skulas-Ray, AC 2015, 'Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: Results of a randomized crossover study and in vitro experiments', Journal of Translational Medicine, vol. 13, no. 1, 7.
Kwon, SJ, Lambert, JD, Yang, CS & Hong, J 2015, 'Role of reactive oxygen species from the green tea catechin, (−)-epigallocatechin-3-gallate in growth modulation of intestinal cells' Food Science and Biotechnology, vol. 24, no. 4, pp. 1541-1548.
Forester, SC & Lambert, JD 2015, 'The catechol-O-methyltransferase inhibitor, tolcapone, increases the bioavailability of unmethylated (-)-epigallocatechin-3-gallate in mice' Journal of Functional Foods, vol. 17, pp. 183-188.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)