Researcher Profile

Researcher Profile

Joshua D. Lambert, PhD

Joshua D. Lambert, PhD

Associate Professor, Food Science
Scientific Program:Cancer Control
jdl134@psu.edu

Research Interests

  • Tea
  • Polyphenols
  • epigallocatechin gallate
  • Neoplasms
  • Catechin
  • Biological Availability
  • Inflammation
  • Carcinogenesis
  • Fats
  • Liver
  • Growth
  • Antioxidants

Recent Publications

2019

Racine, KC, Lee, AH, Wiersema, BD, Huang, H, Lambert, JD, Stewart, AC & Neilson, AP 2019, 'Development and characterization of a pilot-scale model cocoa fermentation system suitable for studying the impact of fermentation on putative bioactive compounds and bioactivity of cocoa', Foods, vol. 8, no. 3, 102. https://doi.org/10.3390/foods8030102
Dabas, D, Elias, R, Ziegler, GR & Lambert, JD 2019, 'In Vitro Antioxidant and Cancer Inhibitory Activity of a Colored Avocado Seed Extract' International Journal of Food Science, vol. 2019, 6509421. https://doi.org/10.1155/2019/6509421
Hatzakis, E, Mazzola, EP, Shegog, RM, Ziegler, GR & Lambert, JD 2019, 'Perseorangin: A natural pigment from avocado (Persea americana) seed', Food Chemistry, vol. 293, pp. 15-22. https://doi.org/10.1016/j.foodchem.2019.04.064

2018

Lambert, JD, VanDusen, SR, Cockroft, JE, Smith, EC, Greenwood, DC & Cade, JE 2019, 'Bitter taste sensitivity, food intake, and risk of malignant cancer in the UK Women’s Cohort Study', European Journal of Nutrition, vol. 58, no. 5, pp. 2111-2121. https://doi.org/10.1007/s00394-018-1772-4
Van Buiten, CB, Lambert, JD & Elias, R 2018, 'Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro', Molecular Nutrition and Food Research, vol. 62, no. 12, 1700879. https://doi.org/10.1002/mnfr.201700879
Stanley, TH, Van Buiten, CB, Baker, SA, Elias, R, Anantheswaran, RC & Lambert, JD 2018, 'Impact of roasting on the flavan-3-ol composition, sensory-related chemistry, and in vitro pancreatic lipase inhibitory activity of cocoa beans', Food Chemistry, vol. 255, pp. 414-420. https://doi.org/10.1016/j.foodchem.2018.02.036
James, KD, Kennett, MJ & Lambert, JD 2018, 'Potential role of the mitochondria as a target for the hepatotoxic effects of (-)-epigallocatechin-3-gallate in mice', Food and Chemical Toxicology, vol. 111, pp. 302-309. https://doi.org/10.1016/j.fct.2017.11.029
Khoo, WY, Chrisfield, BJ, Colantonio, AJ & Lambert, JD 2018, 'Vitamin-supplemented chewing gum can increase salivary and plasma levels of a panel of vitamins in healthy human participants' Journal of Functional Foods, vol. 50, pp. 37-44. https://doi.org/10.1016/j.jff.2018.09.026

2017

Ryan, CM, Khoo, W, Stewart, AC, O'Keefe, SF, Lambert, JD & Neilson, AP 2017, 'Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories', Food and Function, vol. 8, no. 2, pp. 746-756. https://doi.org/10.1039/c6fo01730d
Vernarelli, JA & Lambert, JD 2017, 'Flavonoid intake is inversely associated with obesity and C-reactive protein, a marker for inflammation, in US adults', Nutrition and Diabetes, vol. 7, no. 5, e276. https://doi.org/10.1038/nutd.2017.22
Hao, X, Xiao, H, Ju, J, Lee, MJ, Lambert, JD & Yang, CS 2017, 'Green Tea Polyphenols Inhibit Colorectal Tumorigenesis in Azoxymethane-Treated F344 Rats', Nutrition and Cancer, vol. 69, no. 4, pp. 623-631. https://doi.org/10.1080/01635581.2017.1295088
Richter, CK, Skulas-Ray, AC, Gaugler, TL, Lambert, JD, Proctor, DN & Kris-Etherton, PM 2017, 'Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: A randomized controlled trial', American Journal of Clinical Nutrition, vol. 105, no. 2, pp. 313-322. https://doi.org/10.3945/ajcn.116.141804
Glisan, SL, Grove, KA, Yennawar, N & Lambert, JD 2017, 'Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies', Food Chemistry, vol. 216, pp. 296-300. https://doi.org/10.1016/j.foodchem.2016.08.052
Darvesh, AS, Mcclure, M, Sadana, P, Paxos, C, Geldenhuys, WJ, Lambert, JD, Haqqi, TM & Richardson, JR 2017, Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease. in Neuroprotective Effects of Phytochemicals in Neurological Disorders. wiley, pp. 243-263. https://doi.org/10.1002/9781119155195.ch11
Bitzer, ZT, Wopperer, AL, Chrisfield, BJ, Tao, L, Cooper, T, Vanamala, JKP, Elias, R, Hayes, JE & Lambert, JD 2017, 'Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo', Journal of Nutritional Biochemistry, vol. 40, pp. 201-208. https://doi.org/10.1016/j.jnutbio.2016.11.012

2016

Bitzer, ZT, Elias, R, Kumar, MV & Lambert, JD 2016, '(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss', Molecular Nutrition and Food Research, vol. 60, no. 10, pp. 2267-2274. https://doi.org/10.1002/mnfr.201501042
Ziegler, GR, Hayes, JE & Lambert, JD 2016, 'Chocolate not necessarily healthier or tastier', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 42, pp. E6318. https://doi.org/10.1073/pnas.1614178113
Glisan, SL, Ryan, C, Neilson, AP & Lambert, JD 2016, 'Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice', Journal of Nutritional Biochemistry, vol. 37, pp. 60-66. https://doi.org/10.1016/j.jnutbio.2016.07.009
Yeoh, BS, Aguilera Olvera, R, Singh, V, Xiao, X, Kennett, MJ, Joe, B, Lambert, JD & Kumar, MV 2016, 'Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation', American Journal of Pathology, vol. 186, no. 4, pp. 912-926. https://doi.org/10.1016/j.ajpath.2015.12.004
Hao, L, Huang, KH, Ito, K, Sae-Tan, S, Lambert, JD & Ross, AC 2016, 'Fibroblast growth factor 21 (FGF21) gene expression is elevated in the liver of mice fed a high-carbohydrate liquid diet and attenuated by a lipid emulsion but is not upregulated in the liver of mice fed a high-fat obesogenic diet', Journal of Nutrition, vol. 146, no. 2, pp. 184-190. https://doi.org/10.3945/jn.115.216572
Reddivari, L, Charepalli, V, Radhakrishnan, S, Vadde, R, Elias, R, Lambert, JD & Vanamala, JKP 2016, 'Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis', BMC Complementary and Alternative Medicine, vol. 16, no. 1, 278. https://doi.org/10.1186/s12906-016-1254-2
Ryan, CM, Khoo, W, Ye, L, Lambert, JD, Okeefe, SF & Neilson, AP 2016, 'Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa', Journal of agricultural and food chemistry, vol. 64, no. 18, pp. 3616-3625. https://doi.org/10.1021/acs.jafc.6b01725
O'Shea, D, Law, J, Egli, A, Douglas, D, Lund, G, Forester, S, Lambert, JD, Law, M, Burton, DR, Tyrrell, DLJ, Houghton, M, Humar, A & Kneteman, N 2016, 'Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate', Liver Transplantation, vol. 22, no. 3, pp. 324-332. https://doi.org/10.1002/lt.24344

2015

Stanley, TH, Smithson, AT, Neilson, AP, Anantheswaran, RC & Lambert, JD 2015, 'Analysis of Cocoa Proanthocyanidins Using Reversed Phase High-Performance Liquid Chromatography and Electrochemical Detection: Application to Studies on the Effect of Alkaline Processing', Journal of agricultural and food chemistry, vol. 63, no. 25, pp. 5970-5975. https://doi.org/10.1021/acs.jafc.5b02661
Bitzer, ZT, Glisan, SL, Dorenkott, MR, Goodrich, KM, Ye, L, O'Keefe, SF, Lambert, JD & Neilson, AP 2015, 'Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation', Journal of Nutritional Biochemistry, vol. 26, no. 8, pp. 827-831. https://doi.org/10.1016/j.jnutbio.2015.02.007
Sae-tan, S, Rogers, CJ & Lambert, JD 2015, 'Decaffeinated green tea and voluntary exercise induce gene changes related to beige adipocyte formation in high fat-fed obese mice' Journal of Functional Foods, vol. 14, pp. 210-214. https://doi.org/10.1016/j.jff.2015.01.036
James, KD, Forester, SC & Lambert, JD 2015, 'Dietary pretreatment with green tea polyphenol, (-)-epigallocatechin-3-gallate reduces the bioavailability and hepatotoxicity of subsequent oral bolus doses of (-)-epigallocatechin-3-gallate' Food and Chemical Toxicology, vol. 76, pp. 103-108. https://doi.org/10.1016/j.fct.2014.12.009
Tao, L, Park, JY & Lambert, JD 2015, 'Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling', Molecular Nutrition and Food Research, vol. 59, no. 2, pp. 203-211. https://doi.org/10.1002/mnfr.201400485
McCrea, CE, West, SG, Kris-Etherton, PM, Lambert, JD, Gaugler, TL, Teeter, DL, Sauder, KA, Gu, Y, Glisan, SL & Skulas-Ray, AC 2015, 'Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: Results of a randomized crossover study and in vitro experiments', Journal of Translational Medicine, vol. 13, no. 1, 7. https://doi.org/10.1186/s12967-014-0360-5
Kwon, SJ, Lambert, JD, Yang, CS & Hong, J 2015, 'Role of reactive oxygen species from the green tea catechin, (−)-epigallocatechin-3-gallate in growth modulation of intestinal cells' Food Science and Biotechnology, vol. 24, no. 4, pp. 1541-1548. https://doi.org/10.1007/s10068-015-0198-5
Forester, SC & Lambert, JD 2015, 'The catechol-O-methyltransferase inhibitor, tolcapone, increases the bioavailability of unmethylated (-)-epigallocatechin-3-gallate in mice' Journal of Functional Foods, vol. 17, pp. 183-188. https://doi.org/10.1016/j.jff.2015.05.012

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