Researcher Profile

Researcher Profile

Hong-Gang Wang, PhD

Hong-Gang Wang, PhD

Lois High Berstler Professor, Department of Pediatrics
Division of Hematology and Oncology
Lois High Berstler Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
huw11@psu.edu
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Research Interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

  • Apoptosis
  • Proteins
  • Autophagy
  • Neoplasms
  • Cell Death
  • Membranes
  • Mitochondria
  • Phosphorylation
  • Acute Myeloid Leukemia
  • Cell Survival
  • Autophagosomes
  • Caspase 3

Recent Publications

2020

Flower, TG, Takahashi, Y, Hudait, A, Rose, K, Tjahjono, N, Pak, AJ, Yokom, AL, Liang, X, Wang, HG, Bouamr, F, Voth, GA & Hurley, JH 2020, 'A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission', Nature Structural and Molecular Biology, vol. 27, no. 6, pp. 570-580. https://doi.org/10.1038/s41594-020-0426-4
Pearson, JM, Tan, SF, Sharma, A, Annageldiyev, C, Fox, TE, Abad, JL, Fabrias, G, Desai, D, Amin, S, Wang, HG, Cabot, MC, Claxton, DF, Kester, M, Feith, DJ & Loughran, TP 2020, 'Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia', Molecular Cancer Research, vol. 18, no. 3, pp. 352-363. https://doi.org/10.1158/1541-7786.MCR-19-0619
Sun, L, Jiang, L, Grant, CN, Wang, HG, Gragnoli, C, Liu, Z & Wu, R 2020, 'Computational identification of gene networks as a biomarker of neuroblastoma risk', Cancers, vol. 12, no. 8, 2086, pp. 1-17. https://doi.org/10.3390/cancers12082086
Zhou, M, Weber, SR, Zhao, Y, Chen, H, Barber, AJ, Grillo, SL, Wills, CA, Wang, HG, Hulleman, JD & Sundstrom, JM 2020, 'Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells', Frontiers in Cell and Developmental Biology, vol. 8, 469. https://doi.org/10.3389/fcell.2020.00469
Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16. https://doi.org/10.3390/cancers12071739
Gebru, MT, Atkinson, JM, Young, MM, Zhang, L, Tang, Z, Liu, Z, Lu, P, Dower, CM, Chen, L, Annageldiyev, C, Sharma, A, Kawasawa, YI, Zhao, Z, Miller, BA, Claxton, DF & Wang, HG 2020, 'Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia', Blood, vol. 136, no. 9, pp. 1067-1079. https://doi.org/10.1182/blood.2019003124
Hattori, T, Takahashi, Y, Chen, L, Tang, Z, Wills, CA, Liang, X & Wang, H-G 2020, 'Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes', Cell Death and Differentiation. https://doi.org/10.1038/s41418-020-00610-0
Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247. https://doi.org/10.1038/s41419-020-2454-8

2019

Tang, Z, Takahashi, Y & Wang, HG 2019, 'ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes', Autophagy, vol. 15, no. 12, pp. 2165-2166. https://doi.org/10.1080/15548627.2019.1666594
Tan, SF, Dunton, W, Liu, X, Fox, TE, Morad, SAF, Desai, D, Doi, K, Conaway, MR, Amin, S, Claxton, DF, Wang, HG, Kester, M, Cabot, MC, Feith, DJ & Loughran, TP 2019, 'Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation', Journal of Lipid Research, vol. 60, no. 6, pp. 1078-1086. https://doi.org/10.1194/jlr.M091876
Cho, SG, Xiao, X, Wang, S, Gao, H, Rafikov, R, Black, S, Huang, S, Ding, HF, Yoon, Y, Kirken, RA, Yin, XM, Wang, HG & Dong, Z 2019, 'Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis', Journal of the American Society of Nephrology, vol. 30, no. 7, pp. 1174-1191. https://doi.org/10.1681/ASN.2018111117
Rice, SJ, Liu, X, Wang, HG & Belani, CP 2019, 'EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer', PloS one, vol. 14, no. 5, e0217657. https://doi.org/10.1371/journal.pone.0217657
Young, MM, Bui, V, Chen, C & Wang, HG 2019, 'FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia', Cell Death and Disease, vol. 10, no. 11, 847. https://doi.org/10.1038/s41419-019-2080-5
Morad, SAF, MacDougall, MR, Abdelmageed, N, Kao, LP, Feith, DJ, Tan, SF, Kester, M, Loughran, TP, Wang, HG & Cabot, MC 2019, 'Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen', Experimental Cell Research, vol. 381, no. 2, pp. 256-264. https://doi.org/10.1016/j.yexcr.2019.05.021
Barth, BM, Wang, W, Toran, PT, Fox, TE, Annageldiyev, C, Ondrasik, RM, Keasey, NR, Brown, TJ, Devine, VG, Sullivan, EC, Cote, AL, Papakotsi, V, Tan, SF, Shanmugavelandy, SS, Deering, TG, Needle, DB, Stern, ST, Zhu, J, Liao, J, Viny, AD, Feith, DJ, Levine, RL, Wang, HG, Loughran, TP, Sharma, A, Kester, M & Claxton, DF 2019, 'Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia', Blood Advances, vol. 3, no. 17, pp. 2598-2603. https://doi.org/10.1182/bloodadvances.2018021295
Tang, Z, Takahashi, Y, He, H, Hattori, T, Chen, C, Liang, X, Chen, H, Young, MM & Wang, HG 2019, 'TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion', Cell Reports, vol. 28, no. 7, pp. 1744-1757.e5. https://doi.org/10.1016/j.celrep.2019.07.036
Bao, L, Festa, F, Freet, CS, Lee, JP, Hirschler-Laszkiewicz, IM, Chen, SJ, Keefer, KA, Wang, HG, Patterson, AD, Cheung, JY & Miller, BA 2019, 'The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2', Scientific reports, vol. 9, no. 1, 14132. https://doi.org/10.1038/s41598-019-50661-8
Atkinson, JM, Ye, Y, Gebru, MT, Liu, Q, Zhou, S, Young, MM, Takahashi, Y, Lin, Q, Tian, F & Wang, HG 2019, 'Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins', Journal of Biological Chemistry, vol. 294, no. 38, pp. 14033-14042. https://doi.org/10.1074/jbc.RA119.008723
Takahashi, Y, Liang, X, Hattori, T, Tang, Z, He, H, Chen, H, Liu, X, Abraham, T, Imamura-Kawasawa, Y, Buchkovich, NJ, Young, MM & Wang, HG 2019, 'VPS37A directs ESCRT recruitment for phagophore closure', The Journal of cell biology, vol. 218, no. 10, pp. 3336-3354. https://doi.org/10.1083/jcb.201902170

2018

Takahashi, Y, He, H, Tang, Z, Hattori, T, Liu, Y, Young, MM, Serfass, JM, Chen, L, Gebru, M, Chen, C, Wills, CA, Atkinson, JM, Chen, H, Abraham, T & Wang, HG 2018, 'An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure', Nature communications, vol. 9, no. 1, 2855. https://doi.org/10.1038/s41467-018-05254-w
Liu, Z, Wei, Y, Zhang, L, Yee, PP, Johnson, M, Zhang, X, Gulley, M, Atkinson, JM, Trebak, M, Wang, H-G & Li, W 2019, 'Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ', Oncogene, vol. 38, no. 1, pp. 120-139. https://doi.org/10.1038/s41388-018-0425-7
Clements, KE, Thakar, T, Nicolae, CM, Liang, X, Wang, HG & Moldovan, GL 2018, 'Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells', Nucleic acids research, vol. 46, no. 17, pp. 8898-8907. https://doi.org/10.1093/nar/gky657
Dower, CM, Wills, CA, Frisch, SM & Wang, HG 2018, 'Mechanisms and context underlying the role of autophagy in cancer metastasis', Autophagy, vol. 14, no. 7, pp. 1110-1128. https://doi.org/10.1080/15548627.2018.1450020
Young, MM & Wang, HG 2018, Sphingolipids as Regulators of Autophagy and Endocytic Trafficking. in CE Chalfant & PB Fisher (eds), Advances in Cancer Research. Advances in Cancer Research, vol. 140, Academic Press Inc., pp. 27-60. https://doi.org/10.1016/bs.acr.2018.04.008
Lima, S, Takabe, K, Newton, J, Saurabh, K, Young, MM, Leopoldino, AM, Hait, NC, Roberts, JL, Wang, HG, Dent, P, Milstien, S, Booth, L & Spiegel, S 2018, 'TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition', Autophagy, vol. 14, no. 6, pp. 942-957. https://doi.org/10.1080/15548627.2018.1429875
Dower, CM, Bhat, N, Gebru, MT, Chen, L, Wills, CA, Miller, BA & Wang, HG 2018, 'Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma', Molecular cancer therapeutics, vol. 17, no. 11, pp. 2365-2376. https://doi.org/10.1158/1535-7163.MCT-18-0176

2017

Tang, Z, Takahashi, Y, Chen, C, Liu, Y, He, H, Tsotakos, N, Serfass, JM, Gebru, MT, Chen, H, Young, MM & Wang, HG 2017, 'Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis', Cell Death and Differentiation, vol. 24, no. 12, pp. 2127-2138. https://doi.org/10.1038/cdd.2017.133
Serfass, JM, Takahashi, Y, Zhou, Z, Kawasawa, YI, Liu, Y, Tsotakos, N, Young, MM, Tang, Z, Yang, L, Atkinson, JM, Chroneos, ZC & Wang, HG 2017, 'Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection', Journal of Biological Chemistry, vol. 292, no. 24, pp. 10097-10111. https://doi.org/10.1074/jbc.M117.792747
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Kawasawa, YI, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, DF, Rybka, WB, Drabick, JJ, Wang, HG, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, JJ 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features', Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Fino, KK, Yang, L, Silveyra, P, Hu, S, Umstead, TM, Diangelo, S, Halstead, ES, Cooper, TK, Abraham, T, Takahashi, Y, Zhou, Z, Wang, HG & Chroneos, ZC 2017, 'SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection', Scientific reports, vol. 7, no. 1, 7262. https://doi.org/10.1038/s41598-017-07724-5
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models', Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121. <http://www.cancertm.com/article.asp?issn=2395-3977;year=2017;volume=3;issue=4;spage=109;epage=121;aulast=Hengst;type=0>
Dower, CM, Bhat, N, Wang, EW & Wang, HG 2017, 'Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis', Cancer Research, vol. 77, no. 3, pp. 646-657. https://doi.org/10.1158/0008-5472.CAN-15-3458

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