Researcher Profile

Researcher Profile

Hong-Gang Wang, PhD

Hong-Gang Wang, PhD

Lois High Berstler Professor, Department of Pediatrics
Division of Hematology and Oncology
Lois High Berstler Professor, Department of Pharmacology
Scientific Program:Experimental Therapeutics
huw11@psu.edu
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Research Interests

Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.

  • Apoptosis
  • Proteins
  • Autophagy
  • Neoplasms
  • Cell Death
  • Membranes
  • Mitochondria
  • Therapeutics
  • Caspase 3
  • Phosphorylation
  • Cell Survival
  • Breast Neoplasms

Recent Publications

2019

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Cho, SG, Xiao, X, Wang, S, Gao, H, Rafikov, R, Black, S, Huang, S, Ding, HF, Yoon, Y, Kirken, RA, Yin, XM, Wang, H-G & Dong, Z 2019, 'Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis', Journal of the American Society of Nephrology, vol. 30, no. 7, pp. 1174-1191. https://doi.org/10.1681/ASN.2018111117
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Morad, SAF, MacDougall, MR, Abdelmageed, N, Kao, LP, Feith, DJ, Tan, SF, Kester, M, Loughran, TP, Wang, H-G & Cabot, MC 2019, 'Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen' Experimental Cell Research, vol. 381, no. 2, pp. 256-264. https://doi.org/10.1016/j.yexcr.2019.05.021
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2018

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2017

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Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models' Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.
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2016

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2015

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Ren, T, Takahashi, Y, Liu, X, Loughran, TP, Sun, SC, Wang, H-G & Cheng, H 2015, 'HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains', Oncogene, vol. 34, no. 3, pp. 373-384. https://doi.org/10.1038/onc.2013.552
Wang, DB, Kinoshita, Y, Kinoshita, C, Uo, T, Sopher, BL, Cudaback, E, Keene, CD, Bilousova, T, Gylys, K, Case, A, Jayadev, S, Wang, H-G, Garden, GA & Morrison, RS 2015, 'Loss of endophilin-B1 exacerbates Alzheimer's disease pathology', Brain, vol. 138, no. 7, pp. 2005-2019. https://doi.org/10.1093/brain/awv128
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Sun, X, Hasanali, ZS, Chen, A, Zhang, D, Liu, X, Wang, H-G, Feith, DJ, Loughran, TP & Xu, K 2015, 'Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia', British Journal of Haematology, vol. 168, no. 3, pp. 371-383. https://doi.org/10.1111/bjh.13143
Dick, TE, Hengst, J, Fox, TE, Colledge, AL, Kale, VP, Sung, S, Sharma, A, Amin, S, Loughran, TP, Kester, M, Wang, H-G & Yun, J 2015, 'The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines', Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 3, pp. 494-508. https://doi.org/10.1124/jpet.114.219659
Niu, G, Zhang, H, Liu, D, Chen, L, Belani, C, Wang, H-G & Cheng, H 2015, 'Tid1, the mammalian homologue of Drosophila tumor suppressor Tid56, mediates macroautophagy by interacting with beclin1-containing autophagy protein complex', Journal of Biological Chemistry, vol. 290, no. 29, pp. 18102-18110. https://doi.org/10.1074/jbc.M115.665950

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