Researcher Profile

Researcher Profile

Heath Mackley, MD, MBA

Heath Mackley, MD, MBA

Professor, Department of Radiation Oncology
Professor, Department of Medicine
Professor, Department of Pediatrics
Professor, Department of Radiology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Central Nervous System Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Head and Neck Cancer
Immunotherapy
Leukemia and Lymphoma
Liver, Pancreas and Foregut Cancer
Melanoma and Skin Cancer
Pediatric Cancer
Sarcoma Cancer
hbm11@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Radiotherapy
  • Survival
  • Radiation
  • Colorectal Neoplasms
  • Melanoma
  • Appalachian Region
  • Breast Neoplasms
  • Elderly
  • Drug Therapy
  • Mouth Neoplasms

Clinical Trials

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1-21 years
Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin
A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, Commercially Labeled) in Combination With Chemotherapy for Newly Diagnosed Patients With Anaplastic Large Cell Lymphoma (ALCL)

Recent Publications

2019

Zaorsky, NG, Zhang, Y, Tchelebi, LT, Mackley, HB, Chinchilli, VM & Zacharia, BE 2019, 'Stroke among cancer patients', Nature communications, vol. 10, no. 1, 5172. https://doi.org/10.1038/s41467-019-13120-6

2018

Yee, NS, Lengerich, EJ, Schmitz, KH, Maranki, JL, Gusani, NJ, Tchelebi, L, Mackley, HB, Krok, KL, Baker, MJ, de Boer, C & Yee, JD 2018, 'Frontiers in gastrointestinal oncology: Advances in multi-disciplinary patient care', Biomedicines, vol. 6, no. 2, 64. https://doi.org/10.3390/biomedicines6020064
Tchelebi, L, Zaorsky, N & Mackley, H 2018, 'Stereotactic body radiation therapy in the management of upper GI malignancies', Biomedicines, vol. 6, no. 1, 7. https://doi.org/10.3390/biomedicines6010007

2017

Koller, KM, Mackley, HB, Liu, J, Wagner, H, Talamo, G, Schell, TD, Pameijer, C, Neves, RI, Anderson, B, Kokolus, KM, Mallon, CA & Drabick, JJ 2017, 'Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone', Cancer Biology and Therapy, vol. 18, no. 1, pp. 36-42. https://doi.org/10.1080/15384047.2016.1264543
Liu, J, Goldenberg, D, Almokadem, S, Crist, H & Mackley, HB 2017, 'Long-term recurrence-free survival after an unplanned reduction in radiotherapy for HPV-positive oropharyngeal SCC: Two cases and a review of the literature', Ear, Nose and Throat Journal, vol. 96, no. 7, E23.

2016

Baker, A, Camacho, F, Andrews, G & Mackley, H 2016, 'A retrospective analysis of the role of adjuvant radiotherapy in the treatment of cutaneous melanoma', Cancer Biology and Therapy, vol. 17, no. 10, pp. 1030-1034. https://doi.org/10.1080/15384047.2016.1219811
Baker, MJ, Goldstein, AM, Gordon, PL, Harbaugh, KS, Mackley, HB, Glantz, MJ & Drabick, JJ 2016, 'An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies', Journal of medical genetics, vol. 53, no. 11, pp. 721-727. https://doi.org/10.1136/jmedgenet-2015-103446
Al-Marrawi, MY, Mackley, HB, Ali, S, Wagner, H, Joshi, M, Holder, S, Kaag, M, Mallon, C, Talamo, G & Drabick, JJ 2016, 'Consolidation With Radiation or Concurrent Chemo-Radiation After Chemotherapy Results in Durable Complete Remissions of Isolated Nodal Recurrences of Urothelial Cancer: A Case Series and Review', Clinical Genitourinary Cancer, vol. 14, no. 4, pp. e393-e399. https://doi.org/10.1016/j.clgc.2016.01.004
Short, PF, Moran, JR, Yang, TC, Camacho, F, Gusani, NJ, MacKley, HB, Matthews, SA & Anderson, RT 2016, 'Effects of hospital type and distance on lymph node assessment for colon cancer among metropolitan and nonmetropolitan patients in appalachia', Medical Care Research and Review, vol. 73, no. 5, pp. 546-564. https://doi.org/10.1177/1077558715619052
Koller, KM, Wang, W, Schell, T, Cozza, EM, Kokolus, KM, Neves, R, Mackley, H, Pameijer, CR, Leung, A, Anderson, B, Mallon, CA, Robertson, G & Drabick, J 2016, 'Malignant melanoma—The cradle of anti-neoplastic immunotherapy', Critical Reviews in Oncology/Hematology, vol. 106, pp. 25-54. https://doi.org/10.1016/j.critrevonc.2016.04.010
Varlotto, J, DiMaio, C, Grassberger, C, Tangel, M, Mackley, H, Pavelic, M, Specht, C, Sogge, S, Nguyen, D, Glantz, M, Saw, C, Upadhyay, U, Moser, R, Yunus, S, Rava, P, Fitzgerald, T, Glanzman, J & Sheehan, J 2016, 'Multi-modality management of craniopharyngioma: A review of various treatments and their outcomes', Neuro-Oncology Practice, vol. 3, no. 3, pp. 173-187. https://doi.org/10.1093/nop/npv029
Fleming, ST, Mackley, HB, Camacho, F, Yao, N, Gusani, NJ, Seiber, EE, Matthews, SA, Yang, TC & Hwang, W 2016, 'Patterns of Care for Metastatic Colorectal Cancer in Appalachia, and the Clinical, Sociodemographic, and Service Provider Determinants', Journal of Rural Health, vol. 32, no. 2, pp. 113-124. https://doi.org/10.1111/jrh.12132
Yin, M, MacKley, HB, Drabick, JJ & Harvey, HA 2016, 'Primary female breast sarcoma: Clinicopathological features, treatment and prognosis', Scientific reports, vol. 6, 31497. https://doi.org/10.1038/srep31497

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)