Researcher Profile

Researcher Profile

Heath Mackley, MD, MBA

Heath Mackley, MD, MBA

Professor, Department of Radiation Oncology
Professor, Department of Medicine
Professor, Department of Pediatrics
Professor, Department of Radiology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Central Nervous System Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Head and Neck Cancer
Leukemia and Lymphoma
Liver, Pancreas and Foregut Cancer
Melanoma and Skin Cancer
Pediatric Cancer
Sarcoma Cancer

Research Interests

  • Therapeutics
  • Neoplasms
  • Radiotherapy
  • Survival
  • Radiation
  • Melanoma
  • Colorectal Neoplasms
  • Appalachian Region
  • Breast Neoplasms
  • Elderly
  • Mortality
  • Drug Therapy

Clinical Trials

A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Recent Publications


Liu, J, Xu, C, Zhu, J, Sivik, J, Drabick, JJ & Mackley, HB 2020, 'Identifying the optimal fractionation schedules for improved response rates and survival in patients with metastatic melanoma treated with ipilimumab and radiotherapy', Current Cancer Therapy Reviews, vol. 16, no. 1, pp. 78-85.
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113.
Tchelebi, LT, Zaorsky, NG, Rosenberg, JC, Sharma, NK, Tuanquin, LC, MacKley, HB & Ellis, RJ 2020, 'Reducing the Toxicity of Radiotherapy for Pancreatic Cancer with Magnetic Resonance-guided Radiotherapy', Toxicological Sciences, vol. 175, no. 1, pp. 19-23.


Zaorsky, NG, Zhang, Y, Tchelebi, LT, Mackley, HB, Chinchilli, VM & Zacharia, BE 2019, 'Stroke among cancer patients', Nature communications, vol. 10, no. 1, 5172.


Yee, NS, Lengerich, EJ, Schmitz, KH, Maranki, JL, Gusani, NJ, Tchelebi, L, Mackley, HB, Krok, KL, Baker, MJ, de Boer, C & Yee, JD 2018, 'Frontiers in gastrointestinal oncology: Advances in multi-disciplinary patient care', Biomedicines, vol. 6, no. 2, 64.
Tchelebi, L, Zaorsky, N & Mackley, H 2018, 'Stereotactic body radiation therapy in the management of upper GI malignancies', Biomedicines, vol. 6, no. 1, 7.


Koller, KM, Mackley, HB, Liu, J, Wagner, H, Talamo, G, Schell, TD, Pameijer, C, Neves, RI, Anderson, B, Kokolus, KM, Mallon, CA & Drabick, JJ 2017, 'Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone', Cancer Biology and Therapy, vol. 18, no. 1, pp. 36-42.
Liu, J, Goldenberg, D, Almokadem, S, Crist, H & Mackley, HB 2017, 'Long-term recurrence-free survival after an unplanned reduction in radiotherapy for HPV-positive oropharyngeal SCC: Two cases and a review of the literature', Ear, Nose and Throat Journal, vol. 96, no. 7, E23.


Baker, A, Camacho, F, Andrews, G & Mackley, H 2016, 'A retrospective analysis of the role of adjuvant radiotherapy in the treatment of cutaneous melanoma', Cancer Biology and Therapy, vol. 17, no. 10, pp. 1030-1034.
Baker, MJ, Goldstein, AM, Gordon, PL, Harbaugh, KS, Mackley, HB, Glantz, MJ & Drabick, JJ 2016, 'An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies', Journal of medical genetics, vol. 53, no. 11, pp. 721-727.
Al-Marrawi, MY, Mackley, HB, Ali, S, Wagner, H, Joshi, M, Holder, S, Kaag, M, Mallon, C, Talamo, G & Drabick, JJ 2016, 'Consolidation With Radiation or Concurrent Chemo-Radiation After Chemotherapy Results in Durable Complete Remissions of Isolated Nodal Recurrences of Urothelial Cancer: A Case Series and Review', Clinical Genitourinary Cancer, vol. 14, no. 4, pp. e393-e399.
Short, PF, Moran, JR, Yang, TC, Camacho, F, Gusani, NJ, MacKley, HB, Matthews, SA & Anderson, RT 2016, 'Effects of hospital type and distance on lymph node assessment for colon cancer among metropolitan and nonmetropolitan patients in appalachia', Medical Care Research and Review, vol. 73, no. 5, pp. 546-564.
Koller, KM, Wang, W, Schell, TD, Cozza, EM, Kokolus, KM, Neves, RI, Mackley, HB, Pameijer, C, Leung, A, Anderson, B, Mallon, CA, Robertson, G & Drabick, JJ 2016, 'Malignant melanoma—The cradle of anti-neoplastic immunotherapy', Critical Reviews in Oncology/Hematology, vol. 106, pp. 25-54.
Varlotto, J, DiMaio, C, Grassberger, C, Tangel, M, Mackley, H, Pavelic, M, Specht, C, Sogge, S, Nguyen, D, Glantz, M, Saw, C, Upadhyay, U, Moser, R, Yunus, S, Rava, P, Fitzgerald, T, Glanzman, J & Sheehan, J 2016, 'Multi-modality management of craniopharyngioma: A review of various treatments and their outcomes', Neuro-Oncology Practice, vol. 3, no. 3, pp. 173-187.
Fleming, ST, Mackley, HB, Camacho, F, Yao, N, Gusani, NJ, Seiber, EE, Matthews, SA, Yang, TC & Hwang, W 2016, 'Patterns of Care for Metastatic Colorectal Cancer in Appalachia, and the Clinical, Sociodemographic, and Service Provider Determinants', Journal of Rural Health, vol. 32, no. 2, pp. 113-124.
Yin, M, MacKley, HB, Drabick, JJ & Harvey, HA 2016, 'Primary female breast sarcoma: Clinicopathological features, treatment and prognosis', Scientific reports, vol. 6, 31497.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)