Researcher Profile

Researcher Profile

Heath Mackley, MD, FACRO

Heath Mackley, MD, FACRO

Associate Professor, Department of Radiation Oncology
Associate Professor, Department of Medicine
Associate Professor, Department of Pediatrics
Associate Professor, Department of Radiology
Scientific Program:Experimental Therapeutics
Disease Teams:
Bone Marrow Transplantation
Central Nervous System Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Head and Neck Cancer
Leukemia and Lymphoma
Liver, Pancreas and Foregut Cancer
Melanoma and Skin Cancer
Pediatric Cancer
Sarcoma Cancer

Research Interests

  • Therapeutics
  • Neoplasms
  • Radiotherapy
  • Radiation
  • Survival
  • Colorectal Neoplasms
  • Melanoma
  • Drug Therapy
  • Appalachian Region
  • Breast Neoplasms
  • Mouth Neoplasms
  • Mouth

Clinical Trials

Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1-21 years
MATCH Treatment Subprotocol C2: Crizotinib in Patients with Tumors with MET Exon 14 Deletion
MATCH Treatment Subprotocol E: AZD9291 in Patients with Tumors Having EGFR T790M Mutations (Except Non-Small Cell Lung Cancer) or Rare Activating Mutations of EGFR
MATCH Treatment Subprotocol F: Crizotinib in Patients with Tumors (Other Than Adenocarcinoma of Lung or ALCL) with ALK Rearrangements
MATCH Treatment Subprotocol G: Phase II Study of Crizotinib in Patients with ROS1 Translocations (Other Than Patients with Non-Small Cell Lung Cancer)
MATCH Treatment Subprotocol L: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with mTOR Mutations
MATCH Treatment Subprotocol M: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with TSC1 or TSC2 Mutations
MATCH Treatment Subprotocol T: GDC-0449 (vismodegib) in Patients with Tumors (except basal cell skin carcinoma) with Smoothened (SMO) or Patched 1 (PTCH1) Mutations
MATCH Treatment Subprotocol V: Phase II Study of Sunitinib in Patients with Tumors with c-Kit Mutations (Excluding GIST, Renal Cell Carcinoma or Pancreatic Neuroendocrine Tumor).
A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, Commercially Labeled) in Combination With Chemotherapy for Newly Diagnosed Patients With Anaplastic Large Cell Lymphoma (ALCL)

Recent Publications


Yee, NS-S, Lengerich, E, Schmitz, K, Maranki, J, Gusani, NJ, Tchelebi, L, Mackley, H, Krok, K, Baker, M, de Boer, C & Yee, JD 2018, 'Frontiers in gastrointestinal oncology: Advances in multi-disciplinary patient care', Biomedicines, vol. 6, no. 2, 64.
Tchelebi, L, Zaorsky, N & Mackley, H 2018, 'Stereotactic body radiation therapy in the management of upper GI malignancies', Biomedicines, vol. 6, no. 1, 7.


Koller, KM, Mackley, H, Liu, J, Wagner Jr., H, Talamo, G, Schell, T, Pameijer, CR, Neves, R, Anderson, B, Kokolus, KM, Mallon, CA & Drabick, J 2017, 'Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone', Cancer Biology and Therapy, vol. 18, no. 1, pp. 36-42.
Liu, J, Goldenberg, D, Almokadem, S, Crist, H & Mackley, H 2017, 'Long-term recurrence-free survival after an unplanned reduction in radiotherapy for HPV-positive oropharyngeal SCC: Two cases and a review of the literature' Ear, Nose and Throat Journal, vol. 96, no. 7, E23.


Baker, A, Camacho, F, Andrews, GA & Mackley, H 2016, 'A retrospective analysis of the role of adjuvant radiotherapy in the treatment of cutaneous melanoma' Cancer Biology and Therapy, vol. 17, no. 10, pp. 1030-1034.
Baker, M, Goldstein, AM, Gordon, P, Harbaugh, K, Mackley, H, Glantz, M & Drabick, J 2016, 'An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies', Journal of medical genetics, vol. 53, no. 11, pp. 721-727.
Al-Marrawi, MY, Mackley, H, Ali, S, Wagner Jr., H, Joshi, M, Holder, S, Kaag, MG, Mallon, C, Talamo, G & Drabick, J 2016, 'Consolidation With Radiation or Concurrent Chemo-Radiation After Chemotherapy Results in Durable Complete Remissions of Isolated Nodal Recurrences of Urothelial Cancer: A Case Series and Review', Clinical Genitourinary Cancer, vol. 14, no. 4, pp. e393-e399.
Short, PF, Moran, Jr., JR, Yang, TC, Camacho, F, Gusani, NJ, Mackley, H, Matthews, SA & Anderson, RT 2016, 'Effects of hospital type and distance on lymph node assessment for colon cancer among metropolitan and nonmetropolitan patients in appalachia', Medical Care Research and Review, vol. 73, no. 5, pp. 546-564.
Koller, KM, Wang, W, Schell, T, Cozza, EM, Kokolus, KM, Neves, R, Mackley, H, Pameijer, CR, Leung, A, Anderson, B, Mallon, CA, Robertson, G & Drabick, J 2016, 'Malignant melanoma—The cradle of anti-neoplastic immunotherapy', Critical Reviews in Oncology/Hematology, vol. 106, pp. 25-54.
Varlotto, J, DiMaio, C, Grassberger, C, Tangel, M, Mackley, H, Pavelic, M, Specht, C, Sogge, S, Nguyen, DT, Glantz, M, Saw, C, Upadhyay, U, Moser, R, Yunus, S, Rava, P, Fitzgerald, T, Glanzman, J & Sheehan, J 2016, 'Multi-modality management of craniopharyngioma: A review of various treatments and their outcomes', Neuro-Oncology Practice, vol. 3, no. 3, pp. 173-187.
Fleming, ST, Mackley, H, Camacho, F, Yao, N, Gusani, NJ, Seiber, EE, Matthews, SA, Yang, TC & Hwang, W 2016, 'Patterns of Care for Metastatic Colorectal Cancer in Appalachia, and the Clinical, Sociodemographic, and Service Provider Determinants', Journal of Rural Health, vol. 32, no. 2, pp. 113-124.
Yin, M, Mackley, H, Drabick, J & Harvey, H 2016, 'Primary female breast sarcoma: Clinicopathological features, treatment and prognosis', Scientific reports, vol. 6, 31497.


Hollenbeak, CS, Kulaylat, AN, Mackley, H, Koch, W, Schaefer, EW & Goldenberg, D 2015, 'Determinants of medicare costs for elderly patients with oral cavity and pharyngeal cancers', JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 7, pp. 628-635.
Wyluda, EJ, Cheng, J, Schell, T, Haley, JS, Mallon, C, Neves, R, Robertson, G, Sivik, J, Mackley, H, Talamo, G & Drabick, J 2015, 'Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy' Cancer Biology and Therapy, vol. 16, no. 5, pp. 662-670.
Schaefer, EW, Wilson, MZ, Goldenberg, D, Mackley, H, Koch, W & Hollenbeak, CS 2015, 'Effect of marriage on outcomes for elderly patients with head and neck cancer' Head and Neck, vol. 37, no. 5, pp. 735-742.
Kimmick, GG, Camacho, F, Mackley, H, Kern, T, Yao, N, Matthews, SA, Fleming, S, Lipscomb, J, Liao, JJ, Hwang, W & Anderson, RT 2015, 'Individual, area, and provider characteristics associated with care received for stages I to III breast cancer in a multistate region of Appalachia' Journal of oncology practice, vol. 11, no. 1, pp. e9-e18.
Hess, CB, Singer, M, Khaku, A, Malinou, J, Juliano, JJ, Varlotto, JM, Wagner Jr., H, Liao, JJ, Myers, K, Levine, M & Mackley, H 2015, 'Optimal frequency of psychosocial distress screening in radiation oncology', Journal of oncology practice, vol. 11, no. 4, pp. 298-302.
Enomoto, LM, Schaefer, EW, Goldenberg, D, Mackley, H, Koch, WM & Hollenbeak, CS 2015, 'The cost of hospice services in terminally ill patients with head and neck cancer' JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 12, pp. 1066-1074.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)