Researcher Profile

Researcher Profile

Gregory Yochum, PhD

Gregory Yochum, PhD

Associate Professor, Department of Biochemistry and Molecular Biology
Associate Professor, Department of Surgery
Scientific Program:Mechanisms of Carcinogenesis
gsy3@psu.edu

Research Interests

  • Catenins
  • Colorectal Neoplasms
  • Transcription Factors
  • Gene Expression
  • Genes
  • Chromatin
  • DNA
  • Diverticulitis
  • Proteins
  • TCF Transcription Factors
  • Carcinogenesis
  • Wnt Signaling Pathway

Recent Publications

2019

Matthews, SM, Eshelman, MA, Berg, A, Koltun, W & Yochum, G 2019, 'The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells' PloS one, vol. 14, no. 2, e0212850. https://doi.org/10.1371/journal.pone.0212850

2018

Schieffer, KM, Kline, BP, Harris, LR, Deiling, S, Koltun, W & Yochum, G 2018, 'A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients' Journal of Gastrointestinal and Liver Diseases, vol. 27, no. 3, pp. 249-255. https://doi.org/10.15403/jgld.2014.1121.273.sch
Kline, BP, Schieffer, KM, Choi, CS, Connelly, T, Chen, J, Harris, L, Deiling, S, Yochum, G & Koltun, W 2018, 'Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-018-5403-y
Schieffer, KM, Kline, BP, Yochum, G & Koltun, W 2018, 'Pathophysiology of diverticular disease', Expert Review of Gastroenterology and Hepatology, vol. 12, no. 7, pp. 683-692. https://doi.org/10.1080/17474124.2018.1481746
Raup-Konsavage, WM, Johnson, M, Legare, CA, Yochum, G, Morgan, D & Vrana, K 2018, 'Synthetic cannabinoid activity against colorectal cancer cells', Cannabis and Cannabinoid Research, vol. 3, no. 1, pp. 272-281. https://doi.org/10.1089/can.2018.0065

2017

Schieffer, KM, Poritz, L, Yochum, G & Koltun, W 2017, 'Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia' Journal of Surgical Research, vol. 218, pp. 217-225. https://doi.org/10.1016/j.jss.2017.05.120
Coble, JL, Yue, F, Salameh, TJ, Harris, LR, Deiling, S, Ruggiero, FM, Eshelman, MA, Yochum, GS, Koltun, WA, Gerhard, GS & Broach, JR 2017, 'Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing', Human Molecular Genetics, vol. 26, no. 16, ddx204, pp. 3212-3220. https://doi.org/10.1093/hmg/ddx204
Schieffer, KM, Wright, JR, Harris, LR, Deiling, S, Yang, Z, Lamendellab, R, Yochum, G & Koltun, W 2017, 'NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis' Journal of Crohn's and Colitis, vol. 11, no. 11, pp. 1393-1397. https://doi.org/10.1093/ecco-jcc/jjx083
Schieffer, KM, Choi, CS, Emrich, S, Harris, L, Deiling, S, Karamchandani, D, Salzberg, A, Imamura, Y, Yochum, G & Koltun, W 2017, 'RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 313, no. 3, pp. G277-G284. https://doi.org/10.1152/ajpgi.00136.2017
Schieffer, KM, Bruffy, SM, Rauscher, R, Koltun, W, Yochum, G & Gallagher, CJ 2017, 'Reduced total serum bilirubin levels are associated with ulcerative colitis', PloS one, vol. 12, no. 6, e0179267. https://doi.org/10.1371/journal.pone.0179267
Eshelman, MA, Shah, M, Raup-Konsavage, WM, Rennoll, SA & Yochum, G 2017, 'TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells', Biochemical and Biophysical Research Communications, vol. 487, no. 3, pp. 716-722. https://doi.org/10.1016/j.bbrc.2017.04.123
Schieffer, KM, Sabey, K, Wright, JR, Toole, DR, Drucker, R, Tokarev, V, Harris, LR, Deiling, S, Eshelman, MA, Hegarty, JP, Yochum, G, Koltun, W, Lamendella, R & Stewart, D 2017, 'The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients', Scientific reports, vol. 7, no. 1, 8467. https://doi.org/10.1038/s41598-017-06787-8

2016

Raup-Konsavage, WM, Cooper, T & Yochum, G 2016, 'A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice', Digestive Diseases and Sciences, vol. 61, no. 2, pp. 410-422. https://doi.org/10.1007/s10620-015-3852-0
Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440. https://doi.org/10.1038/leu.2015.331
Schieffer, KM, Williams, E, Yochum, G & Koltun, W 2016, 'Review article: the pathogenesis of pouchitis', Alimentary Pharmacology and Therapeutics, vol. 44, no. 8, pp. 817-835. https://doi.org/10.1111/apt.13780
Rennoll, SA, Eshelman, MA, Raup-Konsavage, WM, Imamura, Y & Yochum, G 2016, 'The MYC 3′ Wnt-responsive element drives oncogenic MYC expression in human colorectal cancer cells', Cancers, vol. 8, no. 5, 52. https://doi.org/10.3390/cancers8050052
Eshelman, MA & Yochum, G 2016, 'The Wnt/β-catenin pathway is activated by miR-1246 in liver cancer stem cells', Translational Cancer Research, vol. 5, pp. S1457-S1460. https://doi.org/10.21037/tcr.2016.12.57

2015

Shah, M, Rennoll, SA, Raup-Konsavage, WM & Yochum, G 2015, 'A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells' Cell Cycle, vol. 14, no. 3, pp. 232-332. https://doi.org/10.4161/15384101.2014.980643

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)