Researcher Profile

Researcher Profile

Gregory Yochum, PhD

Gregory Yochum, PhD

Associate Professor, Department of Biochemistry and Molecular Biology
Associate Professor, Department of Surgery
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Catenins
  • Colorectal Neoplasms
  • Transcription Factors
  • Gene Expression
  • Genes
  • Chromatin
  • DNA
  • Diverticulitis
  • Proteins
  • TCF Transcription Factors
  • Carcinogenesis
  • Wnt Signaling Pathway

Recent Publications


Matthews, SM, Eshelman, MA, Berg, A, Koltun, W & Yochum, G 2019, 'The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells' PloS one, vol. 14, no. 2, e0212850.


Schieffer, KM, Kline, BP, Harris, LR, Deiling, S, Koltun, W & Yochum, G 2018, 'A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients' Journal of Gastrointestinal and Liver Diseases, vol. 27, no. 3, pp. 249-255.
Kline, BP, Schieffer, KM, Choi, CS, Connelly, T, Chen, J, Harris, L, Deiling, S, Yochum, G & Koltun, W 2018, 'Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics', Digestive Diseases and Sciences.
Schieffer, KM, Kline, BP, Yochum, G & Koltun, W 2018, 'Pathophysiology of diverticular disease', Expert Review of Gastroenterology and Hepatology, vol. 12, no. 7, pp. 683-692.
Raup-Konsavage, WM, Johnson, M, Legare, CA, Yochum, G, Morgan, D & Vrana, K 2018, 'Synthetic cannabinoid activity against colorectal cancer cells', Cannabis and Cannabinoid Research, vol. 3, no. 1, pp. 272-281.


Schieffer, KM, Poritz, L, Yochum, G & Koltun, W 2017, 'Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia' Journal of Surgical Research, vol. 218, pp. 217-225.
Coble, JL, Yue, F, Salameh, TJ, Harris, LR, Deiling, S, Ruggiero, FM, Eshelman, MA, Yochum, GS, Koltun, WA, Gerhard, GS & Broach, JR 2017, 'Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing', Human Molecular Genetics, vol. 26, no. 16, ddx204, pp. 3212-3220.
Schieffer, KM, Wright, JR, Harris, LR, Deiling, S, Yang, Z, Lamendellab, R, Yochum, G & Koltun, W 2017, 'NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis' Journal of Crohn's and Colitis, vol. 11, no. 11, pp. 1393-1397.
Schieffer, KM, Choi, CS, Emrich, S, Harris, L, Deiling, S, Karamchandani, D, Salzberg, A, Imamura, Y, Yochum, G & Koltun, W 2017, 'RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 313, no. 3, pp. G277-G284.
Schieffer, KM, Bruffy, SM, Rauscher, R, Koltun, W, Yochum, G & Gallagher, CJ 2017, 'Reduced total serum bilirubin levels are associated with ulcerative colitis', PloS one, vol. 12, no. 6, e0179267.
Eshelman, MA, Shah, M, Raup-Konsavage, WM, Rennoll, SA & Yochum, G 2017, 'TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells', Biochemical and Biophysical Research Communications, vol. 487, no. 3, pp. 716-722.
Schieffer, KM, Sabey, K, Wright, JR, Toole, DR, Drucker, R, Tokarev, V, Harris, LR, Deiling, S, Eshelman, MA, Hegarty, JP, Yochum, G, Koltun, W, Lamendella, R & Stewart, D 2017, 'The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients', Scientific reports, vol. 7, no. 1, 8467.


Raup-Konsavage, WM, Cooper, T & Yochum, G 2016, 'A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice', Digestive Diseases and Sciences, vol. 61, no. 2, pp. 410-422.
Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440.
Schieffer, KM, Williams, E, Yochum, G & Koltun, W 2016, 'Review article: the pathogenesis of pouchitis', Alimentary Pharmacology and Therapeutics, vol. 44, no. 8, pp. 817-835.
Rennoll, SA, Eshelman, MA, Raup-Konsavage, WM, Imamura, Y & Yochum, G 2016, 'The MYC 3′ Wnt-responsive element drives oncogenic MYC expression in human colorectal cancer cells', Cancers, vol. 8, no. 5, 52.
Eshelman, MA & Yochum, G 2016, 'The Wnt/β-catenin pathway is activated by miR-1246 in liver cancer stem cells', Translational Cancer Research, vol. 5, pp. S1457-S1460.


Shah, M, Rennoll, SA, Raup-Konsavage, WM & Yochum, G 2015, 'A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells' Cell Cycle, vol. 14, no. 3, pp. 232-332.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)