Researcher Profile

Researcher Profile

Gavin Robertson, PhD

Gavin Robertson, PhD

Professor, Department of Pharmacology
Professor, Department of Dermatology
Scientific Program:Next-Generation Therapies
Disease Teams:
Institute for CyberScience (ICS) - Associate
gpr11@psu.edu

Research Interests

Dr. Gavin Robertson's research program focuses on malignant melanoma, the most deadly form of skin cancer. The central goal of his program is to unravel the biology and signaling pathways involved in melanoma tumor development in order to develop the next generation of therapeutic agents to treat this disease. Specifically, it involves identification and validation of novel therapeutic targets, discovery and development of new therapies and clinical evaluation of these drugs in patients.

Generally,the types of studies occurring the Robertson laboratory are:

Genetic and cell culture studies using animal and human models are used to identify and validate the involvement of candidate melanoma-causing genes. A recent example is the discovery of Akt3 involvement in approximately 70 percent of human melanomas.

Drug screens and medicinal chemistry are used to identify and develop new therapeutic agents. A recent example is the melanoma-treating drug ISC-4, which targets Akt3 signaling.

Nanotechnology and bioengineering are used to better deliver experimental agents into cancer cells. A recent example of this is the use of nanoliposomes and ultrasound that deliver therapeutic siRNA into melanoma cells.

Finally, agents are tested in the clinic for toxicity and tumor inhibitory efficacy. A recent example is a killed mycobacterium called CADI-5 that is being evaluated in clinical trials.

The ultimate goal of Dr. Robertson's translational research program is to develop better therapeutics for the treatment of melanoma based on the biology of the disease.

  • Melanoma
  • Neoplasms
  • Therapeutics
  • Genes
  • Proteins
  • Growth
  • Neoplasm Metastasis
  • Pharmaceutical Preparations
  • Apoptosis
  • Phosphotransferases
  • Cholesterol
  • Mitogen-Activated Protein Kinases

Clinical Trials

Application for Discarded Tissue From Surgery For Research Use

Recent Publications

2022

Elbezanti, WO, Al-Odat, OS, Chitren, R, Singh, JK, Srivastava, SK, Gowda, K, Amin, S, Robertson, GP, Nemmara, VV, Jonnalagadda, SC, Budak-Alpdogan, T & Pandey, MK 2022, 'Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells', Frontiers in Pharmacology, vol. 13, 894535. https://doi.org/10.3389/fphar.2022.894535
Dhanyamraju, PK, Schell, TD, Amin, S & Robertson, GP 2022, 'Drug-Tolerant Persister Cells in Cancer Therapy Resistance', Cancer Research, vol. 82, no. 14, pp. 2503-2514. https://doi.org/10.1158/0008-5472.CAN-21-3844
Dinavahi, SS, Chen, YC, Gowda, R, Dhanyamraju, PK, Punnath, K, Desai, D, Berg, A, Kimball, SR, Amin, S, Yang, JM & Robertson, GP 2022, 'Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development', International journal of molecular sciences, vol. 23, no. 7, 3481. https://doi.org/10.3390/ijms23073481
Dinavahi, SS, Chen, YC, Punnath, K, Berg, A, Herlyn, M, Foroutan, M, Huntington, ND & Robertson, GP 2022, 'Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma', Cancer Immunology Research, vol. 10, no. 6, pp. 757-769. https://doi.org/10.1158/2326-6066.CIR-21-0587

2021

Chen, YC, Dinavahi, SS, Feng, Q, Gowda, R, Ramisetti, S, Xia, X, LaPenna, KB, Chirasani, VR, Cho, SH, Hafenstein, SL, Battu, MB, Berg, A, Sharma, AK, Kirchhausen, T, Dokholyan, NV, Amin, S, He, P & Robertson, GP 2021, 'Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis', Cancer Letters, vol. 506, pp. 107-119. https://doi.org/10.1016/j.canlet.2021.01.004
Xu, T, Cheng, D, Zhao, Y, Zhang, J, Zhu, X, Zhang, F, Chen, G, Wang, Y, Yan, X, Robertson, GP, Gaddameedhi, S, Lazarus, P, Wang, S & Zhu, J 2021, 'Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 26, e2019043118. https://doi.org/10.1073/pnas.2019043118

2020

Dinavahi, SS, Gowda, R, Bazewicz, CG, Battu, MB, Lin, JM, Chitren, RJ, Pandey, MK, Amin, S, Robertson, GP & Gowda, K 2020, 'Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents', European Journal of Medicinal Chemistry, vol. 187, 111962. https://doi.org/10.1016/j.ejmech.2019.111962
Dinavahi, SS, Gowda, R, Gowda, K, Bazewicz, CG, Chirasani, VR, Battu, MB, Berg, A, Dokholyan, NV, Amin, S & Robertson, GP 2020, 'Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent', Molecular cancer therapeutics, vol. 19, no. 2, pp. 447-459. https://doi.org/10.1158/1535-7163.MCT-19-0360
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Kardos, GR, Gowda, R, Dinavahi, SS, Kimball, S & Robertson, GP 2020, 'Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery', Frontiers in Oncology, vol. 10, 834. https://doi.org/10.3389/fonc.2020.00834
Gowda, R, Robertson, BM, Iyer, S, Barry, J, Dinavahi, SS & Robertson, GP 2020, 'The role of exosomes in metastasis and progression of melanoma', Cancer Treatment Reviews, vol. 85, 101975. https://doi.org/10.1016/j.ctrv.2020.101975

2019

Dinavahi, SS, Bazewicz, CG, Gowda, R & Robertson, GP 2019, 'Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics', Trends in Pharmacological Sciences, vol. 40, no. 10, pp. 774-789. https://doi.org/10.1016/j.tips.2019.08.002
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, VS, Robertson, GP & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219. https://doi.org/10.1097/CMR.0000000000000545
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540. https://doi.org/10.1038/s41388-019-0810-x
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8. https://doi.org/10.1016/j.celrep.2019.07.084

Clinical Trials Search


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