Gavin Robertson, PhD - Penn State Cancer Institute
Researcher Profile
Gavin Robertson, PhD
Professor, Department of Pharmacology
Professor, Department of Dermatology
Professor, Department of Dermatology
Scientific Program:Next-Generation Therapies
Disease Teams:
Institute for CyberScience (ICS) - Associate
Recent Publications
2024
Gowda, K, Raza, A, Vangala, V, Lone, NA, Lin, JM, Singh, JK, Srivastava, SK, Schell, TD, Robertson, GP, Amin, S & Sharma, AK 2024, 'Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor', Molecules, vol. 29, no. 13, 3114. https://doi.org/10.3390/molecules29133114
Chen, YC, Gowda, K, Amin, S, Schell, TD, Sharma, AK & Robertson, GP 2024, 'Pharmacological agents targeting drug-tolerant persister cells in cancer', Pharmacological Research, vol. 203, 107163. https://doi.org/10.1016/j.phrs.2024.107163
Zhang, J, Zhang, F, Porter, KI, Dakup, PP, Wang, S, Robertson, GP, Gaddameedhi, S & Zhu, J 2024, 'Telomere dysfunction in Tert knockout mice delays BrafV600E-induced melanoma development', International Journal of Cancer, vol. 154, no. 3, pp. 548-560. https://doi.org/10.1002/ijc.34713
Vangala, V, Chen, YC, Dinavahi, SS, Gowda, K, Lone, NA, Herlyn, M, Drabick, J, Helm, K, Zhu, J, Neves, RI, Sharma, AK, Berg, A, Archetti, M, Amin, S, Schell, TD & Robertson, GP 2024, 'Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations', ACS Pharmacology and Translational Science, vol. 7, no. 11, pp. 3573-3584. https://doi.org/10.1021/acsptsci.4c00453
2022
Elbezanti, WO, Al-Odat, OS, Chitren, R, Singh, JK, Srivastava, SK, Gowda, K, Amin, S, Robertson, GP, Nemmara, VV, Jonnalagadda, SC, Budak-Alpdogan, T & Pandey, MK 2022, 'Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells', Frontiers in Pharmacology, vol. 13, 894535. https://doi.org/10.3389/fphar.2022.894535
Dhanyamraju, PK, Schell, TD, Amin, S & Robertson, GP 2022, 'Drug-Tolerant Persister Cells in Cancer Therapy Resistance', Cancer Research, vol. 82, no. 14, pp. 2503-2514. https://doi.org/10.1158/0008-5472.CAN-21-3844
Dinavahi, SS, Chen, YC, Gowda, R, Dhanyamraju, PK, Punnath, K, Desai, D, Berg, A, Kimball, SR, Amin, S, Yang, JM & Robertson, GP 2022, 'Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development', International journal of molecular sciences, vol. 23, no. 7, 3481. https://doi.org/10.3390/ijms23073481
Dinavahi, SS, Chen, YC, Punnath, K, Berg, A, Herlyn, M, Foroutan, M, Huntington, ND & Robertson, GP 2022, 'Targeting WEE1/AKT Restores p53-Dependent Natural Killer–Cell Activation to Induce Immune Checkpoint Blockade Responses in “Cold” Melanoma', Cancer Immunology Research, vol. 10, no. 6, pp. 757-769. https://doi.org/10.1158/2326-6066.CIR-21-0587
2021
Chen, YC, Dinavahi, SS, Feng, Q, Gowda, R, Ramisetti, S, Xia, X, LaPenna, KB, Chirasani, VR, Cho, SH, Hafenstein, SL, Battu, MB, Berg, A, Sharma, AK, Kirchhausen, T, Dokholyan, NV, Amin, S, He, P & Robertson, GP 2021, 'Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis', Cancer Letters, vol. 506, pp. 107-119. https://doi.org/10.1016/j.canlet.2021.01.004
Xu, T, Cheng, D, Zhao, Y, Zhang, J, Zhu, X, Zhang, F, Chen, G, Wang, Y, Yan, X, Robertson, GP, Gaddameedhi, S, Lazarus, P, Wang, S & Zhu, J 2021, 'Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 26, e2019043118. https://doi.org/10.1073/pnas.2019043118
2020
Dinavahi, SS, Gowda, R, Bazewicz, CG, Battu, MB, Lin, JM, Chitren, RJ, Pandey, MK, Amin, S, Robertson, GP & Gowda, K 2020, 'Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents', European Journal of Medicinal Chemistry, vol. 187, 111962. https://doi.org/10.1016/j.ejmech.2019.111962
Dinavahi, SS, Gowda, R, Gowda, K, Bazewicz, CG, Chirasani, VR, Battu, MB, Berg, A, Dokholyan, NV, Amin, S & Robertson, GP 2020, 'Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent', Molecular cancer therapeutics, vol. 19, no. 2, pp. 447-459. https://doi.org/10.1158/1535-7163.MCT-19-0360
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Kardos, GR, Gowda, R, Dinavahi, SS, Kimball, S & Robertson, GP 2020, 'Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery', Frontiers in Oncology, vol. 10, 834. https://doi.org/10.3389/fonc.2020.00834
Gowda, R, Robertson, BM, Iyer, S, Barry, J, Dinavahi, SS & Robertson, GP 2020, 'The role of exosomes in metastasis and progression of melanoma', Cancer Treatment Reviews, vol. 85, 101975. https://doi.org/10.1016/j.ctrv.2020.101975