Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Genes
  • Polychlorinated Dibenzodioxins
  • Liver
  • Dioxins
  • Transcriptional Activation
  • human AHR protein
  • Gene Expression
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications


Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831.


Murray, IA & Perdew, GH 2020, 'How ah receptor ligand specificity became important in understanding its physiological function', International journal of molecular sciences, vol. 21, no. 24, 9614, pp. 1-19.
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24.
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1.
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621.
Dong, F & Perdew, GH 2020, 'The aryl hydrocarbon receptor as a mediator of host-microbiota interplay', Gut microbes, vol. 12, no. 1, 1859812.
Zhou, X, Li, D, Xu, W, Zhang, H, Wang, H & Perdew, GH 2020, 'β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice', Antioxidants, vol. 9, no. 12, 1264, pp. 1-14.


Muku, GE, Murray, IA & Perdew, GH 2019, 'Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome', Current Pharmacology Reports, vol. 5, no. 5, pp. 319-331.
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294.
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724.
Gourronc, FA, Perdew, GH, Robertson, LW & Klingelhutz, AJ 2020, 'PCB126 blocks the thermogenic beiging response of adipocytes', Environmental Science and Pollution Research, vol. 27, no. 9, pp. 8897-8904.
Muku, GE, Blazanin, N, Dong, F, Smith, PB, Thiboutot, D, Gowda, K, Amin, S, Murray, IA & Perdew, GH 2019, 'Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes', Toxicological Sciences, vol. 171, no. 1, pp. 146-158.
Muku, GE, Kusnadi, A, Kuzu, G, Tanos, R, Murray, IA, Gowda, K, Amin, S & Perdew, GH 2020, 'Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity', Laboratory Investigation, vol. 100, no. 2, pp. 250-264.


Smith, KJ, Murray, IA, Boyer, JA & Perdew, GH 2018, 'Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice', Toxicology, vol. 394, pp. 27-34.
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382.
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283.
Esser, C, Lawrence, BP, Sherr, DH, Perdew, GH, Puga, A, Barouki, R & Coumoul, X 2018, 'Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France', International journal of molecular sciences, vol. 19, no. 11, 3603.
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54.
Muku, GE, Murray, IA, Espín, JC & Perdew, GH 2018, 'Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist', Metabolites, vol. 8, no. 4.


Smith, KJ, Boyer, JA, Muku, GE, Murray, IA, Gowda, K, Desai, D, Amin, SG, Glick, AB & Perdew, GH 2017, 'Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin', Toxicological Sciences, vol. 160, no. 1, pp. 83-94.
Organtini, KL, Hubbard, TD, Perdew, GH & Dorman, FL 2017, 'Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems', Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, vol. 52, no. 14, pp. 1295-1302.
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, P, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698.
Moyer, BJ, Rojas, IY, Murray, IA, Lee, S, Hazlett, HF, Perdew, GH & Tomlinson, CR 2017, 'Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor', Toxicology and Applied Pharmacology, vol. 323, pp. 74-80.
Murray, IA & Perdew, GH 2017, 'Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis', Current Opinion in Toxicology, vol. 1, pp. 15-23.
Muku, GE, Lahoti, TS, Murray, IA, Podolsky, MA, Smith, KJ, Hubbard, TD, Kuzu, G, Gowda, K, Amin, SG & Perdew, GH 2017, 'Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses', Laboratory Investigation, vol. 97, no. 12, pp. 1471-1487.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)