Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Genes
  • Polychlorinated Dibenzodioxins
  • Liver
  • Dioxins
  • Transcriptional Activation
  • human AHR protein
  • Gene Expression
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications


Rikken, G, Smith, KJ, van den Brink, NJM, Smits, JPH, Gowda, K, Alnemri, A, Kuzu, GE, Murray, IA, Lin, JM, Smits, JGA, van Vlijmen-Willems, IM, Amin, SG, Perdew, GH & van den Bogaard, EH 2023, 'Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders', Biochemical Pharmacology, vol. 208, 115400.


Granados, JC, Falah, K, Koo, I, Morgan, EW, Perdew, GH, Patterson, AD, Jamshidi, N & Nigam, SK 2022, 'AHR is a master regulator of diverse pathways in endogenous metabolism', Scientific reports, vol. 12, no. 1, 16625.
Tian, Y, Rimal, B, Gui, W, Koo, I, Yokoyama, S, Perdew, GH & Patterson, AD 2022, 'Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood', International journal of molecular sciences, vol. 23, no. 15, 8220.
Priyadarshini, M, Navarro, G, Reiman, DJ, Sharma, A, Xu, K, Lednovich, K, Manzella, CR, Khan, MW, Garcia, MS, Allard, S, Wicksteed, B, Chlipala, GE, Szynal, B, Bernabe, BP, Maki, PM, Gill, RK, Perdew, GH, Gilbert, J, Dai, Y & Layden, BT 2022, 'Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis', Gastroenterology, vol. 162, no. 6, pp. 1675-1689.e11.
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological sciences : an official journal of the Society of Toxicology, vol. 187, no. 2, pp. 189-213.


van den Bogaard, EH & Perdew, GH 2021, 'The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability', Journal of Investigative Dermatology, vol. 141, no. 6, pp. 1385-1388.
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831.
van den Bogaard, EH, Esser, C & Perdew, GH 2021, 'The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications', Experimental Dermatology, vol. 30, no. 10, pp. 1477-1483.


Murray, IA & Perdew, GH 2020, 'How ah receptor ligand specificity became important in understanding its physiological function', International journal of molecular sciences, vol. 21, no. 24, 9614, pp. 1-19.
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24.
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1.
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621.
Dong, F & Perdew, GH 2020, 'The aryl hydrocarbon receptor as a mediator of host-microbiota interplay', Gut microbes, vol. 12, no. 1, 1859812.
Zhou, X, Li, D, Xu, W, Zhang, H, Wang, H & Perdew, GH 2020, 'β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice', Antioxidants, vol. 9, no. 12, 1264, pp. 1-14.


Muku, GE, Murray, IA & Perdew, GH 2019, 'Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome', Current Pharmacology Reports, vol. 5, no. 5, pp. 319-331.
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294.
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724.
Gourronc, FA, Perdew, GH, Robertson, LW & Klingelhutz, AJ 2020, 'PCB126 blocks the thermogenic beiging response of adipocytes', Environmental Science and Pollution Research, vol. 27, no. 9, pp. 8897-8904.
Muku, GE, Blazanin, N, Dong, F, Smith, PB, Thiboutot, D, Gowda, K, Amin, S, Murray, IA & Perdew, GH 2019, 'Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes', Toxicological Sciences, vol. 171, no. 1, pp. 146-158.
Muku, GE, Kusnadi, A, Kuzu, G, Tanos, R, Murray, IA, Gowda, K, Amin, S & Perdew, GH 2020, 'Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity', Laboratory Investigation, vol. 100, no. 2, pp. 250-264.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)