Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Liver
  • Genes
  • Dioxins
  • Transcriptional Activation
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors
  • Gene Expression
  • Response Elements
  • Aryl Hydrocarbon Receptor Nuclear Translocator

Recent Publications


Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline' Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724.


Smith, KJ, Murray, IA, Boyer, JA & Perdew, GH 2018, 'Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice', Toxicology, vol. 394, pp. 27-34.
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382.
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283.
Esser, C, Lawrence, BP, Sherr, DH, Perdew, GH, Puga, A, Barouki, R & Coumoul, X 2018, 'Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France', International journal of molecular sciences, vol. 19, no. 11, 3603.
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists' Current Protocols in Toxicology, vol. 78, no. 1, e54.
Muku, GE, Murray, IA, Espín, JC & Perdew, GH 2018, 'Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist', Metabolites, vol. 8, no. 4.


Smith, KJ, Boyer, JA, Muku, GE, Murray, IA, Gowda, K, Desai, D, Amin, S, Glick, AB & Perdew, GH 2017, 'Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin', Toxicological Sciences, vol. 160, no. 1, pp. 83-94.
Organtini, KL, Hubbard, TD, Perdew, GH & Dorman, Jr., FL 2017, 'Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems', Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, vol. 52, no. 14, pp. 1295-1302.
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, PB, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698.
Moyer, BJ, Rojas, IY, Murray, IA, Lee, S, Hazlett, HF, Perdew, GH & Tomlinson, CR 2017, 'Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor', Toxicology and Applied Pharmacology, vol. 323, pp. 74-80.
Murray, IA & Perdew, GH 2017, 'Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis', Current Opinion in Toxicology, vol. 1, pp. 15-23.
Muku, GE, Lahoti, TS, Murray, IA, Podolsky, MA, Smith, KJ, Hubbard, TD, Kuzu, G, Gowda, K, Amin, S & Perdew, GH 2017, 'Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses', Laboratory Investigation, vol. 97, no. 12, pp. 1471-1487.


Gutierrez, MA, Davis, SS, Rosko, A, Nguyen, SM, Mitchell, KP, Mateen, S, Neves, J, Garcia, TY, Mooney, S, Perdew, GH, Hubbard, TD, Lamba, DA & Ramanathan, A 2016, 'A novel AhR ligand, 2AI, protects the retina from environmental stress', Scientific reports, vol. 6, 29025.
Hubbard, TD, Murray, IA, Bisson, WH, Sullivan, AP, Sebastian, A, Perry, GH, Jablonski, NG & Perdew, GH 2016, 'Divergent Ah Receptor Ligand Selectivity during Hominin Evolution', Molecular Biology and Evolution, vol. 33, no. 10, pp. 2648-2658.
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969.
Girer, NG, Murray, IA, Omiecinski, CJ & Perdew, GH 2016, 'Hepatic aryl hydrocarbon receptor attenuates fibroblast growth factor 21 expression', Journal of Biological Chemistry, vol. 291, no. 29, pp. 15378-15387.
Balandaram, G, Kramer, LR, Kang, BH, Murray, IA, Perdew, GH, Gonzalez, FJ & Peters, JM 2016, 'Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice', Toxicology, vol. 363-364, pp. 1-9.
Koga, T, Yao, PL, Goudarzi, M, Murray, IA, Balandaram, G, Gonzalez, FJ, Perdew, GH, Fornace, AJ & Peters, JM 2016, 'Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy', Journal of Biological Chemistry, vol. 291, no. 48, pp. 25255-25263.
Yang, J, Hu, S, Zhao, L, Kaplan, DH, Perdew, GH & Xiong, N 2016, 'Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation', Nature Immunology, vol. 17, no. 1, pp. 48-56.


Hubbard, TD, Murray, IA, Bisson, WH, Lahoti, TS, Gowda, K, Amin, S, Patterson, AD & Perdew, GH 2015, 'Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles', Scientific reports, vol. 5, 12689.
Lahoti, TS, Boyer, JA, Kusnadi, A, Muku, GE, Murray, IA & Perdew, GH 2015, 'Aryl hydrocarbon receptor activation synergistically induces lipopolysaccharide-mediated expression of proinflammatory chemokine (c-c motif) ligand 20', Toxicological Sciences, vol. 148, no. 1, kfv178, pp. 229-240.
Mohinta, S, Kannan, AK, Gowda, K, Amin, S, Perdew, GH & August, A 2015, 'Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways' Toxicological Sciences, vol. 145, no. 2, pp. 233-243.
Van Den Bogaard, EH, Podolsky, MA, Smits, JP, Cui, X, John, C, Gowda, K, Desai, D, Amin, S, Schalkwijk, J, Perdew, GH & Glick, AB 2015, 'Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation', Journal of Investigative Dermatology, vol. 135, no. 5, pp. 1320-1328.
Zhang, L, Hatzakis, E, Nichols, RG, Hao, R, Correll, J, Smith, PB, Chiaro, CR, Perdew, GH & Patterson, AD 2015, 'Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice', Environmental Science and Technology, vol. 49, no. 13, pp. 8067-8077.
Zhang, L, Nichols, RG, Correll, J, Murray, IA, Tanaka, N, Smith, PB, Hubbard, TD, Sebastian, A, Albert, I, Hatzakis, E, Gonzalez, FJ, Perdew, GH & Patterson, AD 2015, 'Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation', Environmental health perspectives, vol. 123, no. 7, pp. 679-688.
Hubbard, TD, Murray, IA & Perdew, GH 2015, 'Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation', Drug Metabolism and Disposition, vol. 43, no. 10, pp. 1522-1535.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)