Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
ghp2@psu.edu

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Liver
  • Genes
  • Dioxins
  • Transcriptional Activation
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors
  • Gene Expression
  • Response Elements
  • Aryl Hydrocarbon Receptor Nuclear Translocator

Recent Publications

2019

Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline' Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946

2018

Smith, KJ, Murray, IA, Boyer, JA & Perdew, GH 2018, 'Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice', Toxicology, vol. 394, pp. 27-34. https://doi.org/10.1016/j.tox.2017.11.020
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Esser, C, Lawrence, BP, Sherr, DH, Perdew, GH, Puga, A, Barouki, R & Coumoul, X 2018, 'Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France', International journal of molecular sciences, vol. 19, no. 11, 3603. https://doi.org/10.3390/ijms19113603
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists' Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Muku, GE, Murray, IA, Espín, JC & Perdew, GH 2018, 'Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist', Metabolites, vol. 8, no. 4. https://doi.org/10.3390/metabo8040086

2017

Smith, KJ, Boyer, JA, Muku, GE, Murray, IA, Gowda, K, Desai, D, Amin, S, Glick, AB & Perdew, GH 2017, 'Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin', Toxicological Sciences, vol. 160, no. 1, pp. 83-94. https://doi.org/10.1093/toxsci/kfx160
Organtini, KL, Hubbard, TD, Perdew, GH & Dorman, Jr., FL 2017, 'Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems', Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, vol. 52, no. 14, pp. 1295-1302. https://doi.org/10.1080/10934529.2017.1362290
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, PB, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698. https://doi.org/10.1016/j.jff.2017.08.038
Moyer, BJ, Rojas, IY, Murray, IA, Lee, S, Hazlett, HF, Perdew, GH & Tomlinson, CR 2017, 'Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor', Toxicology and Applied Pharmacology, vol. 323, pp. 74-80. https://doi.org/10.1016/j.taap.2017.03.012
Murray, IA & Perdew, GH 2017, 'Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis', Current Opinion in Toxicology, vol. 1, pp. 15-23. https://doi.org/10.1016/j.cotox.2017.01.003
Muku, GE, Lahoti, TS, Murray, IA, Podolsky, MA, Smith, KJ, Hubbard, TD, Kuzu, G, Gowda, K, Amin, S & Perdew, GH 2017, 'Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses', Laboratory Investigation, vol. 97, no. 12, pp. 1471-1487. https://doi.org/10.1038/labinvest.2017.92

2016

Gutierrez, MA, Davis, SS, Rosko, A, Nguyen, SM, Mitchell, KP, Mateen, S, Neves, J, Garcia, TY, Mooney, S, Perdew, GH, Hubbard, TD, Lamba, DA & Ramanathan, A 2016, 'A novel AhR ligand, 2AI, protects the retina from environmental stress', Scientific reports, vol. 6, 29025. https://doi.org/10.1038/srep29025
Hubbard, TD, Murray, IA, Bisson, WH, Sullivan, AP, Sebastian, A, Perry, GH, Jablonski, NG & Perdew, GH 2016, 'Divergent Ah Receptor Ligand Selectivity during Hominin Evolution', Molecular Biology and Evolution, vol. 33, no. 10, pp. 2648-2658. https://doi.org/10.1093/molbev/msw143
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969. https://doi.org/10.1038/srep33969
Girer, NG, Murray, IA, Omiecinski, CJ & Perdew, GH 2016, 'Hepatic aryl hydrocarbon receptor attenuates fibroblast growth factor 21 expression', Journal of Biological Chemistry, vol. 291, no. 29, pp. 15378-15387. https://doi.org/10.1074/jbc.M116.715151
Balandaram, G, Kramer, LR, Kang, BH, Murray, IA, Perdew, GH, Gonzalez, FJ & Peters, JM 2016, 'Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice', Toxicology, vol. 363-364, pp. 1-9. https://doi.org/10.1016/j.tox.2016.07.010
Koga, T, Yao, PL, Goudarzi, M, Murray, IA, Balandaram, G, Gonzalez, FJ, Perdew, GH, Fornace, AJ & Peters, JM 2016, 'Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy', Journal of Biological Chemistry, vol. 291, no. 48, pp. 25255-25263. https://doi.org/10.1074/jbc.M116.755447
Yang, J, Hu, S, Zhao, L, Kaplan, DH, Perdew, GH & Xiong, N 2016, 'Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation', Nature Immunology, vol. 17, no. 1, pp. 48-56. https://doi.org/10.1038/ni.3312

2015

Hubbard, TD, Murray, IA, Bisson, WH, Lahoti, TS, Gowda, K, Amin, S, Patterson, AD & Perdew, GH 2015, 'Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles', Scientific reports, vol. 5, 12689. https://doi.org/10.1038/srep12689
Lahoti, TS, Boyer, JA, Kusnadi, A, Muku, GE, Murray, IA & Perdew, GH 2015, 'Aryl hydrocarbon receptor activation synergistically induces lipopolysaccharide-mediated expression of proinflammatory chemokine (c-c motif) ligand 20', Toxicological Sciences, vol. 148, no. 1, kfv178, pp. 229-240. https://doi.org/10.1093/toxsci/kfv178
Mohinta, S, Kannan, AK, Gowda, K, Amin, S, Perdew, GH & August, A 2015, 'Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways' Toxicological Sciences, vol. 145, no. 2, pp. 233-243. https://doi.org/10.1093/toxsci/kfv046
Van Den Bogaard, EH, Podolsky, MA, Smits, JP, Cui, X, John, C, Gowda, K, Desai, D, Amin, S, Schalkwijk, J, Perdew, GH & Glick, AB 2015, 'Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation', Journal of Investigative Dermatology, vol. 135, no. 5, pp. 1320-1328. https://doi.org/10.1038/jid.2015.6
Zhang, L, Hatzakis, E, Nichols, RG, Hao, R, Correll, J, Smith, PB, Chiaro, CR, Perdew, GH & Patterson, AD 2015, 'Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice', Environmental Science and Technology, vol. 49, no. 13, pp. 8067-8077. https://doi.org/10.1021/acs.est.5b01389
Zhang, L, Nichols, RG, Correll, J, Murray, IA, Tanaka, N, Smith, PB, Hubbard, TD, Sebastian, A, Albert, I, Hatzakis, E, Gonzalez, FJ, Perdew, GH & Patterson, AD 2015, 'Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation', Environmental health perspectives, vol. 123, no. 7, pp. 679-688. https://doi.org/10.1289/ehp.1409055
Hubbard, TD, Murray, IA & Perdew, GH 2015, 'Special section on drug metabolism and the microbiome - Minireview indole and tryptophan metabolism: Endogenous and dietary routes to ah receptor activation', Drug Metabolism and Disposition, vol. 43, no. 10, pp. 1522-1535. https://doi.org/10.1124/dmd.115.064246

Clinical Trials Search


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Adults (age >= 18 years)