Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
ghp2@psu.edu

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Genes
  • Polychlorinated Dibenzodioxins
  • Liver
  • Dioxins
  • Transcriptional Activation
  • human AHR protein
  • Gene Expression
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications

2022

Priyadarshini, M, Navarro, G, Reiman, DJ, Sharma, A, Xu, K, Lednovich, K, Manzella, CR, Khan, MW, Garcia, MS, Allard, S, Wicksteed, B, Chlipala, GE, Szynal, B, Bernabe, BP, Maki, PM, Gill, RK, Perdew, GH, Gilbert, J, Dai, Y & Layden, BT 2022, 'Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis', Gastroenterology, vol. 162, no. 6, pp. 1675-1689.e11. https://doi.org/10.1053/j.gastro.2022.01.008
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological sciences : an official journal of the Society of Toxicology, vol. 187, no. 2, pp. 189-213. https://doi.org/10.1093/toxsci/kfac029

2021

van den Bogaard, EH & Perdew, GH 2021, 'The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability', Journal of Investigative Dermatology, vol. 141, no. 6, pp. 1385-1388. https://doi.org/10.1016/j.jid.2020.12.013
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831. https://doi.org/10.1016/j.tox.2021.152831
van den Bogaard, EH, Esser, C & Perdew, GH 2021, 'The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications', Experimental Dermatology, vol. 30, no. 10, pp. 1477-1483. https://doi.org/10.1111/exd.14409

2020

Murray, IA & Perdew, GH 2020, 'How ah receptor ligand specificity became important in understanding its physiological function', International journal of molecular sciences, vol. 21, no. 24, 9614, pp. 1-19. https://doi.org/10.3390/ijms21249614
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24. https://doi.org/10.1080/19490976.2020.1788899
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621. https://doi.org/10.15252/emmm.201911621
Dong, F & Perdew, GH 2020, 'The aryl hydrocarbon receptor as a mediator of host-microbiota interplay', Gut microbes, vol. 12, no. 1, 1859812. https://doi.org/10.1080/19490976.2020.1859812
Zhou, X, Li, D, Xu, W, Zhang, H, Wang, H & Perdew, GH 2020, 'β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice', Antioxidants, vol. 9, no. 12, 1264, pp. 1-14. https://doi.org/10.3390/antiox9121264

2019

Muku, GE, Murray, IA & Perdew, GH 2019, 'Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome', Current Pharmacology Reports, vol. 5, no. 5, pp. 319-331. https://doi.org/10.1007/s40495-019-00197-2
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Gourronc, FA, Perdew, GH, Robertson, LW & Klingelhutz, AJ 2020, 'PCB126 blocks the thermogenic beiging response of adipocytes', Environmental Science and Pollution Research, vol. 27, no. 9, pp. 8897-8904. https://doi.org/10.1007/s11356-019-06663-0
Muku, GE, Blazanin, N, Dong, F, Smith, PB, Thiboutot, D, Gowda, K, Amin, S, Murray, IA & Perdew, GH 2019, 'Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes', Toxicological Sciences, vol. 171, no. 1, pp. 146-158. https://doi.org/10.1093/toxsci/kfz140
Muku, GE, Kusnadi, A, Kuzu, G, Tanos, R, Murray, IA, Gowda, K, Amin, S & Perdew, GH 2020, 'Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity', Laboratory Investigation, vol. 100, no. 2, pp. 250-264. https://doi.org/10.1038/s41374-019-0306-x

2018

Smith, KJ, Murray, IA, Boyer, JA & Perdew, GH 2018, 'Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice', Toxicology, vol. 394, pp. 27-34. https://doi.org/10.1016/j.tox.2017.11.020
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Esser, C, Lawrence, BP, Sherr, DH, Perdew, GH, Puga, A, Barouki, R & Coumoul, X 2018, 'Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France', International journal of molecular sciences, vol. 19, no. 11, 3603. https://doi.org/10.3390/ijms19113603
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Muku, GE, Murray, IA, Espín, JC & Perdew, GH 2018, 'Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist', Metabolites, vol. 8, no. 4. https://doi.org/10.3390/metabo8040086

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)