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Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Liver
  • Polychlorinated Dibenzodioxins
  • Dioxins
  • Gene Expression
  • Transcriptional Activation
  • human AHR protein
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors
  • Microbiota

Recent Publications


Chakraborty, D, Coslo, DM, Murray, IA, Vijay, A, Patterson, AD & Perdew, GH 2024, 'Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine', FASEB Journal, vol. 38, no. 4, e23471.
Eaton, DL, Simon, TW, Kaminski, NE, Perdew, GH & Nebert, DW 2024, 'Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors', Regulatory Toxicology and Pharmacology, vol. 149, 105598.
Eaton, DL, Simon, TW, Kaminski, NE, Perdew, GH & Nebert, DW 2024, 'The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment', Regulatory Toxicology and Pharmacology, vol. 149, 105599.


Ganapathy, AS, Saha, K, Wang, A, Arumugam, P, Dharmaprakash, V, Yochum, G, Koltun, W, Nighot, M, Perdew, G, Thompson, TA, Ma, T & Nighot, P 2023, 'Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways', Cell Reports, vol. 42, no. 7, 112705.
Saha, K, Subramenium Ganapathy, A, Wang, A, Arumugam, P, Michael Morris, N, Harris, L, Yochum, G, Koltun, W, Perdew, GH, Nighot, M, Ma, T & Nighot, P 2023, 'Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation', Mucosal Immunology, vol. 16, no. 6, pp. 826-842.
Zhou, X, Chakraborty, D, Murray, IA, Coslo, D, Kehs, Z, Vijay, A, Ton, C, Desai, D, Amin, SG, Patterson, AD & Perdew, GH 2023, 'Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming', Laboratory Investigation, vol. 103, no. 2, 100012.
Vijay, A, Boyle, NR, Kumar, SM, Perdew, GH, Srinivasan, S & Patterson, AD 2023, 'Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice', Toxicological Sciences, vol. 192, no. 1, pp. 117-128.
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010.
Morgan, EW, Dong, F, Annalora, AJ, Murray, IA, Wolfe, T, Erickson, R, Gowda, K, Amin, SG, Petersen, KS, Kris-Etherton, PM, Marcus, CB, Walk, ST, Patterson, AD & Perdew, GH 2023, 'Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation', International Journal of Tryptophan Research, vol. 16.
Dong, F, Annalora, AJ, Murray, IA, Tian, Y, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback', International Journal of Tryptophan Research, vol. 16.
Patel, D, Murray, IA, Dong, F, Annalora, AJ, Gowda, K, Coslo, DM, Krzeminski, J, Koo, I, Hao, F, Amin, SG, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites', Metabolites, vol. 13, no. 9, 985.
Rikken, G, Smith, KJ, van den Brink, NJM, Smits, JPH, Gowda, K, Alnemri, A, Kuzu, GE, Murray, IA, Lin, JM, Smits, JGA, van Vlijmen-Willems, IM, Amin, SG, Perdew, GH & van den Bogaard, EH 2023, 'Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders', Biochemical Pharmacology, vol. 208, 115400.
Chen, X, Patterson, AD, Perdew, GH, Murray, IA & Kellogg, JJ 2023, 'Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)', Journal of Functional Foods, vol. 106, 105602.
Perdew, GH, Esser, C, Snyder, M, Sherr, DH, van den Bogaard, EH, McGovern, K, Fernández-Salguero, PM, Coumoul, X & Patterson, AD 2023, 'The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022', International journal of molecular sciences, vol. 24, no. 6, 5550.
Isaacs, JT, Dalrymple, SL, Antony, L, Marc Rosen, D, Coleman, IM, Nelson, PS, Kostova, M, Murray, IA, Perdew, GH, Denmeade, SR, Akinboye, ES & Brennen, WN 2023, 'Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer', Prostate, vol. 83, no. 15, pp. 1470-1493.


Granados, JC, Falah, K, Koo, I, Morgan, EW, Perdew, GH, Patterson, AD, Jamshidi, N & Nigam, SK 2022, 'AHR is a master regulator of diverse pathways in endogenous metabolism', Scientific reports, vol. 12, no. 1, 16625.
Tian, Y, Rimal, B, Gui, W, Koo, I, Yokoyama, S, Perdew, GH & Patterson, AD 2022, 'Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood', International journal of molecular sciences, vol. 23, no. 15, 8220.
Priyadarshini, M, Navarro, G, Reiman, DJ, Sharma, A, Xu, K, Lednovich, K, Manzella, CR, Khan, MW, Garcia, MS, Allard, S, Wicksteed, B, Chlipala, GE, Szynal, B, Bernabe, BP, Maki, PM, Gill, RK, Perdew, GH, Gilbert, J, Dai, Y & Layden, BT 2022, 'Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis', Gastroenterology, vol. 162, no. 6, pp. 1675-1689.e11.
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological Sciences, vol. 187, no. 2, pp. 189-213.


van den Bogaard, EH & Perdew, GH 2021, 'The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability', Journal of Investigative Dermatology, vol. 141, no. 6, pp. 1385-1388.
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831.
van den Bogaard, EH, Esser, C & Perdew, GH 2021, 'The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications', Experimental Dermatology, vol. 30, no. 10, pp. 1477-1483.


Murray, IA & Perdew, GH 2020, 'How ah receptor ligand specificity became important in understanding its physiological function', International journal of molecular sciences, vol. 21, no. 24, 9614, pp. 1-19.
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24.
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1.
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621.
Dong, F & Perdew, GH 2020, 'The aryl hydrocarbon receptor as a mediator of host-microbiota interplay', Gut microbes, vol. 12, no. 1, 1859812.
Zhou, X, Li, D, Xu, W, Zhang, H, Wang, H & Perdew, GH 2020, 'β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice', Antioxidants, vol. 9, no. 12, 1264, pp. 1-14.