Gary H. Perdew, PhD - Penn State Cancer Institute
Researcher Profile
Gary H. Perdew, PhD
John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Aryl Hydrocarbon Receptors
- Ligands
- Proteins
- Liver
- Polychlorinated Dibenzodioxins
- Dioxins
- Gene Expression
- Transcriptional Activation
- human AHR protein
- HSP90 Heat-Shock Proteins
- Peroxisome Proliferator-Activated Receptors
- Microbiota
Recent Publications
2023
Ganapathy, AS, Saha, K, Wang, A, Arumugam, P, Dharmaprakash, V, Yochum, G, Koltun, W, Nighot, M, Perdew, G, Thompson, TA, Ma, T & Nighot, P 2023, 'Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways', Cell Reports, vol. 42, no. 7, 112705. https://doi.org/10.1016/j.celrep.2023.112705
Zhou, X, Chakraborty, D, Murray, IA, Coslo, D, Kehs, Z, Vijay, A, Ton, C, Desai, D, Amin, SG, Patterson, AD & Perdew, GH 2023, 'Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming', Laboratory Investigation, vol. 103, no. 2, pp. 100012. https://doi.org/10.1016/j.labinv.2022.100012
Vijay, A, Boyle, NR, Kumar, SM, Perdew, GH, Srinivasan, S & Patterson, AD 2023, 'Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice', Toxicological Sciences, vol. 192, no. 1, pp. 117-128. https://doi.org/10.1093/toxsci/kfad014
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010. https://doi.org/10.1096/fj.202300703R
Morgan, EW, Dong, F, Annalora, AJ, Murray, IA, Wolfe, T, Erickson, R, Gowda, K, Amin, SG, Petersen, KS, Kris-Etherton, PM, Marcus, CB, Walk, ST, Patterson, AD & Perdew, GH 2023, 'Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182510
Rikken, G, Smith, KJ, van den Brink, NJM, Smits, JPH, Gowda, K, Alnemri, A, Kuzu, GE, Murray, IA, Lin, JM, Smits, JGA, van Vlijmen-Willems, IM, Amin, SG, Perdew, GH & van den Bogaard, EH 2023, 'Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders', Biochemical Pharmacology, vol. 208, 115400. https://doi.org/10.1016/j.bcp.2022.115400
Chen, X, Patterson, AD, Perdew, GH, Murray, IA & Kellogg, JJ 2023, 'Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)', Journal of Functional Foods, vol. 106, 105602. https://doi.org/10.1016/j.jff.2023.105602
Perdew, GH, Esser, C, Snyder, M, Sherr, DH, van den Bogaard, EH, McGovern, K, Fernández-Salguero, PM, Coumoul, X & Patterson, AD 2023, 'The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022', International journal of molecular sciences, vol. 24, no. 6, 5550. https://doi.org/10.3390/ijms24065550
Isaacs, JT, Dalrymple, SL, Antony, L, Marc Rosen, D, Coleman, IM, Nelson, PS, Kostova, M, Murray, IA, Perdew, GH, Denmeade, SR, Akinboye, ES & Brennen, WN 2023, 'Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer', Prostate. https://doi.org/10.1002/pros.24606
2022
Granados, JC, Falah, K, Koo, I, Morgan, EW, Perdew, GH, Patterson, AD, Jamshidi, N & Nigam, SK 2022, 'AHR is a master regulator of diverse pathways in endogenous metabolism', Scientific reports, vol. 12, no. 1, 16625. https://doi.org/10.1038/s41598-022-20572-2
Tian, Y, Rimal, B, Gui, W, Koo, I, Yokoyama, S, Perdew, GH & Patterson, AD 2022, 'Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood', International journal of molecular sciences, vol. 23, no. 15, 8220. https://doi.org/10.3390/ijms23158220
Priyadarshini, M, Navarro, G, Reiman, DJ, Sharma, A, Xu, K, Lednovich, K, Manzella, CR, Khan, MW, Garcia, MS, Allard, S, Wicksteed, B, Chlipala, GE, Szynal, B, Bernabe, BP, Maki, PM, Gill, RK, Perdew, GH, Gilbert, J, Dai, Y & Layden, BT 2022, 'Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis', Gastroenterology, vol. 162, no. 6, pp. 1675-1689.e11. https://doi.org/10.1053/j.gastro.2022.01.008
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological Sciences, vol. 187, no. 2, pp. 189-213. https://doi.org/10.1093/toxsci/kfac029
2021
van den Bogaard, EH & Perdew, GH 2021, 'The Enigma of AHR Activation in the Skin: Interplay among Ligands, Metabolism, and Bioavailability', Journal of Investigative Dermatology, vol. 141, no. 6, pp. 1385-1388. https://doi.org/10.1016/j.jid.2020.12.013
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831. https://doi.org/10.1016/j.tox.2021.152831
van den Bogaard, EH, Esser, C & Perdew, GH 2021, 'The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications', Experimental Dermatology, vol. 30, no. 10, pp. 1477-1483. https://doi.org/10.1111/exd.14409
2020
Murray, IA & Perdew, GH 2020, 'How ah receptor ligand specificity became important in understanding its physiological function', International journal of molecular sciences, vol. 21, no. 24, 9614, pp. 1-19. https://doi.org/10.3390/ijms21249614
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24. https://doi.org/10.1080/19490976.2020.1788899
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621. https://doi.org/10.15252/emmm.201911621
Dong, F & Perdew, GH 2020, 'The aryl hydrocarbon receptor as a mediator of host-microbiota interplay', Gut microbes, vol. 12, no. 1, 1859812. https://doi.org/10.1080/19490976.2020.1859812
Zhou, X, Li, D, Xu, W, Zhang, H, Wang, H & Perdew, GH 2020, 'β-Naphthoflavone activation of the Ah receptor alleviates irradiation-induced intestinal injury in mice', Antioxidants, vol. 9, no. 12, 1264, pp. 1-14. https://doi.org/10.3390/antiox9121264
2019
Muku, GE, Murray, IA & Perdew, GH 2019, 'Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome', Current Pharmacology Reports, vol. 5, no. 5, pp. 319-331. https://doi.org/10.1007/s40495-019-00197-2
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Gourronc, FA, Perdew, GH, Robertson, LW & Klingelhutz, AJ 2020, 'PCB126 blocks the thermogenic beiging response of adipocytes', Environmental Science and Pollution Research, vol. 27, no. 9, pp. 8897-8904. https://doi.org/10.1007/s11356-019-06663-0
Muku, GE, Blazanin, N, Dong, F, Smith, PB, Thiboutot, D, Gowda, K, Amin, S, Murray, IA & Perdew, GH 2019, 'Selective Ah Receptor Ligands Mediate Enhanced SREBP1 Proteolysis to Restrict Lipogenesis in Sebocytes', Toxicological Sciences, vol. 171, no. 1, pp. 146-158. https://doi.org/10.1093/toxsci/kfz140
Muku, GE, Kusnadi, A, Kuzu, G, Tanos, R, Murray, IA, Gowda, K, Amin, S & Perdew, GH 2020, 'Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity', Laboratory Investigation, vol. 100, no. 2, pp. 250-264. https://doi.org/10.1038/s41374-019-0306-x