Researcher Profile

Researcher Profile

Gary H. Perdew, PhD

Gary H. Perdew, PhD

John T. And Paige S. Smith Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
ghp2@psu.edu

Research Interests

  • Aryl Hydrocarbon Receptors
  • Ligands
  • Proteins
  • Polychlorinated Dibenzodioxins
  • Genes
  • Dioxins
  • Liver
  • Transcriptional Activation
  • human AHR protein
  • Gene Expression
  • HSP90 Heat-Shock Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications

2020

Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Dvořák, Z, Kopp, F, Costello, CM, Kemp, JS, Li, H, Vrzalová, A, Štěpánková, M, Bartoňková, I, Jiskrová, E, Poulíková, K, Vyhlídalová, B, Nordstroem, LU, Karunaratne, CV, Ranhotra, HS, Mun, KS, Naren, AP, Murray, IA, Perdew, GH, Brtko, J, Toporova, L, Schön, A, Wallace, WG, Walton, WG, Redinbo, MR, Sun, K, Beck, A, Kortagere, S, Neary, MC, Chandran, A, Vishveshwara, S, Cavalluzzi, MM, Lentini, G, Cui, JY, Gu, H, March, JC, Chatterjee, S, Matson, A, Wright, D, Flannigan, KL, Hirota, SA, Sartor, RB & Mani, S 2020, 'Targeting the pregnane X receptor using microbial metabolite mimicry', EMBO Molecular Medicine, vol. 12, no. 4, e11621. https://doi.org/10.15252/emmm.201911621

2019

Muku, GE, Murray, IA & Perdew, GH 2019, 'Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome', Current Pharmacology Reports, vol. 5, no. 5, pp. 319-331. https://doi.org/10.1007/s40495-019-00197-2
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Gourronc, FA, Perdew, GH, Robertson, LW & Klingelhutz, AJ 2020, 'PCB126 blocks the thermogenic beiging response of adipocytes', Environmental Science and Pollution Research, vol. 27, no. 9, pp. 8897-8904. https://doi.org/10.1007/s11356-019-06663-0
Muku, GE, Kusnadi, A, Kuzu, G, Tanos, R, Murray, IA, Gowda, K, Amin, S & Perdew, GH 2020, 'Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity', Laboratory Investigation, vol. 100, no. 2, pp. 250-264. https://doi.org/10.1038/s41374-019-0306-x

2018

Smith, KJ, Murray, IA, Boyer, JA & Perdew, GH 2018, 'Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice', Toxicology, vol. 394, pp. 27-34. https://doi.org/10.1016/j.tox.2017.11.020
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Esser, C, Lawrence, BP, Sherr, DH, Perdew, GH, Puga, A, Barouki, R & Coumoul, X 2018, 'Old receptor, new tricks—The ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR meeting, 29–31 August 2018 in Paris, France', International journal of molecular sciences, vol. 19, no. 11, 3603. https://doi.org/10.3390/ijms19113603
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Muku, GE, Murray, IA, Espín, JC & Perdew, GH 2018, 'Urolithin a is a dietary microbiota-derived human aryl hydrocarbon receptor antagonist', Metabolites, vol. 8, no. 4. https://doi.org/10.3390/metabo8040086

2017

Smith, KJ, Boyer, JA, Muku, GE, Murray, IA, Gowda, K, Desai, D, Amin, SG, Glick, AB & Perdew, GH 2017, 'Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin', Toxicological Sciences, vol. 160, no. 1, pp. 83-94. https://doi.org/10.1093/toxsci/kfx160
Organtini, KL, Hubbard, TD, Perdew, GH & Dorman, FL 2017, 'Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems', Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, vol. 52, no. 14, pp. 1295-1302. https://doi.org/10.1080/10934529.2017.1362290
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, P, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698. https://doi.org/10.1016/j.jff.2017.08.038
Moyer, BJ, Rojas, IY, Murray, IA, Lee, S, Hazlett, HF, Perdew, GH & Tomlinson, CR 2017, 'Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor', Toxicology and Applied Pharmacology, vol. 323, pp. 74-80. https://doi.org/10.1016/j.taap.2017.03.012
Murray, IA & Perdew, GH 2017, 'Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis', Current Opinion in Toxicology, vol. 1, pp. 15-23. https://doi.org/10.1016/j.cotox.2017.01.003
Muku, GE, Lahoti, TS, Murray, IA, Podolsky, MA, Smith, KJ, Hubbard, TD, Kuzu, G, Gowda, K, Amin, SG & Perdew, GH 2017, 'Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses', Laboratory Investigation, vol. 97, no. 12, pp. 1471-1487. https://doi.org/10.1038/labinvest.2017.92

2016

Gutierrez, MA, Davis, SS, Rosko, A, Nguyen, SM, Mitchell, KP, Mateen, S, Neves, J, Garcia, TY, Mooney, S, Perdew, GH, Hubbard, TD, Lamba, DA & Ramanathan, A 2016, 'A novel AhR ligand, 2AI, protects the retina from environmental stress', Scientific reports, vol. 6, 29025. https://doi.org/10.1038/srep29025
Hubbard, TD, Murray, IA, Bisson, WH, Sullivan, AP, Sebastian, A, Perry, GH, Jablonski, NG & Perdew, GH 2016, 'Divergent Ah Receptor Ligand Selectivity during Hominin Evolution', Molecular biology and evolution, vol. 33, no. 10, pp. 2648-2658. https://doi.org/10.1093/molbev/msw143
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969. https://doi.org/10.1038/srep33969
Girer, NG, Murray, IA, Omiecinski, CJ & Perdew, GH 2016, 'Hepatic aryl hydrocarbon receptor attenuates fibroblast growth factor 21 expression', Journal of Biological Chemistry, vol. 291, no. 29, pp. 15378-15387. https://doi.org/10.1074/jbc.M116.715151
Balandaram, G, Kramer, LR, Kang, BH, Murray, IA, Perdew, GH, Gonzalez, FJ & Peters, JM 2016, 'Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice', Toxicology, vol. 363-364, pp. 1-9. https://doi.org/10.1016/j.tox.2016.07.010
Koga, T, Yao, PL, Goudarzi, M, Murray, IA, Balandaram, G, Gonzalez, FJ, Perdew, GH, Fornace, AJ & Peters, JM 2016, 'Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy', Journal of Biological Chemistry, vol. 291, no. 48, pp. 25255-25263. https://doi.org/10.1074/jbc.M116.755447
Yang, J, Hu, S, Zhao, L, Kaplan, DH, Perdew, GH & Xiong, N 2016, 'Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation', Nature Immunology, vol. 17, no. 1, pp. 48-56. https://doi.org/10.1038/ni.3312

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)