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Jiafen Hu, MSc, PhD

Jiafen Hu, MSc, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Rabbits
  • Cottontail rabbit papillomavirus
  • Papillomavirus Infections
  • Immunity
  • Infections
  • Neoplasms
  • Papilloma
  • Skin
  • DNA
  • Vaccination
  • Genome
  • Epitopes

Recent Publications


Kozak, M & Hu, J 2023, 'The Integrated Consideration of Vaccine Platforms, Adjuvants, and Delivery Routes for Successful Vaccine Development', Vaccines, vol. 11, no. 3, 695.


Hu, J, Brendle, SA, Li, JJ, Walter, V, Cladel, NM, Cooper, T, Shearer, DA, Balogh, KK & Christensen, ND 2022, 'Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model', Viruses, vol. 14, no. 5, 980.
Cladel, NM, Xu, J, Peng, X, Jiang, P, Christensen, ND, Zheng, ZM & Hu, J 2022, 'Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus', Viruses, vol. 14, no. 9, 1964.
Brendle, SA, Li, J, Cladel, NM, Balogh, KK, Booth, J, Shearer, DA, Walter, V, Lu, S, Christensen, ND, Covington, D, DeBroff, J, Milici, J, Zhu, Y, Viscidi, R & Hu, J 2022, 'Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections', Journal of virology, vol. 96, no. 16.
Olczak, P, Matsui, K, Wong, M, Alvarez, J, Lambert, P, Christensen, ND, Hu, J, Huber, B, Kirnbauer, R, Wang, JW & Roden, RBS 2022, 'RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer', Journal of virology, vol. 96, no. 13.


Brendle, S, Cladel, N, Balogh, K, Alam, S, Christensen, N, Meyers, C & Hu, J 2021, 'A comparative study on delivery of externally attached dna by papillomavirus vlps and pseudoviruses', Vaccines, vol. 9, no. 12, 1501.
Hartmann, SR, Goetschius, DJ, Hu, J, Graff, JJ, Bator, CM, Christensen, ND & Hafenstein, SL 2021, 'Cryo em analysis reveals inherent flexibility of authentic murine papillomavirus capsids', Viruses, vol. 13, no. 10, 2023.
Xu, J, Zhang, J, Yang, D, Song, J, Pallas, B, Zhang, C, Hu, J, Peng, X, Christensen, ND, Han, R & Chen, YE 2021, 'Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research', Frontiers in Genetics, vol. 12, 642444.
Béziat, V, Rapaport, F, Hu, J, Titeux, M, Bonnet des Claustres, M, Bourgey, M, Griffin, H, Bandet, É, Ma, CS, Sherkat, R, Rokni-Zadeh, H, Louis, DM, Changi-Ashtiani, M, Delmonte, OM, Fukushima, T, Habib, T, Guennoun, A, Khan, T, Bender, N, Rahman, M, About, F, Yang, R, Rao, G, Rouzaud, C, Li, J, Shearer, D, Balogh, K, Al Ali, F, Ata, M, Dabiri, S, Momenilandi, M, Nammour, J, Alyanakian, MA, Leruez-Ville, M, Guenat, D, Materna, M, Marcot, L, Vladikine, N, Soret, C, Vahidnezhad, H, Youssefian, L, Saeidian, AH, Uitto, J, Catherinot, É, Navabi, SS, Zarhrate, M, Woodley, DT, Jeljeli, M, Abraham, T, Belkaya, S, Lorenzo, L, Rosain, J, Bayat, M, Lanternier, F, Lortholary, O, Zakavi, F, Gros, P, Orth, G, Abel, L, Prétet, JL, Fraitag, S, Jouanguy, E, Davis, MM, Tangye, SG, Notarangelo, LD, Marr, N, Waterboer, T, Langlais, D, Doorbar, J, Hovnanian, A, Christensen, N, Bossuyt, X, Shahrooei, M & Casanova, JL 2021, 'Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy', Cell, vol. 184, no. 14, pp. 3812-3828.e30.
Brendle, S, Li, JJ, Cladel, NM, Shearer, DA, Budgeon, LR, Balogh, KK, Atkins, H, Costa-Fujishima, M, Lopez, P, Christensen, ND, Doorbar, J, Murooka, TT & Hu, J 2021, 'Mouse papillomavirus l1 and l2 are dispensable for viral infection and persistence at both cutaneous and mucosal tissues', Viruses, vol. 13, no. 9, 1824.


El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660.
Osborne, AJ, Atkins, HM, Balogh, KK, Brendle, SA, Shearer, DA, Hu, J, Sample, CE & Christensen, ND 2020, 'Antibody-mediated immune subset depletion modulates the immune response in a rabbit (Oryctolagus cuniculus) model of Epstein-Barr virus infection', Comparative Medicine, vol. 70, no. 5, pp. 312-322.
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321.


Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, de Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2019, 'Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)', Experimental and Molecular Medicine, vol. 51, no. 7, 71.
Cladel, NM, Jiang, P, Li, JJ, Peng, X, Cooper, TK, Majerciak, V, Balogh, KK, Meyer, TJ, Brendle, SA, Budgeon, LR, Shearer, DA, Munden, R, Cam, M, Vallur, R, Christensen, ND, Zheng, ZM & Hu, J 2019, 'Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models', Emerging Microbes and Infections, vol. 8, no. 1, pp. 1108-1121.
Cladel, NM, Peng, X, Christensen, N & Hu, J 2019, 'The rabbit papillomavirus model: A valuable tool to study viral-host interactions', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1773, 20180294.