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Edward Fox, MD

Edward Fox, MD

Professor, Department of Orthopaedics and Rehabilitation
Chief, Division of Orthopaedic Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Sarcoma Cancer Team
EJF18@psu.edu

Research Interests

As a professor of orthopaedic surgery specializing in musculoskeletal oncology surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased health care expenditures, and Dr. Fox's research focuses on improvements in this area.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

  • Neoplasms
  • Therapeutics
  • Bone and Bones
  • Osteoporosis
  • Extremities
  • Wounds and Injuries
  • Neoplasm Metastasis
  • Hip Fractures
  • Orthopedics
  • Prostheses and Implants
  • Drug Therapy
  • Femur

Recent Publications

2022

Sciamanna, CN, Ballentine, NH, Bopp, M, Chinchilli, VM, Ciccolo, JT, Delauter, G, Fisher, A, Fox, EJ, Jan De Beur, SM, Kearcher, K, Kraschnewski, JL, Lehman, E, McTigue, KM, McAuley, E, Paranjape, A, Rodriguez-Colon, S, Rovniak, LS, Rutt, K, Smyth, JM, Stewart, KJ, Stuckey, HL & Tsay, A 2022, 'Correction to: Working to increase stability through exercise (WISE): screening, recruitment, and baseline characteristics (Trials, (2021), 22, 1, (809), 10.1186/s13063-021-05761-0)', Trials, vol. 23, no. 1, 34. https://doi.org/10.1186/s13063-022-06018-0
Flemming, DJ, White, C, Fox, E, Fanburg-Smith, J & Cochran, E 2023, 'Diagnostic errors in musculoskeletal oncology and possible mitigation strategies', Skeletal Radiology, vol. 52, no. 3, pp. 493-503. https://doi.org/10.1007/s00256-022-04166-7

2021

Tilton, M, Lewis, GS, Hast, MW, Fox, E & Manogharan, G 2021, 'Additively manufactured patient-specific prosthesis for tumor reconstruction: Design, process, and properties', PloS one, vol. 16, no. 7 July, e0253786. https://doi.org/10.1371/journal.pone.0253786
Johnson, T, Fox, E & Hassanbein, S 2021, 'Implementing an Electronic Medical Record Osteoporosis Self-Assessment Tool Score Which Identifies Patients at Risk for Osteoporosis Promotes Osteoporosis Evaluation', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 12. https://doi.org/10.1177/21514593211002157
Chen, T, Wang, Y, Goetz, L, Corey, Z, Dougher, MC, Smith, JD, Fox, EJ, Freiberg, AS, Flemming, D & Fanburg-Smith, JC 2021, 'Novel fusion sarcomas including targetable NTRK and ALK', Annals of Diagnostic Pathology, vol. 54, 151800. https://doi.org/10.1016/j.anndiagpath.2021.151800
Bagley, JJ, Piazza, B, Lazarus, MD, Fox, EJ & Zhan, X 2021, 'Resident Training and the Assessment of Orthopaedic Surgical Skills', JBJS Open Access, vol. 6, no. 4, e2000173. https://doi.org/10.2106/JBJS.OA.20.00173
Mrowczynski, OD, Vasekar, M, Fox, E, Harbaugh, K, Aregawi, D, Pameijer, CR, Zaorsky, N, Payne, R & Rizk, E 2021, 'Spontaneous Hip Dislocation Complicating the Management of Malignant Peripheral Nerve Sheath Tumor Arising Within a Plexiform Neurofibroma', Cureus, vol. 13, no. 7, e16320. https://doi.org/10.7759/cureus.16320
Zaorsky, NG, Liang, M, Patel, R, Lin, C, Tchelebi, LT, Newport, KB, Fox, EJ & Wang, M 2021, 'Survival after palliative radiation therapy for cancer: The METSSS model', Radiotherapy and Oncology, vol. 158, pp. 104-111. https://doi.org/10.1016/j.radonc.2021.02.011

2020

Burton, A, Davis, CM, Boateng, H, Fox, EJ, McQuillan, PM, Mets, B, Hassenbein, S, Black, KP, Munyon, R, McGillen, B & Armstrong, AD 2020, 'A Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 11. https://doi.org/10.1177/2151459319898646
Ryan, C, Stoltzfus, KC, Horn, S, Chen, H, Louie, AV, Lehrer, EJ, Trifiletti, DM, Fox, EJ, Abraham, JA & Zaorsky, NG 2022, 'Epidemiology of bone metastases', Bone, vol. 158, 115783. https://doi.org/10.1016/j.bone.2020.115783
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Burton, A, Davis, C, Boateng, H, Fox, E, McQuillan, P, Mets, B, Hassenbein, SE, Black, K, Munyon, R, McGillen, B & Armstrong, A 2020, 'Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation. <https://journals.sagepub.com/doi/10.1177/2151459319898646>