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Researcher Profile

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Edward Fox, MD

Edward Fox, MD

Professor, Department of Orthopaedics and Rehabilitation
Chief, Division of Orthopaedic Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Sarcoma Cancer Team

Research Interests

As a professor of orthopaedic surgery specializing in musculoskeletal oncology surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased health care expenditures, and Dr. Fox's research focuses on improvements in this area.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

  • Neoplasms
  • Therapeutics
  • Bone and Bones
  • Osteoporosis
  • Extremities
  • Wounds and Injuries
  • Neoplasm Metastasis
  • Hip Fractures
  • Orthopedics
  • Prostheses and Implants
  • Drug Therapy
  • Femur

Recent Publications


Sciamanna, CN, Ballentine, NH, Bopp, M, Chinchilli, VM, Ciccolo, JT, Delauter, G, Fisher, A, Fox, EJ, Jan De Beur, SM, Kearcher, K, Kraschnewski, JL, Lehman, E, McTigue, KM, McAuley, E, Paranjape, A, Rodriguez-Colon, S, Rovniak, LS, Rutt, K, Smyth, JM, Stewart, KJ, Stuckey, HL & Tsay, A 2022, 'Correction to: Working to increase stability through exercise (WISE): screening, recruitment, and baseline characteristics (Trials, (2021), 22, 1, (809), 10.1186/s13063-021-05761-0)', Trials, vol. 23, no. 1, 34.
Flemming, DJ, White, C, Fox, E, Fanburg-Smith, J & Cochran, E 2023, 'Diagnostic errors in musculoskeletal oncology and possible mitigation strategies', Skeletal Radiology, vol. 52, no. 3, pp. 493-503.


Tilton, M, Lewis, GS, Hast, MW, Fox, E & Manogharan, G 2021, 'Additively manufactured patient-specific prosthesis for tumor reconstruction: Design, process, and properties', PloS one, vol. 16, no. 7 July, e0253786.
Johnson, T, Fox, E & Hassanbein, S 2021, 'Implementing an Electronic Medical Record Osteoporosis Self-Assessment Tool Score Which Identifies Patients at Risk for Osteoporosis Promotes Osteoporosis Evaluation', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 12.
Chen, T, Wang, Y, Goetz, L, Corey, Z, Dougher, MC, Smith, JD, Fox, EJ, Freiberg, AS, Flemming, D & Fanburg-Smith, JC 2021, 'Novel fusion sarcomas including targetable NTRK and ALK', Annals of Diagnostic Pathology, vol. 54, 151800.
Bagley, JJ, Piazza, B, Lazarus, MD, Fox, EJ & Zhan, X 2021, 'Resident Training and the Assessment of Orthopaedic Surgical Skills', JBJS Open Access, vol. 6, no. 4, e2000173.
Zaorsky, NG, Liang, M, Patel, R, Lin, C, Tchelebi, LT, Newport, KB, Fox, EJ & Wang, M 2021, 'Survival after palliative radiation therapy for cancer: The METSSS model', Radiotherapy and Oncology, vol. 158, pp. 104-111.


Burton, A, Davis, CM, Boateng, H, Fox, EJ, McQuillan, PM, Mets, B, Hassenbein, S, Black, KP, Munyon, R, McGillen, B & Armstrong, AD 2020, 'A Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 11.
Ryan, C, Stoltzfus, KC, Horn, S, Chen, H, Louie, AV, Lehrer, EJ, Trifiletti, DM, Fox, EJ, Abraham, JA & Zaorsky, NG 2022, 'Epidemiology of bone metastases', Bone, vol. 158, 115783.
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113.
Burton, A, Davis, C, Boateng, H, Fox, E, McQuillan, P, Mets, B, Hassenbein, SE, Black, K, Munyon, R, McGillen, B & Armstrong, A 2020, 'Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation. <>


Grap, SM, Fox, E, Freeman, M, Blackall, GF & Dalal, PG 2019, 'Acute Postoperative Pain Management After Major Limb Amputation in a Pediatric Patient: A Case Report', Journal of Perianesthesia Nursing, vol. 34, no. 4, pp. 801-809.
Tucker, SM, Wee, H, Fox, E, Reid, JS & Lewis, GS 2019, 'Parametric Finite Element Analysis of Intramedullary Nail Fixation of Proximal Femur Fractures', Journal of Orthopaedic Research, vol. 37, no. 11, pp. 2358-2366.
Hain, BA, Jude, B, Xu, H, Smuin, DM, Fox, EJ, Elfar, JC & Waning, DL 2020, 'Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy', Journal of Bone and Mineral Research, vol. 35, no. 2, pp. 368-381.