Researcher Profile

Researcher Profile

Edward Fox, MD

Edward Fox, MD

Professor, Department of Orthopaedics and Rehabilitation
Chief, Division of Orthopaedic Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Sarcoma Cancer
ejf18@psu.edu

Research Interests

As a professor of orthopaedic surgery specializing in musculoskeletal oncology surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased health care expenditures, and Dr. Fox's research focuses on improvements in this area.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

  • Neoplasms
  • Therapeutics
  • Bone and Bones
  • Osteoporosis
  • Extremities
  • Hip Fractures
  • Wounds and Injuries
  • Neoplasm Metastasis
  • Drug Therapy
  • Pelvis
  • Biopsy
  • Femur

Recent Publications

2021

Johnson, T, Fox, E & Hassanbein, S 2021, 'Implementing an Electronic Medical Record Osteoporosis Self-Assessment Tool Score Which Identifies Patients at Risk for Osteoporosis Promotes Osteoporosis Evaluation', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 12. https://doi.org/10.1177/21514593211002157
Zaorsky, NG, Liang, M, Patel, R, Lin, C, Tchelebi, LT, Newport, KB, Fox, EJ & Wang, M 2021, 'Survival after palliative radiation therapy for cancer: The METSSS model', Radiotherapy and Oncology, vol. 158, pp. 104-111. https://doi.org/10.1016/j.radonc.2021.02.011

2020

Burton, A, Davis, CM, Boateng, H, Fox, EJ, McQuillan, PM, Mets, B, Hassenbein, S, Black, KP, Munyon, R, McGillen, B & Armstrong, AD 2020, 'A Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation, vol. 11. https://doi.org/10.1177/2151459319898646
Ryan, C, Stoltzfus, KC, Horn, S, Chen, H, Louie, AV, Lehrer, EJ, Trifiletti, DM, Fox, EJ, Abraham, JA & Zaorsky, NG 2020, 'Epidemiology of bone metastases', Bone. https://doi.org/10.1016/j.bone.2020.115783
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Burton, A, Davis, C, Boateng, H, Fox, E, McQuillan, P, Mets, B, Hassenbein, SE, Black, K, Munyon, R, McGillen, B & Armstrong, A 2020, 'Multidisciplinary Approach to Expedite Surgical Hip Fracture Care', Geriatric Orthopaedic Surgery and Rehabilitation. <https://journals.sagepub.com/doi/10.1177/2151459319898646>

2019

Grap, SM, Fox, E, Freeman, M, Blackall, GF & Dalal, PG 2019, 'Acute Postoperative Pain Management After Major Limb Amputation in a Pediatric Patient: A Case Report', Journal of Perianesthesia Nursing, vol. 34, no. 4, pp. 801-809. https://doi.org/10.1016/j.jopan.2018.11.004
Tucker, SM, Wee, H, Fox, E, Reid, JS & Lewis, GS 2019, 'Parametric Finite Element Analysis of Intramedullary Nail Fixation of Proximal Femur Fractures', Journal of Orthopaedic Research, vol. 37, no. 11, pp. 2358-2366. https://doi.org/10.1002/jor.24401
Hain, BA, Jude, B, Xu, H, Smuin, DM, Fox, EJ, Elfar, JC & Waning, DL 2020, 'Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy', Journal of Bone and Mineral Research, vol. 35, no. 2, pp. 368-381. https://doi.org/10.1002/jbmr.3890

2018

Reynolds, AW, Liu, G, Kocis, PT, Skowronski, JN, Leslie, DL & Fox, EJ 2018, 'Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort', International Journal of Endocrinology and Metabolism, vol. 16, no. 3, e12104. https://doi.org/10.5812/ijem.12104
Nikkel, LE, Mahmood, B, Lander, S, Maceroli, M, Fox, EJ, Tyler, W, Karbach, L & Elfar, JC 2018, 'Hospitalizations for fracture in patients with metastatic disease: Primary source lesions in the United States', Journal of Community and Supportive Oncology, vol. 16, no. 1, pp. e14-e20. https://doi.org/10.12788/jcso.0385
Tian, Y, Fox, E, Drabick, J & Pameijer, C 2018, 'Isolated limb infusion as a treatment option for malignant granular cell tumour', BMJ case reports, vol. 2018, 224618. https://doi.org/10.1136/bcr-2018-224618
Sciamanna, C, Ballentine, NH, Bopp, M, Brach, JS, Chinchilli, VM, Ciccolo, JT, Conroy, MB, Fisher, A, Fox, EJ, Greenspan, SL, Jan De Beur, Suzanne, M, Kearcher, K, Kraschnewski, JL, McTigue, KM, McAuley, E, Morone, NE, Paranjape, A, Rodriguez-Colon, S, Rosenzweig, A, Smyth, JM, Stewart, KJ & Stuckey, HL 2018, 'Working to Increase Stability through Exercise (WISE): Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries', Contemporary Clinical Trials, vol. 74, pp. 1-10. https://doi.org/10.1016/j.cct.2018.09.006

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)