Researcher Profile

Researcher Profile

Edward Fox, MD

Edward Fox, MD

Professor, Department of Orthopaedics and Rehabilitation
Professor, Department of Medicine
Scientific Program:Experimental Therapeutics
Disease Teams:
Sarcoma Cancer

Research Interests

As a Professor of Orthopaedic Surgery specializing in Musculoskeletal Oncology Surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased healthcare expenditures.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

  • Neoplasms
  • Therapeutics
  • Differential Diagnosis
  • Bone and Bones
  • Pain
  • Biopsy
  • Osteoporosis
  • Femur
  • Orthopedics
  • Thigh
  • Wounds and Injuries
  • Magnetic Resonance Imaging

Recent Publications


Tucker, SM, Wee, H, Fox, E, Reid, J & Lewis, G 2019, 'Parametric Finite Element Analysis of Intramedullary Nail Fixation of Proximal Femur Fractures', Journal of Orthopaedic Research, vol. 37, no. 11, pp. 2358-2366.
Hain, BA, Jude, B, Xu, H, Smuin, DM, Fox, EJ, Elfar, JC & Waning, DL 2019, 'Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy', Journal of Bone and Mineral Research.


Reynolds, AW, Liu, G, Kocis, PT, Skowronski, JN, Leslie, DL & Fox, EJ 2018, 'Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort', International Journal of Endocrinology and Metabolism, vol. 16, no. 3, e12104.
Nikkel, LE, Mahmood, B, Lander, S, Maceroli, M, Fox, EJ, Tyler, W, Karbach, L & Elfar, JC 2018, 'Hospitalizations for fracture in patients with metastatic disease: Primary source lesions in the United States', Journal of Community and Supportive Oncology, vol. 16, no. 1, pp. e14-e20.
Tian, Y, Fox, E, Drabick, J & Pameijer, C 2018, 'Isolated limb infusion as a treatment option for malignant granular cell tumour', BMJ case reports, vol. 2018, 224618.
Sciamanna, C, Ballentine, NH, Bopp, M, Brach, JS, Chinchilli, VM, Ciccolo, JT, Conroy, MB, Fisher, A, Fox, EJ, Greenspan, SL, Jan De Beur, Suzanne, M, Kearcher, K, Kraschnewski, JL, McTigue, KM, McAuley, E, Morone, NE, Paranjape, A, Rodriguez-Colon, S, Rosenzweig, A, Smyth, JM, Stewart, KJ & Stuckey, HL 2018, 'Working to Increase Stability through Exercise (WISE): Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries', Contemporary Clinical Trials, vol. 74, pp. 1-10.


Andrews, CR, Stapinski, B & Fox, E 2016, 'Intraoperative catastrophic failure of a Mizuho OSI orthopedic trauma table top', JBJS Case Connector, vol. 6, no. 1, e14.
Payne, R, Sieg, E, Fox, E, Harbaugh, K & Rizk, E 2016, 'Management of nerve compression in multiple hereditary exostoses: a report of two cases and review of the literature', Child's Nervous System, vol. 32, no. 12, pp. 2453-2458.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)