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Elias Rizk, MD, MSc

Elias Rizk, MD, MSc

Associate Professor, Department of Neurosurgery
Professor, Department of Neurosurgery
Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Cancer Institute, Pediatric Cancer Team
EBR10@psu.edu

Research Interests

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  • Therapeutics
  • Neoplasms
  • Child
  • Wounds and Injuries
  • Bone and Bones
  • Pediatrics
  • Anatomy
  • Regeneration
  • Folic Acid
  • Hydrocephalus
  • Survival
  • Bioprinting
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Recent Publications

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2023

Bhanja, D, Sciscent, BY, Daggubati, LC, Ryan, CA, Pahapill, NK, Hazard, SW & Rizk, EB 2023, 'Awake craniotomies in the pediatric population: a systematic review', Journal of Neurosurgery: Pediatrics, vol. 32, no. 4, pp. 248-436. https://doi.org/10.3171/2023.4.PEDS22296
Moncal, KK, Yeo, M, Celik, N, Acri, TM, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2023, 'Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting', Biofabrication, vol. 15, no. 1, 015011. https://doi.org/10.1088/1758-5090/ac9f70
Bhanja, D, Hallan, DR, Staub, J, Rizk, E & Zacko, JC 2023, 'Early Celecoxib use in Patients with Traumatic Brain Injury', Neurocritical Care. https://doi.org/10.1007/s12028-023-01827-w
Dias, M, Wang, M, Liang, M, Rizk, EB, Bowman, R, Partington, MD, Blount, JP, Rocque, BG, Hopson, B, Lee, A & Walker, WO 2023, 'First-time tethered cord release among adults with myelomeningocele: an analysis of people in the National Spina Bifida Patient Registry', Journal of neurosurgery. Spine, vol. 39, no. 4, pp. 527-533. https://doi.org/10.3171/2023.5.SPINE2328
Tankam, CS, Stoltzfus, MT, Tachie-Baffour, Y, Fanburg-Smith, JC & Rizk, EB 2023, 'Intravascular fasciitis of the scalp as a complication of ICP monitor placement: a case report and review of the literature', Child's Nervous System. https://doi.org/10.1007/s00381-023-06050-8
Sciscent, BY, Hallan, DR & Rizk, EB 2023, 'Mental health and substance use disorders in young adults with spina bifida', Journal of Neurosurgery: Pediatrics, vol. 31, no. 6, pp. 633-639. https://doi.org/10.3171/2023.2.PEDS22504
Rizk, E, Madrid, A, Koueik, J, Sun, D, Stewart, K, Chen, D, Luo, S, Hong, F, Papale, LA, Hariharan, N, Alisch, RS & Iskandar, BJ 2023, 'Purified regenerating retinal neurons reveal regulatory role of DNA methylation-mediated Na+/K+-ATPase in murine axon regeneration', Communications Biology, vol. 6, no. 1, 120. https://doi.org/10.1038/s42003-023-04463-4
Madrid, A, Alisch, RS, Rizk, E, Papale, LA, Hogan, KJ & Iskandar, BJ 2023, 'Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury', Environmental Epigenetics, vol. 9, no. 1, dvad002. https://doi.org/10.1093/eep/dvad002

2022

Fritch, C & Rizk, EB 2022, Arachnoid Cysts: an overview of concepts and review of the treatment literature. in Cerebrospinal Fluid and Subarachnoid Space: Pathology and Disorders: Volume 2. Elsevier, pp. 1-6. https://doi.org/10.1016/B978-0-12-819507-9.00020-X
Li, Q, Song, W, Li, J, Ma, C, Zhao, X, Jiao, J, Mrowczynski, O, Webb, BS, Rizk, EB, Lu, D & Liu, C 2022, 'Bioinspired super-strong aqueous synthetic tissue adhesives', Matter, vol. 5, no. 3, pp. 933-956. https://doi.org/10.1016/j.matt.2021.12.018
Tubbs, SS, Iwanaga, J, Rizk, EB, D’Antoni, AV & Dumont, AS 2022, Cerebrospinal Fluid and Subarachnoid Space: Clinical Anatomy and Physiology: Volume 1. vol. 1, Elsevier. https://doi.org/10.1016/C2018-0-05591-7
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333. https://doi.org/10.1016/j.biomaterials.2021.121333
Tan, X, Gerhard, E, Wang, Y, Tran, RT, Xu, H, Yan, S, Rizk, EB, Armstrong, AD, Zhou, Y, Du, J, Bai, X & Yang, J 2022, 'Development of Biodegradable Osteopromotive Citrate-Based Bone Putty', Small, vol. 18, no. 36, 2203003. https://doi.org/10.1002/smll.202203003
Tankam, CS, Padmanaban, V, Pazniokas, J, Lane, J, Clark, JB & Rizk, EB 2023, 'Direct ventriculoatrial shunt in a pediatric patient: case report and technical note', Child's Nervous System, vol. 39, no. 1, pp. 255-259. https://doi.org/10.1007/s00381-022-05717-y
Bailey, D, Mau, C, Toepke, C, Finch, E & Rizk, E 2022, 'Extracranial medulloepithelioma: a review of the literature', Child's Nervous System, vol. 38, no. 7, pp. 1259-1266. https://doi.org/10.1007/s00381-022-05525-4
Tankam, CS, Peterson, MR, Tachie-Baffour, Y, Zammar, S & Rizk, EB 2023, 'Fatty filum terminale and low-lying conus medullaris in Gollop-Wolfgang complex: a case report and review of literature', Child's Nervous System, vol. 39, no. 2, pp. 517-526. https://doi.org/10.1007/s00381-022-05679-1
Lo, A, Massand, S & Rizk, EB 2022, Hydrocephalus in craniosynostosis. in Cerebrospinal Fluid and Subarachnoid Space: Pathology and Disorders: Volume 2. Elsevier, pp. 195-208. https://doi.org/10.1016/B978-0-12-819507-9.00023-5
Jareczek, FJ, Majid, SS, Davanzo, JR & Rizk, EB 2022, Intracranial pressure and autoregulation in trauma. in Cerebrospinal Fluid and Subarachnoid Space: Pathology and Disorders: Volume 2. Elsevier, pp. 79-91. https://doi.org/10.1016/B978-0-12-819507-9.00012-0
Rizk, EB 2022, Lumbar punctures and postprocedure headaches. in Cerebrospinal Fluid and Subarachnoid Space: Pathology and Disorders: Volume 2. Elsevier, pp. 47-59. https://doi.org/10.1016/B978-0-12-819507-9.00025-9
Sciscent, BY, Bhanja, D, Daggubati, LC, Ryan, C, Hallan, DR & Rizk, EB 2022, 'Pregnancy in spina bifida patients: a comparative analysis of peripartum procedures and complications', Child's Nervous System. https://doi.org/10.1007/s00381-022-05705-2
Rizk, EB 2022, Syringomyelia; an update on clinicopathological studies, diagnosis, and management. in Cerebrospinal Fluid and Subarachnoid Space: Pathology and Disorders: Volume 2. Elsevier, pp. 7-30. https://doi.org/10.1016/B978-0-12-819507-9.00006-5
Khristov, V, Lin, A, Freedman, Z, Staub, J, Shenoy, G, Mrowczynski, O, Rizk, E, Zacharia, B & Connor, J 2023, 'Tumor-Derived Biomarkers in Liquid Biopsy of Glioblastoma', World neurosurgery, vol. 170, pp. 182-194. https://doi.org/10.1016/j.wneu.2022.11.012

2021

Gigliotti, MJ, Pooshpas, P, Patel, N & Rizk, EB 2021, 'A male patient with pseudobulbar affect caused by post-traumatic normal pressure hydrocephalus successfully managed with ventriculoperitoneal shunt', Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, vol. 23, 100916. https://doi.org/10.1016/j.inat.2020.100916
Mrowczynski, OD, McNutt, S, Bourcier, AJ, Jafrani, R, Lane, JR, Padmanaban, V & Rizk, EB 2021, 'Aneurysmal and arteriovenous malformation hemorrhage during pregnancy: An update on the epidemiology, risk factors and prognosis', Clinical Neurology and Neurosurgery, vol. 208, 106897. https://doi.org/10.1016/j.clineuro.2021.106897
Harbaugh, K, Patel, NT & Rizk, E 2021, Genetics of Nerve Tumors. in Diagnostic Assessment and Treatment of Peripheral Nerve Tumors. Springer International Publishing, pp. 17-28. https://doi.org/10.1007/978-3-030-69555-2_2
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858. https://doi.org/10.1002/adfm.202010858
Gigliotti, MJ, Mau, C, Specht, CS, Lawson, C, McNutt, S, Natarajan, S, Rizk, EB & Iantosca, M 2021, 'Malignant spindle cell tumors of the posterior fossa in children: case series and review of management', Journal of Neurosurgery: Pediatrics, vol. 28, no. 5, pp. 609-619. https://doi.org/10.3171/2021.3.PEDS2148
Khristov, V, Shenoy, G, Mau, C, Mrowczynski, O, Rizk, E, Pu, C, Specht, CS & Aregawi, D 2022, 'Myxopapillary Ependymoma with Anaplastic Features: A Case Series and Review of the Literature', World neurosurgery, vol. 158, pp. e735-e745. https://doi.org/10.1016/j.wneu.2021.11.053
Bailey, D & Rizk, EB 2021, 'Origin and Use of Hydrogen Peroxide in Neurosurgery', Neurosurgery, vol. 89, no. 1, pp. E3-E7. https://doi.org/10.1093/neuros/nyab107
Gigliotti, MJ, Patel, N, McLaughlin, C, Rothermel, A, Henry, C & Rizk, E 2023, 'Osteoradionecrosis and microvascular free flap failure managed with negative pressure wound therapy: A case report', British Journal of Neurosurgery, vol. 37, no. 6, pp. 1938-1943. https://doi.org/10.1080/02688697.2021.1940845
Padmanaban, V, Payne, R, Corbani, K, Corl, S & Rizk, EB 2021, 'Phrenic Nerve Stimulator Placement via the Cervical Approach: Technique and Anatomic Considerations', Operative Neurosurgery, vol. 21, no. 3, pp. E215-E220. https://doi.org/10.1093/ons/opab047
Mrowczynski, OD, Vasekar, M, Fox, E, Harbaugh, K, Aregawi, D, Pameijer, CR, Zaorsky, N, Payne, R & Rizk, E 2021, 'Spontaneous Hip Dislocation Complicating the Management of Malignant Peripheral Nerve Sheath Tumor Arising Within a Plexiform Neurofibroma', Cureus, vol. 13, no. 7, e16320. https://doi.org/10.7759/cureus.16320
National Spina Bifida Patient Registry Group 2021, 'Tethered spinal cord among individuals with myelomeningocele: An analysis of the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 28, no. 1, pp. 21-27. https://doi.org/10.3171/2020.12.PEDS20868

2020

Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Vadakkadath Meethal, S, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny', Molecular Neurobiology, vol. 57, no. 4, pp. 2048-2071. https://doi.org/10.1007/s12035-019-01812-5
McNutt, SE, Mrowczynski, OD, Lane, J, Jafrani, R, Rohatgi, P, Specht, C, Tubbs, RS, Zacharia, TT & Rizk, EB 2021, 'Congenital Spinal Cysts: An Update and Review of the Literature', World neurosurgery, vol. 145, pp. 480-491.e9. https://doi.org/10.1016/j.wneu.2020.08.092
Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Meethal, SV, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (Molecular Neurobiology, (2020), 57, 4, (2048-2071), 10.1007/s12035-019-01812-5)', Molecular Neurobiology, vol. 57, no. 4, pp. 2072-2073. https://doi.org/10.1007/s12035-020-01886-6
SECTION ON NEUROLOGIC SURGERY, SECTION ON PLASTIC AND RECONSTRUCTIVE SURGERY 2020, 'Identifying the misshapen head: Craniosynostosis and related disorders', Pediatrics, vol. 146, no. 3, e2020015511. https://doi.org/10.1542/PEDS.2020-015511
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Padmanaban, V, Hussein, R & Rizk, E 2020, 'Nontuberculous Mycobacterial Infection in Patients with Neurosurgical Hardware: Two Cases and A Review of the Literature', Cureus, vol. 12, no. 3, e7398. https://doi.org/10.7759/cureus.7398
Daggubati, LC, Davanzo, JR & Rizk, EB 2020, 'Peripheral nerve stimulator for terminal sciatic nerve neuromas in an amputee', Neurosurgical Focus: Video, vol. 3, no. 2, V7. https://doi.org/10.3171/2020.7.FOCVID2029
Mrowczynski, OD, Lane, JR, Specht, CS, Greiner, RJ, Iantosca, MR & Rizk, EB 2020, 'Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature', Child's Nervous System, vol. 36, no. 11, pp. 2845-2849. https://doi.org/10.1007/s00381-020-04597-4

2019

Koueik, J, Kraemer, MR, Hsu, D, Rizk, E, Zea, R, Haldeman, C & Iskandar, BJ 2019, 'A 12-year single-center retrospective analysis of antisiphon devices to prevent proximal ventricular shunt obstruction for hydrocephalus', Journal of Neurosurgery: Pediatrics, vol. 24, no. 6, pp. 642-651. https://doi.org/10.3171/2019.6.PEDS1951
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Church, EW, Church, EB, Rizk, EB & Knuckey, NW 2019, 'Commentary: neurosurgery in Western Australia', Clinical Neurosurgery, vol. 84, no. 4, pp. E251-E256. https://doi.org/10.1093/neuros/nyy631
Dias, MS & Rizk, EB 2019, Embryology of Occult Spinal Dysraphisms. in Occult Spinal Dysraphism. Springer International Publishing, pp. 17-58. https://doi.org/10.1007/978-3-030-10994-3_2
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mau, C, Ghali, MGZ, Styler, M, Malysz, J, Specht, CS & Rizk, E 2019, 'Neuroleukemiosis: Diagnosis and management', Clinical Neurology and Neurosurgery, vol. 184, 105340. https://doi.org/10.1016/j.clineuro.2019.04.019
Stewart, KJ, Iskandar, BJ, Meier, BM, Rizk, EB, Hariharan, N, Koueik, J, Andrei, AC & Hogan, KJ 2019, 'Nitrous oxide impairs axon regeneration after nervous system injury in male rats', Anesthesiology, vol. 131, no. 5, pp. 1063-1076. https://doi.org/10.1097/ALN.0000000000002906
Chern, JJ, Bollo, RJ, Governale, LS, Halvorson, KG, Hooten, K, Kulkarni, AV, Lo, W, Mathieu, F, Mrowczynski, O, Piatt, J, Rizk, E & Thompson, E 2019, 'Pediatrics', Operative Neurosurgery, vol. 17, pp. S182-S208. https://doi.org/10.1093/ONS/OPZ078
Ghali, MGZ, Davanzo, J, Leo, M & Rizk, E 2019, 'Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management', Leukemia and Lymphoma, vol. 60, no. 10, pp. 2365-2372. https://doi.org/10.1080/10428194.2019.1594210
Rizk, EB & Payne, RA 2019, Surgical Treatment of Meralgia Paresthetica. in Evidence for Neurosurgery: Effective Procedures and Treatment. Springer International Publishing, pp. 353-360. https://doi.org/10.1007/978-3-030-16323-5_21
Mrowczynski, OD, Payne, RA, Bourcier, AJ, Mau, CY, Slagle-Webb, B, Shenoy, G, Madhankumar, AB, Abramson, SB, Wolfe, D, Harbaugh, KS, Rizk, EB & Connor, JR 2019, 'Targeting IL-13Ra2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models', Journal of neurosurgery, vol. 131, no. 5, pp. 1369-1379. https://doi.org/10.3171/2018.7.JNS18284
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632
Joseph, SC, Rizk, E & Shane Tubbs, R 2019, Variations of the Intracranial Dural Venous Sinuses. in Anatomy, Imaging and Surgery of the Intracranial Dural Venous Sinuses. Elsevier, pp. 205-220. https://doi.org/10.1016/B978-0-323-65377-0.00025-8
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