Researcher Profile

Researcher Profile

Elias Rizk, MD, MSc

Elias Rizk, MD, MSc

Associate Professor, Department of Neurosurgery
Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
Disease Teams:
Brain and Central Nervous System Cancer
Pediatric Cancer
ebr10@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Child
  • Wounds and Injuries
  • Anatomy
  • Pediatrics
  • Bone and Bones
  • Folic Acid
  • Survival
  • Neurofibrosarcoma
  • Cranial Nerves
  • Hydrocephalus

Recent Publications

2022

Li, Q, Song, W, Li, J, Ma, C, Zhao, X, Jiao, J, Mrowczynski, O, Webb, BS, Rizk, EB, Lu, D & Liu, C 2022, 'Bioinspired super-strong aqueous synthetic tissue adhesives', Matter, vol. 5, no. 3, pp. 933-956. https://doi.org/10.1016/j.matt.2021.12.018
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333. https://doi.org/10.1016/j.biomaterials.2021.121333
Tan, X, Gerhard, E, Wang, Y, Tran, RT, Xu, H, Yan, S, Rizk, EB, Armstrong, AD, Zhou, Y, Du, J, Bai, X & Yang, J 2022, 'Development of Biodegradable Osteopromotive Citrate-Based Bone Putty', Small. https://doi.org/10.1002/smll.202203003
Bailey, D, Mau, C, Toepke, C, Finch, E & Rizk, E 2022, 'Extracranial medulloepithelioma: a review of the literature', Child's Nervous System, vol. 38, no. 7, pp. 1259-1266. https://doi.org/10.1007/s00381-022-05525-4

2021

Gigliotti, MJ, Pooshpas, P, Patel, N & Rizk, EB 2021, 'A male patient with pseudobulbar affect caused by post-traumatic normal pressure hydrocephalus successfully managed with ventriculoperitoneal shunt', Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, vol. 23, 100916. https://doi.org/10.1016/j.inat.2020.100916
Mrowczynski, OD, McNutt, S, Bourcier, AJ, Jafrani, R, Lane, JR, Padmanaban, V & Rizk, EB 2021, 'Aneurysmal and arteriovenous malformation hemorrhage during pregnancy: An update on the epidemiology, risk factors and prognosis', Clinical Neurology and Neurosurgery, vol. 208, 106897. https://doi.org/10.1016/j.clineuro.2021.106897
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858. https://doi.org/10.1002/adfm.202010858
Gigliotti, MJ, Mau, C, Specht, CS, Lawson, C, McNutt, S, Natarajan, S, Rizk, EB & Iantosca, M 2021, 'Malignant spindle cell tumors of the posterior fossa in children: case series and review of management', Journal of Neurosurgery: Pediatrics, vol. 28, no. 5, pp. 609-619. https://doi.org/10.3171/2021.3.PEDS2148
Khristov, V, Shenoy, G, Mau, C, Mrowczynski, O, Rizk, E, Pu, C, Specht, CS & Aregawi, D 2022, 'Myxopapillary Ependymoma with Anaplastic Features: A Case Series and Review of the Literature', World neurosurgery, vol. 158, pp. e735-e745. https://doi.org/10.1016/j.wneu.2021.11.053
Bailey, D & Rizk, EB 2021, 'Origin and Use of Hydrogen Peroxide in Neurosurgery', Neurosurgery, vol. 89, no. 1, pp. E3-E7. https://doi.org/10.1093/neuros/nyab107
Gigliotti, MJ, Patel, N, McLaughlin, C, Rothermel, A, Henry, C & Rizk, E 2021, 'Osteoradionecrosis and microvascular free flap failure managed with negative pressure wound therapy: A case report', British Journal of Neurosurgery. https://doi.org/10.1080/02688697.2021.1940845
Padmanaban, V, Payne, R, Corbani, K, Corl, S & Rizk, EB 2021, 'Phrenic Nerve Stimulator Placement via the Cervical Approach: Technique and Anatomic Considerations', Operative Neurosurgery, vol. 21, no. 3, pp. E215-E220. https://doi.org/10.1093/ons/opab047
National Spina Bifida Patient Registry Group 2021, 'Tethered spinal cord among individuals with myelomeningocele: An analysis of the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 28, no. 1, pp. 21-27. https://doi.org/10.3171/2020.12.PEDS20868

2020

Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Vadakkadath Meethal, S, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny', Molecular Neurobiology, vol. 57, no. 4, pp. 2048-2071. https://doi.org/10.1007/s12035-019-01812-5
McNutt, SE, Mrowczynski, OD, Lane, J, Jafrani, R, Rohatgi, P, Specht, C, Tubbs, RS, Zacharia, TT & Rizk, EB 2021, 'Congenital Spinal Cysts: An Update and Review of the Literature', World neurosurgery, vol. 145, pp. 480-491.e9. https://doi.org/10.1016/j.wneu.2020.08.092
Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Meethal, SV, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (Molecular Neurobiology, (2020), 57, 4, (2048-2071), 10.1007/s12035-019-01812-5)', Molecular Neurobiology, vol. 57, no. 4, pp. 2072-2073. https://doi.org/10.1007/s12035-020-01886-6
SECTION ON NEUROLOGIC SURGERY, SECTION ON PLASTIC AND RECONSTRUCTIVE SURGERY 2020, 'Identifying the misshapen head: Craniosynostosis and related disorders', Pediatrics, vol. 146, no. 3, e2020015511. https://doi.org/10.1542/PEDS.2020-015511
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Padmanaban, V, Hussein, R & Rizk, E 2020, 'Nontuberculous Mycobacterial Infection in Patients with Neurosurgical Hardware: Two Cases and A Review of the Literature', Cureus, vol. 12, no. 3, e7398. https://doi.org/10.7759/cureus.7398
Mrowczynski, OD, Lane, JR, Specht, CS, Greiner, RJ, Iantosca, MR & Rizk, EB 2020, 'Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature', Child's Nervous System, vol. 36, no. 11, pp. 2845-2849. https://doi.org/10.1007/s00381-020-04597-4

2019

Koueik, J, Kraemer, MR, Hsu, D, Rizk, E, Zea, R, Haldeman, C & Iskandar, BJ 2019, 'A 12-year single-center retrospective analysis of antisiphon devices to prevent proximal ventricular shunt obstruction for hydrocephalus', Journal of Neurosurgery: Pediatrics, vol. 24, no. 6, pp. 642-651. https://doi.org/10.3171/2019.6.PEDS1951
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Church, EW, Church, EB, Rizk, EB & Knuckey, NW 2019, 'Commentary: neurosurgery in Western Australia', Clinical Neurosurgery, vol. 84, no. 4, pp. E251-E256. https://doi.org/10.1093/neuros/nyy631
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mau, C, Ghali, MGZ, Styler, M, Malysz, J, Specht, CS & Rizk, E 2019, 'Neuroleukemiosis: Diagnosis and management', Clinical Neurology and Neurosurgery, vol. 184, 105340. https://doi.org/10.1016/j.clineuro.2019.04.019
Stewart, KJ, Iskandar, BJ, Meier, BM, Rizk, EB, Hariharan, N, Koueik, J, Andrei, AC & Hogan, KJ 2019, 'Nitrous oxide impairs axon regeneration after nervous system injury in male rats', Anesthesiology, vol. 131, no. 5, pp. 1063-1076. https://doi.org/10.1097/ALN.0000000000002906
Chern, JJ, Bollo, RJ, Governale, LS, Halvorson, KG, Hooten, K, Kulkarni, AV, Lo, W, Mathieu, F, Mrowczynski, O, Piatt, J, Rizk, E & Thompson, E 2019, 'Pediatrics', Operative Neurosurgery, vol. 17, pp. S182-S208. https://doi.org/10.1093/ONS/OPZ078
Ghali, MGZ, Davanzo, J, Leo, M & Rizk, E 2019, 'Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management', Leukemia and Lymphoma, vol. 60, no. 10, pp. 2365-2372. https://doi.org/10.1080/10428194.2019.1594210
Mrowczynski, OD, Payne, RA, Bourcier, AJ, Mau, CY, Slagle-Webb, B, Shenoy, G, Madhankumar, AB, Abramson, SB, Wolfe, D, Harbaugh, KS, Rizk, EB & Connor, JR 2019, 'Targeting IL-13Ra2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models', Journal of neurosurgery, vol. 131, no. 5, pp. 1369-1379. https://doi.org/10.3171/2018.7.JNS18284
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632
Joseph, SC, Rizk, E & Shane Tubbs, R 2019, Variations of the Intracranial Dural Venous Sinuses. in Anatomy, Imaging and Surgery of the Intracranial Dural Venous Sinuses. Elsevier, pp. 205-220. https://doi.org/10.1016/B978-0-323-65377-0.00025-8

2018

Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Alimi, Y, Iwanaga, J, Loukas, M, Oskouian, RJ, Rizk, E, Oakes, WJ & Tubbs, RS 2018, 'A comprehensive review of Mongolian spots with an update on atypical presentations', Child's Nervous System, vol. 34, no. 12, pp. 2371-2376. https://doi.org/10.1007/s00381-018-3929-0
Lahoud, N, Salameh, P, Hosseini, H, Saleh, N, Rizk, E, Hallit, S, Abbas, MH & Gebeily, S 2018, 'Care and Discharge Outcome of Acute Stroke in Lebanon: A Hospital-Based Study', The Journal of nervous and mental disease, vol. 206, no. 8, pp. 637-643. https://doi.org/10.1097/NMD.0000000000000856
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Craniopharyngiomas: A systematic review and evaluation of the current intratumoral treatment landscape', Clinical Neurology and Neurosurgery, vol. 166, pp. 124-130. https://doi.org/10.1016/j.clineuro.2018.01.039
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 652-658. https://doi.org/10.3171/2018.5.PEDS18160
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, EB, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Payne, RA, Sieg, EP, Patrick, N, Darowish, M, Rizk, E, Langan, S & Harbaugh, K 2018, 'Fracture related ulnar and sciatic nerve transections: a report of two cases and literature review', Child's Nervous System, vol. 34, no. 11, pp. 2187-2194. https://doi.org/10.1007/s00381-018-3961-0
Mrowczynski, OD, Langan, ST & Rizk, EB 2018, 'Intra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update', Clinical Neurology and Neurosurgery, vol. 170, pp. 140-158. https://doi.org/10.1016/j.clineuro.2018.05.007
Mrowczynski, OD, Greiner, RJ, Kapadia, M, Fanburg-Smith, JC, Iantosca, MR & Rizk, EB 2018, 'Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone', Child's Nervous System, vol. 34, no. 8, pp. 1605-1608. https://doi.org/10.1007/s00381-018-3789-7
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, EB, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059
Mrowczynski, OD, Bourcier, AJ, Liao, J, Langan, ST, Specht, C & Rizk, E 2018, 'The predictive potential of hyponatremia for glioblastoma patient survival', Journal of neuro-oncology, vol. 138, no. 1, pp. 99-104. https://doi.org/10.1007/s11060-018-2774-z
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 646-651. https://doi.org/10.3171/2018.5.PEDS18161
Madhankumar, AB, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, KS, Rizk, E & Connor, JR 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529
Mrowczynski, OD, Zammar, S, Bourcier, AJ, Langan, ST, Liao, J, Specht, C & Rizk, E 2018, 'Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival', World neurosurgery, vol. 120, pp. e1171-e1174. https://doi.org/10.1016/j.wneu.2018.09.027

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)