Researcher Profile

Researcher Profile

Elias Rizk, MD, MSc

Elias Rizk, MD, MSc

Associate Professor, Department of Neurosurgery
Assistant Professor, Department of Neurosurgery
Scientific Program:Experimental Therapeutics
Disease Teams:
Central Nervous System Cancer
Pediatric Cancer
ebr10@psu.edu

Research Interests

  • Therapeutics
  • Wounds and Injuries
  • Neoplasms
  • Anatomy
  • Survival
  • Cranial Nerves
  • Pediatrics
  • Bone and Bones
  • Neurilemmoma
  • Embryology
  • Occipital Bone
  • Glioblastoma

Recent Publications

2019

Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, G, Hayes, DJ & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Church, EW, Church, EB, Rizk, E & Knuckey, NW 2019, 'Commentary: neurosurgery in Western Australia', Clinical neurosurgery, vol. 84, no. 4, pp. E251-E256. https://doi.org/10.1093/neuros/nyy631
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, A, Lee, SY, Harbaugh, K, Connor, J & Rizk, E 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mau, C, Ghali, MGZ, Styler, M, Malysz, J, Specht, C & Rizk, E 2019, 'Neuroleukemiosis: Diagnosis and management', Clinical Neurology and Neurosurgery, vol. 184, 105340. https://doi.org/10.1016/j.clineuro.2019.04.019
Chern, JJ, Bollo, RJ, Governale, LS, Halvorson, KG, Hooten, K, Kulkarni, AV, Lo, W, Mathieu, F, Mrowczynski, O, Piatt, J, Rizk, E & Thompson, E 2019, 'Pediatrics', Operative neurosurgery (Hagerstown, Md.), vol. 17, no. 2, pp. S182-S208. https://doi.org/10.1093/ons/opz078
Dhawan, A, Kennedy, PM, Rizk, E & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632

2018

Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, G, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Alimi, Y, Iwanaga, J, Loukas, M, Oskouian, RJ, Rizk, E, Oakes, WJ & Tubbs, RS 2018, 'A comprehensive review of Mongolian spots with an update on atypical presentations', Child's Nervous System, vol. 34, no. 12, pp. 2371-2376. https://doi.org/10.1007/s00381-018-3929-0
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Craniopharyngiomas: A systematic review and evaluation of the current intratumoral treatment landscape', Clinical Neurology and Neurosurgery, vol. 166, pp. 124-130. https://doi.org/10.1016/j.clineuro.2018.01.039
Kim, I, Hopson, B, Aban, I, Rizk, E, Dias, M, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 652-658. https://doi.org/10.3171/2018.5.PEDS18160
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, E, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Mrowczynski, OD, Madhankumar, A, Sundstrom, J, Zhao, Y, Imamura, Y, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, E, Zacharia, B & Connor, J 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101.
Payne, RA, Sieg, EP, Patrick, N, Darowish, M, Rizk, E, Langan, S & Harbaugh, K 2018, 'Fracture related ulnar and sciatic nerve transections: a report of two cases and literature review', Child's Nervous System, vol. 34, no. 11, pp. 2187-2194. https://doi.org/10.1007/s00381-018-3961-0
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Intra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update', Clinical Neurology and Neurosurgery, vol. 170, pp. 140-158. https://doi.org/10.1016/j.clineuro.2018.05.007
Mrowczynski, OD, Greiner, R, Kapadia, M, Fanburg-Smith, J, Iantosca, M & Rizk, E 2018, 'Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone', Child's Nervous System, vol. 34, no. 8, pp. 1605-1608. https://doi.org/10.1007/s00381-018-3789-7
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059
Mrowczynski, OD, Bourcier, AJ, Liao, JJ, Langan, ST, Specht, C & Rizk, E 2018, 'The predictive potential of hyponatremia for glioblastoma patient survival', Journal of neuro-oncology, vol. 138, no. 1, pp. 99-104. https://doi.org/10.1007/s11060-018-2774-z
Kim, I, Hopson, B, Aban, I, Rizk, E, Dias, M, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 646-651. https://doi.org/10.3171/2018.5.PEDS18161
Madhankumar, A, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, K, Rizk, E & Connor, J 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529
Mrowczynski, OD, Zammar, S, Bourcier, AJ, Langan, ST, Liao, JJ, Specht, C & Rizk, E 2018, 'Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival' World Neurosurgery, vol. 120, pp. e1171-e1174. https://doi.org/10.1016/j.wneu.2018.09.027

2017

Alonso, F, Iwanaga, J, Fisahn, C, Watanabe, K, Rizk, E, Chern, J, Oskouian, RJ, Tubbs, RS & Oakes, WJ 2017, 'Adjacent segment level disease in Klippel-Feil syndrome patients with congenital cervical fusion in the setting of anterolisthesis: Should management be altered in the presence of anterolisthesis?' Translational Research in Anatomy, vol. 6, pp. 1-3. https://doi.org/10.1016/j.tria.2016.12.002
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, E & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286. https://doi.org/10.1016/j.biomaterials.2016.10.010
Mrowczynski, OD, Lane, JR, Shoja, MM, Specht, C, Langan, ST & Rizk, E 2018, 'Double dermal sinus tracts of the cervical and thoracic regions: a case in a 3-year-old child and review of the literature' Child's Nervous System, vol. 34, no. 5, pp. 987-990. https://doi.org/10.1007/s00381-017-3707-4
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature' Child's Nervous System, vol. 34, no. 1, pp. 173-176. https://doi.org/10.1007/s00381-017-3591-y
Payne, R, Nasralah, Z, Sieg, E, Rizk, E, Glantz, M & Harbaugh, K 2017, 'The angular course of the median nerve in the distal forearm and its anatomical importance in preventing nerve injury in a modern era of carpal tunnel release', Journal of neurosurgery, vol. 126, no. 3, pp. 979-984. https://doi.org/10.3171/2016.4.JNS152672
Ravnic, D, Leberfinger, AN, Koduru, S, Hospodiuk, M, Moncal, KK, Datta, P, Dey, M, Rizk, E & Ozbolat, IT 2017, 'Transplantation of Bioprinted Tissues and Organs: Technical and Clinical Challenges and Future Perspectives', Annals of Surgery, vol. 266, no. 1, pp. 48-58. https://doi.org/10.1097/SLA.0000000000002141

2016

Budinich, M, Burgess, B, Fisahn, C, Oskouian, RJ, Tubbs, RS & Rizk, E 2016, 'A previously unreported variant of the synostotic sagittal suture: Case report and review of salient literature' Translational Research in Anatomy, vol. 5, pp. 12-14. https://doi.org/10.1016/j.tria.2016.12.001
Budinich, M, Johal, J, Oskouian, RJ, Thamburaj, K, Tubbs, RS & Rizk, E 2016, 'Appearing-disappearing-reappearing Rathke's cleft cyst: An extraordinary finding and review of the literature' Translational Research in Anatomy, vol. 3-4, pp. 15-17. https://doi.org/10.1016/j.tria.2016.08.002
Brown, TJ, Brennan, MC, Li, M, Church, EW, Brandmeir, NJ, Rakszawski, KL, Patel, AS, Rizk, E, Suki, D, Sawaya, R & Glantz, M 2016, 'Association of the extent of resection with survival in glioblastoma a systematic review and meta-Analysis', JAMA Oncology, vol. 2, no. 11, pp. 1460-1469. https://doi.org/10.1001/jamaoncol.2016.1373
Tubbs, RS, Demerdash, A, Rizk, E, Chapman, JR & Oskouian, RJ 2016, 'Complications of transoral and transnasal odontoidectomy: a comprehensive review', Child's Nervous System, vol. 32, no. 1, pp. 55-59. https://doi.org/10.1007/s00381-015-2864-6
Tubbs, RS, Kirkpatrick, CM, Rizk, E, Chern, JJ, Oskouian, RJ & Oakes, WJ 2016, 'Do the cerebellar tonsils move during flexion and extension of the neck in patients with Chiari I malformation? A radiological study with clinical implications', Child's Nervous System, vol. 32, no. 3, pp. 527-530. https://doi.org/10.1007/s00381-016-3014-5
Davanzo, JR, Zacko, JC, Specht, C & Rizk, E 2016, 'Duplicate filum terminale noted in an adult: A rare finding', Journal of Neurosurgery: Spine, vol. 25, no. 3, pp. 415-417. https://doi.org/10.3171/2016.2.SPINE15759
Sieg, EP, Payne, RA, Hazard, SW & Rizk, E 2016, 'Evaluating the evidence: is phrenic nerve stimulation a safe and effective tool for decreasing ventilator dependence in patients with high cervical spinal cord injuries and central hypoventilation?', Child's Nervous System, vol. 32, no. 6, pp. 1033-1038. https://doi.org/10.1007/s00381-016-3086-2
Tubbs, RS, Benzie, AL, Rizk, E, Chern, JJ, Loukas, M & Oakes, WJ 2016, 'Histological study of the occipital bone from patients with Chiari I malformation', Child's Nervous System, vol. 32, no. 2, pp. 351-353. https://doi.org/10.1007/s00381-015-2907-z
Liu, X, Madhankumar, A, Miller, PA, Duck, KA, Hafenstein, S, Rizk, E, Slagle-Webb, B, Sheehan, JM, Connor, J & Yang, Q 2016, 'MRI contrast agent for targeting glioma: Interleukin-13 labeled liposome encapsulating gadolinium-DTPA', Neuro-Oncology, vol. 18, no. 5, pp. 691-699. https://doi.org/10.1093/neuonc/nov263
Payne, R, Sieg, E, Fox, E, Harbaugh, K & Rizk, E 2016, 'Management of nerve compression in multiple hereditary exostoses: a report of two cases and review of the literature', Child's Nervous System, vol. 32, no. 12, pp. 2453-2458. https://doi.org/10.1007/s00381-016-3166-3
Heller, M, Bauer, HK, Goetze, E, Gielisch, M, Ozbolat, IT, Moncal, KK, Rizk, E, Seitz, H, Gelinsky, M, Schröder, HC, Wang, XH, Werner, WE & Al-Nawas, B 2016, 'Materialien und gerüste im medizinischen 3-D-druck und bioprinting im kontext der knochenregeneration', International Journal of Computerized Dentistry, vol. 19, no. 4, pp. 301-321.
Miller, JH, Montalbano, MJ, Raborn, J, Gordon, A, Rizk, E, Tubbs, RS, Kim, H & Wellons, JC 2016, 'Successful surgical treatment of intractable hemifacial spasm: A case report and review of cerebellar hamartomas of the floor of the fourth ventricle' Translational Research in Anatomy, vol. 5, pp. 1-4. https://doi.org/10.1016/j.tria.2016.09.001

2015

Davanzo, JR & Rizk, E 2015, 'Baclofen overdose from possible intrinsic malfunction of SynchroMed II pump' Journal of Neurosurgery: Pediatrics, vol. 16, no. 2, pp. 232-234. https://doi.org/10.3171/2015.1.PEDS14500
Tubbs, RS, Rizk, E, Shoja, MM, Loukas, M, Barbaro, N & Spinner, RJ 2015, Nerves and Nerve Injuries. in History, Embryology, Anatomy, Imaging, and Diagnostics. vol. 1, Elsevier Ltd, pp. 1-673. https://doi.org/10.1016/C2012-0-06700-2
Baccon, J, Wellons, JC & Rizk, E 2015, Pediatric Peripheral Nerve Tumors. in Pain, Treatment, Injury, Disease and Future Directions. vol. 2, Elsevier, pp. 839-846. https://doi.org/10.1016/B978-0-12-802653-3.00102-0
Tubbs, RS, Rizk, E, Shoja, MM, Loukas, M, Barbaro, N & Spinner, RJ 2015, Preface. in Pain, Treatment, Injury, Disease and Future Directions. vol. 2, Elsevier, pp. xxxiii. https://doi.org/10.1016/B978-0-12-802653-3.09983-8
Bernard, S, Loukas, M, Rizk, E, Oskouian, RJ, Delashaw, J & Shane Tubbs, R 2015, 'The human occipital bone: review and update on its embryology and molecular development', Child's Nervous System, vol. 31, no. 12, pp. 2217-2223. https://doi.org/10.1007/s00381-015-2870-8
Akobo, S, Rizk, E, Loukas, M, Chapman, JR, Oskouian, RJ & Tubbs, RS 2015, 'The odontoid process: a comprehensive review of its anatomy, embryology, and variations', Child's Nervous System, vol. 31, no. 11, pp. 2025-2034. https://doi.org/10.1007/s00381-015-2866-4

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Adults (age >= 18 years)