Researcher Profile

Researcher Profile

Elias Rizk, MD, MSc

Elias Rizk, MD, MSc

Associate Professor, Department of Neurosurgery
Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
Disease Teams:
Central Nervous System Cancer
Pediatric Cancer
ebr10@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Child
  • Wounds and Injuries
  • Pediatrics
  • Anatomy
  • Folic Acid
  • Survival
  • Neurofibrosarcoma
  • Cranial Nerves
  • Regeneration
  • Hydrocephalus

Recent Publications

2021

Gigliotti, MJ, Pooshpas, P, Patel, N & Rizk, EB 2021, 'A male patient with pseudobulbar affect caused by post-traumatic normal pressure hydrocephalus successfully managed with ventriculoperitoneal shunt', Interdisciplinary Neurosurgery: Advanced Techniques and Case Management, vol. 23, 100916. https://doi.org/10.1016/j.inat.2020.100916
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, D, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, T & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials. https://doi.org/10.1002/adfm.202010858

2020

Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Vadakkadath Meethal, S, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny', Molecular Neurobiology, vol. 57, no. 4, pp. 2048-2071. https://doi.org/10.1007/s12035-019-01812-5
McNutt, SE, Mrowczynski, OD, Lane, J, Jafrani, R, Rohatgi, P, Specht, C, Tubbs, RS, Zacharia, TT & Rizk, EB 2021, 'Congenital Spinal Cysts: An Update and Review of the Literature', World neurosurgery, vol. 145, pp. 480-491.e9. https://doi.org/10.1016/j.wneu.2020.08.092
Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Meethal, SV, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (Molecular Neurobiology, (2020), 57, 4, (2048-2071), 10.1007/s12035-019-01812-5)', Molecular Neurobiology, vol. 57, no. 4, pp. 2072-2073. https://doi.org/10.1007/s12035-020-01886-6
SECTION ON NEUROLOGIC SURGERY, SECTION ON PLASTIC AND RECONSTRUCTIVE SURGERY 2020, 'Identifying the misshapen head: Craniosynostosis and related disorders', Pediatrics, vol. 146, no. 3, e2020015511. https://doi.org/10.1542/PEDS.2020-015511
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Padmanaban, V, Hussein, R & Rizk, E 2020, 'Nontuberculous Mycobacterial Infection in Patients with Neurosurgical Hardware: Two Cases and A Review of the Literature', Cureus, vol. 12, no. 3, e7398. https://doi.org/10.7759/cureus.7398
Mrowczynski, OD, Lane, JR, Specht, CS, Greiner, RJ, Iantosca, MR & Rizk, EB 2020, 'Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature', Child's Nervous System, vol. 36, no. 11, pp. 2845-2849. https://doi.org/10.1007/s00381-020-04597-4

2019

Koueik, J, Kraemer, MR, Hsu, D, Rizk, E, Zea, R, Haldeman, C & Iskandar, BJ 2019, 'A 12-year single-center retrospective analysis of antisiphon devices to prevent proximal ventricular shunt obstruction for hydrocephalus', Journal of Neurosurgery: Pediatrics, vol. 24, no. 6, pp. 642-651. https://doi.org/10.3171/2019.6.PEDS1951
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Church, EW, Church, EB, Rizk, EB & Knuckey, NW 2019, 'Commentary: neurosurgery in Western Australia', Clinical Neurosurgery, vol. 84, no. 4, pp. E251-E256. https://doi.org/10.1093/neuros/nyy631
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mau, C, Ghali, MGZ, Styler, M, Malysz, J, Specht, CS & Rizk, E 2019, 'Neuroleukemiosis: Diagnosis and management', Clinical Neurology and Neurosurgery, vol. 184, 105340. https://doi.org/10.1016/j.clineuro.2019.04.019
Stewart, KJ, Iskandar, BJ, Meier, BM, Rizk, EB, Hariharan, N, Koueik, J, Andrei, AC & Hogan, KJ 2019, 'Nitrous oxide impairs axon regeneration after nervous system injury in male rats', Anesthesiology, vol. 131, no. 5, pp. 1063-1076. https://doi.org/10.1097/ALN.0000000000002906
Chern, JJ, Bollo, RJ, Governale, LS, Halvorson, KG, Hooten, K, Kulkarni, AV, Lo, W, Mathieu, F, Mrowczynski, O, Piatt, J, Rizk, E & Thompson, E 2019, 'Pediatrics', Operative neurosurgery (Hagerstown, Md.), vol. 17, pp. S182-S208. https://doi.org/10.1093/ons/opz078
Ghali, MGZ, Davanzo, J, Leo, M & Rizk, E 2019, 'Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management', Leukemia and Lymphoma, vol. 60, no. 10, pp. 2365-2372. https://doi.org/10.1080/10428194.2019.1594210
Mrowczynski, OD, Payne, RA, Bourcier, AJ, Mau, CY, Slagle-Webb, B, Shenoy, G, Madhankumar, AB, Abramson, SB, Wolfe, D, Harbaugh, KS, Rizk, EB & Connor, JR 2019, 'Targeting IL-13Ra2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models', Journal of neurosurgery, vol. 131, no. 5, pp. 1369-1379. https://doi.org/10.3171/2018.7.JNS18284
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632

2018

Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Alimi, Y, Iwanaga, J, Loukas, M, Oskouian, RJ, Rizk, E, Oakes, WJ & Tubbs, RS 2018, 'A comprehensive review of Mongolian spots with an update on atypical presentations', Child's Nervous System, vol. 34, no. 12, pp. 2371-2376. https://doi.org/10.1007/s00381-018-3929-0
Lahoud, N, Salameh, P, Hosseini, H, Saleh, N, Rizk, E, Hallit, S, Abbas, MH & Gebeily, S 2018, 'Care and Discharge Outcome of Acute Stroke in Lebanon: A Hospital-Based Study', The Journal of nervous and mental disease, vol. 206, no. 8, pp. 637-643. https://doi.org/10.1097/NMD.0000000000000856
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Craniopharyngiomas: A systematic review and evaluation of the current intratumoral treatment landscape', Clinical Neurology and Neurosurgery, vol. 166, pp. 124-130. https://doi.org/10.1016/j.clineuro.2018.01.039
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 652-658. https://doi.org/10.3171/2018.5.PEDS18160
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, EB, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Payne, RA, Sieg, EP, Patrick, N, Darowish, M, Rizk, E, Langan, S & Harbaugh, K 2018, 'Fracture related ulnar and sciatic nerve transections: a report of two cases and literature review', Child's Nervous System, vol. 34, no. 11, pp. 2187-2194. https://doi.org/10.1007/s00381-018-3961-0
Mrowczynski, OD, Langan, ST & Rizk, EB 2018, 'Intra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update', Clinical Neurology and Neurosurgery, vol. 170, pp. 140-158. https://doi.org/10.1016/j.clineuro.2018.05.007
Mrowczynski, OD, Greiner, RJ, Kapadia, M, Fanburg-Smith, JC, Iantosca, MR & Rizk, EB 2018, 'Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone', Child's Nervous System, vol. 34, no. 8, pp. 1605-1608. https://doi.org/10.1007/s00381-018-3789-7
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, EB, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059
Mrowczynski, OD, Bourcier, AJ, Liao, JJ, Langan, ST, Specht, C & Rizk, E 2018, 'The predictive potential of hyponatremia for glioblastoma patient survival', Journal of neuro-oncology, vol. 138, no. 1, pp. 99-104. https://doi.org/10.1007/s11060-018-2774-z
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 646-651. https://doi.org/10.3171/2018.5.PEDS18161
Madhankumar, AB, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, KS, Rizk, E & Connor, JR 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529
Mrowczynski, OD, Zammar, S, Bourcier, AJ, Langan, ST, Liao, JJ, Specht, C & Rizk, E 2018, 'Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival', World neurosurgery, vol. 120, pp. e1171-e1174. https://doi.org/10.1016/j.wneu.2018.09.027

2017

Leberfinger, AN, Ravnic, DJ, Payne, R, Rizk, E, Koduru, SV & Hazard, SW 2017, 'Adipose-derived stem cells in peripheral nerve regeneration', Current Surgery Reports, vol. 5, no. 2, 5. https://doi.org/10.1007/s40137-017-0169-2
Alonso, F, Iwanaga, J, Fisahn, C, Watanabe, K, Rizk, E, Chern, J, Oskouian, RJ, Tubbs, RS & Oakes, WJ 2017, 'Adjacent segment level disease in Klippel-Feil syndrome patients with congenital cervical fusion in the setting of anterolisthesis: Should management be altered in the presence of anterolisthesis?', Translational Research in Anatomy, vol. 6, pp. 1-3. https://doi.org/10.1016/j.tria.2016.12.002
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, EB & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286. https://doi.org/10.1016/j.biomaterials.2016.10.010
Mrowczynski, OD, Lane, JR, Shoja, MM, Specht, C, Langan, ST & Rizk, E 2018, 'Double dermal sinus tracts of the cervical and thoracic regions: a case in a 3-year-old child and review of the literature', Child's Nervous System, vol. 34, no. 5, pp. 987-990. https://doi.org/10.1007/s00381-017-3707-4
Mrowczynski, OD, Langan, ST & Rizk, EB 2018, 'Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature', Child's Nervous System, vol. 34, no. 1, pp. 173-176. https://doi.org/10.1007/s00381-017-3591-y
Payne, R, Nasralah, Z, Sieg, E, Rizk, EB, Glantz, M & Harbaugh, K 2017, 'The angular course of the median nerve in the distal forearm and its anatomical importance in preventing nerve injury in a modern era of carpal tunnel release', Journal of neurosurgery, vol. 126, no. 3, pp. 979-984. https://doi.org/10.3171/2016.4.JNS152672
Ravnic, DJ, Leberfinger, AN, Koduru, SV, Hospodiuk, M, Moncal, KK, Datta, P, Dey, M, Rizk, E & Ozbolat, IT 2017, 'Transplantation of Bioprinted Tissues and Organs: Technical and Clinical Challenges and Future Perspectives', Annals of surgery, vol. 266, no. 1, pp. 48-58. https://doi.org/10.1097/SLA.0000000000002141

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)