Researcher Profile

Researcher Profile

Elias Rizk, MD, MSc

Elias Rizk, MD, MSc

Associate Professor, Department of Neurosurgery
Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
Disease Teams:
Central Nervous System Cancer
Pediatric Cancer
ebr10@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Child
  • Wounds and Injuries
  • Anatomy
  • Pediatrics
  • Folic Acid
  • Survival
  • Neurofibrosarcoma
  • Cranial Nerves
  • Regeneration
  • Bone and Bones

Recent Publications

2020

Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Vadakkadath Meethal, S, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny', Molecular Neurobiology, vol. 57, no. 4, pp. 2048-2071. https://doi.org/10.1007/s12035-019-01812-5
Patel, NJ, Hogan, KJ, Rizk, E, Stewart, K, Madrid, A, Meethal, SV, Alisch, R, Borth, L, Papale, LA, Ondoma, S, Gorges, LR, Weber, K, Lake, W, Bauer, A, Hariharan, N, Kuehn, T, Cook, T, Keles, S, Newton, MA & Iskandar, BJ 2020, 'Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (Molecular Neurobiology, (2020), 57, 4, (2048-2071), 10.1007/s12035-019-01812-5)', Molecular Neurobiology, vol. 57, no. 4, pp. 2072-2073. https://doi.org/10.1007/s12035-020-01886-6
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Padmanaban, V, Hussein, R & Rizk, E 2020, 'Nontuberculous Mycobacterial Infection in Patients with Neurosurgical Hardware: Two Cases and A Review of the Literature', Cureus, vol. 12, no. 3, e7398. https://doi.org/10.7759/cureus.7398
Mrowczynski, OD, Lane, JR, Specht, CS, Greiner, RJ, Iantosca, MR & Rizk, EB 2020, 'Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature', Child's Nervous System. https://doi.org/10.1007/s00381-020-04597-4

2019

Koueik, J, Kraemer, MR, Hsu, D, Rizk, E, Zea, R, Haldeman, C & Iskandar, BJ 2019, 'A 12-year single-center retrospective analysis of antisiphon devices to prevent proximal ventricular shunt obstruction for hydrocephalus', Journal of Neurosurgery: Pediatrics, vol. 24, no. 6, pp. 642-651. https://doi.org/10.3171/2019.6.PEDS1951
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Church, EW, Church, EB, Rizk, EB & Knuckey, NW 2019, 'Commentary: neurosurgery in Western Australia', Clinical Neurosurgery, vol. 84, no. 4, pp. E251-E256. https://doi.org/10.1093/neuros/nyy631
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mau, C, Ghali, MGZ, Styler, M, Malysz, J, Specht, C & Rizk, E 2019, 'Neuroleukemiosis: Diagnosis and management', Clinical Neurology and Neurosurgery, vol. 184, 105340. https://doi.org/10.1016/j.clineuro.2019.04.019
Stewart, KJ, Iskandar, BJ, Meier, BM, Rizk, EB, Hariharan, N, Koueik, J, Andrei, AC & Hogan, KJ 2019, 'Nitrous oxide impairs axon regeneration after nervous system injury in male rats', Anesthesiology, vol. 131, no. 5, pp. 1063-1076. https://doi.org/10.1097/ALN.0000000000002906
Chern, JJ, Bollo, RJ, Governale, LS, Halvorson, KG, Hooten, K, Kulkarni, AV, Lo, W, Mathieu, F, Mrowczynski, O, Piatt, J, Rizk, E & Thompson, E 2019, 'Pediatrics', Operative neurosurgery (Hagerstown, Md.), vol. 17, pp. S182-S208. https://doi.org/10.1093/ons/opz078
Ghali, MGZ, Davanzo, J, Leo, M & Rizk, E 2019, 'Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management', Leukemia and Lymphoma, vol. 60, no. 10, pp. 2365-2372. https://doi.org/10.1080/10428194.2019.1594210
Mrowczynski, OD, Payne, RA, Bourcier, AJ, Mau, CY, Slagle-Webb, B, Shenoy, G, Madhankumar, AB, Abramson, SB, Wolfe, D, Harbaugh, KS, Rizk, EB & Connor, JR 2019, 'Targeting IL-13Ra2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models', Journal of neurosurgery, vol. 131, no. 5, pp. 1369-1379. https://doi.org/10.3171/2018.7.JNS18284
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632

2018

Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Alimi, Y, Iwanaga, J, Loukas, M, Oskouian, RJ, Rizk, E, Oakes, WJ & Tubbs, RS 2018, 'A comprehensive review of Mongolian spots with an update on atypical presentations', Child's Nervous System, vol. 34, no. 12, pp. 2371-2376. https://doi.org/10.1007/s00381-018-3929-0
Lahoud, N, Salameh, P, Hosseini, H, Saleh, N, Rizk, E, Hallit, S, Abbas, MH & Gebeily, S 2018, 'Care and Discharge Outcome of Acute Stroke in Lebanon: A Hospital-Based Study', The Journal of nervous and mental disease, vol. 206, no. 8, pp. 637-643. https://doi.org/10.1097/NMD.0000000000000856
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Craniopharyngiomas: A systematic review and evaluation of the current intratumoral treatment landscape', Clinical Neurology and Neurosurgery, vol. 166, pp. 124-130. https://doi.org/10.1016/j.clineuro.2018.01.039
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 652-658. https://doi.org/10.3171/2018.5.PEDS18160
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, EB, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Payne, RA, Sieg, EP, Patrick, N, Darowish, M, Rizk, E, Langan, S & Harbaugh, K 2018, 'Fracture related ulnar and sciatic nerve transections: a report of two cases and literature review', Child's Nervous System, vol. 34, no. 11, pp. 2187-2194. https://doi.org/10.1007/s00381-018-3961-0
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Intra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update', Clinical Neurology and Neurosurgery, vol. 170, pp. 140-158. https://doi.org/10.1016/j.clineuro.2018.05.007
Mrowczynski, OD, Greiner, RJ, Kapadia, M, Fanburg-Smith, JC, Iantosca, MR & Rizk, EB 2018, 'Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone', Child's Nervous System, vol. 34, no. 8, pp. 1605-1608. https://doi.org/10.1007/s00381-018-3789-7
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, EB, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059
Mrowczynski, OD, Bourcier, AJ, Liao, JJ, Langan, ST, Specht, C & Rizk, E 2018, 'The predictive potential of hyponatremia for glioblastoma patient survival', Journal of neuro-oncology, vol. 138, no. 1, pp. 99-104. https://doi.org/10.1007/s11060-018-2774-z
Kim, I, Hopson, B, Aban, I, Rizk, EB, Dias, MS, Bowman, R, Ackerman, LL, Partington, MD, Castillo, H, Castillo, J, Peterson, PR, Blount, JP & Rocque, BG 2018, 'Treated hydrocephalus in individuals with myelomeningocele in the National Spina Bifida Patient Registry', Journal of Neurosurgery: Pediatrics, vol. 22, no. 6, pp. 646-651. https://doi.org/10.3171/2018.5.PEDS18161
Madhankumar, AB, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, KS, Rizk, E & Connor, JR 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529
Mrowczynski, OD, Zammar, S, Bourcier, AJ, Langan, ST, Liao, JJ, Specht, C & Rizk, E 2018, 'Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival', World Neurosurgery, vol. 120, pp. e1171-e1174. https://doi.org/10.1016/j.wneu.2018.09.027

2017

Leberfinger, AN, Ravnic, DJ, Payne, R, Rizk, E, Koduru, SV & Hazard, SW 2017, 'Adipose-derived stem cells in peripheral nerve regeneration', Current Surgery Reports, vol. 5, no. 2, 5. https://doi.org/10.1007/s40137-017-0169-2
Alonso, F, Iwanaga, J, Fisahn, C, Watanabe, K, Rizk, E, Chern, J, Oskouian, RJ, Tubbs, RS & Oakes, WJ 2017, 'Adjacent segment level disease in Klippel-Feil syndrome patients with congenital cervical fusion in the setting of anterolisthesis: Should management be altered in the presence of anterolisthesis?', Translational Research in Anatomy, vol. 6, pp. 1-3. https://doi.org/10.1016/j.tria.2016.12.002
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, EB & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286. https://doi.org/10.1016/j.biomaterials.2016.10.010
Mrowczynski, OD, Lane, JR, Shoja, MM, Specht, C, Langan, ST & Rizk, E 2018, 'Double dermal sinus tracts of the cervical and thoracic regions: a case in a 3-year-old child and review of the literature', Child's Nervous System, vol. 34, no. 5, pp. 987-990. https://doi.org/10.1007/s00381-017-3707-4
Mrowczynski, OD, Langan, ST & Rizk, E 2018, 'Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature', Child's Nervous System, vol. 34, no. 1, pp. 173-176. https://doi.org/10.1007/s00381-017-3591-y
Payne, R, Nasralah, Z, Sieg, E, Rizk, EB, Glantz, M & Harbaugh, K 2017, 'The angular course of the median nerve in the distal forearm and its anatomical importance in preventing nerve injury in a modern era of carpal tunnel release', Journal of neurosurgery, vol. 126, no. 3, pp. 979-984. https://doi.org/10.3171/2016.4.JNS152672
Ravnic, DJ, Leberfinger, AN, Koduru, SV, Hospodiuk, M, Moncal, KK, Datta, P, Dey, M, Rizk, E & Ozbolat, IT 2017, 'Transplantation of Bioprinted Tissues and Organs: Technical and Clinical Challenges and Future Perspectives', Annals of surgery, vol. 266, no. 1, pp. 48-58. https://doi.org/10.1097/SLA.0000000000002141

2016

Budinich, M, Burgess, B, Fisahn, C, Oskouian, RJ, Tubbs, RS & Rizk, E 2016, 'A previously unreported variant of the synostotic sagittal suture: Case report and review of salient literature', Translational Research in Anatomy, vol. 5, pp. 12-14. https://doi.org/10.1016/j.tria.2016.12.001
Budinich, M, Johal, J, Oskouian, RJ, Thamburaj, K, Tubbs, RS & Rizk, E 2016, 'Appearing-disappearing-reappearing Rathke's cleft cyst: An extraordinary finding and review of the literature', Translational Research in Anatomy, vol. 3-4, pp. 15-17. https://doi.org/10.1016/j.tria.2016.08.002
Brown, TJ, Brennan, MC, Li, M, Church, EW, Brandmeir, NJ, Rakszawski, KL, Patel, AS, Rizk, EB, Suki, D, Sawaya, R & Glantz, M 2016, 'Association of the extent of resection with survival in glioblastoma a systematic review and meta-Analysis', JAMA Oncology, vol. 2, no. 11, pp. 1460-1469. https://doi.org/10.1001/jamaoncol.2016.1373
Tubbs, RS, Demerdash, A, Rizk, E, Chapman, JR & Oskouian, RJ 2016, 'Complications of transoral and transnasal odontoidectomy: a comprehensive review', Child's Nervous System, vol. 32, no. 1, pp. 55-59. https://doi.org/10.1007/s00381-015-2864-6
Tubbs, RS, Kirkpatrick, CM, Rizk, E, Chern, JJ, Oskouian, RJ & Oakes, WJ 2016, 'Do the cerebellar tonsils move during flexion and extension of the neck in patients with Chiari I malformation? A radiological study with clinical implications', Child's Nervous System, vol. 32, no. 3, pp. 527-530. https://doi.org/10.1007/s00381-016-3014-5
Davanzo, JR, Zacko, JC, Specht, CS & Rizk, EB 2016, 'Duplicate filum terminale noted in an adult: A rare finding', Journal of Neurosurgery: Spine, vol. 25, no. 3, pp. 415-417. https://doi.org/10.3171/2016.2.SPINE15759
Sieg, EP, Payne, RA, Hazard, S & Rizk, E 2016, 'Evaluating the evidence: is phrenic nerve stimulation a safe and effective tool for decreasing ventilator dependence in patients with high cervical spinal cord injuries and central hypoventilation?', Child's Nervous System, vol. 32, no. 6, pp. 1033-1038. https://doi.org/10.1007/s00381-016-3086-2
Tubbs, RS, Benzie, AL, Rizk, E, Chern, JJ, Loukas, M & Oakes, WJ 2016, 'Histological study of the occipital bone from patients with Chiari I malformation', Child's Nervous System, vol. 32, no. 2, pp. 351-353. https://doi.org/10.1007/s00381-015-2907-z
Liu, X, Madhankumar, AB, Miller, PA, Duck, KA, Hafenstein, S, Rizk, E, Slagle-Webb, B, Sheehan, JM, Connor, JR & Yang, QX 2016, 'MRI contrast agent for targeting glioma: Interleukin-13 labeled liposome encapsulating gadolinium-DTPA', Neuro-oncology, vol. 18, no. 5, pp. 691-699. https://doi.org/10.1093/neuonc/nov263
Payne, R, Sieg, E, Fox, E, Harbaugh, K & Rizk, E 2016, 'Management of nerve compression in multiple hereditary exostoses: a report of two cases and review of the literature', Child's Nervous System, vol. 32, no. 12, pp. 2453-2458. https://doi.org/10.1007/s00381-016-3166-3
Heller, M, Bauer, HK, Goetze, E, Gielisch, M, Ozbolat, IT, Moncal, KK, Rizk, E, Seitz, H, Gelinsky, M, Schröder, HC, Wang, XH, Werner, WE & Al-Nawas, B 2016, 'Materialien und gerüste im medizinischen 3-D-druck und bioprinting im kontext der knochenregeneration', International Journal of Computerized Dentistry, vol. 19, no. 4, pp. 301-321.
Miller, JH, Montalbano, MJ, Raborn, J, Gordon, A, Rizk, E, Tubbs, RS, Kim, H & Wellons, JC 2016, 'Successful surgical treatment of intractable hemifacial spasm: A case report and review of cerebellar hamartomas of the floor of the fourth ventricle', Translational Research in Anatomy, vol. 5, pp. 1-4. https://doi.org/10.1016/j.tria.2016.09.001

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Children (age < 18 years)
Adults (age >= 18 years)