Researcher Profile

Researcher Profile

David Goldenberg, MD, FACS

David Goldenberg, MD, FACS

Steven and Sharon Baron Professor and Chair, Department of Otolaryngology - Head and Neck Surgery
Professor and Vice Chair for Clinical, Department of Surgery
Professor, Department of Medicine
Scientific Program:Cancer Control
Disease Teams:
Head and Neck Cancer
dug5@psu.edu

Research Interests

Dr. David Goldenberg's basic science research focuses on thyroid cancer genomics as well as radiation-included and familial thyroid cancer. His clinical research focus is on outcomes and etiology of the rise in incidence of thyroid cancer. 

  • Neoplasms
  • Neck
  • Thyroid Neoplasms
  • Therapeutics
  • Head and Neck Neoplasms
  • Head
  • Tracheotomy
  • Thyroid Gland
  • Incidence
  • Guidelines
  • Robotics
  • Anatomy

Clinical Trials

Head and Neck Cells: Tissue Repository
Understanding Factors that Impact Thyroid Cancer Incidence in Women

Recent Publications

2019

Zafereo, M, Yu, J, Angelos, P, Brumund, K, Chuang, HH, Goldenberg, D, Lango, M, Perrier, N, Randolph, G, Shindo, ML, Singer, M, Smith, R, Stack, BC, Steward, D, Terris, DJ, Vu, T, Yao, M & Tufano, RP 2019, 'American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism' Head and Neck, vol. 41, no. 7, pp. 2398-2409. https://doi.org/10.1002/hed.25781
Pool, C, Walter, V, Bann, D, Goldenberg, D, Broach, J, Hennessy, M, Cottrill, E, Washburn, E, Williams, N, Crist, H, Imamura, Y & Warrick, J 2019, 'Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)' Virchows Archiv, vol. 474, no. 3, pp. 341-351. https://doi.org/10.1007/s00428-018-02512-6
Goldenberg, D 2019, 'We cannot ignore the real component of the rise in thyroid cancer incidence', Cancer, vol. 125, no. 14, pp. 2362-2363. https://doi.org/10.1002/cncr.32123

2018

Slonimsky, G, Baker, A, Crist, H & Goldenberg, D 2018, 'A midline mediastinal parathyroid cyst' Ear, Nose and Throat Journal, vol. 97, no. 3, pp. 58-60.
Ferster, APOC, Slonimsky, G, Slonimsky, E, Crist, H & Goldenberg, D 2018, 'Burkitt lymphoma of the thyroid gland' Ear, Nose and Throat Journal, vol. 97, no. 7, pp. 196-197.
Saadi, R, LaRusso, S, Vijay, K & Goldenberg, D 2018, 'Elastography as a potential modality for screening cervical lymph nodes in patients with papillary thyroid cancer: A review of literature' Ear, Nose and Throat Journal, vol. 97, no. 1-2, pp. 31-39.
Labarge, B, Walter, V, Lengerich, E, Crist, H, Karamchandani, D, Williams, N, Goldenberg, D, Bann, DV & Warrick, J 2018, 'Evidence of a positive association between malpractice climate and thyroid cancer incidence in the United States', PloS one, vol. 13, no. 7, e0199862. https://doi.org/10.1371/journal.pone.0199862
Goldenberg, D, Swegal, W, Dunklebarger, M & Pellitteri, PK 2018, 'Surgery for fibro-adherent inflammatory thyroid disease' Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 29, no. 1, pp. 2-9. https://doi.org/10.1016/j.otot.2017.12.002
Goldenberg, D, Ferris, RL, Shindo, ML, Shaha, A, Stack, B & Tufano, RP 2018, 'Thyroidectomy in patients who have undergone gastric bypass surgery' Head and Neck, vol. 40, no. 6, pp. 1237-1244. https://doi.org/10.1002/hed.25098
Cottrill, EE, Funk, EK, Goldenberg, D & Goyal, N 2019, 'Transoral Thyroidectomy Using A Flexible Robotic System: A Preclinical Cadaver Feasibility Study', Laryngoscope, vol. 129, no. 6, pp. 1482-1487. https://doi.org/10.1002/lary.27543
Persky, MJ, Issa, M, Bonfili, JR, Goyal, N, Goldenberg, D & Duvvuri, U 2018, 'Transoral surgery using the Flex Robotic System: Initial experience in the United States', Head and Neck, vol. 40, no. 11, pp. 2482-2486. https://doi.org/10.1002/hed.25375
Stahl, LE, Stewart, R, Carr, MM, Goldenberg, D & Schubart, JR 2018, 'Treatment preferences and decision-making in patients diagnosed with indeterminate thyroid nodules' Psycho-Oncology, vol. 27, no. 12, pp. 2862-2864. https://doi.org/10.1002/pon.4865
Saadi, R, Goldenberg, D & Goldenberg, D 2018, Using Technology in Global Otolaryngology. in L Mansur, B Riemer & D McClintock (eds), Otolaryngologic Clinics of North America. 3 edn, vol. 51, W.B. Saunders, pp. 555-561. https://doi.org/10.1016/j.otc.2018.01.004

2017

Yesensky, J, Agrawal, N, Bayan, S, Blair, E, Portugal, L, Chan, J, Goldenberg, D & Gooi, Z 2017, 'AHNS Series – Do you know your guidelines? Principles of treatment for glottic cancer: A review of the National Comprehensive Cancer Network guidelines', Head and Neck, vol. 39, no. 9, pp. 1729-1732. https://doi.org/10.1002/hed.24816
Gooi, Z, Richmon, J, Agrawal, N, Blair, E, Portugal, L, Vokes, E, Seiwert, T, de Souza, J, Saloura, V, Haraf, D, Goldenberg, D & Chan, J 2017, 'AHNS Series – Do you know your guidelines? Principles of treatment for nasopharyngeal cancer: A review of the National Comprehensive Cancer Network guidelines', Head and Neck, vol. 39, no. 2, pp. 201-205. https://doi.org/10.1002/hed.24635
Guo, T, Goldenberg, D & Fakhry, C 2017, 'AHNS series: Do you know your guidelines? Management of head and neck cancer in the era of human papillomavirus: Educating our patients on human papillomavirus', Head and Neck, vol. 39, no. 5, pp. 833-839. https://doi.org/10.1002/hed.24693
Goldenberg, D, Russo, M, Houser, K, Crist, H, Derr, JB, Walter, V, Warrick, J, Sheldon, KE, Broach, J & Bann, DV 2017, 'Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident', Laryngoscope, vol. 127, pp. S1-S9. https://doi.org/10.1002/lary.26687
Ferster, APOC, Schubart, JR, Kim, Y & Goldenberg, D 2017, 'Association between laryngeal cancer and asbestos exposure: A systematic review', JAMA Otolaryngology - Head and Neck Surgery, vol. 143, no. 4, pp. 409-416. https://doi.org/10.1001/jamaoto.2016.3421
Clark, CM, Payne, SJ, Warrick, J & Goldenberg, D 2017, 'Atypical parathyroid adenoma with diffuse fibrosis' Ear, Nose and Throat Journal, vol. 96, no. 2, pp. 57-58.
Shah-Becker, S, Pennock, M, Sinoway, L, Goldenberg, D & Goyal, N 2017, 'Baroreceptor reflex failure: Review of the literature and the potential impact on patients with head and neck cancer', Head and Neck, vol. 39, no. 10, pp. 2135-2141. https://doi.org/10.1002/hed.24857
Estes, S, Goldenberg, D, Winder, JS, Juza, RM & Lyn-Sue, J 2017, 'Best practices for robotic surgery programs', Journal of the Society of Laparoendoscopic Surgeons, vol. 21, no. 2, e2016.00102. https://doi.org/10.4293/JSLS.2016.00102
Funk, E, Goldenberg, D & Goyal, N 2017, 'Demonstration of transoral robotic supraglottic laryngectomy and total laryngectomy in cadaveric specimens using the Medrobotics Flex System', Head and Neck, vol. 39, no. 6, pp. 1218-1225. https://doi.org/10.1002/hed.24746
Shah-Becker, S, Derr, J, Oberman, BS, Baker, A, Saunders, B, Carr, M & Goldenberg, D 2018, 'Early neurocognitive improvements following parathyroidectomy for primary hyperparathyroidism', Laryngoscope, vol. 128, no. 3, pp. 775-780. https://doi.org/10.1002/lary.26617
Shokri, T & Goldenberg, D 2017, 'Emergency operative airway techniques' Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 28, no. 4, pp. 252-257. https://doi.org/10.1016/j.otot.2017.08.010
Patel, VA, Zacharia, TT, Goldenberg, D & McGinn, J 2017, 'End-organ radiographic manifestations of cranial neuropathies: A concise review' Clinical Imaging, vol. 44, pp. 5-11. https://doi.org/10.1016/j.clinimag.2017.03.014
Khaku, A, Patel, V, Zacharia, TT, Goldenberg, D & McGinn, J 2017, 'Guidelines for radiographic imaging of cranial neuropathies' Ear, Nose and Throat Journal, vol. 96, no. 10-11, E23.
Baker, A, Cottrill, EE, Munizza, O, McGillen, K, McKinnon, T & Goldenberg, D 2017, 'Intrathyroidal carotid artery and nonrecurring right recurrent laryngeal nerve: A case report' Head and Neck, vol. 39, no. 12, pp. E123-E126. https://doi.org/10.1002/hed.24970
Liu, J, Goldenberg, D, Almokadem, S, Crist, H & Mackley, H 2017, 'Long-term recurrence-free survival after an unplanned reduction in radiotherapy for HPV-positive oropharyngeal SCC: Two cases and a review of the literature' Ear, Nose and Throat Journal, vol. 96, no. 7, E23.
Goyal, N, Pakdaman, M, Kamani, D, Caragacianu, D, Goldenberg, D & Randolph, GW 2017, 'Mapping the distribution of nodal metastases in papillary thyroid carcinoma: Where exactly are the nodes?', Laryngoscope, vol. 127, no. 8, pp. 1959-1964. https://doi.org/10.1002/lary.26495
Gerhard, GS, Bann, DV, Broach, J & Goldenberg, D 2017, 'Pitfalls of exome sequencing: A case study of the attribution of HABP2 rs7080536 in familial non-medullary thyroid cancer', npj Genomic Medicine, vol. 2, no. 1, 8. https://doi.org/10.1038/s41525-017-0011-x
Goyal, N, Funk, E & Goldenberg, D 2018, 'Reply to Letter to the Editor regarding “Robotic or non-robotic transoral laryngectomy”' Head and Neck, vol. 40, no. 1. https://doi.org/10.1002/hed.25010

2016

Gooi, Z, Fakhry, C, Goldenberg, D, Richmon, J & Kiess, AP 2016, 'AHNS Series: Do you know your guidelines?Principles of radiation therapy for head and neck cancer: A review of the National Comprehensive Cancer Network guidelines', Head and Neck, vol. 38, no. 7, pp. 987-992. https://doi.org/10.1002/hed.24448
Roman, BR, Goldenberg, D & Givi, B 2016, 'AHNS Series - Do you know your guidelines? Guideline recommended follow-up and surveillance of head and neck cancer survivors', Head and Neck, vol. 38, no. 2, pp. 168-174. https://doi.org/10.1002/hed.24100
The Education Committee of the American Head and Neck Society (AHNS) 2016, 'AHNS series – Do you know your guidelines? Diagnosis and management of cutaneous squamous cell carcinoma', Head and Neck, vol. 38, no. 11, pp. 1589-1595. https://doi.org/10.1002/hed.24512
Kim, Y & Goldenberg, D 2016, 'Anatomy, physiology, and genetics of paragangliomas', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 27, no. 1, pp. 2-6. https://doi.org/10.1016/j.otot.2015.12.003
Miller, MC & Goldenberg, D 2016, 'Do you know your guidelines? An initiative of the American Head and Neck Society's Education Committee', Head and Neck, vol. 38, no. 2, pp. 165-167. https://doi.org/10.1002/hed.24104
Pachuski, J, Vaida, S, Donahue, K, Roberts, J, Kunselman, A, Oberman, B, Patel, H & Goldenberg, D 2016, 'Effect of laryngotracheal topical anesthesia on recurrent laryngeal nerve monitoring during thyroid Surgery', Journal of Clinical Anesthesia, vol. 29, pp. 10-13. https://doi.org/10.1016/j.jclinane.2015.09.003
Bann, DV & Goldenberg, D 2016, 'Four cystic parathyroid adenomas in a 71-year-old man' Ear, Nose and Throat Journal, vol. 95, no. 1, pp. 21-22.
Magister, MJ & Goldenberg, D 2016, 'In reply' JAMA Otolaryngology - Head and Neck Surgery, vol. 142, no. 1. https://doi.org/10.1001/jamaoto.2015.2908
The Education Committee of the American Head and Neck Society (AHNS) 2016, 'Merkel cell carcinoma: Do you know your guidelines?', Head and Neck, vol. 38, no. 5, pp. 647-652. https://doi.org/10.1002/hed.24359
Shah-Becker, S & Goldenberg, D 2016, 'Minimally invasive parathyroidectomy' Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 27, no. 3, pp. 152-156. https://doi.org/10.1016/j.otot.2016.06.008
DiSalvo, DS, Oberman, BS, Warrick, J & Goldenberg, D 2016, 'Pharyngeal Presentation of Goltz Syndrome: A Case Report with Review of the Literature' Head and Neck Pathology, vol. 10, no. 2, pp. 188-191. https://doi.org/10.1007/s12105-015-0667-4
Gross, ND, Holsinger, FC, Magnuson, JS, Duvvuri, U, Genden, EM, Ghanem, TA, Yaremchuk, KL, Goldenberg, D, Miller, MC, Moore, EJ, Morris, LG, Netterville, J, Weinstein, GS & Richmon, J 2016, 'Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee, AAO-HNS robotic task force and AAO-HNS sleep disorders committee', Head and Neck, vol. 38, pp. E151-E158. https://doi.org/10.1002/hed.24207
Abdulghani, J, Gokare, P, Gallant, JN, Dicker, D, Whitcomb, T, Cooper, T, Liao, JJ, Derr, J, Liu, J, Goldenberg, D, Finnberg, NK & El-Deiry, WS 2016, 'Sorafenib and quinacrine target anti-apoptotic protein MCL1: A poor prognostic marker in Anaplastic Thyroid Cancer (ATC)', Clinical Cancer Research, vol. 22, no. 24, pp. 6192-6203. https://doi.org/10.1158/1078-0432.CCR-15-2792
Hennessy, M & Goldenberg, D 2016, 'Surgical anatomy and physiology of swallowing', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 27, no. 2, pp. 60-66. https://doi.org/10.1016/j.otot.2016.04.002
Shah-Becker, S & Goldenberg, D 2016, 'Surgical exploration for hyperparathyroidism', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 27, no. 3, pp. 129-135. https://doi.org/10.1016/j.otot.2016.06.005
Khan, MJ, Goldenberg, D & Myssiorek, D 2016, 'Surgical management of vagal paraganglioma', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 27, no. 1, pp. 25-29. https://doi.org/10.1016/j.otot.2015.12.007
Bann, DV, Kim, Y, Zacharia, TT & Goldenberg, D 2017, 'The effect of aging on the anatomic position of the thyroid gland', Clinical Anatomy, vol. 30, no. 2, pp. 205-212. https://doi.org/10.1002/ca.22804
Harounian, JA, Goldenberg, D & May, JG 2016, 'The rare fourth branchial cleft anomaly' Ear, Nose and Throat Journal, vol. 95, no. 4-5, pp. 154-156.
Enomoto, LM, Bann, DV, Hollenbeak, CS & Goldenberg, D 2016, 'Trends in the incidence of oropharyngeal cancers in the United States', Otolaryngology - Head and Neck Surgery (United States), vol. 154, no. 6, pp. 1034-1040. https://doi.org/10.1177/0194599816633690

2015

AACE Endocrine Surgery Scientific Committee 2015, 'AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: THE INCREASING INCIDENCE OF THYROID CANCER', Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 21, no. 6, pp. 686-696. https://doi.org/10.4158/EP14466.DSCR
Saadi, R & Goldenberg, D 2015, 'An intrathyroidal thyroglossal duct cyst' Ear, Nose and Throat Journal, vol. 94, no. 10-11, pp. 446-447.
Magister, MJ, Chaikhoutdinov, I, Schaefer, E, Williams, N, Saunders, B & Goldenberg, D 2015, 'Association of thyroid nodule size and Bethesda class with rate of malignant disease', JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 12, pp. 1089-1095. https://doi.org/10.1001/jamaoto.2015.1451
Setabutr, D, Vakharia, K, Nogan, SJ, Kamel, GN, Allen, T, Saunders, B & Goldenberg, D 2015, 'Comparison of SPECT/CT and planar MIBI in terms of operating time and cost in the surgical management of primary hyperparathyroidism' Ear, Nose and Throat Journal, vol. 94, no. 10-11, pp. 448-452.
Hollenbeak, CS, Kulaylat, AN, Mackley, H, Koch, W, Schaefer, EW & Goldenberg, D 2015, 'Determinants of medicare costs for elderly patients with oral cavity and pharyngeal cancers', JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 7, pp. 628-635. https://doi.org/10.1001/jamaoto.2015.0940
Schaefer, EW, Wilson, MZ, Goldenberg, D, Mackley, H, Koch, W & Hollenbeak, CS 2015, 'Effect of marriage on outcomes for elderly patients with head and neck cancer' Head and Neck, vol. 37, no. 5, pp. 735-742. https://doi.org/10.1002/hed.23657
Goyal, N, Camacho, F, Mangano, J & Goldenberg, D 2015, 'Evaluating for a geospatial relationship between radon levels and thyroid cancer in Pennsylvania', Laryngoscope, vol. 125, no. 1, pp. E45-E49. https://doi.org/10.1002/lary.24815
Roman, BR, Patel, SG, Wang, MB, Pou, AM, Holsinger, FC, Myssiorek, D, Goldenberg, D, Swisher-McClure, S, Lin, A, Shah, JP & Shea, JA 2015, 'Guideline familiarity predicts variation in self-reported use of routine surveillance PET/CT by physicians who treat head and neck cancer' JNCCN Journal of the National Comprehensive Cancer Network, vol. 13, no. 1, pp. 69-77. https://doi.org/10.6004/jnccn.2015.0010
Goldenberg, D & Goyal, N 2015, 'Impact factor: What is it and is it still relevant' Ear, Nose and Throat Journal, vol. 94, no. 1, pp. 14-19.
Adil, E, Setabutr, D, Ghossaini, SN & Goldenberg, D 2015, 'Metastatic squamous cell carcinoma of the tonsil presenting as otorrhea: A case report' Ear, Nose and Throat Journal, vol. 94, no. 1, E7.
Sharma, J, Goldenberg, D, Crist, H & McGinn, J 2015, 'Multifocal inverted papillomas in the head and neck', Ear, Nose and Throat Journal, vol. 94, no. 3, pp. E20.
Bann, DV, Zacharia, TT, Goldenberg, D & Goyal, N 2015, 'Parathyroid localization using 4D-computed tomography', Ear, Nose and Throat Journal, vol. 94, no. 4-5, pp. E55.
Williams, MU, Carr, M & Goldenberg, D 2015, 'Public awareness of human papillomavirus as a causative factor for oropharyngeal cancer', Otolaryngology - Head and Neck Surgery (United States), vol. 152, no. 6, pp. 1029-1034. https://doi.org/10.1177/0194599815577781
Payne, SJ, Smucker, JE, Bruno, M, Winner, L, Saunders, B & Goldenberg, D 2015, 'Radiographic evaluation of non-localizing parathyroid adenomas', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 36, no. 2, pp. 217-222. https://doi.org/10.1016/j.amjoto.2014.10.036
Oberman, B, Khaku, A, Camacho, F & Goldenberg, D 2015, 'Relationship between obesity, diabetes and the risk of thyroid cancer' American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 36, no. 4, pp. 535-541. https://doi.org/10.1016/j.amjoto.2015.02.015
Goyal, N & Goldenberg, D 2015, 'Reply to letter to the editor regarding course of lingual artery' Head and Neck, vol. 37, no. 3, pp. 461-462. https://doi.org/10.1002/hed.23855
Patel, HH, Siltumens, A, Bess, L, Camacho, F & Goldenberg, D 2015, 'The Decline of Tracheotomy among Otolaryngologists: A 14-Year Review' Otolaryngology-Head and Neck Surgery, vol. 152, no. 3, pp. 465-469. https://doi.org/10.1177/0194599814563513
Enomoto, LM, Schaefer, EW, Goldenberg, D, Mackley, H, Koch, WM & Hollenbeak, CS 2015, 'The cost of hospice services in terminally ill patients with head and neck cancer' JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 12, pp. 1066-1074. https://doi.org/10.1001/jamaoto.2015.2162
Magreni, A, Bann, DV, Schubart, JR & Goldenberg, D 2015, 'The effects of race and ethnicity on thyroid cancer incidence', JAMA Otolaryngology - Head and Neck Surgery, vol. 141, no. 4, pp. 319-323. https://doi.org/10.1001/jamaoto.2014.3740
Portela, RA, Choby, GW, Manni, A, Campbell, D, Crist, H & Goldenberg, D 2015, 'Unusual sites of metastasis of papillary thyroid cancer: Case series and review of the literature' Ear, Nose and Throat Journal, vol. 94, no. 8, pp. E43.

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)