Researcher Profile

Researcher Profile

David Degraff, PhD

David Degraff, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Surgery
Scientific Program:Experimental Therapeutics
djd32@psu.edu

Research Interests

  • Urinary Bladder Neoplasms
  • Neoplasms
  • Carcinoma
  • Prostate
  • Prostatic Neoplasms
  • Urinary Bladder
  • Proteins
  • Androgen Receptors
  • Androgens
  • Gene Expression
  • Transcription Factors
  • Insulin-Like Growth Factor Binding Protein 2

Clinical Trials

Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens

Recent Publications

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, J, Wu, XR, Kaag, MG, Raman, J & Degraff, D 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Yee, CH, Zheng, Z, Shuman, L, Yamashita, H, Warrick, J, Wu, XR, Raman, J & Degraff, D 2019, 'Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS', Scientific reports, vol. 9, no. 1, 270. https://doi.org/10.1038/s41598-018-36720-6
Zaleski, M, Gogoj, A, Walter, V, Raman, J, Kaag, MG, Merrill, S, Drabick, J, Joshi, M, Holder, S, Degraff, D & Warrick, J 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system' Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008

2018

Warrick, J, Sjödahl, G, Kaag, MG, Raman, J, Merrill, S, Shuman, L, Chen, G, Walter, V & Degraff, D 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22. https://doi.org/10.1016/j.eururo.2018.09.003

2017

Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96. https://doi.org/10.1016/j.humpath.2016.10.021
Warrick, J, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345. https://doi.org/10.1007/s00428-017-2190-3
Flaig, TW, Kamat, AM, Hansel, D, Ingersoll, MA, Barton Grossman, H, Mendelsohn, C, Degraff, D, Liao, JC & Taylor, JA 2017, 'Proceedings of the 3rd annual albert institute for bladder cancer research symposium', Bladder Cancer, vol. 3, no. 3, pp. 211-223. https://doi.org/10.3233/BLC-170111

2016

Raman, J, Warrick, J, Caruso, C, Yang, Z, Shuman, L, Bruggeman, RD, Shariat, S, Karam, JA, Wood, C, Weizer, AZ, Remzi, M, Haitel, A, Bensalah, K, Rioux-Leclerq, N, Bolenz, C, Roscigno, M, Krabbe, LM, Kapur, P, Lotan, Y, Margulis, V & Degraff, D 2016, 'Altered Expression of the Transcription Factor Forkhead Box A1 (FOXA1) Is Associated With Poor Prognosis in Urothelial Carcinoma of the Upper Urinary Tract', Urology, vol. 94, pp. 314.e1-314.e7. https://doi.org/10.1016/j.urology.2016.05.030
Warrick, J, Raman, J, Kaag, MG, Bruggeman, T, Cates, J, Clark, P & Degraff, D 2016, 'Enhancer of zeste homolog 2 (EZH2) expression in bladder cancer', Urologic Oncology: Seminars and Original Investigations, vol. 34, no. 6, pp. 258.e1-258.e6. https://doi.org/10.1016/j.urolonc.2016.02.011
Warrick, J, Walter, V, Yamashita, H, Chung, E, Shuman, L, Amponsa, VO, Zheng, Z, Chan, W, Whitcomb, T, Yue, F, Iyyanki, T, Imamura, Y, Kaag, MG, Guo, W, Raman, J, Park, JS & Degraff, D 2016, 'FOXA1, GATA3 and PPARIγ Cooperate to drive luminal subtype in bladder cancer: A molecular analysis of established human cell lines', Scientific reports, vol. 6, 38531. https://doi.org/10.1038/srep38531
Vasekar, M, Degraff, D & Joshi, M 2016, 'Immunotherapy in bladder cancer', Current Molecular Pharmacology, vol. 9, no. 3, pp. 242-251. https://doi.org/10.2174/1874467208666150716120945
Grabowska, MM, Kelly, SM, Reese, AL, Cates, JM, Case, TC, Zhang, J, Degraff, D, Strand, DW, Miller, NL, Clark, PE, Hayward, SW, Gronostajski, RM, Anderson, PD & Matusik, RJ 2016, 'NFIB regulates transcriptional networks that control the development of prostatic hyperplasia', Endocrinology, vol. 157, no. 3, pp. 1094-1109. https://doi.org/10.1210/en.2015-1312
Yamashita, H, Amponsa, VO, Warrick, J, Zheng, Z, Clark, PE, Raman, J, Wu, XR, Mendelsohn, C & Degraff, D 2017, 'On a FOX hunt: Functions of FOX transcriptional regulators in bladder cancer', Nature Reviews Urology, vol. 14, no. 2, pp. 98-106. https://doi.org/10.1038/nrurol.2016.239

2015

Reddy, OL, Cates, JM, Gellert, LL, Crist, H, Yang, Z, Yamashita, H, Taylor, JA, Smith, JA, Chang, SS, Cookson, MS, You, C, Barocas, DA, Grabowska, MM, Ye, F, Wu, XR, Yi, Y, Matusik, RJ, Kaestner, KH, Clark, PE & Degraff, D 2015, 'Loss of FOXA1 drives sexually dimorphic changes in urothelial differentiation and is an independent predictor of poor prognosis in bladder cancer', American Journal of Pathology, vol. 185, no. 5, 1980, pp. 1385-1395. https://doi.org/10.1016/j.ajpath.2015.01.014
Adam, RM & Degraff, D 2015, 'Molecular mechanisms of squamous differentiation in urothelial cell carcinoma: A paradigm for molecular subtyping of urothelial cell carcinoma of the bladder', Urologic Oncology: Seminars and Original Investigations, vol. 33, no. 10, pp. 444-450. https://doi.org/10.1016/j.urolonc.2015.06.006
Warrick, J, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Degraff, D & Chen, G 2015, 'Squamous Dysplasia of the Urinary Bladder', International Journal of Surgical Pathology, vol. 24, no. 4, pp. 306-314. https://doi.org/10.1177/1066896916629783
Wu, XR, Mendelsohn, C & Degraff, D 2015, 'Tumorigenicity of RTK/RAS in urothelium' Oncoscience, vol. 2, no. 9, pp. 739-740. https://doi.org/10.18632/oncoscience.188

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)