Researcher Profile

Researcher Profile

David Degraff, PhD

David Degraff, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Urology
Assistant Professor, Department of Surgery
Scientific Program:Next-Generation Therapies
djd32@psu.edu

Research Interests

  • Urinary Bladder Neoplasms
  • Neoplasms
  • Carcinoma
  • Prostate
  • Prostatic Neoplasms
  • Urinary Bladder
  • Proteins
  • Transcription Factors
  • Androgens
  • Gene Expression
  • Androgen Receptors
  • Insulin-Like Growth Factor Binding Protein 2

Clinical Trials

Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens

Recent Publications

2021

Lindskrog, SV, Prip, F, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, JB, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, DG, Goel, A, Hurst, CD, Raman, JD, Warrick, JI, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, RT, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w
Joshi, M, Holder, SL, Zhu, J, Zheng, H, Komanduri, S, Warrick, J, Yasin, H, Gajre, R, Jia, B, Drabick, JJ, DeGraff, DJ & Zakharia, Y 2021, 'Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study', European Urology Focus. https://doi.org/10.1016/j.euf.2021.03.005
Xia, Y, Liu, Y, Yang, C, Simeone, DM, Sun, TT, DeGraff, DJ, Tang, MS, Zhang, Y & Wu, XR 2021, 'Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis', Nature communications, vol. 12, no. 1, 2047. https://doi.org/10.1038/s41467-021-22327-5
Iyyanki, T, Zhang, B, Wang, Q, Hou, Y, Jin, Q, Xu, J, Yang, H, Liu, T, Wang, X, Song, F, Luan, Y, Yamashita, H, Chien, R, Lyu, H, Zhang, L, Wang, L, Warrick, J, Raman, JD, Meeks, JJ, DeGraff, DJ & Yue, F 2021, 'Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer', Genome biology, vol. 22, no. 1, 105. https://doi.org/10.1186/s13059-021-02325-y

2020

Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Connelly, ZM, Jin, R, Zhang, J, Yang, S, Cheng, S, Shi, M, Cates, JMM, Shi, R, DeGraff, DJ, Nelson, PS, Liu, Y, Morrissey, C, Corey, E & Yu, X 2020, 'FOXA2 promotes prostate cancer growth in the bone', American Journal of Translational Research, vol. 12, no. 9, pp. 5619-5629.
Meeks, JJ, Al-Ahmadie, H, Faltas, BM, Taylor, JA, Flaig, TW, DeGraff, DJ, Christensen, E, Woolbright, BL, McConkey, DJ & Dyrskjøt, L 2020, 'Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes', Nature Reviews Urology, vol. 17, no. 5, pp. 259-270. https://doi.org/10.1038/s41585-020-0304-1
Russo, M, Newell, JM, Budurlean, L, Houser, KR, Sheldon, K, Kesterson, J, Phaeton, R, Hossler, C, Rosenberg, J, DeGraff, D, Shuman, L, Broach, JR & Warrick, JI 2020, 'Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma', Cancer, vol. 126, no. 12, pp. 2775-2783. https://doi.org/10.1002/cncr.32822
Torab, P, Yan, Y, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2020, 'Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer', Analytical Chemistry, vol. 92, no. 13, pp. 8768-8775. https://doi.org/10.1021/acs.analchem.0c00057

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, JI, Wu, XR, Kaag, M, Raman, JD & Degraff, DJ 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Osei-Amponsa, V, Buckwalter, JM, Shuman, L, Zheng, Z, Yamashita, H, Walter, V, Wildermuth, T, Ellis-Mohl, J, Liu, C, Warrick, JI, Shantz, LM, Feehan, RP, Al-Ahmadie, H, Mendelsohn, C, Raman, JD, Kaestner, KH, Wu, XR & DeGraff, DJ 2020, 'Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer', Oncogene, vol. 39, no. 6, pp. 1302-1317. https://doi.org/10.1038/s41388-019-1063-4
Yee, CH, Zheng, Z, Shuman, L, Yamashita, H, Warrick, J, Wu, XR, Raman, J & Degraff, D 2019, 'Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS', Scientific reports, vol. 9, no. 1, 270. https://doi.org/10.1038/s41598-018-36720-6
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Seyer, AK, Lehman, HL & Degraff, DJ 2019, 'Modeling Tumor Heterogeneity in Bladder Cancer: The Current State of the Field and Future Needs', Bladder Cancer, vol. 5, no. 4, pp. 251-261. https://doi.org/10.3233/BLC-199009
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8. https://doi.org/10.1016/j.celrep.2019.07.084

2018

Warrick, JI, Sjödahl, G, Kaag, M, Raman, JD, Merrill, S, Shuman, L, Chen, G, Walter, V & DeGraff, DJ 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22. https://doi.org/10.1016/j.eururo.2018.09.003

2017

Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96. https://doi.org/10.1016/j.humpath.2016.10.021
Warrick, JI, Kaag, M, Raman, JD, Chan, W, Tran, T, Kunchala, S, Shuman, L, DeGraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345. https://doi.org/10.1007/s00428-017-2190-3
Flaig, TW, Kamat, AM, Hansel, D, Ingersoll, MA, Barton Grossman, H, Mendelsohn, C, Degraff, D, Liao, JC & Taylor, JA 2017, 'Proceedings of the 3rd annual albert institute for bladder cancer research symposium', Bladder Cancer, vol. 3, no. 3, pp. 211-223. https://doi.org/10.3233/BLC-170111

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)