Researcher Profile

Researcher Profile

David Degraff, PhD

David Degraff, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Surgery
Scientific Program:Next-Generation Therapies
djd32@psu.edu

Research Interests

  • Urinary Bladder Neoplasms
  • Neoplasms
  • Carcinoma
  • Prostate
  • Prostatic Neoplasms
  • Urinary Bladder
  • Proteins
  • Transcription Factors
  • Androgens
  • Gene Expression
  • Androgen Receptors
  • Insulin-Like Growth Factor Binding Protein 2

Clinical Trials

Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens

Recent Publications

2021

Lindskrog, SV, Prip, F, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, JB, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, DG, Goel, A, Hurst, CD, Raman, J, Warrick, J, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, RT, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w
Joshi, M, Holder, SL, Zhu, J, Zheng, H, Komanduri, S, Warrick, J, Yasin, H, Gajre, R, Jia, B, Drabick, J, Degraff, D & Zakharia, Y 2021, 'Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study', European Urology Focus. https://doi.org/10.1016/j.euf.2021.03.005
Xia, Y, Liu, Y, Yang, C, Simeone, DM, Sun, TT, DeGraff, DJ, Tang, MS, Zhang, Y & Wu, XR 2021, 'Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis', Nature communications, vol. 12, no. 1, 2047. https://doi.org/10.1038/s41467-021-22327-5
Iyyanki, T, Zhang, B, Wang, Q, Hou, Y, Jin, Q, Xu, J, Yang, H, Liu, T, Wang, X, Song, F, Luan, Y, Yamashita, H, Chien, R, Lyu, H, Zhang, L, Wang, L, Warrick, J, Raman, JD, Meeks, JJ, DeGraff, DJ & Yue, F 2021, 'Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer', Genome biology, vol. 22, no. 1, 105. https://doi.org/10.1186/s13059-021-02325-y

2020

Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Connelly, ZM, Jin, R, Zhang, J, Yang, S, Cheng, S, Shi, M, Cates, JMM, Shi, R, DeGraff, DJ, Nelson, PS, Liu, Y, Morrissey, C, Corey, E & Yu, X 2020, 'FOXA2 promotes prostate cancer growth in the bone', American Journal of Translational Research, vol. 12, no. 9, pp. 5619-5629.
Meeks, JJ, Al-Ahmadie, H, Faltas, BM, Taylor, JA, Flaig, TW, DeGraff, DJ, Christensen, E, Woolbright, BL, McConkey, DJ & Dyrskjøt, L 2020, 'Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes', Nature Reviews Urology, vol. 17, no. 5, pp. 259-270. https://doi.org/10.1038/s41585-020-0304-1
Russo, M, Newell, JM, Budurlean, L, Houser, KR, Sheldon, K, Kesterson, J, Phaeton, R, Hossler, C, Rosenberg, J, DeGraff, D, Shuman, L, Broach, JR & Warrick, JI 2020, 'Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma', Cancer, vol. 126, no. 12, pp. 2775-2783. https://doi.org/10.1002/cncr.32822
Torab, P, Yan, Y, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2020, 'Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer', Analytical Chemistry, vol. 92, no. 13, pp. 8768-8775. https://doi.org/10.1021/acs.analchem.0c00057

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, JI, Wu, XR, Kaag, M, Raman, JD & Degraff, DJ 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Osei-Amponsa, V, Buckwalter, JM, Shuman, L, Zheng, Z, Yamashita, H, Walter, V, Wildermuth, T, Ellis-Mohl, J, Liu, C, Warrick, JI, Shantz, LM, Feehan, RP, Al-Ahmadie, H, Mendelsohn, C, Raman, JD, Kaestner, KH, Wu, XR & DeGraff, DJ 2020, 'Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer', Oncogene, vol. 39, no. 6, pp. 1302-1317. https://doi.org/10.1038/s41388-019-1063-4
Yee, CH, Zheng, Z, Shuman, L, Yamashita, H, Warrick, J, Wu, XR, Raman, J & Degraff, D 2019, 'Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS', Scientific reports, vol. 9, no. 1, 270. https://doi.org/10.1038/s41598-018-36720-6
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Seyer, AK, Lehman, HL & Degraff, DJ 2019, 'Modeling Tumor Heterogeneity in Bladder Cancer: The Current State of the Field and Future Needs', Bladder Cancer, vol. 5, no. 4, pp. 251-261. https://doi.org/10.3233/BLC-199009
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8. https://doi.org/10.1016/j.celrep.2019.07.084

2018

Warrick, JI, Sjödahl, G, Kaag, M, Raman, JD, Merrill, S, Shuman, L, Chen, G, Walter, V & DeGraff, DJ 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22. https://doi.org/10.1016/j.eururo.2018.09.003

2017

Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96. https://doi.org/10.1016/j.humpath.2016.10.021
Warrick, JI, Kaag, M, Raman, JD, Chan, W, Tran, T, Kunchala, S, Shuman, L, DeGraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345. https://doi.org/10.1007/s00428-017-2190-3
Flaig, TW, Kamat, AM, Hansel, D, Ingersoll, MA, Barton Grossman, H, Mendelsohn, C, Degraff, D, Liao, JC & Taylor, JA 2017, 'Proceedings of the 3rd annual albert institute for bladder cancer research symposium', Bladder Cancer, vol. 3, no. 3, pp. 211-223. https://doi.org/10.3233/BLC-170111

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)