Researcher Profile

Researcher Profile

Dhimant Desai, PhD

Dhimant Desai, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Experimental Therapeutics
dhd11@psu.edu

Research Interests

Dr. Dhimant Desai’s research interest is to study the structural activity relationship of organic chemopreventive and chemotherapeutic agents against cancers of colon, lung, melanoma and leukemia. He specializes in micro- and macro-scale organic and bio-organic syntheses of carbocyclic nucleosides, carcinogens, chemopreventive and chemotherapeutic agents including organoselenium compounds, cytodifferentiating agents and nitric oxide inhibitors.

The focus of Dr. Desai's research is on the synthesis of carcinogenic polycyclic aromatic hydrocarbons, tobacco-specific N-nitrosamines and their metabolites and adducts. It further extends his research in animal bioassays (studies in mice, rats, hamsters); isotopic and radiochemical preparations; animal tissue distribution studies; and in vitro studies with synthetic standards, including 14C, 2H and 3H-labeled compounds.

Dr. Desai has focused on the prevention and treatment of colon cancer by selenium-containing COX-2 inhibitors. In another recently funded project, Dr. Desai has investigated PK/PD studies of PAN-antiviral agent in the treatment of HCMV infections. He is also involved in the research on gut microbiota and metabolomics studies with bile acid analogs in the treatment of non-fatty liver disease, COPD and asthma.

  • Neoplasms
  • Lung
  • Carcinogenesis
  • 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • Tobacco
  • Selenium
  • Carcinogens
  • Nitrosamines
  • Therapeutics
  • Epoxy Compounds
  • DNA Adducts
  • DNA

Recent Publications

2019

[C@50538b46
[C@3bc5e54b
[C@181d9be8
[C@6cf2be55
Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors' Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803. https://doi.org/10.1016/j.bmc.2019.03.026

2018

Dyba, M, Da Silva, B, Coia, H, Hou, Y, Noguchi, S, Pan, J, Berry, D, Creswell, K, Krzeminski, J, Desai, D, Amin, S, Yang, D & Chung, FL 2018, 'Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids', Chemical research in toxicology, vol. 31, no. 8, pp. 772-783. https://doi.org/10.1021/acs.chemrestox.8b00111

2017

[C@4957f187
[C@23c2681d
[C@345363ff
[C@f98e016
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models' Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.

2016

[C@1610a516
[C@3f15699
[C@6b35251d
[C@281d87e8
[C@8abfc87
[C@5346d9f6
[C@4c8e9b0e

2015

Van Den Bogaard, EH, Podolsky, MA, Smits, JP, Cui, X, John, C, Gowda, K, Desai, D, Amin, S, Schalkwijk, J, Perdew, GH & Glick, AB 2015, 'Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation', Journal of Investigative Dermatology, vol. 135, no. 5, pp. 1320-1328. https://doi.org/10.1038/jid.2015.6
[C@6317f2a9
[C@7849de21
[C@4ab20731
[C@4e413e24
[C@67c80e49

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)