Researcher Profile

Researcher Profile

David D. Boehr, PhD

David D. Boehr, PhD

Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
ddb12@psu.edu

Research Interests

  • Enzymes
  • Proteins
  • Catalytic Domain
  • Aminoglycosides
  • RNA Replicase
  • Nucleotides
  • Anti-Bacterial Agents
  • Catalysis
  • Phosphotransferases
  • Ligands
  • Amino Acids
  • RNA

Recent Publications

2018

Gorman, SD, Sahu, D, O'Rourke, KF & Boehr, DD 2018, 'Assigning methyl resonances for protein solution-state NMR studies', Methods, vol. 148, pp. 88-99. https://doi.org/10.1016/j.ymeth.2018.06.010
Boehr, DD, D'Amico, RN & O'Rourke, KF 2018, 'Engineered control of enzyme structural dynamics and function', Protein Science, vol. 27, no. 4, pp. 825-838. https://doi.org/10.1002/pro.3379
O'Rourke, KF, Axe, JM, D'Amico, RN, Sahu, D & Boehr, DD 2018, 'Millisecond timescale motions connect amino acid interaction networks in alpha tryptophan synthase' Frontiers in Molecular Biosciences, vol. 5, no. NOV, 92. https://doi.org/10.3389/fmolb.2018.00092
Boehr, DD 2018, 'NMR Methods of Characterizing Biomolecular Structural Dynamics and Conformational Ensembles', Methods, vol. 148, pp. 1-3. https://doi.org/10.1016/j.ymeth.2018.08.011

2017

Shengjuler, D, Chan, YM, Sun, S, Moustafa, I, Li, ZL, Gohara, DW, Buck, M, Cremer, PS, Boehr, DD & Cameron, CE 2017, 'The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain', Structure, vol. 25, no. 12, pp. 1875-1886.e7. https://doi.org/10.1016/j.str.2017.11.001
Yang, X, Liu, X, Musser, DM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2017, 'Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases', Journal of Biological Chemistry, vol. 292, no. 9, pp. 3810-3826. https://doi.org/10.1074/jbc.M116.750638

2016

O'Rourke, KF, Gorman, SD & Boehr, DD 2016, 'Biophysical and computational methods to analyze amino acid interaction networks in proteins', Computational and Structural Biotechnology Journal, vol. 14, pp. 245-251. https://doi.org/10.1016/j.csbj.2016.06.002
O’Rourke, KF, Jelowicki, AM & Boehr, DD 2016, 'Controlling active site loop dynamics in the (β/α)8 barrel enzyme indole-3-glycerol phosphate synthase', Catalysts, vol. 6, no. 9, 129. https://doi.org/10.3390/catal6090129
Chan, YM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2016, 'Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein' Structure, vol. 24, no. 4, pp. 509-517. https://doi.org/10.1016/j.str.2016.02.019

2015

Liu, X, Musser, DM, Lee, CA, Yang, X, Arnold, JJ, Cameron, CE & Boehr, DD 2015, 'Nucleobase but not sugar fidelity is maintained in the Sabin I RNA-dependent RNA polymerase' Viruses, vol. 7, no. 10, A26, pp. 5571-5586. https://doi.org/10.3390/v7102894
Axe, JM, O'Rourke, KF, Kerstetter, NE, Yezdimer, EM, Chan, YM, Chasin, A & Boehr, DD 2015, 'Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase' Protein Science, vol. 24, no. 4, pp. 484-494. https://doi.org/10.1002/pro.2598
van der Linden, L, Vives-Adrián, L, Selisko, B, Ferrer-Orta, C, Liu, X, Lanke, K, Ulferts, R, De Palma, AM, Tanchis, F, Goris, N, Lefebvre, D, De Clercq, K, Leyssen, P, Lacroix, C, Pürstinger, G, Coutard, B, Canard, B, Boehr, DD, Arnold, JJ, Cameron, CE, Verdaguer, N, Neyts, J & van Kuppeveld, FJM 2015, 'The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family', PLoS pathogens, vol. 11, no. 3, e1004733, pp. 1-23. https://doi.org/10.1371/journal.ppat.1004733

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)