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Researcher Profile

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David D. Boehr, PhD

David D. Boehr, PhD

Professor of Chemistry, Chemistry
Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Enzymes
  • Proteins
  • Catalytic Domain
  • RNA Replicase
  • Nucleotides
  • Catalysis
  • Aminoglycosides
  • Magnetic Resonance Spectroscopy
  • Amino Acids
  • Tryptophan Synthase
  • RNA
  • Anti-Bacterial Agents

Recent Publications


Boehr, DD 2024, 'Editorial: Allosteric functions and inhibitions: structural insights', Frontiers in Molecular Biosciences, vol. 11, 1363100.


D'Amico, RN & Boehr, DD 2023, 'Allostery, engineering and inhibition of tryptophan synthase', Current Opinion in Structural Biology, vol. 82, 102657.
Mondal, S, Sarvari, G & Boehr, DD 2023, 'Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNA', Viruses, vol. 15, no. 12, 2413.
Yu, J & Boehr, DD 2023, 'Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces', Frontiers in Molecular Biosciences, vol. 10, 1306483.


Winston, DS & Boehr, DD 2022, 'Catalyst-Based Biomolecular Logic Gates', Catalysts, vol. 12, no. 7, 712.
Winston, DS, Gorman, SD & Boehr, DD 2022, 'Conformational Transitions in Yeast Chorismate Mutase Important for Allosteric Regulation as Identified by Nuclear Magnetic Resonance Spectroscopy', Journal of Molecular Biology, vol. 434, no. 17, 167531.
Topakas, E, Boehr, D & Wohlgemuth, R 2022, 'Special Issue “10th Anniversary of Catalysts: Biocatalysis in Analysis and Synthesis—Past, Present and Future”', Catalysts, vol. 12, no. 12, 1626.


Winston, DS & Boehr, DD 2021, Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part A. Enzymes, vol. 49, Academic Press, pp. 149-193.
O'Rourke, KF, D'Amico, RN, Sahu, D & Boehr, DD 2021, 'Distinct conformational dynamics and allosteric networks in alpha tryptophan synthase during active catalysis', Protein Science, vol. 30, no. 3, pp. 543-557.
D’Amico, RN, Bosken, YK, O’Rourke, KF, Murray, AM, Admasu, W, Chang, CEA & Boehr, DD 2021, 'Substitution of a Surface-Exposed Residue Involved in an Allosteric Network Enhances Tryptophan Synthase Function in Cells', Frontiers in Molecular Biosciences, vol. 8, 679915.
Winston, DS & Boehr, DD 2021, 'The picornavirus precursor 3cd has different conformational dynamics compared to 3cpro and 3dpol in functionally relevant regions', Viruses, vol. 13, no. 3, 442.


Gorman, SD, Winston, DS, Sahu, D & Boehr, DD 2020, 'Different Solvent and Conformational Entropy Contributions to the Allosteric Activation and Inhibition Mechanisms of Yeast Chorismate Mutase', Biochemistry, vol. 59, no. 27, pp. 2528-2540.
D'Amico, RN, Murray, AM & Boehr, DD 2020, 'Driving Protein Conformational Cycles in Physiology and Disease: “Frustrated” Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle', BioEssays, vol. 42, no. 9, 2000092.