David D. Boehr, PhD - Penn State Cancer Institute
Researcher Profile
David D. Boehr, PhD
Professor of Chemistry, Chemistry
Associate Professor of Chemistry, Chemistry
Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Enzymes
- Proteins
- Catalytic Domain
- RNA Replicase
- Nucleotides
- Catalysis
- Aminoglycosides
- Magnetic Resonance Spectroscopy
- Amino Acids
- Tryptophan Synthase
- RNA
- Anti-Bacterial Agents
Recent Publications
2023
D'Amico, RN & Boehr, DD 2023, 'Allostery, engineering and inhibition of tryptophan synthase', Current Opinion in Structural Biology, vol. 82, 102657. https://doi.org/10.1016/j.sbi.2023.102657
2022
Winston, DS & Boehr, DD 2022, 'Catalyst-Based Biomolecular Logic Gates', Catalysts, vol. 12, no. 7, 712. https://doi.org/10.3390/catal12070712
Winston, DS, Gorman, SD & Boehr, DD 2022, 'Conformational Transitions in Yeast Chorismate Mutase Important for Allosteric Regulation as Identified by Nuclear Magnetic Resonance Spectroscopy', Journal of Molecular Biology, vol. 434, no. 17, 167531. https://doi.org/10.1016/j.jmb.2022.167531
Topakas, E, Boehr, D & Wohlgemuth, R 2022, 'Special Issue “10th Anniversary of Catalysts: Biocatalysis in Analysis and Synthesis—Past, Present and Future”', Catalysts, vol. 12, no. 12, 1626. https://doi.org/10.3390/catal12121626
2021
Winston, DS & Boehr, DD 2021, Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part A. Enzymes, vol. 49, Academic Press, pp. 149-193. https://doi.org/10.1016/bs.enz.2021.06.001
O'Rourke, KF, D'Amico, RN, Sahu, D & Boehr, DD 2021, 'Distinct conformational dynamics and allosteric networks in alpha tryptophan synthase during active catalysis', Protein Science, vol. 30, no. 3, pp. 543-557. https://doi.org/10.1002/pro.4011
D’Amico, RN, Bosken, YK, O’Rourke, KF, Murray, AM, Admasu, W, Chang, CEA & Boehr, DD 2021, 'Substitution of a Surface-Exposed Residue Involved in an Allosteric Network Enhances Tryptophan Synthase Function in Cells', Frontiers in Molecular Biosciences, vol. 8, 679915. https://doi.org/10.3389/fmolb.2021.679915
Winston, DS & Boehr, DD 2021, 'The picornavirus precursor 3cd has different conformational dynamics compared to 3cpro and 3dpol in functionally relevant regions', Viruses, vol. 13, no. 3, 442. https://doi.org/10.3390/v13030442
2020
Gorman, SD, Winston, DS, Sahu, D & Boehr, DD 2020, 'Different Solvent and Conformational Entropy Contributions to the Allosteric Activation and Inhibition Mechanisms of Yeast Chorismate Mutase', Biochemistry, vol. 59, no. 27, pp. 2528-2540. https://doi.org/10.1021/acs.biochem.0c00277
D'Amico, RN, Murray, AM & Boehr, DD 2020, 'Driving Protein Conformational Cycles in Physiology and Disease: “Frustrated” Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle', BioEssays, vol. 42, no. 9, 2000092. https://doi.org/10.1002/bies.202000092
2019
Boehr, AK, Arnold, JJ, Oh, HS, Cameron, CE & Boehr, DD 2019, '2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase', Journal of Biological Chemistry, vol. 294, no. 45, pp. 16897-16907. https://doi.org/10.1074/jbc.RA119.010214
O'Rourke, KF, Sahu, D, Bosken, YK, D'Amico, RN, Chang, CEA & Boehr, DD 2019, 'Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase', Structure, vol. 27, no. 9, pp. 1405-1415.e5. https://doi.org/10.1016/j.str.2019.05.013
Gorman, SD & Boehr, DD 2019, 'Energy and Enzyme Activity Landscapes of Yeast Chorismate Mutase at Cellular Concentrations of Allosteric Effectors', Biochemistry, vol. 58, no. 39, pp. 4058-4069. https://doi.org/10.1021/acs.biochem.9b00721
Gorman, SD, D’Amico, RN, Winston, DS & Boehr, DD 2019, Engineering allostery into proteins. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1163, Springer, pp. 359-384. https://doi.org/10.1007/978-981-13-8719-7_15
Shi, J, Perryman, JM, Yang, X, Liu, X, Musser, DM, Boehr, AK, Moustafa, IM, Arnold, JJ, Cameron, CE & Boehr, DD 2019, 'Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics', Biochemistry, vol. 58, no. 36, pp. 3735-3743. https://doi.org/10.1021/acs.biochem.9b00497