Researcher Profile

Researcher Profile

David D. Boehr, PhD

David D. Boehr, PhD

Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Enzymes
  • Proteins
  • Catalytic Domain
  • RNA Replicase
  • Nucleotides
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Catalysis
  • Amino Acids
  • Phosphotransferases
  • Ligands
  • RNA

Recent Publications


O'Rourke, KF, Sahu, D, Bosken, YK, D'Amico, RN, Chang, CEA & Boehr, DD 2019, 'Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase', Structure, vol. 27, no. 9, pp. 1405-1415.e5.
Shi, J, Perryman, JM, Yang, X, Liu, X, Musser, DM, Boehr, AK, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2019, 'Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics', Biochemistry, vol. 58, no. 36, pp. 3735-3743.


Gorman, SD, Sahu, D, O'Rourke, KF & Boehr, DD 2018, 'Assigning methyl resonances for protein solution-state NMR studies', Methods, vol. 148, pp. 88-99.
Boehr, DD, D'Amico, RN & O'Rourke, KF 2018, 'Engineered control of enzyme structural dynamics and function', Protein Science, vol. 27, no. 4, pp. 825-838.
O'Rourke, KF, Axe, JM, D'Amico, RN, Sahu, D & Boehr, DD 2018, 'Millisecond timescale motions connect amino acid interaction networks in alpha tryptophan synthase', Frontiers in Molecular Biosciences, vol. 5, no. NOV, 92.
Boehr, DD 2018, 'NMR Methods of Characterizing Biomolecular Structural Dynamics and Conformational Ensembles', Methods, vol. 148, pp. 1-3.


Shengjuler, D, Chan, YM, Sun, S, Moustafa, I, Li, ZL, Gohara, DW, Buck, M, Cremer, PS, Boehr, DD & Cameron, CE 2017, 'The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain', Structure, vol. 25, no. 12, pp. 1875-1886.e7.
Yang, X, Liu, X, Musser, DM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2017, 'Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases', Journal of Biological Chemistry, vol. 292, no. 9, pp. 3810-3826.


O'Rourke, KF, Gorman, SD & Boehr, DD 2016, 'Biophysical and computational methods to analyze amino acid interaction networks in proteins', Computational and Structural Biotechnology Journal, vol. 14, pp. 245-251.
O’Rourke, KF, Jelowicki, AM & Boehr, DD 2016, 'Controlling active site loop dynamics in the (β/α)8 barrel enzyme indole-3-glycerol phosphate synthase', Catalysts, vol. 6, no. 9, 129.
Chan, YM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2016, 'Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein', Structure, vol. 24, no. 4, pp. 509-517.


Liu, X, Musser, DM, Lee, CA, Yang, X, Arnold, JJ, Cameron, CE & Boehr, DD 2015, 'Nucleobase but not sugar fidelity is maintained in the Sabin I RNA-dependent RNA polymerase' Viruses, vol. 7, no. 10, A26, pp. 5571-5586.
Axe, JM, O'Rourke, KF, Kerstetter, NE, Yezdimer, EM, Chan, YM, Chasin, A & Boehr, DD 2015, 'Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase', Protein Science, vol. 24, no. 4, pp. 484-494.
van der Linden, L, Vives-Adrián, L, Selisko, B, Ferrer-Orta, C, Liu, X, Lanke, K, Ulferts, R, De Palma, AM, Tanchis, F, Goris, N, Lefebvre, D, De Clercq, K, Leyssen, P, Lacroix, C, Pürstinger, G, Coutard, B, Canard, B, Boehr, DD, Arnold, JJ, Cameron, CE, Verdaguer, N, Neyts, J & van Kuppeveld, FJM 2015, 'The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family', PLoS pathogens, vol. 11, no. 3, e1004733, pp. 1-23.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)