Researcher Profile

Researcher Profile

David D. Boehr, PhD

David D. Boehr, PhD

Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Enzymes
  • Proteins
  • Catalytic Domain
  • RNA Replicase
  • Nucleotides
  • Catalysis
  • Aminoglycosides
  • Amino Acids
  • RNA
  • Anti-Bacterial Agents
  • Tryptophan Synthase
  • Ligands

Recent Publications


O'Rourke, KF, D'Amico, RN, Sahu, D & Boehr, DD 2021, 'Distinct conformational dynamics and allosteric networks in alpha tryptophan synthase during active catalysis', Protein Science, vol. 30, no. 3, pp. 543-557.
Winston, DS & Boehr, DD 2021, 'The picornavirus precursor 3cd has different conformational dynamics compared to 3cpro and 3dpol in functionally relevant regions', Viruses, vol. 13, no. 3, 442.


Gorman, SD, Winston, DS, Sahu, D & Boehr, DD 2020, 'Different Solvent and Conformational Entropy Contributions to the Allosteric Activation and Inhibition Mechanisms of Yeast Chorismate Mutase', Biochemistry, vol. 59, no. 27, pp. 2528-2540.
D'Amico, RN, Murray, AM & Boehr, DD 2020, 'Driving Protein Conformational Cycles in Physiology and Disease: “Frustrated” Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle', BioEssays, vol. 42, no. 9, 2000092.


Boehr, AK, Arnold, JJ, Oh, HS, Cameron, CE & Boehr, DD 2019, '2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase', Journal of Biological Chemistry, vol. 294, no. 45, pp. 16897-16907.
O'Rourke, KF, Sahu, D, Bosken, YK, D'Amico, RN, Chang, CEA & Boehr, DD 2019, 'Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase', Structure, vol. 27, no. 9, pp. 1405-1415.e5.
Gorman, SD & Boehr, DD 2019, 'Energy and Enzyme Activity Landscapes of Yeast Chorismate Mutase at Cellular Concentrations of Allosteric Effectors', Biochemistry, vol. 58, no. 39, pp. 4058-4069.
Gorman, SD, D’Amico, RN, Winston, DS & Boehr, DD 2019, Engineering allostery into proteins. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1163, Springer, pp. 359-384.
Shi, J, Perryman, JM, Yang, X, Liu, X, Musser, DM, Boehr, AK, Moustafa, IM, Arnold, JJ, Cameron, CE & Boehr, DD 2019, 'Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics', Biochemistry, vol. 58, no. 36, pp. 3735-3743.


Gorman, SD, Sahu, D, O'Rourke, KF & Boehr, DD 2018, 'Assigning methyl resonances for protein solution-state NMR studies', Methods, vol. 148, pp. 88-99.
Boehr, DD, D'Amico, RN & O'Rourke, KF 2018, 'Engineered control of enzyme structural dynamics and function', Protein Science, vol. 27, no. 4, pp. 825-838.
O'Rourke, KF, Axe, JM, D'Amico, RN, Sahu, D & Boehr, DD 2018, 'Millisecond timescale motions connect amino acid interaction networks in alpha tryptophan synthase', Frontiers in Molecular Biosciences, vol. 5, no. NOV, 92.
Boehr, DD 2018, 'NMR Methods of Characterizing Biomolecular Structural Dynamics and Conformational Ensembles', Methods, vol. 148, pp. 1-3.


Shengjuler, D, Chan, YM, Sun, S, Moustafa, IM, Li, ZL, Gohara, DW, Buck, M, Cremer, PS, Boehr, DD & Cameron, CE 2017, 'The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain', Structure, vol. 25, no. 12, pp. 1875-1886.e7.
Yang, X, Liu, X, Musser, DM, Moustafa, IM, Arnold, JJ, Cameron, CE & Boehr, DD 2017, 'Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases', Journal of Biological Chemistry, vol. 292, no. 9, pp. 3810-3826.

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