Researcher Profile

Researcher Profile

David D. Boehr, PhD

David D. Boehr, PhD

Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
ddb12@psu.edu

Research Interests

  • Enzymes
  • Proteins
  • Catalytic Domain
  • RNA Replicase
  • Nucleotides
  • Aminoglycosides
  • Amino Acids
  • Catalysis
  • Anti-Bacterial Agents
  • RNA
  • Ligands
  • Phosphotransferases

Recent Publications

2020

Gorman, SD, Winston, DS, Sahu, D & Boehr, DD 2020, 'Different Solvent and Conformational Entropy Contributions to the Allosteric Activation and Inhibition Mechanisms of Yeast Chorismate Mutase', Biochemistry, vol. 59, no. 27, pp. 2528-2540. https://doi.org/10.1021/acs.biochem.0c00277
D'Amico, RN, Murray, AM & Boehr, DD 2020, 'Driving Protein Conformational Cycles in Physiology and Disease: “Frustrated” Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle', BioEssays, vol. 42, no. 9, 2000092. https://doi.org/10.1002/bies.202000092

2019

Boehr, AK, Arnold, JJ, Oh, HS, Cameron, CE & Boehr, DD 2019, '2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase', Journal of Biological Chemistry, vol. 294, no. 45, pp. 16897-16907. https://doi.org/10.1074/jbc.RA119.010214
O'Rourke, KF, Sahu, D, Bosken, YK, D'Amico, RN, Chang, CEA & Boehr, DD 2019, 'Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase', Structure, vol. 27, no. 9, pp. 1405-1415.e5. https://doi.org/10.1016/j.str.2019.05.013
Gorman, SD & Boehr, DD 2019, 'Energy and Enzyme Activity Landscapes of Yeast Chorismate Mutase at Cellular Concentrations of Allosteric Effectors', Biochemistry, vol. 58, no. 39, pp. 4058-4069. https://doi.org/10.1021/acs.biochem.9b00721
Gorman, SD, D’Amico, RN, Winston, DS & Boehr, DD 2019, Engineering allostery into proteins. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1163, Springer, pp. 359-384. https://doi.org/10.1007/978-981-13-8719-7_15
Shi, J, Perryman, JM, Yang, X, Liu, X, Musser, DM, Boehr, AK, Moustafa, IM, Arnold, JJ, Cameron, CE & Boehr, DD 2019, 'Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics', Biochemistry, vol. 58, no. 36, pp. 3735-3743. https://doi.org/10.1021/acs.biochem.9b00497

2018

Gorman, SD, Sahu, D, O'Rourke, KF & Boehr, DD 2018, 'Assigning methyl resonances for protein solution-state NMR studies', Methods, vol. 148, pp. 88-99. https://doi.org/10.1016/j.ymeth.2018.06.010
Boehr, DD, D'Amico, RN & O'Rourke, KF 2018, 'Engineered control of enzyme structural dynamics and function', Protein Science, vol. 27, no. 4, pp. 825-838. https://doi.org/10.1002/pro.3379
O'Rourke, KF, Axe, JM, D'Amico, RN, Sahu, D & Boehr, DD 2018, 'Millisecond timescale motions connect amino acid interaction networks in alpha tryptophan synthase', Frontiers in Molecular Biosciences, vol. 5, no. NOV, 92. https://doi.org/10.3389/fmolb.2018.00092
Boehr, DD 2018, 'NMR Methods of Characterizing Biomolecular Structural Dynamics and Conformational Ensembles', Methods, vol. 148, pp. 1-3. https://doi.org/10.1016/j.ymeth.2018.08.011

2017

Shengjuler, D, Chan, YM, Sun, S, Moustafa, IM, Li, ZL, Gohara, DW, Buck, M, Cremer, PS, Boehr, DD & Cameron, CE 2017, 'The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain', Structure, vol. 25, no. 12, pp. 1875-1886.e7. https://doi.org/10.1016/j.str.2017.11.001
Yang, X, Liu, X, Musser, DM, Moustafa, IM, Arnold, JJ, Cameron, CE & Boehr, DD 2017, 'Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases', Journal of Biological Chemistry, vol. 292, no. 9, pp. 3810-3826. https://doi.org/10.1074/jbc.M116.750638

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