Researcher Profile

Researcher Profile

Douglas Stairs, PhD

Douglas Stairs, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Pharmacology
Scientific Program:Experimental Therapeutics
dbs18@psu.edu

Research Interests

The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

  • Barrett Esophagus
  • Neoplasms
  • Epithelium
  • Human Mammary Glands
  • Breast
  • Down-Regulation
  • Mutation
  • Epidermal Growth Factor Receptor
  • Adenocarcinoma
  • Genes
  • Esophageal Neoplasms
  • Epithelial Cells

Recent Publications

2019

Nelson, A, Cong, Z, Gettle, SL, Longenecker, AL, Kidacki, M, Sciacca Kirby, J, Adams, D, Stairs, D & Danby, FW 2019, 'E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions', Experimental Dermatology, vol. 28, no. 7, pp. 867-871. https://doi.org/10.1111/exd.13973

2018

Lehman, HL, Kidacki, M, Warrick, J & Stairs, D 2018, 'NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation', Oncotarget, vol. 9, no. 13, pp. 11180-11196. https://doi.org/10.18632/oncotarget.24358

2017

Kidacki, M, Lehman, HL, Green, MV, Warrick, J & Stairs, D 2017, 'p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC', Molecular Cancer Research, vol. 15, no. 10, pp. 1398-1409. https://doi.org/10.1158/1541-7786.MCR-17-0108

2016

Karamchandani, D, Lehman, HL, Ohanessian, SE, Massé, J, Welsh, PA, Odze, RD, Goldblum, JR, Berg, A & Stairs, D 2016, 'Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1', Diagnostic Pathology, vol. 11, no. 1, 23. https://doi.org/10.1186/s13000-016-0473-7
Karagoz, K, Lehman, HL, Stairs, D, Sinha, R & Arga, KY 2016, 'Proteomic and metabolic signatures of esophageal squamous cell carcinoma', Current Cancer Drug Targets, vol. 16, no. 8, pp. 721-736. https://doi.org/10.2174/1568009616666160203113721

2015

Lehman, HL, Yang, X, Welsh, PA & Stairs, D 2015, 'P120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma', American Journal of Pathology, vol. 185, no. 1, pp. 240-251. https://doi.org/10.1016/j.ajpath.2014.09.008

Clinical Trials Search


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Adults (age >= 18 years)