Researcher Profile

Researcher Profile

Douglas Stairs, PhD

Douglas Stairs, PhD

Associate Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Associate Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies

Research Interests

The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

  • Neoplasms
  • delta catenin
  • Barrett Esophagus
  • Epithelium
  • Esophageal Squamous Cell Carcinoma
  • Human Mammary Glands
  • Breast
  • ErbB Receptors
  • Down-Regulation
  • Keratinocytes
  • Mutation
  • Genes

Recent Publications


El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660.
Landmesser, ME, Raup-Konsavage, WM, Lehman, HL & Stairs, DB 2020, 'Loss of p120ctn causes EGFR-targeted therapy resistance and failure', PloS one, vol. 15, no. 10 October, e0241299.
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321.
Lehman, HL, Kidacki, M & Stairs, DB 2020, 'Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes', Scientific reports, vol. 10, no. 1, 18829.


Nelson, AM, Cong, Z, Gettle, SL, Longenecker, AL, Kidacki, M, Kirby, JS, Adams, DR, Stairs, DB & Danby, FW 2019, 'E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions', Experimental Dermatology, vol. 28, no. 7, pp. 867-871.


Lehman, HL, Kidacki, M, Warrick, JI & Stairs, DB 2018, 'NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation', Oncotarget, vol. 9, no. 13, pp. 11180-11196.


Kidacki, M, Lehman, HL, Green, MV, Warrick, JI & Stairs, DB 2017, 'p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC', Molecular Cancer Research, vol. 15, no. 10, pp. 1398-1409.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)