Researcher Profile

Researcher Profile

Douglas Stairs, PhD

Douglas Stairs, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
dbs18@psu.edu

Research Interests

The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

  • Neoplasms
  • delta catenin
  • Barrett Esophagus
  • Epithelium
  • Esophageal Squamous Cell Carcinoma
  • Human Mammary Glands
  • Breast
  • ErbB Receptors
  • Down-Regulation
  • Keratinocytes
  • Mutation
  • Genes

Recent Publications

2020

El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis', Cancer prevention research (Philadelphia, Pa.), vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Landmesser, ME, Raup-Konsavage, WM, Lehman, HL & Stairs, DB 2020, 'Loss of p120ctn causes EGFR-targeted therapy resistance and failure', PloS one, vol. 15, no. 10 October, e0241299. https://doi.org/10.1371/journal.pone.0241299
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321
Lehman, HL, Kidacki, M & Stairs, DB 2020, 'Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes', Scientific reports, vol. 10, no. 1, 18829. https://doi.org/10.1038/s41598-020-75866-0

2019

Nelson, AM, Cong, Z, Gettle, SL, Longenecker, AL, Kidacki, M, Kirby, JS, Adams, DR, Stairs, DB & Danby, FW 2019, 'E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions', Experimental Dermatology, vol. 28, no. 7, pp. 867-871. https://doi.org/10.1111/exd.13973

2018

Lehman, HL, Kidacki, M, Warrick, JI & Stairs, DB 2018, 'NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation', Oncotarget, vol. 9, no. 13, pp. 11180-11196. https://doi.org/10.18632/oncotarget.24358

2017

Kidacki, M, Lehman, HL, Green, MV, Warrick, JI & Stairs, DB 2017, 'p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC', Molecular Cancer Research, vol. 15, no. 10, pp. 1398-1409. https://doi.org/10.1158/1541-7786.MCR-17-0108

Clinical Trials Search


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