Researcher Profile

Researcher Profile

Chandrika Gowda, MD

Chandrika Gowda, MD

John Wawrynovic Leukemia Research Scholar Endowment, College of Medicine (Hershey)
Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Pediatric Cancer
cxg40@psu.edu

Research Interests

Dr. Chandrika Gowda is a board-certified hematologist/oncologist who has strong commitment to research in childhood cancer, including leukemia and neuroblastoma. Her major research project is to study Role of Ikaros tumor suppressor and pro-oncogenic casein Kinase II(CK2) in leukemogenesis and drug resistance. Dr.Gowda's current work is focused on targeting CK2 for treatment of hematological malignancies.

Her most notable work, published in Blood in 2015, established the novel approach of using specific CK2 inhibitors for treatment of high-risk B cell lineage leukemia using PDX models. She has presented her work at various national and international scientific forums and gained national recognition as an outstanding young investigator.

Dr. Gowda's research is currently supported by several extramural grants. She has also authored several chapters and review articles related to leukemia, CK2 and Ikaros. Her other projects are focused on designing novel therapeutic strategies for treatment of high risk neuroblastoma, which is the most common abdominal solid tumor in young children, with poor prognosis.

  • Leukemia
  • Casein Kinase II
  • Neoplasms
  • Therapeutics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Genes
  • Cell Proliferation
  • B-Lymphocytes
  • Phosphorylation
  • Phosphatidylinositol 3-Kinase
  • Proteins
  • Hematologic Neoplasms

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications

2019

Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia. https://doi.org/10.1038/s41375-019-0474-0

2017

Gowda, C, Soliman, M, Kapadia, M, Ding, Y, Payne, K & Dovat, S 2017, 'Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia', Advances in Biological Regulation, vol. 65, pp. 16-25. https://doi.org/10.1016/j.jbior.2017.06.001
Gowda, C, Sachdev, M, Muthusami, S, Kapadia, M, Petrovic-Dovat, L, Hartman, M, Ding, Y, Song, C, Payne, JL, Tan, B & Dovat, S 2017, 'Casein kinase II (CK2) as a therapeutic target for hematological malignancies', Current Pharmaceutical Design, vol. 23, no. 1, pp. 95-107. https://doi.org/10.2174/1381612822666161006154311

2016

Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440. https://doi.org/10.1038/leu.2015.331
Gowda, C, Song, C, Ding, Y, Kapadia, M & Dovat, S 2016, 'Protein signaling and regulation of gene transcription in leukemia: Role of the Casein Kinase II-Ikaros axis', Journal of Investigative Medicine, vol. 64, no. 3, pp. 735-739. https://doi.org/10.1136/jim-2016-000075
Gowda, C, Song, C, Kapadia, M, Payne, JL, Hu, T, Ding, Y & Dovat, S 2017, 'Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros', Advances in Biological Regulation, vol. 63, pp. 71-80. https://doi.org/10.1016/j.jbior.2016.09.003
Wang, H, Song, C, Ding, Y, Pan, X, Ge, Z, Tan, B, Gowda, C, Sachdev, M, Muthusami, S, Ouyang, H, Lai, L, Francis, OL, Morris, CL, Abdel-Azim, H, Dorsam, G, Xiang, M, Payne, KJ & Dovat, S 2016, 'Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia', Journal of Biological Chemistry, vol. 291, no. 8, pp. 4004-4018. https://doi.org/10.1074/jbc.M115.679332

2015

Song, C, Gowda, C, Pan, X, Ding, Y, Tong, Y, Tan, B, Wang, H, Muthusami, S, Ge, Z, Sachdev, M, Amin, S, Desai, D, Gowda, K, Gowda, R, Robertson, G, Schjerven, H, Muschen, M, Payne, KJ & Dovat, S 2015, 'Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia', Blood, vol. 126, no. 15, pp. 1813-1822. https://doi.org/10.1182/blood-2015-06-651505

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)