Researcher Profile

Researcher Profile

Chandrika Gowda, MD

Chandrika Gowda, MD

John Wawrynovic Leukemia Research Scholar Endowment, Penn State College of Medicine
Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Pediatric Cancer
cxg40@psu.edu

Research Interests

Dr. Chandrika Gowda is a board-certified hematologist/oncologist who has strong commitment to research in childhood cancer, including leukemia and neuroblastoma. Her major research project is to study Role of Ikaros tumor suppressor and pro-oncogenic casein Kinase II(CK2) in leukemogenesis and drug resistance. Dr.Gowda's current work is focused on targeting CK2 for treatment of hematological malignancies.

Her most notable work, published in Blood in 2015, established the novel approach of using specific CK2 inhibitors for treatment of high-risk B cell lineage leukemia using PDX models. She has presented her work at various national and international scientific forums and gained national recognition as an outstanding young investigator.

Dr. Gowda's research is currently supported by several extramural grants. She has also authored several chapters and review articles related to leukemia, CK2 and Ikaros. Her other projects are focused on designing novel therapeutic strategies for treatment of high risk neuroblastoma, which is the most common abdominal solid tumor in young children, with poor prognosis.

  • Leukemia
  • Casein Kinase II
  • Therapeutics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Neoplasms
  • B-Lymphocytes
  • Genes
  • Cell Proliferation
  • Epigenomics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Phosphorylation
  • 5-(3-chlorophenylamino)benzo(c)(2,6)naphthyridine-8-carboxylic acid

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications

2021

Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Raca, G, Abdel-Azim, H, Yue, F, Broach, J, Payne, JL, Reeves, ME, Gowda, C, Schramm, J, Desai, D, Dovat, E, Hu, T, Berg, AS, Bhojwani, D, Payne, KJ & Dovat, S 2021, 'Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity', Leukemia, vol. 35, no. 8, pp. 2399-2402. https://doi.org/10.1038/s41375-021-01133-4
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21. https://doi.org/10.3390/cancers13051127
Dovat, E, Song, C, Hu, T, Rahman, MA, Dhanyamraju, PK, Klink, M, Bogush, D, Soliman, M, Kane, S, McGrath, M, Ding, Y, Desai, D, Sharma, A & Gowda, C 2021, 'Transcriptional regulation of PIK3CD and PIKFYVE in T-cell acute lymphoblastic leukemia by IKAROS and protein kinase CK2', International journal of molecular sciences, vol. 22, no. 2, 819, pp. 1-14. https://doi.org/10.3390/ijms22020819

2020

Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718. https://doi.org/10.3390/ijms21051718

2019

Gowda, C, Song, C, Ding, Y, Iyer, S, Dhanyamraju, PK, McGrath, M, Bamme, Y, Soliman, M, Kane, S, Payne, JL & Dovat, S 2020, 'Cellular signaling and epigenetic regulation of gene expression in leukemia', Advances in Biological Regulation, vol. 75, 100665. https://doi.org/10.1016/j.jbior.2019.100665
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia, vol. 33, no. 11, pp. 2720-2731. https://doi.org/10.1038/s41375-019-0474-0

2017

Gowda, C, Soliman, M, Kapadia, M, Ding, Y, Payne, K & Dovat, S 2017, 'Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia', Advances in Biological Regulation, vol. 65, pp. 16-25. https://doi.org/10.1016/j.jbior.2017.06.001
Gowda, C, Sachdev, M, Muthusami, S, Kapadia, M, Petrovic-Dovat, L, Hartman, M, Ding, Y, Song, C, Payne, JL, Tan, BH & Dovat, S 2017, 'Casein kinase II (CK2) as a therapeutic target for hematological malignancies', Current Pharmaceutical Design, vol. 23, no. 1, pp. 95-107. https://doi.org/10.2174/1381612822666161006154311

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)