Researcher Profile

Researcher Profile

Cheng Dong, PhD

Cheng Dong, PhD

Department Head and Distinguished Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics
cxd23@psu.edu

Research Interests

  • Neoplasms
  • Melanoma
  • Neutrophils
  • Cell Adhesion
  • Leukocytes
  • Neoplasm Metastasis
  • Endothelial Cells
  • Intercellular Adhesion Molecule-1
  • Integrins
  • Endothelium
  • Pseudopodia
  • Interleukin-8

Recent Publications

2019

He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191. https://doi.org/10.1016/j.actbio.2019.03.050

2018

Ye, K, Kaplan, DL, Bao, G, Bettinger, C, Forgacs, G, Dong, C, Khademhosseini, A, Ke, Y, Leong, K, Sambanis, A, Sun, W & Yin, P 2018, 'Advanced Cell and Tissue Biomanufacturing', ACS Biomaterials Science and Engineering, vol. 4, no. 7, pp. 2292-2307. https://doi.org/10.1021/acsbiomaterials.8b00650
Aragon-Sanabria, V, Kim, GB & Dong, C 2018, From cancer immunoediting to new strategies in cancer immunotherapy: The roles of immune cells and mechanics in oncology. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1092, Springer New York LLC, pp. 113-138. https://doi.org/10.1007/978-3-319-95294-9_7
Sanabria, VA & Dong, C 2018, 'Integration of biochemical and biomechanical signals regulating endothelial barrier function', MCB Molecular and Cellular Biomechanics, vol. 15, no. 1, pp. 1-19. https://doi.org/10.3970/mcb.2018.015.001
Dong, C, Zahir, N & Konstantopoulos, K 2018, 'Preface' Advances in experimental medicine and biology, vol. 1092, pp. v-vi.
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059

2017

Tang, X, Loc, WS, Dong, C, Matters, G, Butler, PJ, Kester, M, Meyers, C, Jiang, Y & Adair, JH 2017, 'The use of nanoparticulates to treat breast cancer', Nanomedicine, vol. 12, no. 19, pp. 2367-2388. https://doi.org/10.2217/nnm-2017-0202
Aragon-Sanabria, V, Pohler, SE, Eswar, VJ, Bierowski, M, Gomez, EW & Dong, C 2017, 'VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells', Scientific reports, vol. 7, 45835. https://doi.org/10.1038/srep45835

2016

Zhang, P, Feng, S, Liu, G, Wang, H, Fu, A, Zhu, H, Ren, Q, Wang, B, Xu, X, Bai, H & Dong, C 2016, 'CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation', Oncogene, vol. 35, no. 38, pp. 5056-5069. https://doi.org/10.1038/onc.2016.67
Xie, Z, Su, Y, Kim, GB, Selvi, E, Ma, C, Aragon-Sanabria, V, Hsieh, JT, Dong, C & Yang, J 2017, 'Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery', Small, vol. 13, no. 10, 1603121. https://doi.org/10.1002/smll.201603121
Zhang, P, Feng, S, Liu, G, Wang, H, Zhu, H, Ren, Q, Bai, H, Fu, C & Dong, C 2016, 'Mutant B-Raf(V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown', Journal of Biological Chemistry, vol. 291, no. 5, pp. 2087-2106. https://doi.org/10.1074/jbc.M115.696419

2015

Zhang, P, Fu, C, Hu, Y, Dong, C, Song, Y & Song, E 2015, ' C 6 -ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCĪ¶ tumor-suppressive activities and regulating integrin affinity modulation ', Scientific reports, vol. 5, 9275. https://doi.org/10.1038/srep09275
Wu, J, Cai, Y, Fu, Y, Tan, Z, Sun, R, Xu, S, Ding, Z & Dong, C 2015, '3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization' Applied Mathematics and Mechanics (English Edition), vol. 36, no. 2, pp. 153-162. https://doi.org/10.1007/s10483-015-1907-7
Li, S, Chen, N, Gaddes, ER, Zhang, X, Dong, C & Wang, Y 2015, 'A Drosera-bioinspired hydrogel for catching and killing cancer cells' Scientific reports, vol. 5, 14297. https://doi.org/10.1038/srep14297
Gaddes, ER, Gydush, G, Li, S, Chen, N, Dong, C & Wang, Y 2015, 'Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface' Biomacromolecules, vol. 16, no. 4, pp. 1382-1389. https://doi.org/10.1021/acs.biomac.5b00165
Wu, J, Tan, Z, Chen, J & Dong, C 2015, 'Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cells' Molecules, vol. 20, no. 11, pp. 20659-20668. https://doi.org/10.3390/molecules201119729
Su, Y, Xie, Z, Kim, GB, Dong, C & Yang, J 2015, 'Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems', ACS Biomaterials Science and Engineering, vol. 1, no. 4, pp. 201-217. https://doi.org/10.1021/ab500179h
Fu, Y, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'Effects of ghost red blood cells on tumor cell adhesion in shear flow' Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 30, no. 2, pp. 99-103. https://doi.org/10.3871/j.1004-7220.2015.02.099
Zhang, P, Fu, C, Bai, H, Song, E, Dong, C & Song, Y 2015, 'Erratum: CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells (FEBS Lett. (2014) 588:24 (4573-4582) doi:10.1016/j.febslet.2015.01.016))', FEBS Letters, vol. 589, no. 4. https://doi.org/10.1016/j.febslet.2015.01.016
Bai, F, Dong, C, Cao, C & Sun, R 2015, 'Investigation of cell aggregation on the substrate of a parallel-plate flow chamber' Cellular and Molecular Biology, vol. 61, no. 2, pp. 86-93. https://doi.org/10.14715/cmb/2015.61.2.15
Behr, J, Gaskin, B, Fu, C, Dong, C & Kunz, RF 2015, 'Localized modeling of biochemical and flow interactions during cancer cell adhesion', PloS one, vol. 10, no. 9, e0136926. https://doi.org/10.1371/journal.pone.0136926
Haakenson, JK, Khokhlatchev, AV, Choi, YJ, Linton, SS, Zhang, P, Zaki, PM, Fu, C, Cooper, T, Manni, A, Zhu, J, Fox, TE, Dong, C & Kester, M 2015, 'Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells' Journal of Biological Chemistry, vol. 290, no. 13, pp. 8632-8643. https://doi.org/10.1074/jbc.M114.609677
Fu, Y, Wu, JH, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'Micro-PIV measurements of the flow field around cells in flow chamber' Journal of Hydrodynamics, vol. 27, no. 4, pp. 562-568. https://doi.org/10.1016/S1001-6058(15)60517-0
Kunz, RF, Gaskin, BJ, Li, Q, Davanloo-Tajbakhsh, S & Dong, C 2015, 'Multi-scale biological and physical modelling of the tumour micro-environment' Drug Discovery Today: Disease Models, vol. 16, pp. 7-15. https://doi.org/10.1016/j.ddmod.2015.03.001
Ozdemir, T, Gaddes, E, Wang, Y & Dong, C 2015, 'Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow' Cellular and Molecular Bioengineering, vol. 8, no. 1, pp. 86-95. https://doi.org/10.1007/s12195-014-0369-0
Zhang, P, Bai, H, Fu, C, Chen, F, Zeng, P, Wu, C, Ye, Q, Dong, C, Song, Y & Song, E 2015, 'RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly' Biochemical and Biophysical Research Communications, vol. 459, no. 1, pp. 1-9. https://doi.org/10.1016/j.bbrc.2014.11.088
Gaddes, ER, Lee, D, Gydush, G, Wang, Y & Dong, C 2015, 'Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer' Experimental Cell Research, vol. 339, no. 2, pp. 417-426. https://doi.org/10.1016/j.yexcr.2015.10.010
Fu, Y, Wang, Y, Bai, F, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'The effect of concentration ratio on tumor cell adhesion in shear flow' Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 30, no. 5, pp. 392-396. https://doi.org/10.3871/j.1004-7220.2015.05.392

Clinical Trials Search


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