Researcher Profile

Researcher Profile

Cheng Dong, PhD

Cheng Dong, PhD

Department Head and Distinguished Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics

Research Interests

  • Neoplasms
  • Melanoma
  • Neutrophils
  • Cell Adhesion
  • Leukocytes
  • Neoplasm Metastasis
  • Endothelial Cells
  • Intercellular Adhesion Molecule-1
  • Integrins
  • Endothelium
  • Pseudopodia
  • Interleukin-8

Recent Publications


He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191.


Ye, K, Kaplan, DL, Bao, G, Bettinger, C, Forgacs, G, Dong, C, Khademhosseini, A, Ke, Y, Leong, K, Sambanis, A, Sun, W & Yin, P 2018, 'Advanced Cell and Tissue Biomanufacturing', ACS Biomaterials Science and Engineering, vol. 4, no. 7, pp. 2292-2307.
Aragon-Sanabria, V, Kim, GB & Dong, C 2018, From cancer immunoediting to new strategies in cancer immunotherapy: The roles of immune cells and mechanics in oncology. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1092, Springer New York LLC, pp. 113-138.
Sanabria, VA & Dong, C 2018, 'Integration of biochemical and biomechanical signals regulating endothelial barrier function', MCB Molecular and Cellular Biomechanics, vol. 15, no. 1, pp. 1-19.
Dong, C, Zahir, N & Konstantopoulos, K 2018, 'Preface' Advances in experimental medicine and biology, vol. 1092, pp. v-vi.
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516.


Tang, X, Loc, WS, Dong, C, Matters, G, Butler, PJ, Kester, M, Meyers, C, Jiang, Y & Adair, JH 2017, 'The use of nanoparticulates to treat breast cancer', Nanomedicine, vol. 12, no. 19, pp. 2367-2388.
Aragon-Sanabria, V, Pohler, SE, Eswar, VJ, Bierowski, M, Gomez, EW & Dong, C 2017, 'VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells', Scientific reports, vol. 7, 45835.


Zhang, P, Feng, S, Liu, G, Wang, H, Fu, A, Zhu, H, Ren, Q, Wang, B, Xu, X, Bai, H & Dong, C 2016, 'CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation', Oncogene, vol. 35, no. 38, pp. 5056-5069.
Xie, Z, Su, Y, Kim, GB, Selvi, E, Ma, C, Aragon-Sanabria, V, Hsieh, JT, Dong, C & Yang, J 2017, 'Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery', Small, vol. 13, no. 10, 1603121.
Zhang, P, Feng, S, Liu, G, Wang, H, Zhu, H, Ren, Q, Bai, H, Fu, C & Dong, C 2016, 'Mutant B-Raf(V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown', Journal of Biological Chemistry, vol. 291, no. 5, pp. 2087-2106.


Zhang, P, Fu, C, Hu, Y, Dong, C, Song, Y & Song, E 2015, ' C 6 -ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCĪ¶ tumor-suppressive activities and regulating integrin affinity modulation ', Scientific reports, vol. 5, 9275.
Wu, J, Cai, Y, Fu, Y, Tan, Z, Sun, R, Xu, S, Ding, Z & Dong, C 2015, '3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization' Applied Mathematics and Mechanics (English Edition), vol. 36, no. 2, pp. 153-162.
Li, S, Chen, N, Gaddes, ER, Zhang, X, Dong, C & Wang, Y 2015, 'A Drosera-bioinspired hydrogel for catching and killing cancer cells' Scientific reports, vol. 5, 14297.
Gaddes, ER, Gydush, G, Li, S, Chen, N, Dong, C & Wang, Y 2015, 'Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface' Biomacromolecules, vol. 16, no. 4, pp. 1382-1389.
Wu, J, Tan, Z, Chen, J & Dong, C 2015, 'Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cells' Molecules, vol. 20, no. 11, pp. 20659-20668.
Su, Y, Xie, Z, Kim, GB, Dong, C & Yang, J 2015, 'Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems', ACS Biomaterials Science and Engineering, vol. 1, no. 4, pp. 201-217.
Fu, Y, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'Effects of ghost red blood cells on tumor cell adhesion in shear flow' Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 30, no. 2, pp. 99-103.
Zhang, P, Fu, C, Bai, H, Song, E, Dong, C & Song, Y 2015, 'Erratum: CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells (FEBS Lett. (2014) 588:24 (4573-4582) doi:10.1016/j.febslet.2015.01.016))', FEBS Letters, vol. 589, no. 4.
Bai, F, Dong, C, Cao, C & Sun, R 2015, 'Investigation of cell aggregation on the substrate of a parallel-plate flow chamber' Cellular and Molecular Biology, vol. 61, no. 2, pp. 86-93.
Behr, J, Gaskin, B, Fu, C, Dong, C & Kunz, RF 2015, 'Localized modeling of biochemical and flow interactions during cancer cell adhesion', PloS one, vol. 10, no. 9, e0136926.
Haakenson, JK, Khokhlatchev, AV, Choi, YJ, Linton, SS, Zhang, P, Zaki, PM, Fu, C, Cooper, T, Manni, A, Zhu, J, Fox, TE, Dong, C & Kester, M 2015, 'Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells' Journal of Biological Chemistry, vol. 290, no. 13, pp. 8632-8643.
Fu, Y, Wu, JH, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'Micro-PIV measurements of the flow field around cells in flow chamber' Journal of Hydrodynamics, vol. 27, no. 4, pp. 562-568.
Kunz, RF, Gaskin, BJ, Li, Q, Davanloo-Tajbakhsh, S & Dong, C 2015, 'Multi-scale biological and physical modelling of the tumour micro-environment' Drug Discovery Today: Disease Models, vol. 16, pp. 7-15.
Ozdemir, T, Gaddes, E, Wang, Y & Dong, C 2015, 'Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow' Cellular and Molecular Bioengineering, vol. 8, no. 1, pp. 86-95.
Zhang, P, Bai, H, Fu, C, Chen, F, Zeng, P, Wu, C, Ye, Q, Dong, C, Song, Y & Song, E 2015, 'RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly' Biochemical and Biophysical Research Communications, vol. 459, no. 1, pp. 1-9.
Gaddes, ER, Lee, D, Gydush, G, Wang, Y & Dong, C 2015, 'Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer' Experimental Cell Research, vol. 339, no. 2, pp. 417-426.
Fu, Y, Wang, Y, Bai, F, Wu, J, Sun, R, Ding, ZR & Dong, C 2015, 'The effect of concentration ratio on tumor cell adhesion in shear flow' Yiyong Shengwu Lixue/Journal of Medical Biomechanics, vol. 30, no. 5, pp. 392-396.

Clinical Trials Search

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Adults (age >= 18 years)