Researcher Profile

Researcher Profile

Chunhua Song, MD, MS, PhD

Chunhua Song, MD, MS, PhD

Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
cus21@psu.edu

Research Interests

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Mutation
  • Leukemia
  • Neoplasms
  • Casein Kinase II
  • Genes
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • DNA
  • Apoptosis
  • Phosphorylation
  • Proteins
  • Cell Proliferation

Recent Publications

2019

Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia. https://doi.org/10.1038/s41375-019-0474-0
Zhang, Q, Han, Q, Zi, J, Ma, J, Song, H, Tian, Y, McGrath, M, Song, C & Ge, Z 2019, 'Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms', Genes and Diseases. https://doi.org/10.1016/j.gendis.2019.05.001
Nicolae, C, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, G-L 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540. https://doi.org/10.1038/s41388-019-0810-x

2018

Tong, Y, Zhao, Z, Liu, B, Bao, A, Zheng, H, Gu, J, McGrath, M, Xia, Y, Tan, B, Song, C & Li, Y 2018, '5′/ 3′ imbalance strategy to detect ALK fusion genes in circulating tumor RNA from patients with non-small cell lung cancer', Journal of Experimental and Clinical Cancer Research, vol. 37, no. 1, 68. https://doi.org/10.1186/s13046-018-0735-1
Ge, Z, Han, Q, Gu, Y, Ge, Q, Ma, J, Sloane, J, Gao, G, Payne, KJ, Szekely, L, Song, C & Dovat, S 2018, 'Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia', Oncogenesis, vol. 7, no. 11, 84. https://doi.org/10.1038/s41389-018-0095-x
Hu, J, Han, Q, Gu, Y, Ma, J, McGrath, M, Qiao, F, Chen, B, Song, C & Ge, Z 2018, 'Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia', Epigenomics, vol. 10, no. 6, pp. 723-732. https://doi.org/10.2217/epi-2017-0142
Gu, Y, Han, Q, McGrath, M, Song, C & Ge, Z 2018, 'Clinical significance of novel SH2B3 mutations in adult Chinese acute lymphoblastic leukemia patients', Leukemia Research, vol. 72, pp. 67-70. https://doi.org/10.1016/j.leukres.2018.07.006
Tong, YQ, Zhao, ZJ, Liu, B, Bao, AY, Zheng, HY, Gu, J, Xia, Y, McGrath, M, Dovat, S, Song, C & Li, Y 2018, 'New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time', Leukemia Research, vol. 69, pp. 47-53. https://doi.org/10.1016/j.leukres.2018.04.001
He, X, Li, X, Guo, Y, Zhao, Y, Dong, H, Dong, J, Zhong, L, Shi, Z, Zhang, Y, Soliman, M, Song, C & Zhao, Z 2018, 'Newborn screening of genetic mutations in common deafness genes with bloodspot-based gene chip array', American Journal of Audiology, vol. 27, no. 1, pp. 57-66. https://doi.org/10.1044/2017_AJA-17-0042
Ge, Z, Gu, Y, Han, Q, Sloane, J, Ge, Q, Gao, G, Ma, J, Song, H, Hu, J, Chen, B, Dovat, S & Song, C 2018, 'Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia', Epigenomics, vol. 10, no. 1, pp. 59-69. https://doi.org/10.2217/epi-2017-0092
Che, Z, Liu, F, Zhang, W, McGrath, M, Hou, D, Chen, P, Song, C & Yang, D 2018, 'Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells', American Journal of Translational Research, vol. 10, no. 5, AJTR0072335, pp. 1357-1372.

2017

Gowda, C, Sachdev, M, Muthusami, S, Kapadia, M, Petrovic-Dovat, L, Hartman, M, Ding, Y, Song, C, Payne, JL, Tan, B & Dovat, S 2017, 'Casein kinase II (CK2) as a therapeutic target for hematological malignancies', Current Pharmaceutical Design, vol. 23, no. 1, pp. 95-107. https://doi.org/10.2174/1381612822666161006154311
Zhou, X, Gu, Y, Han, Q, Soliman, M, Song, C & Ge, Z 2017, 'Erişkin T-hücre akut lenfoblastik lösemi’sinde EZH2, NOTCH1, IL7R ve PHF6 mutasyonlarının birlikteliği', Turkish Journal of Hematology, vol. 34, no. 4, pp. 366-368. https://doi.org/10.4274/tjh.2017.0194
Yoshida, N, Sakaguchi, H, Muramatsu, H, Okuno, Y, Song, C, Dovat, S, Shimada, A, Ozeki, M, Ohnishi, H, Teramoto, T, Fukao, T, Kondo, N, Takahashi, Y, Matsumoto, K, Kato, K & Kojima, S 2017, 'Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia', Leukemia, vol. 31, no. 5, pp. 1221-1223. https://doi.org/10.1038/leu.2017.25
Ge, Z, Zhou, X, Gu, Y, Han, Q, Li, J, Chen, B, Ge, Q, Dovat, E, Payne, JL, Sun, T, Song, C & Dovat, S 2017, 'Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia', Oncotarget, vol. 8, no. 5, pp. 8022-8034. https://doi.org/10.18632/oncotarget.14038

2016

Francis, OL, Milford, TAM, Martinez, SR, Baez, I, Coats, JS, Mayagoitia, K, Concepcion, KR, Ginelli, E, Beldiman, C, Benitez, A, Weldon, AJ, Arogyaswamy, K, Shiraz, P, Fisher, R, Morris, CL, Zhang, XB, Filippov, V, van Handel, B, Ge, Z, Song, C, Dovat, S, Su, RJ & Payne, KJ 2016, 'A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis', Haematologica, vol. 101, no. 4, pp. 417-426. https://doi.org/10.3324/haematol.2015.125336
Xiang, M, Su, H, Shu, G, Wan, D, He, F, Loaec, M, Ding, Y, Li, J, Dovat, S, Yang, G & Song, C 2016, 'Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer', Oncotarget, vol. 7, no. 14, pp. 18521-18530. https://doi.org/10.18632/oncotarget.7848
Ge, Z, Gu, Y, Xiao, L, Han, Q, Li, J, Chen, B, Yu, J, Imamura, Y, Payne, KJ, Dovat, S & Song, C 2016, 'Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction', Oncotarget, vol. 7, no. 29, pp. 46014-46027. https://doi.org/10.18632/oncotarget.10014
Li, M, Xiao, L, Xu, J, Zhang, R, Guo, J, Olson, J, Wu, Y, Li, J, Song, C & Ge, Z 2016, 'Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia', Oncology Letters, vol. 12, no. 1, pp. 16-22. https://doi.org/10.3892/ol.2016.4581
Tong, Y, Liu, B, Liu, H, Zheng, H, Gu, J, Liu, H, Ding, Y, Song, C & Li, Y 2016, 'Comparison of pyrosequencing and sanger sequencing for HBV DNA genotyping and resistance mutations', International Journal of Clinical and Experimental Medicine, vol. 9, no. 7, pp. 14283-14293.
Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440. https://doi.org/10.1038/leu.2015.331
Ge, Z, Gu, Y, Zhao, G, Li, J, Chen, B, Han, Q, Guo, X, Liu, J, Li, H, Yu, MD, Olson, J, Steffens, S, Payne, KJ, Song, C & Dovat, S 2016, 'High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement', Oncotarget, vol. 7, no. 31, pp. 49722-49732. https://doi.org/10.18632/oncotarget.10437
Tong, Y, Liu, B, Liu, H, Zheng, H, Gu, J, Liu, H, Lin, M, Ding, Y, Song, C & Li, Y 2016, 'New universal primers for genotyping and resistance detection of low HBV DNA levels', Medicine (United States), vol. 95, no. 33, 232. https://doi.org/10.1097/MD.0000000000004618
Ge, Z, Li, M, Zhao, G, Xiao, L, Gu, Y, Zhou, X, Yu, MD, Li, J, Dovat, S & Song, C 2016, 'Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia', Oncology Letters, vol. 12, no. 4, pp. 2746-2751. https://doi.org/10.3892/ol.2016.4993
Gowda, C, Song, C, Ding, Y, Kapadia, M & Dovat, S 2016, 'Protein signaling and regulation of gene transcription in leukemia: Role of the Casein Kinase II-Ikaros axis', Journal of Investigative Medicine, vol. 64, no. 3, pp. 735-739. https://doi.org/10.1136/jim-2016-000075
Gowda, C, Song, C, Kapadia, M, Payne, JL, Hu, T, Ding, Y & Dovat, S 2017, 'Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros', Advances in Biological Regulation, vol. 63, pp. 71-80. https://doi.org/10.1016/j.jbior.2016.09.003
Ge, Z, Gu, Y, Han, Q, Zhao, G, Li, M, Li, J, Chen, B, Sun, T, Dovat, S, Gale, RP & Song, C 2016, 'Targeting high dynamin-2 (DNM2) expression by restoring ikaros function in acute lymphoblastic leukemia', Scientific reports, vol. 6, 38004. https://doi.org/10.1038/srep38004
Wang, H, Song, C, Ding, Y, Pan, X, Ge, Z, Tan, B, Gowda, C, Sachdev, M, Muthusami, S, Ouyang, H, Lai, L, Francis, OL, Morris, CL, Abdel-Azim, H, Dorsam, G, Xiang, M, Payne, KJ & Dovat, S 2016, 'Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia', Journal of Biological Chemistry, vol. 291, no. 8, pp. 4004-4018. https://doi.org/10.1074/jbc.M115.679332
Ge, Z, Song, EJ, Imamura, Y, Li, J, Dovat, S & Song, C 2016, 'WDR5 high expression and its effect on tumorigenesis in leukemia', Oncotarget, vol. 7, no. 25, pp. 37740-37754. https://doi.org/10.18632/oncotarget.9312

2015

Tong, YQ, Liu, B, Liu, H, Zheng, HY, Gu, J, Liu, H, Song, EJ, Song, C & Li, Y 2015, 'Accurate genotyping of hepatitis C virus through nucleotide sequencing and identification of new HCV subtypes in China population', Clinical Microbiology and Infection, vol. 21, no. 9, pp. 874.e9-874.e21. https://doi.org/10.1016/j.cmi.2015.05.034
Hu, RM, Tan, B, Tester, DJ, Song, C, He, Y, Dovat, S, Peterson, B, Ackerman, MJ & Makielski, JC 2015, 'Arrhythmogenic biophysical phenotype for SCN5A mutation S1787N depends upon splice variant background and intracellular acidosis' PloS one, vol. 10, no. 4, e0124921. https://doi.org/10.1371/journal.pone.0124921
Guo, X, Zhang, R, Liu, J, Li, M, Song, C, Dovat, S, Li, J & Ge, Z 2015, 'Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia', PloS one, vol. 10, no. 5, e0125429. https://doi.org/10.1371/journal.pone.0125429
Ge, Z, Guo, X, Li, J, Hartman, M, Imamura, Y, Dovat, S & Song, C 2015, 'Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia', Oncotarget, vol. 6, no. 39, pp. 42300-42311. https://doi.org/10.18632/oncotarget.5982
Tong, YQ, Liu, B, Zheng, HY, Gu, J, Liu, H, Li, F, Tan, B, Hartman, M, Song, C & Li, Y 2015, 'MiR-215, an activator of the CTNNBIP1/ß-catenin pathway, is a marker of poor prognosis in human glioma' Oncotarget, vol. 6, no. 28, pp. 25024-25033. https://doi.org/10.18632/oncotarget.4622
Lv, B, Song, C, Wu, L, Zhang, Q, Hou, D, Chen, P, Yu, S, Wang, Z, Chu, Y, Zhang, J, Yang, D & Liu, J 2015, 'Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer' Oncotarget, vol. 6, no. 12, pp. 9794-9806. https://doi.org/10.18632/oncotarget.3400
Song, C, Gowda, C, Pan, X, Ding, Y, Tong, Y, Tan, B, Wang, H, Muthusami, S, Ge, Z, Sachdev, M, Amin, S, Desai, D, Gowda, K, Gowda, R, Robertson, G, Schjerven, H, Muschen, M, Payne, KJ & Dovat, S 2015, 'Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia', Blood, vol. 126, no. 15, pp. 1813-1822. https://doi.org/10.1182/blood-2015-06-651505

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)