Researcher Profile

Researcher Profile

Chandra Belani, MD

Chandra Belani, MD

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Thoracic Cancer
cpb14@psu.edu

Research Interests

  • Non-Small Cell Lung Carcinoma
  • Therapeutics
  • Neoplasms
  • Survival
  • Paclitaxel
  • Carboplatin
  • Drug Therapy
  • Lung Neoplasms
  • Docetaxel
  • Radiotherapy
  • Cisplatin
  • Pharmacokinetics

Clinical Trials

Oncogenic Mutations/Gene Rearrangements in Patients with Advanced Adenocarcinoma Lung
Characterization of Oncogenic Mutations in Patients with Advanced Squamous Cell Lung Cancer
Oncogenic Driver Mutations/Biomarkers in Screening Participants for Early Detection of Lung Cancer
One Time Tissue and Blood Collection from Patients with Lung Cancer at Risk for Developing Lung Cancer
Tissue and Blood Collection from Patients with Suspected Lung Cancer

Recent Publications

2021

Varlotto, JM, Sun, Z, Ky, B, Upshaw, J, Katz, SI, Fitzgerald, TJ, Wakelee, H, Diehn, M, Mankoff, DA, Lovely, C, Belani, C, Oettel, K, Masters, G, Ramalingam, S & Pennell, NA 2021, 'A Review of Immunotherapy for Stage III and Metastatic Non-Small Cell Lung Cancer and the Rationale for the ECOG-ACRIN EA5181 Study', Oncologist, vol. 26, no. 6, pp. 523-532. https://doi.org/10.1002/onco.13725

2020

Sang, M, Rice, S, Jiang, L, Liu, X, Gragnoli, C, Belani, CP & Wu, R 2020, 'A rewiring model of intratumoral interaction networks', Computational and Structural Biotechnology Journal, vol. 18, pp. 45-51. https://doi.org/10.1016/j.csbj.2019.11.009
Rice, SJ, Hyland, V, Behera, M, Ramalingam, SS, Bunn, P & Belani, CP 2020, 'Guidance on the Clinical Management of Electronic Cigarette or Vaping-Associated Lung Injury', Journal of Thoracic Oncology, vol. 15, no. 11, pp. 1727-1737. https://doi.org/10.1016/j.jtho.2020.08.012
Rice, SJ, Liu, X, Hyland, V, Liu, Z & Belani, CP 2020, 'Mutations in genes connected with the TCF7L2 transcription factor are associated with a poor prognosis in non-small cell lung cancer', Lung Cancer, vol. 141, pp. 97-100. https://doi.org/10.1016/j.lungcan.2020.01.015
C14018 study investigators 2020, 'Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses', Journal of Thoracic Oncology, vol. 15, no. 2, pp. 274-287. https://doi.org/10.1016/j.jtho.2019.10.013
Smeltzer, MP, Wynes, MW, Lantuejoul, S, Soo, R, Ramalingam, SS, Varella-Garcia, M, Meadows Taylor, M, Richeimer, K, Wood, K, Howell, KE, Dalurzo, ML, Felip, E, Hollenbeck, G, Kerr, K, Kim, ES, Mathias, C, Pacheco, J, Postmus, P, Powell, C, Tsuboi, M, Wistuba, II, Wakelee, HA, Belani, CP, Scagliotti, GV & Hirsch, FR 2020, 'The International Association for the Study of Lung Cancer Global Survey on Molecular Testing in Lung Cancer', Journal of Thoracic Oncology, vol. 15, no. 9, pp. 1434-1448. https://doi.org/10.1016/j.jtho.2020.05.002
Dingemans, AMC, Soo, RA, Jazieh, AR, Rice, SJ, Kim, YT, Teo, LLS, Warren, GW, Xiao, SY, Smit, EF, Aerts, JG, Yoon, SH, Veronesi, G, De Cobelli, F, Ramalingam, SS, Garassino, MC, Wynes, MW, Behera, M, Haanen, J, Lu, S, Peters, S, Ahn, MJ, Scagliotti, GV, Adjei, AA & Belani, CP 2020, 'Treatment Guidance for Patients With Lung Cancer During the Coronavirus 2019 Pandemic', Journal of Thoracic Oncology, vol. 15, no. 7, pp. 1119-1136. https://doi.org/10.1016/j.jtho.2020.05.001
Behera, M, Steuer, CE, Liu, Y, Fernandez, F, Fu, C, Higgins, KA, Gillespie, TW, Pakkala, S, Pillai, RN, Force, S, Belani, CP, Khuri, FR, Curran, WJ & Ramalingam, SS 2020, 'Trimodality Therapy in the Treatment of Stage III N2-Positive Non-Small Cell Lung Cancer: A National Cancer Database Analysis', Oncologist, vol. 25, no. 6, pp. e964-e975. https://doi.org/10.1634/theoncologist.2019-0661

2019

Takebe, N, Beumer, JH, Kummar, S, Kiesel, BF, Dowlati, A, O'Sullivan Coyne, G, Piekarz, R, Rubinstein, L, Fogli, LK, Vaishampayan, U, Goel, S, O'Bryant, CL, El-Rayes, BF, Chung, V, Lenz, HJ, Kim, R, Belani, CP, Tuscano, JM, Schelman, W, Moore, N, Doroshow, JH & Chen, AP 2019, 'A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction', British Journal of Clinical Pharmacology, vol. 85, no. 11, pp. 2499-2511. https://doi.org/10.1111/bcp.14054
Rice, SJ, Liu, X, Zhang, J & Belani, CP 2019, 'Absolute Quantification of All Identified Plasma Proteins from SWATH Data for Biomarker Discovery', Proteomics, vol. 19, no. 3, 1800135. https://doi.org/10.1002/pmic.201800135
Rice, SJ, Liu, X, Zhang, J, Jia, B, Zheng, H & Belani, CP 2019, 'Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling', Lung Cancer, vol. 131, pp. 58-61. https://doi.org/10.1016/j.lungcan.2019.03.014
Rice, SJ, Liu, X, Wang, HG & Belani, CP 2019, 'EGFR mutations and AKT phosphorylation are markers for sensitivity to combined MCL-1 and BCL-2/xL inhibition in non-small cell lung cancer', PloS one, vol. 14, no. 5, e0217657. https://doi.org/10.1371/journal.pone.0217657
Videtic, GM, Paulus, R, Singh, AK, Chang, JY, Parker, W, Olivier, KR, Timmerman, RD, Komaki, RR, Urbanic, JJ, Stephans, KL, Yom, SS, Robinson, CG, Belani, CP, Iyengar, P, Ajlouni, MI, Gopaul, DD, Gomez Suescun, JB, McGarry, RC, Choy, H & Bradley, JD 2019, 'Long-term Follow-up on NRG Oncology RTOG 0915 (NCCTG N0927): A Randomized Phase 2 Study Comparing 2 Stereotactic Body Radiation Therapy Schedules for Medically Inoperable Patients With Stage I Peripheral Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 103, no. 5, pp. 1077-1084. https://doi.org/10.1016/j.ijrobp.2018.11.051
Yin, R, Rice, SJ, Wang, J, Gao, L, Tsai, J, Anvari, RT, Zhou, F, Liu, X, Wang, G, Tang, Y, Jr, MCM, Belani, CP, Chen, DB, Nelson, JS & Tan, W 2019, 'Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels', Histology and histopathology, vol. 34, no. 5, pp. 479-490. https://doi.org/10.14670/HH-18-051
Ramalingam, SS, Dahlberg, SE, Belani, CP, Saltzman, JN, Pennell, NA, Nambudiri, GS, McCann, JC, Winegarden, JD, Kassem, MA, Mohamed, MK, Rothman, JM, Lyss, AP, Horn, L, Stinchcombe, TE & Schiller, JH 2019, 'Pemetrexed, bevacizumab, or the combination as maintenance therapy for advanced nonsquamous non–small-cell lung cancer: ECOG-ACRIN 5508', Journal of Clinical Oncology, vol. 37, no. 26, pp. 2360-2367. https://doi.org/10.1200/JCO.19.01006
Appleman, LJ, Beumer, JH, Jiang, Y, Lin, Y, Ding, F, Puhalla, S, Swartz, L, Owonikoko, TK, Donald Harvey, R, Stoller, R, Petro, DP, Tawbi, HA, Argiris, A, Strychor, S, Pouquet, M, Kiesel, B, Chen, AP, Gandara, D, Belani, CP, Chu, E & Ramalingam, SS 2019, 'Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies', Cancer Chemotherapy and Pharmacology, vol. 84, no. 6, pp. 1289-1301. https://doi.org/10.1007/s00280-019-03960-w
Reckamp, KL, Frankel, PH, Ruel, N, Mack, PC, Gitlitz, BJ, Li, T, Koczywas, M, Gadgeel, SM, Cristea, MC, Belani, CP, Newman, EM, Gandara, DR & Lara, PN 2019, 'Phase II trial of cabozantinib plus erlotinib in patients with advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer with progressive disease on epidermal growth factor receptor tyrosine kinase inhibitor therapy: A California cancer consortium phase II trial (NCI 9303)', Frontiers in Oncology, vol. 9, no. MAR, 132. https://doi.org/10.3389/fonc.2019.00132
CASSINI Investigators 2019, 'Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer', New England Journal of Medicine, vol. 380, no. 8, pp. 720-728. https://doi.org/10.1056/NEJMoa1814630
Tian, S, Zhang, X, Jiang, R, Pillai, RN, Owonikoko, TK, Steuer, CE, Saba, NF, Pakkala, S, Patel, PR, Belani, CP, Khuri, FR, Curran, WJ, Ramalingam, SS, Behera, M & Higgins, KA 2019, 'Survival Outcomes With Thoracic Radiotherapy in Extensive-Stage Small-Cell Lung Cancer: A Propensity Score-Matched Analysis of the National Cancer Database', Clinical Lung Cancer, vol. 20, no. 6, pp. 484-493.e6. https://doi.org/10.1016/j.cllc.2019.06.014

2018

Liu, SV, Groshen, SG, Kelly, K, Reckamp, KL, Belani, C, Synold, TW, Goldkorn, A, Gitlitz, BJ, Cristea, MC, Gong, IY, Semrad, TJ, Xu, Y, Xu, T, Koczywas, M, Gandara, DR & Newman, EM 2018, 'A phase I trial of topotecan plus tivantinib in patients with advanced solid tumors', Cancer Chemotherapy and Pharmacology, vol. 82, no. 4, pp. 723-732. https://doi.org/10.1007/s00280-018-3672-y
Zhang, L, Belani, C, Zhang, PH, Wang, X, Yang, L, Orlando, M & Wu, YL 2018, 'Dynamic change of fatigue of pemetrexed maintenance treatment in the JMEN trial', Lung Cancer, vol. 115, pp. 121-126. https://doi.org/10.1016/j.lungcan.2017.11.026
Varlotto, JM, Voland, R, McKie, K, Flickinger, JC, DeCamp, MM, Maddox, D, Rava, P, Fitzgerald, TJ, Graeber, G, Rassaei, N, Oliveira, P, Ali, S, Belani, C, Glanzman, J, Wakelee, HA, Patel, M, Baima, J, Zhang, J & Walsh, W 2018, 'Population-based differences in the outcome and presentation of lung cancer patients based upon racial, histologic, and economic factors in all lung patients and those with metastatic disease', Cancer medicine, vol. 7, no. 4, pp. 1211-1220. https://doi.org/10.1002/cam4.1430

2017

Belani, CP, Chakraborty, BC, Modi, RI & Khamar, B 2017, 'A randomized trial of TLR-2 agonist CADI-05 targeting desmocollin-3 for advanced non-small-cell lung cancer', Annals of Oncology, vol. 28, no. 2, pp. 298-304. https://doi.org/10.1093/annonc/mdw608
Steuer, CE, Behera, M, Ernani, V, Higgins, KA, Saba, NF, Shin, DM, Pakkala, S, Pillai, RN, Owonikoko, TK, Curran, WJ, Belani, CP, Khuri, FR & Ramalingam, SS 2017, 'Comparison of concurrent use of thoracic radiation with either carboplatin-paclitaxel or cisplatin-etoposide for patients with stage III non–small-cell lung cancer: A systematic review', JAMA Oncology, vol. 3, no. 8, pp. 1120-1129. https://doi.org/10.1001/jamaoncol.2016.4280
Pillai, RN, Behera, M, Owonikoko, TK, Kamphorst, AO, Pakkala, S, Belani, CP, Khuri, FR, Ahmed, R & Ramalingam, SS 2018, 'Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non–small cell lung cancer: A systematic analysis of the literature', Cancer, vol. 124, no. 2, pp. 271-277. https://doi.org/10.1002/cncr.31043
Higgins, KA, O'Connell, K, Liu, Y, Gillespie, TW, McDonald, MW, Pillai, RN, Patel, KR, Patel, PR, Robinson, CG, Simone, CB, Owonikoko, TK, Belani, CP, Khuri, FR, Curran, WJ, Ramalingam, SS & Behera, M 2017, 'National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 97, no. 1, pp. 128-137. https://doi.org/10.1016/j.ijrobp.2016.10.001
Stoller, R, Schmitz, JC, Ding, F, Puhalla, S, Belani, CP, Appleman, L, Lin, Y, Jiang, Y, Almokadem, S, Petro, D, Holleran, J, Kiesel, BF, Ken Czambel, R, Carneiro, BA, Kontopodis, E, Hershberger, PA, Rachid, M, Chen, A, Chu, E & Beumer, JH 2017, 'Phase I study of veliparib in combination with gemcitabine', Cancer Chemotherapy and Pharmacology, vol. 80, no. 3, pp. 631-643. https://doi.org/10.1007/s00280-017-3409-3
Liegey Dougall, A, Swanson, J, Kyutoku, Y, Belani, CP & Baum, A 2017, 'Posttraumatic Symptoms, Quality of Life, and Survival among Lung Cancer Patients', Journal of Applied Biobehavioral Research, vol. 22, no. 3, e12065. https://doi.org/10.1111/jabr.12065
Wan, Y, Cheng, G, Liu, X, Hao, SJ, Nisic, M, Zhu, CD, Xia, YQ, Li, WQ, Wang, ZG, Zhang, WL, Rice, SJ, Sebastian, A, Albert, I, Belani, CP & Zheng, SY 2017, 'Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes', Nature Biomedical Engineering, vol. 1, no. 4, 0058. https://doi.org/10.1038/s41551-017-0058
Khorana, AA, Vadhan-Raj, S, Kuderer, NM, Wun, T, Liebman, H, Soff, G, Belani, C, O'Reilly, EM, McBane, R, Eikelboom, J, Damaraju, CV, Beyers, K, Dietrich, F, Kakkar, AK, Riess, H, Peixoto, RDA & Lyman, GH 2017, 'Rivaroxaban for preventing venous thromboembolism in high-risk ambulatory patients with cancer: Rationale and design of the CASSINI trial', Thrombosis and Haemostasis, vol. 117, no. 11, pp. 2135-2145. https://doi.org/10.1160/TH17-03-0171

Clinical Trials Search


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Adults (age >= 18 years)