Researcher Profile

Researcher Profile

Chandra Belani, MD

Chandra Belani, MD

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Thoracic Cancer
cpb14@psu.edu

Research Interests

  • Non-Small Cell Lung Carcinoma
  • Therapeutics
  • Lung Neoplasms
  • Neoplasms
  • Carboplatin
  • Paclitaxel
  • Drug Therapy
  • Survival
  • Cisplatin
  • docetaxel
  • Radiotherapy
  • Pharmacokinetics

Clinical Trials

Oncogenic Mutations/Gene Rearrangements in Patients with Advanced Adenocarcinoma Lung
Characterization of Oncogenic Mutations in Patients with Advanced Squamous Cell Lung Cancer
Oncogenic Driver Mutations/Biomarkers in Screening Participants for Early Detection of Lung Cancer
One Time Tissue and Blood Collection from Patients with Lung Cancer at Risk for Developing Lung Cancer
Observational Study to Determine the Differences in Molecular Characterization between Smokers vs. Non-smokers in Patients with Stage IV Bladder Cancer and their Correlation with Clinical Outcome
Tissue and Blood Collection from Patients with Suspected Lung Cancer

Recent Publications

2019

Takebe, N, Beumer, JH, Kummar, S, Kiesel, BF, Dowlati, A, O'Sullivan Coyne, G, Piekarz, R, Rubinstein, L, Fogli, LK, Vaishampayan, U, Goel, S, O'Bryant, CL, El-Rayes, BF, Chung, V, Lenz, HJ, Kim, R, Belani, C, Tuscano, JM, Schelman, W, Moore, N, Doroshow, JH & Chen, AP 2019, 'A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction', British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.14054
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Rice, SJ, Liu, X, Zhang, J, Jia, B, Zheng, H & Belani, C 2019, 'Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling', Lung Cancer, vol. 131, pp. 58-61. https://doi.org/10.1016/j.lungcan.2019.03.014
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Ramalingam, SS, Dahlberg, SE, Belani, C, Saltzman, JN, Pennell, NA, Nambudiri, GS, McCann, JC, Winegarden, JD, Kassem, MA, Mohamed, MK, Rothman, JM, Lyss, AP, Horn, L, Stinchcombe, TE & Schiller, JH 2019, 'Pemetrexed, bevacizumab, or the combination as maintenance therapy for advanced nonsquamous non–small-cell lung cancer: ECOG-ACRIN 5508', Journal of Clinical Oncology, vol. 37, no. 26, pp. 2360-2367. https://doi.org/10.1200/JCO.19.01006
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Tian, S, Zhang, X, Jiang, R, Pillai, RN, Owonikoko, TK, Steuer, CE, Saba, NF, Pakkala, S, Patel, PR, Belani, C, Khuri, FR, Curran, WJ, Ramalingam, SS, Behera, M & Higgins, KA 2019, 'Survival Outcomes With Thoracic Radiotherapy in Extensive-Stage Small-Cell Lung Cancer: A Propensity Score-Matched Analysis of the National Cancer Database', Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2019.06.014

2018

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Zhang, L, Belani, C, Zhang, PH, Wang, X, Yang, L, Orlando, M & Wu, YL 2018, 'Dynamic change of fatigue of pemetrexed maintenance treatment in the JMEN trial' Lung Cancer, vol. 115, pp. 121-126. https://doi.org/10.1016/j.lungcan.2017.11.026
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2017

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2016

Liu, X, Rice, SJ, Jamis-Dow, CA, Abendroth, C, Ali, S, Almokadem, S & Belani, C 2016, 'A patient with complex multiple genomic alk alterations', Thorax, vol. 71, no. 4, pp. 383-385. https://doi.org/10.1136/thoraxjnl-2015-207950
Aronson, KR, Wagstaff, DA, Farace, E, Muscat, J, Belani, C, Almokadem, S & Fossum, T 2016, 'A week in the life of lung cancer survivors: Daily reports of stress, worry, mood, and symptoms', Journal of Health Psychology, vol. 21, no. 10, pp. 2269-2282. https://doi.org/10.1177/1359105315574921
Liu, X & Belani, C 2016, 'Clinical advances in immuno-oncology-progress towards selective cure', Current Molecular Pharmacology, vol. 9, no. 3.
Rice, SJ, Miller, B, Wagman, M, Jamorabo, DS, Liu, X & Belani, C 2016, 'Clinical approaches to immunotherapy in non-small cell lung cancer: Current and future perspectives', Current Molecular Pharmacology, vol. 9, no. 3, pp. 183-195. https://doi.org/10.2174/1874467208666150716120108
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Ardizzoni, A, Tiseo, M, Boni, L, Di Maio, M, Buffoni, L, Belvedere, O, Grossi, F, D'Alessandro, V, de Marinis, F, Barbera, S, Caroti, C, Favaretto, A, Cortinovis, D, Morrica, B, Tixi, L, Ceschia, T, Parisi, S, Ricardi, U, Grimaldi, A, Loreggian, L, Navarria, P, Huber, RM, Belani, C, Bruswig, PF, Scagliotti, GV & Scolaro, T 2016, 'Randomized phase III PITCAP trial and meta-analysis of induction chemotherapy followed by thoracic irradiation with or without concurrent taxane-based chemotherapy in locally advanced NSCLC', Lung Cancer, vol. 100, pp. 30-37. https://doi.org/10.1016/j.lungcan.2016.07.026
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2015

Owonikoko, TK, Dahlberg, SE, Khan, SA, Gerber, DE, Dowell, J, Moss, RA, Belani, C, Hann, CL, Aggarwal, C & Ramalingam, SS 2015, 'A phase 1 safety study of veliparib combined with cisplatin and etoposide in extensive stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E2511)', Lung Cancer, vol. 89, no. 1, pp. 66-70. https://doi.org/10.1016/j.lungcan.2015.04.015
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Joshi, M, Rizvi, SM & Belani, C 2015, 'Afatinib for the treatment of metastatic non-small cell lung cancer', Cancer Management and Research, vol. 7, pp. 75-82. https://doi.org/10.2147/CMAR.S51808
Behera, M, Pillai, RN, Owonikoko, TK, Kim, S, Steuer, C, Chen, Z, Saba, NF, Belani, C, Khuri, FR & Ramalingam, SS 2015, 'Bevacizumab in combination with taxane versus non-taxane containing regimens for advanced/metastatic nonsquamous non-small-cell lung cancer a systematic review', Journal of Thoracic Oncology, vol. 10, no. 8, pp. 1142-1147. https://doi.org/10.1097/JTO.0000000000000572
Jamorabo, DS, Belani, C & Martin, EW 2015, 'Complex chronic conditions in Rhode Island's pediatric populace: Implications for palliative and hospice services, 2000-2012' Journal of palliative medicine, vol. 18, no. 4, pp. 350-357. https://doi.org/10.1089/jpm.2014.0226
Xiang, D, Yuan, Y, Chen, L, Liu, X, Belani, C & Cheng, H 2015, 'Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes', Biochemical and Biophysical Research Communications, vol. 464, no. 1, pp. 221-228. https://doi.org/10.1016/j.bbrc.2015.06.120
Varlotto, JM, Yao, AN, Decamp, MM, Ramakrishna, S, Recht, A, Flickinger, J, Andrei, A, Reed, MF, Toth, J, Fizgerald, TJ, Higgins, K, Zheng, X, Shelkey, J, Medford-Davis, LN, Belani, C & Kelsey, CR 2015, 'Nodal stage of surgically resected non-small cell lung cancer and its effect on recurrence patterns and overall survival', International Journal of Radiation Oncology Biology Physics, vol. 91, no. 4, pp. 765-773. https://doi.org/10.1016/j.ijrobp.2014.12.028
Rice, SJ, Liu, X, Miller, B, Joshi, M, Zhu, J, Caruso, C, Gilbert, C, Toth, J, Reed, MF, Rassaei, N, Das, A, Barochia, A, El-Bayoumy, K & Belani, C 2015, 'Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung' Proteomics, vol. 15, no. 18, pp. 3267-3277. https://doi.org/10.1002/pmic.201500029
Das, A, Bortner, JD, Aliaga, C, Cooper, T, Stanley, A, Stanley, B, Belani, C & El-Bayoumy, K 2015, 'Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection', EuPA Open Proteomics, vol. 9, pp. 23-33. https://doi.org/10.1016/j.euprot.2015.07.015
Ramalingam, SS, Shtivelband, M, Soo, RA, Barrios, CH, Makhson, A, Segalla, JGM, Pittman, KB, Kolman, P, Pereira, JR, Srkalovic, G, Belani, C, Axelrod, R, Owonikoko, TK, Qin, Q, Qian, J, McKeegan, EM, Devanarayan, V, McKee, MD, Ricker, JL, Carlson, DM & Gorbunova, VA 2015, 'Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer', Journal of Clinical Oncology, vol. 33, no. 5, pp. 433-442. https://doi.org/10.1200/JCO.2014.55.7173
Niu, G, Zhang, H, Liu, D, Chen, L, Belani, C, Wang, H-G & Cheng, H 2015, 'Tid1, the mammalian homologue of Drosophila tumor suppressor Tid56, mediates macroautophagy by interacting with beclin1-containing autophagy protein complex', Journal of Biological Chemistry, vol. 290, no. 29, pp. 18102-18110. https://doi.org/10.1074/jbc.M115.665950
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Clinical Trials Search


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Adults (age >= 18 years)