Craig Meyers, MS, PhD
Distinguished Professor, Department of Microbiology and Immunology
Distinguished Professor, Department of Obstetrics and Gynecology
Distinguished Professor, Department of Obstetrics and Gynecology
Scientific Program:Mechanisms of Carcinogenesis
Presently, the central research goals of Dr. Craig Meyers' laboratory are to study the differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis. Studies in the Meyers lab follow five general research themes:
- Investigation of the molecular biology and genetics of HPV morphogenesis and structure in native virus replicated under natural physiological differentiation conditions of the host tissue. The majority of the laboratories studying HPV morphogenesis and structure utilize synthetic particles such as virus-like particles (VLPs) or pseudoviral particles (PsV). The Meyers lab's studies have shown that the morphogenesis, maturation, and structure of native HPV differs in many significant characteristic from VLPs or PsV particles.
- Developing an understanding of ethnic differences in HPV types and variants using a whole-genome analysis, including infection prevalence and carcinogenicity.
- Investigating the epigenetic mechanisms of HPV-associated oral disease. This will be done by measuring genome-wide epigenetic changes occurring at different stages of the HPV16 life cycle, carcinogenic progression, and in response to ART treatment. Determining the interaction of highly active anti-retroviral drugs on oral tissues, HPV and HPV’s infection of oral tissue.
- Comparative analysis of HPV infection, life cycle and oncogenesis at different anatomical sites, including the cervix, foreskin, tonsil and anal canal.
- In addition to HPV, Dr. Meyers is also interested in studying the life cycle of other epitheliotropic infectious agents, such as the Herpes virus family, in three-dimensional human epithelial tissue.
- Human papillomavirus 16
- Life Cycle Stages
- Uterine Cervical Neoplasms
Meyers, C, Kass, R, Goldenberg, D, Milici, J, Alam, S & Robison, R 2021, 'Ethanol and isopropanol inactivation of human coronavirus on hard surfaces', Journal of Hospital Infection, vol. 107, pp. 45-49. https://doi.org/10.1016/j.jhin.2020.09.026
Carvalho, J, Lopes-Nunes, J, Campello, MPC, Paulo, A, Milici, J, Meyers, C, Mergny, JL, Salgado, GF, Queiroz, JA & Cruz, C 2021, 'Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets', Nucleic Acid Therapeutics, vol. 31, no. 1, pp. 68-81. https://doi.org/10.1089/nat.2020.0869
Liu, H, Xu, J, Yang, Y, Wang, X, Wu, E, Majerciak, V, Zhang, T, Steenbergen, RDM, Wang, HK, Banerjee, NS, Li, Y, Lu, W, Meyers, C, Zhu, J, Xie, X, Chow, LT & Zheng, ZM 2021, 'Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 3, e2014195118. https://doi.org/10.1073/PNAS.2014195118
Babaev, M, Khusnutdinova, E, Lobov, A, Galimova, Z, Petrova, A, Rybalova, T, Nguyen, HTT, Meyers, C, Prichard, M & Kazakova, O 2020, 'Allobetulone rearrangement to l8αH,19βH-ursane triterpenoids with antiviral activity', Natural Product Research. https://doi.org/10.1080/14786419.2020.1855159
Alam, S, Chatterjee, S, Kang, SD, Milici, J, Biryukov, J, Chen, H & Meyers, C 2020, 'Anti-retroviral protease inhibitors regulate human papillomavirus 16 infection of primary oral and cervical epithelium', Cancers, vol. 12, no. 9, 2664, pp. 1-34. https://doi.org/10.3390/cancers12092664
Meyers, C, Robison, R, Milici, J, Alam, S, Quillen, D, Goldenberg, D & Kass, R 2021, 'Lowering the transmission and spread of human coronavirus', Journal of Medical Virology, vol. 93, no. 3, pp. 1605-1612. https://doi.org/10.1002/jmv.26514
Meyers, C, Robison, R, Milici, J, Alam, S, Quillen, D, Goldenberg, D & Kass, R 2021, 'Rebuttal to overinterpretation of the antiviral results for human coronavirus 229E relative to severe acute respiratory syndrome coronavirus-2 by Rowpar Pharmaceuticals', Journal of Medical Virology, vol. 93, no. 4, pp. 1903-1904. https://doi.org/10.1002/jmv.26762
Meyers, C, Milici, J & Robison, R 2020, 'The ability of two chlorine dioxide chemistries to inactivate human papillomavirus-contaminated endocavitary ultrasound probes and nasendoscopes', Journal of Medical Virology, vol. 92, no. 8, pp. 1298-1302. https://doi.org/10.1002/jmv.25666
Xu, J, Liu, H, Yang, Y, Wang, X, Liu, P, Li, Y, Meyers, C, Banerjee, NS, Wang, HK, Cam, M, Lu, W, Chow, LT, Xie, X, Zhu, J & Zheng, ZM 2019, 'Genome-wide profiling of cervical rna-binding proteins identifies human papillomavirus regulation of rnaseh2a expression by viral e7 and e2f1', mBio, vol. 10, no. 1, e02687-18. https://doi.org/10.1128/mBio.02687-18
Khusnutdinova, EF, Kazakova, OB, Lobov, AN, Kukovinets, OS, Suponitsky, KY, Meyers, CB & Prichard, MN 2019, 'Synthesis of A-ring quinolones, nine-membered oxolactams and spiroindoles by oxidative transformations of 2,3-indolotriterpenoids', Organic and Biomolecular Chemistry, vol. 17, no. 3, pp. 585-597. https://doi.org/10.1039/c8ob02624f
Chatterjee, S, Kang, SD, Alam, S, Salzberg, AC, Milici, J, Van Der Burg, SH, Freeman, W & Meyers, C 2019, 'Tissue-specific gene expression during productive human papillomavirus 16 infection of cervical, foreskin, and tonsil epithelium', Journal of virology, vol. 93, no. 17, e00915-19. https://doi.org/10.1128/JVI.00915-19
Kang, SD, Chatterjee, S, Alam, S, Salzberg, AC, Milici, J, Van Der Burg, SH & Meyers, C 2018, 'Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium', Journal of virology, vol. 92, no. 20, e01261. https://doi.org/10.1128/JVI.01261-18
Israr, M, Rosenthal, D, Frejo-Navarro, L, Devoti, J, Meyers, C & Bonagura, VR 2018, 'Microarray analysis of human keratinocytes from different anatomic sites reveals site-specific immune signaling and responses to human papillomavirus type 16 transfection', Molecular Medicine, vol. 24, no. 1, 23. https://doi.org/10.1186/s10020-018-0022-9
Bywaters, SM, Brendle, SA, Biryukov, J, Wang, JW, Walston, J, Milici, J, Roden, RB, Meyers, C & Christensen, ND 2018, 'Production and characterization of a novel HPV anti-L2 monoclonal antibody panel', Virology, vol. 524, pp. 106-113. https://doi.org/10.1016/j.virol.2018.08.017
Biryukov, J & Meyers, C 2018, 'Superinfection exclusion between two highrisk human papillomavirus types during a coinfection', Journal of virology, vol. 92, no. 8, e01993-17. https://doi.org/10.1128/JVI.01993-17
Chiang, C, Pauli, EK, Biryukov, J, Feister, KF, Meng, M, White, EA, Münger, K, Howley, PM, Meyers, C & Gack, MU 2018, 'The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling', Journal of virology, vol. 92, no. 6, e01737-17. https://doi.org/10.1128/JVI.01737-17
Bywaters, SM, Brendle, SA, Tossi, KP, Biryukov, J, Meyers, C & Christensen, ND 2017, 'Antibody competition reveals surface location of HPV L2 minor capsid protein residues 17–36', Viruses, vol. 9, no. 11, 336. https://doi.org/10.3390/v9110336
Temple, RM, Meyers, C & Sample, CE 2017, Generation and infection of organotypic cultures with Epstein-Barr virus. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1532, Humana Press Inc., pp. 65-78. https://doi.org/10.1007/978-1-4939-6655-4_4
Biryukov, J, Myers, JC, McLaughlin-Drubin, ME, Griffin, HM, Milici, J, Doorbar, J & Meyers, C 2017, 'Mutations in HPV18 E1ˆE4 impact virus capsid assembly, infectivity competence, and maturation', Viruses, vol. 9, no. 12, 385. https://doi.org/10.3390/v9120385
Tang, X, Loc, WS, Dong, C, Matters, GL, Butler, PJ, Kester, M, Meyers, C, Jiang, Y & Adair, JH 2017, 'The use of nanoparticulates to treat breast cancer', Nanomedicine, vol. 12, no. 19, pp. 2367-2388. https://doi.org/10.2217/nnm-2017-0202
Meyers, C, Milici, J & Robison, R 2017, 'UVC radiation as an effective disinfectant method to inactivate human papillomaviruses', PloS one, vol. 12, no. 10, e0187377. https://doi.org/10.1371/journal.pone.0187377
Wang, X, Liu, H, Ge, H, Ajiro, M, Sharma, NR, Meyers, C, Morozov, P, Tuschl, T, Klar, A, Court, D & Zhenga, ZM 2017, 'Viral DNA replication orientation and hnrnps regulate transcription of the human papillomavirus 18 late promoter', mBio, vol. 8, no. 3, e00713-17. https://doi.org/10.1128/mBio.00713-17