Researcher Profile

Researcher Profile

Craig Meyers, MS, PhD

Craig Meyers, MS, PhD

Distinguished Professor, Department of Microbiology and Immunology
Distinguished Professor, Department of Obstetrics and Gynecology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Presently, the central research goals of Dr. Craig Meyers' laboratory are to study the differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis. Studies in the Meyers lab follow five general research themes:

  • Investigation of the molecular biology and genetics of HPV morphogenesis and structure in native virus replicated under natural physiological differentiation conditions of the host tissue. The majority of the laboratories studying HPV morphogenesis and structure utilize synthetic particles such as virus-like particles (VLPs) or pseudoviral particles (PsV). The Meyers lab's studies have shown that the morphogenesis, maturation, and structure of native HPV differs in many significant characteristic from VLPs or PsV particles. 
  • Developing an understanding of ethnic differences in HPV types and variants using a whole-genome analysis, including infection prevalence and carcinogenicity. 
  • Investigating the epigenetic mechanisms of HPV-associated oral disease. This will be done by measuring genome-wide epigenetic changes occurring at different stages of the HPV16 life cycle, carcinogenic progression, and in response to ART treatment. Determining the interaction of highly active anti-retroviral drugs on oral tissues, HPV and HPV’s infection of oral tissue. 
  • Comparative analysis of HPV infection, life cycle and oncogenesis at different anatomical sites, including the cervix, foreskin, tonsil and anal canal. 
  • In addition to HPV, Dr. Meyers is also interested in studying the life cycle of other epitheliotropic infectious agents, such as the Herpes virus family, in three-dimensional human epithelial tissue.
  • Keratinocytes
  • Virion
  • Epithelium
  • Human papillomavirus 16
  • Life Cycle Stages
  • Viruses
  • Infections
  • Uterine Cervical Neoplasms
  • Neoplasms
  • DNA
  • Growth
  • Genes

Recent Publications


Meyers, C, Kass, R, Goldenberg, D, Milici, J, Alam, S & Robison, R 2021, 'Ethanol and isopropanol inactivation of human coronavirus on hard surfaces', Journal of Hospital Infection, vol. 107, pp. 45-49.
Carvalho, J, Lopes-Nunes, J, Campello, MPC, Paulo, A, Milici, J, Meyers, C, Mergny, JL, Salgado, GF, Queiroz, JA & Cruz, C 2021, 'Human Papillomavirus G-Rich Regions as Potential Antiviral Drug Targets', Nucleic Acid Therapeutics, vol. 31, no. 1, pp. 68-81.
Liu, H, Xu, J, Yang, Y, Wang, X, Wu, E, Majerciak, V, Zhang, T, Steenbergen, RDM, Wang, HK, Banerjee, NS, Li, Y, Lu, W, Meyers, C, Zhu, J, Xie, X, Chow, LT & Zheng, ZM 2021, 'Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 3, e2014195118.


Babaev, M, Khusnutdinova, E, Lobov, A, Galimova, Z, Petrova, A, Rybalova, T, Nguyen, HTT, Meyers, C, Prichard, M & Kazakova, O 2020, 'Allobetulone rearrangement to l8αH,19βH-ursane triterpenoids with antiviral activity', Natural Product Research.
Alam, S, Chatterjee, S, Kang, SD, Milici, J, Biryukov, J, Chen, H & Meyers, C 2020, 'Anti-retroviral protease inhibitors regulate human papillomavirus 16 infection of primary oral and cervical epithelium', Cancers, vol. 12, no. 9, 2664, pp. 1-34.
Meyers, C, Robison, R, Milici, J, Alam, S, Quillen, D, Goldenberg, D & Kass, R 2021, 'Lowering the transmission and spread of human coronavirus', Journal of Medical Virology, vol. 93, no. 3, pp. 1605-1612.
Meyers, C, Robison, R, Milici, J, Alam, S, Quillen, D, Goldenberg, D & Kass, R 2021, 'Rebuttal to overinterpretation of the antiviral results for human coronavirus 229E relative to severe acute respiratory syndrome coronavirus-2 by Rowpar Pharmaceuticals', Journal of Medical Virology, vol. 93, no. 4, pp. 1903-1904.
Meyers, C, Milici, J & Robison, R 2020, 'The ability of two chlorine dioxide chemistries to inactivate human papillomavirus-contaminated endocavitary ultrasound probes and nasendoscopes', Journal of Medical Virology, vol. 92, no. 8, pp. 1298-1302.


Xu, J, Liu, H, Yang, Y, Wang, X, Liu, P, Li, Y, Meyers, C, Banerjee, NS, Wang, HK, Cam, M, Lu, W, Chow, LT, Xie, X, Zhu, J & Zheng, ZM 2019, 'Genome-wide profiling of cervical rna-binding proteins identifies human papillomavirus regulation of rnaseh2a expression by viral e7 and e2f1', mBio, vol. 10, no. 1, e02687-18.
Khusnutdinova, EF, Kazakova, OB, Lobov, AN, Kukovinets, OS, Suponitsky, KY, Meyers, CB & Prichard, MN 2019, 'Synthesis of A-ring quinolones, nine-membered oxolactams and spiroindoles by oxidative transformations of 2,3-indolotriterpenoids', Organic and Biomolecular Chemistry, vol. 17, no. 3, pp. 585-597.
Chatterjee, S, Kang, SD, Alam, S, Salzberg, AC, Milici, J, Van Der Burg, SH, Freeman, W & Meyers, C 2019, 'Tissue-specific gene expression during productive human papillomavirus 16 infection of cervical, foreskin, and tonsil epithelium', Journal of virology, vol. 93, no. 17, e00915-19.


Kang, SD, Chatterjee, S, Alam, S, Salzberg, AC, Milici, J, Van Der Burg, SH & Meyers, C 2018, 'Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium', Journal of virology, vol. 92, no. 20, e01261.
Israr, M, Rosenthal, D, Frejo-Navarro, L, Devoti, J, Meyers, C & Bonagura, VR 2018, 'Microarray analysis of human keratinocytes from different anatomic sites reveals site-specific immune signaling and responses to human papillomavirus type 16 transfection', Molecular Medicine, vol. 24, no. 1, 23.
Bywaters, SM, Brendle, SA, Biryukov, J, Wang, JW, Walston, J, Milici, J, Roden, RB, Meyers, C & Christensen, ND 2018, 'Production and characterization of a novel HPV anti-L2 monoclonal antibody panel', Virology, vol. 524, pp. 106-113.
Biryukov, J & Meyers, C 2018, 'Superinfection exclusion between two highrisk human papillomavirus types during a coinfection', Journal of virology, vol. 92, no. 8, e01993-17.
Chiang, C, Pauli, EK, Biryukov, J, Feister, KF, Meng, M, White, EA, Münger, K, Howley, PM, Meyers, C & Gack, MU 2018, 'The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling', Journal of virology, vol. 92, no. 6, e01737-17.


Bywaters, SM, Brendle, SA, Tossi, KP, Biryukov, J, Meyers, C & Christensen, ND 2017, 'Antibody competition reveals surface location of HPV L2 minor capsid protein residues 17–36', Viruses, vol. 9, no. 11, 336.
Temple, RM, Meyers, C & Sample, CE 2017, Generation and infection of organotypic cultures with Epstein-Barr virus. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1532, Humana Press Inc., pp. 65-78.
Biryukov, J, Myers, JC, McLaughlin-Drubin, ME, Griffin, HM, Milici, J, Doorbar, J & Meyers, C 2017, 'Mutations in HPV18 E1ˆE4 impact virus capsid assembly, infectivity competence, and maturation', Viruses, vol. 9, no. 12, 385.
Tang, X, Loc, WS, Dong, C, Matters, GL, Butler, PJ, Kester, M, Meyers, C, Jiang, Y & Adair, JH 2017, 'The use of nanoparticulates to treat breast cancer', Nanomedicine, vol. 12, no. 19, pp. 2367-2388.
Meyers, C, Milici, J & Robison, R 2017, 'UVC radiation as an effective disinfectant method to inactivate human papillomaviruses', PloS one, vol. 12, no. 10, e0187377.
Wang, X, Liu, H, Ge, H, Ajiro, M, Sharma, NR, Meyers, C, Morozov, P, Tuschl, T, Klar, A, Court, D & Zhenga, ZM 2017, 'Viral DNA replication orientation and hnrnps regulate transcription of the human papillomavirus 18 late promoter', mBio, vol. 8, no. 3, e00713-17.

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