Researcher Profile

Researcher Profile

Cristina Truica, MD

Cristina Truica, MD

Associate Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Breast Cancer
Sarcoma Cancer
cit2@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Breast Neoplasms
  • Circulating Neoplastic Cells
  • Immunotherapy
  • Drug Therapy
  • Equipment and Supplies
  • Aromatase Inhibitors
  • exemestane
  • Catenins
  • Prostatic Neoplasms
  • Placebos

Clinical Trials

Collection of Blood for Investigation and Characterization of Circulating Tumor Cells (CTCs) in Cancer Patients with Microdevices
A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer: THE ABC Trial
A Phase III Multi-center, Randomized, Open-label Trial to Evaluate Efficacy and Safety of Ribociclib With Endocrine Therapy as an Adjuvant Treatment in Patients With Hormone Receptor-positive, HER2-negartive Early Breast Cancer
General Protocol for the Acquisition of Whole Blood for the Detection and Characterization of Circulating Tumor Cells and/or Tumor Specific Immunity/Immune Cell Activation for any Malignancy at any Stage of Disease
Predicting Breast Cancer Metastasis: Signaling Pathway Biomarker Identification Using Reverse Phase Protein Microarray (RPMA) Technology

Recent Publications

2019

Zhu, J, Hussain, M, Joshi, A, Truica, C, Nesterova, D, Collins, J, Saunders, EFH, Hayes, M, Drabick, J & Joshi, M 2019, 'Effect of creative writing on mood in patients with cancer', BMJ Supportive and Palliative Care. https://doi.org/10.1136/bmjspcare-2018-001710
Yardley, DA, Hart, L, Favret, A, Blau, S, Diab, S, Richards, D, Sparano, J, Beck, JT, Richards, P, Ward, P, Ramaswamy, B, Tsai, M, Blackwell, K, Pluard, T, Tolaney, SM, Esteva, FJ, Truica, C, Alemany, C, Volas-Redd, G, Shtivelband, M, Purkayastha, D, Dalal, AA, Miller, M & Hortobagyi, GN 2019, 'Efficacy and Safety of Ribociclib With Letrozole in US Patients Enrolled in the MONALEESA-2 Study', Clinical Breast Cancer, vol. 19, no. 4, pp. 268-277.e1. https://doi.org/10.1016/j.clbc.2019.02.007
Castaman, G, Borchiellini, A, Santagostino, E, Tagariello, G, Serban, M, Uscatescu, M, Truica, C, Albert, F & Morfini, M 2019, 'Pharmacokinetics of a new human plasma-derived double virus inactivated and nanofiltered factor IX concentrate in previously treated severe or moderately severe haemophilia B patients', Haemophilia. https://doi.org/10.1111/hae.13828

2018

Luo, S, Chen, G, Truica, CI, Baird, CC, Xia, Z & Lazarus, P 2018, 'Identification and quantification of novel major metabolites of the steroidal aromatase inhibitor, exemestane', Drug Metabolism and Disposition, vol. 46, no. 12, pp. 1867-1878. https://doi.org/10.1124/dmd.118.081166
Auer, BJ, Sciamanna, C, Smyth, JM, Truica, CI, Cream, LV & Mukherjee, D 2018, 'Interest among primary care patients in group problem-solving gameplay for mental health', Preventing Chronic Disease, vol. 15, no. 6, 170488. https://doi.org/10.5888/pcd15.170488
Trifa, AP, Bănescu, C, Bojan, AS, Voina, CM, Popa, Ș, Vișan, S, Ciubean, AD, Tripon, F, Dima, D, Popov, VM, Vesa, ȘC, Andreescu, M, Török-Vistai, T, Mihăilă, RG, Berbec, N, Macarie, I, Coliţă, A, Iordache, M, Cătană, AC, Farcaș, MF, Tomuleasa, C, Vasile, K, Truică, C, Todincă, A, Pop-Muntean, L, Manolache, R, Bumbea, H, Vlădăreanu, AM, Gaman, M, Ciufu, CM & Popp, RA 2018, 'MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients', American Journal of Hematology, vol. 93, no. 1, pp. 100-106. https://doi.org/10.1002/ajh.24946
Kornblum, N, Zhao, F, Manola, J, Klein, P, Ramaswamy, B, Brufsky, A, Stella, PJ, Burnette, B, Telli, M, Makower, DF, Cheema, P, Truica, CI, Wolff, AC, Soori, GS, Haley, B, Wassenaar, TR, Goldstein, LJ, Miller, KD & Sparano, JA 2018, 'Randomized phase II trial of fulvestrant plus everolimus or placebo in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer resistant to aromatase inhibitor therapy: Results of PrE0102', Journal of Clinical Oncology, vol. 36, no. 16, pp. 1556-1563. https://doi.org/10.1200/JCO.2017.76.9331
Luo, S, Chen, G, Truica, C, Baird, CC, Leitzel, K & Lazarus, P 2018, 'Role of the UGT2B17 deletion in exemestane pharmacogenetics', Pharmacogenomics Journal, vol. 18, no. 2, pp. 295-300. https://doi.org/10.1038/tpj.2017.18
Gineyts, E, Bonnet, N, Bertholon, C, Millet, M, Pagnon-Minot, A, Borel, O, Geraci, S, Bonnelye, E, Croset, M, Suhail, A, Truica, C, Lamparella, N, Leitzel, K, Hartmann, D, Chapurlat, R, Lipton, A, Garnero, P, Ferrari, S, Clézardin, P & Rousseau, JC 2018, 'The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis', Calcified Tissue International, vol. 103, no. 5, pp. 567-580. https://doi.org/10.1007/s00223-018-0444-y

2017

Felts, JL, Zhu, J, Han, B, Smith, JS & Truica, C 2017, 'An Analysis of Oncotype DX Recurrence Scores and Clinicopathologic Characteristics in Invasive Lobular Breast Cancer', Breast Journal, vol. 23, no. 6, pp. 677-686. https://doi.org/10.1111/tbj.12751
Jia, H, Truica, C, Wang, B, Wang, Y, Ren, X, Harvey, H, Song, J & Yang, J-M 2017, 'Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects', Drug Resistance Updates, vol. 32, pp. 1-15. https://doi.org/10.1016/j.drup.2017.07.002

2016

Matthew, EM, Zhou, L, Yang, Z, Dicker, DT, Holder, SL, Lim, B, Harouaka, R, Zheng, SY, Drabick, JJ, Lamparella, NE, Truica, CI & El-Deiry, WS 2016, 'A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells', Oncotarget, vol. 7, no. 4, pp. 3662-3676. https://doi.org/10.18632/oncotarget.6657
Truica, C & Cleary, AS 2016, 'Immunotherapy in breast cancer-paving new roads?', Current Molecular Pharmacology, vol. 9, no. 3, pp. 208-216. https://doi.org/10.2174/1874467208666150716120427

2015

Dao, M, Suresh, S, Huang, TJ, Li, P, Mao, Z, Peng, Z, Zhou, L, Chen, Y, Huang, PH, Truica, CI, Drabick, JJ & El-Deiry, WS 2015, 'Acoustic separation of circulating tumor cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 16, pp. 4970-4975. https://doi.org/10.1073/pnas.1504484112

Clinical Trials Search


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