Researcher Profile

Researcher Profile

Cristina Truica, MD

Cristina Truica, MD

Associate Professor, Department of Medicine
Director of Breast Medical Oncology and Interim Chief, Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Breast Cancer

Research Interests

  • Neoplasms
  • Breast Neoplasms
  • Therapeutics
  • Circulating Neoplastic Cells
  • Drug Therapy
  • Aromatase Inhibitors
  • Immunotherapy
  • Equipment and Supplies
  • Safety
  • Survival
  • Exercise
  • exemestane

Clinical Trials

Collection of Blood for Investigation and Characterization of Circulating Tumor Cells (CTCs) in Cancer Patients with Microdevices
Phase II Palbociclib with Fulvestrant in Individuals with Hormone Receptive Positive HER2 Negative Metastatic Breast Cancer who progressed on treatment with Palbociclib + an Aromatase Inhibitor
EA1181 (CompassHER2-pCR): Preoperative THP and postoperative HP in patients who achieve a pathologic complete response Part 1 Component of:The CompassHER2 Trials (COMprehensive use of Pathologic response Assessment to optimize therapy in HER2-positive breast cancer).
Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients with Metastatic HER-2+ Breast Cancer, Phase III
A Phase II, Single Arm, Non-randomized Study of Alpelisib (BYL719) in Combination with Continued Endocrine Therapy Following Progression on Endocrine Therapy in Hormone Receptor Positive, HER2 Negative, PIK3CA Mutant Metastatic Breast Cancer Big Ten Cancer Research Consortium BTCRC-BRE19-409
NRG-BR007: A Phase III Clinical Trial Evaluating Deescalation of Breast Radiation for Conservative Treatment of Stage I, Hormone sensitive, HER2- Negative Oncotype recurrence Score ≤ 18 Breast Cancer
General Protocol for the Acquisition of Whole Blood for the Detection and Characterization of Circulating Tumor Cells and/or Tumor Specific Immunity/Immune Cell Activation for any Malignancy at any Stage of Disease
Predicting Breast Cancer Metastasis: Signaling Pathway Biomarker Identification Using Reverse Phase Protein Microarray (RPMA) Technology

Recent Publications


Nesterova, D, Zhu, J, Kramer, C, Vasekar, M, Truica, C, Joshi, A, Hayes, M, Kessler, J, Saunders, EFH, Drabick, JJ & Joshi, M 2022, 'Group-led creative writing and behavioural health in cancer: A randomised clinical trial', BMJ Supportive and Palliative Care, vol. 12, no. 1, pp. 91-98.
Bluethmann, SM, Truica, C, Klepin, HD, Olsen, N, Sciamanna, C, Chinchilli, VM & Schmitz, KH 2021, 'Study design and methods for the using exercise to relieve joint pain and improve AI adherence in older breast cancer survivors (REJOIN) trial', Journal of Geriatric Oncology, vol. 12, no. 7, pp. 1146-1153.
Schmitz, KH, Schleicher, E, Doerksen, S, Truica, C, Cream, L, Kass, R, Farnan, M, Suess, R, Gordon, B, Zucker, D & Hayes, M 2021, 'Testing the acceptability and feasibility of a tablet-based supportive cancer platform for patients with metastatic breast cancer', Journal of Cancer Survivorship, vol. 15, no. 3, pp. 410-413.


Yin, M, Verschraegen, C, Vincent, VH, Patel, SM, George, T & Truica, CI 2020, 'Impact of lack of surgery on outcomes in elderly women with nonmetastatic breast cancer-A surveillance, epidemiology, and end results 18 population based study', Medicine (United States), vol. 99, no. 3, e18745.
Castaman, G, Borchiellini, A, Santagostino, E, Radossi, P, Aksu, S, Yilmaz, M, Serban, M, Uscatescu, V, Truica, C, Fasulo, MR, Mancuso, ME, Paladino, E, Valpreda, A, Guarnieri, C, Macchia, R, Scarpellini, M, Mathew, P & Morfini, M 2020, 'Non-Compartment and compartmental pharmacokinetics, efficacy, and safety of Kedrion FIX concentrate', European Journal of Pharmaceutical Sciences, vol. 153, 105485.
Schmitz, KH, Potiaumpai, M, Schleicher, EA, Wolf, LJ, Doerksen, SE, Drabick, JJ, Yee, NS, Truica, CI, Mohamed, AA, Shaw, BW & Farley, DC 2021, 'The exercise in all chemotherapy trial', Cancer, vol. 127, no. 9, pp. 1507-1516.


Zhu, J, Hussain, M, Joshi, A, Truica, CI, Nesterova, D, Collins, J, Saunders, EFH, Hayes, M, Drabick, JJ & Joshi, M 2020, 'Effect of creative writing on mood in patients with cancer', BMJ Supportive and Palliative Care, vol. 10, no. 1, pp. 64-67.
Yardley, DA, Hart, L, Favret, A, Blau, S, Diab, S, Richards, D, Sparano, J, Beck, JT, Richards, P, Ward, P, Ramaswamy, B, Tsai, M, Blackwell, K, Pluard, T, Tolaney, SM, Esteva, FJ, Truica, CI, Alemany, C, Volas-Redd, G, Shtivelband, M, Purkayastha, D, Dalal, AA, Miller, M & Hortobagyi, GN 2019, 'Efficacy and Safety of Ribociclib With Letrozole in US Patients Enrolled in the MONALEESA-2 Study', Clinical Breast Cancer, vol. 19, no. 4, pp. 268-277.e1.
Castaman, G, Borchiellini, A, Santagostino, E, Tagariello, G, Serban, M, Uscatescu, M, Truica, C, Farrugia, A & Morfini, M 2019, 'Pharmacokinetics of a new human plasma-derived double virus inactivated and nanofiltered factor IX concentrate in previously treated severe or moderately severe haemophilia B patients', Haemophilia, vol. 25, no. 6, pp. e364-e367.


LYM-3002 investigators 2018, 'Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study', The Lancet Oncology, vol. 19, no. 11, pp. 1449-1458.
Luo, S, Chen, G, Truica, CI, Baird, CC, Xia, Z & Lazarus, P 2018, 'Identification and quantification of novel major metabolites of the steroidal aromatase inhibitor, exemestane', Drug Metabolism and Disposition, vol. 46, no. 12, pp. 1867-1878.
Auer, BJ, Sciamanna, C, Smyth, JM, Truica, CI, Cream, LV & Mukherjee, D 2018, 'Interest among primary care patients in group problem-solving gameplay for mental health', Preventing Chronic Disease, vol. 15, no. 6, 170488.
Trifa, AP, Bănescu, C, Bojan, AS, Voina, CM, Popa, Ș, Vișan, S, Ciubean, AD, Tripon, F, Dima, D, Popov, VM, Vesa, ȘC, Andreescu, M, Török-Vistai, T, Mihăilă, RG, Berbec, N, Macarie, I, Coliţă, A, Iordache, M, Cătană, AC, Farcaș, MF, Tomuleasa, C, Vasile, K, Truică, C, Todincă, A, Pop-Muntean, L, Manolache, R, Bumbea, H, Vlădăreanu, AM, Gaman, M, Ciufu, CM & Popp, RA 2018, 'MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients', American Journal of Hematology, vol. 93, no. 1, pp. 100-106.
Kornblum, N, Zhao, F, Manola, J, Klein, P, Ramaswamy, B, Brufsky, A, Stella, PJ, Burnette, B, Telli, M, Makower, DF, Cheema, P, Truica, CI, Wolff, AC, Soori, GS, Haley, B, Wassenaar, TR, Goldstein, LJ, Miller, KD & Sparano, JA 2018, 'Randomized phase II trial of fulvestrant plus everolimus or placebo in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer resistant to aromatase inhibitor therapy: Results of PrE0102', Journal of Clinical Oncology, vol. 36, no. 16, pp. 1556-1563.
Luo, S, Chen, G, Truica, C, Baird, CC, Leitzel, K & Lazarus, P 2018, 'Role of the UGT2B17 deletion in exemestane pharmacogenetics', Pharmacogenomics Journal, vol. 18, no. 2, pp. 295-300.
Gineyts, E, Bonnet, N, Bertholon, C, Millet, M, Pagnon-Minot, A, Borel, O, Geraci, S, Bonnelye, E, Croset, M, Suhail, A, Truica, C, Lamparella, N, Leitzel, K, Hartmann, D, Chapurlat, R, Lipton, A, Garnero, P, Ferrari, S, Clézardin, P & Rousseau, JC 2018, 'The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis', Calcified Tissue International, vol. 103, no. 5, pp. 567-580.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)