Christopher Norbury, PhD - Penn State Cancer Institute
Researcher Profile
Christopher Norbury, PhD
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- T-Lymphocytes
- Dendritic Cells
- Antigens
- Peptides
- Cross-Priming
- Virus Diseases
- Viruses
- Proteins
- Vaccinia virus
- Infections
- Antigen Presentation
- Immunity
Recent Publications
2023
Khajuria, DK, Karuppagounder, V, Nowak, I, Sepulveda, DE, Lewis, G, Norbury, CC, Raup-Konsavage, WM, Vrana, KE, Kamal, F & Elbarbary, RA 2023, 'Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice', Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4902
Wu, X, Dayanand, KK, Thylur Puttalingaiah, R, Punnath, K, Norbury, CC & Gowda, DC 2023, 'Different TLR signaling pathways drive pathology in experimental cerebral malaria vs. malaria-driven liver and lung pathology', Journal of Leukocyte Biology, vol. 113, no. 5, pp. 471-488. https://doi.org/10.1093/jleuko/qiad021
Khajuria, DK, Reider, I, Kamal, F, Norbury, CC & Elbarbary, RA 2023, 'Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity', Frontiers in immunology, vol. 14, 1250309. https://doi.org/10.3389/fimmu.2023.1250309
Khajuria, DK, Nowak, I, Leung, M, Karuppagounder, V, Imamura, Y, Norbury, CC, Kamal, F & Elbarbary, RA 2023, 'Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing', Bone Research, vol. 11, no. 1, 5. https://doi.org/10.1038/s41413-022-00236-7
2021
Monticelli, SR, Bryk, P, Brewer, MG, Aguilar, HC, Norbury, CC & Ward, BM 2021, 'An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity', PLoS pathogens, vol. 17, no. 12, e1010177. https://doi.org/10.1371/journal.ppat.1010177
Wu, X, Thylur, RP, Dayanand, KK, Punnath, K, Norbury, CC & Channe Gowda, D 2021, 'IL-4 treatment mitigates experimental cerebral malaria by reducing parasitemia, dampening inflammation, and lessening the cytotoxicity of T cells', Journal of Immunology, vol. 206, no. 1, pp. 118-131. https://doi.org/10.4049/jimmunol.2000779
Wu, X, Brombacher, F, Chroneos, ZC, Norbury, CC & Gowda, DC 2021, 'IL-4Rα signaling by CD8α+ dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8+ T cell responses', Journal of Biological Chemistry, vol. 296, 100615. https://doi.org/10.1016/j.jbc.2021.100615
2020
Monticelli, SR, Earley, AK, Stone, R, Norbury, CC & Ward, BM 2020, 'Vaccinia Virus Glycoproteins A33, A34, and B5 Form a Complex for Efficient Endoplasmic Reticulum to trans-Golgi Network Transport', Journal of virology, vol. 94, no. 7, e0215519. https://doi.org/10.1128/JVI.02155-19
2019
Niu, TK, Princiotta, MF, Sei, JJ & Norbury, CC 2019, 'Analysis of MHC Class I Processing Pathways That Generate a Response to Vaccinia Virus Late Proteins', ImmunoHorizons, vol. 3, no. 12, pp. 559-572. https://doi.org/10.4049/immunohorizons.1900074
Parekh, NJ, Krouse, TE, Reider, IE, Hobbs, RP, Ward, BM & Norbury, CC 2019, 'Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden', PLoS pathogens, vol. 15, no. 10, e1007778. https://doi.org/10.1371/journal.ppat.1007778