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Andry Van De Louw, MD, PhD

Andry Van De Louw, MD, PhD

Associate Professor, Department of Medicine
Professor, Department of Medicine
Division of Pulmonary, Allergy and Critical Care Medicine
Scientific Program:Cancer Control
AXV19@psu.edu

Research Interests

  • Respiratory Insufficiency
  • Mortality
  • Critical Illness
  • Therapeutics
  • Intensive Care Units
  • Immunocompromised Host
  • Neoplasms
  • Lung
  • Cohort Studies
  • Acute Myeloid Leukemia
  • Artificial Respiration
  • Hypoxia

Recent Publications

2023

Secreto, C, Chean, D, van de Louw, A, Kouatchet, A, Bauer, P, Cerrano, M, Lengliné, E, Saillard, C, Chow-Chine, L, Perner, A, Pickkers, P, Soares, M, Rello, J, Pène, F, Lemiale, V, Darmon, M, Fodil, S, Martin-Loeches, I, Mehta, S, Schellongowski, P, Azoulay, E & Mokart, D 2023, 'Characteristics and outcomes of patients with acute myeloid leukemia admitted to intensive care unit with acute respiratory failure: a post-hoc analysis of a prospective multicenter study', Annals of Intensive Care, vol. 13, no. 1, 79. https://doi.org/10.1186/s13613-023-01172-3
on behalf of the PLOT-ICU Collaborators and the Nine-I Study Group 2024, 'Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) (Intensive Care Medicine, (2023), 49, 11, (1327-1338), 10.1007/s00134-023-07225-2)', Intensive Care Medicine, vol. 50, no. 1, pp. 154-155. https://doi.org/10.1007/s00134-023-07291-6
Meert, AP, Toffart, AC, Picard, M, Jaubert, P, Gibelin, A, Bauer, P, Mokart, D, Van De Louw, A, Hatzl, S, Moreno-Gonzales, G, Rousseau-Bussac, G, Bruneel, F, Montini, L, Moreau, AS, Carpentier, D, Seguin, A, Hemelaar, P, Azoulay, E & Lemiale, V 2023, 'Erratum to “When targeted therapy for cancer leads to ICU admission. RETRO-TARGETICU multicentric study” [Bull. Cancer 109 (2022) 916–24](S0007455122001916)(10.1016/j.bulcan.2022.04.014)', Bulletin du Cancer, vol. 110, no. 4, pp. 467-468. https://doi.org/10.1016/j.bulcan.2023.02.001
EFRAIM investigators and Nine-I study group 2023, 'Etiologies and Outcome of Patients with Solid Tumors Admitted to ICU with Acute Respiratory Failure: A Secondary Analysis of the EFRAIM Study', Respiratory care, vol. 68, no. 6, pp. 740-748. https://doi.org/10.4187/respcare.10604
for the Nine-I investigators 2023, 'Research priorities for therapeutic plasma exchange in critically ill patients', Intensive Care Medicine Experimental, vol. 11, no. 1, 26. https://doi.org/10.1186/s40635-023-00510-w
Anthon, CT, Pène, F, Perner, A, Azoulay, E, Puxty, K, Van De Louw, A, Barratt-Due, A, Chawla, S, Castro, P, Póvoa, P, Coelho, L, Metaxa, V, Kochanek, M, Liebregts, T, Kander, T, Hästbacka, J, Andreasen, JB, Péju, E, Nielsen, LB, Hvas, CL, Dufranc, E, Canet, E, Lundqvist, L, Wright, CJ, Schmidt, J, Uhel, F, Ait-Oufella, H, Krag, M, Cos Badia, E, Díaz-Lagares, C, Menat, S, Voiriot, G, Clausen, NE, Lorentzen, K, Kvåle, R, Hildebrandt, T, Holten, AR, Strand, K, Tzalavras, A, Bestle, MH, Klepstad, P, Fernandez, S, Vimpere, D, Paulino, C, Graça, C, Lueck, C, Juhl, CS, Costa, C, Bådstøløkken, PM, Miranda, T, Lêdo, LSA, Sousa Torres, JC, Granholm, A, Møller, MH, Russell, L, Khalil, A, Yehia, A, Salem, H, Farahat, H, Sudevan, M, Biggart, M, Fatima, N, Elkhonezy, M, Bunzel, AM, Siegumfeldt, RM, Vestergaard, SR, Pelle, J, Lê, MP, Vigneron, C, Bertrix, M, Cirera, P, Laghlam, D, Bredin, S, Marin, N, Toppenberg, M, Benelli, B, Seguin, A, Garret, C, Guillotin, F, Blonz, G, Lascarrou, JB, Lemarie, J, Desmedt, L, Agbakou, M, Carpentier, M, Martin, M, Benkalfate, N, Zambon, O, Decamps, P, Wilquin, PL, Benguerfi, S, Gardner, J, Remor, N, Carr, S, Yang, G, Gernez, C, Thiry, I, Missri, L, Denneborg, MKG, Brown, K, Casares, V, Sivula, M, Lappi, E, Pettilä, L, Heinonen, J, Saario, M, Mecheri, MK, Elabbadi, A, Desnos, C, Lafarge, A, Mghirbi, O, Sjøbø, B, Christoffersen, C, Bestle, FH, Lemos, C, Gonçalves, CV, Jacinto, NMB, Anselmo, MP, Hoeper, MM, Hoff, M & Simões Freire, PM 2023, 'Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)', Intensive Care Medicine, vol. 49, no. 11, pp. 1327-1338. https://doi.org/10.1007/s00134-023-07225-2

2022

for the Efraim investigators and the Nine-I study group 2022, 'End of life decisions in immunocompromised patients with acute respiratory failure', Journal of Critical Care, vol. 72, 154152. https://doi.org/10.1016/j.jcrc.2022.154152
the Nine-i Investigators 2022, 'Plasma exchange in the intensive care unit: a narrative review', Intensive Care Medicine, vol. 48, no. 10, pp. 1382-1396. https://doi.org/10.1007/s00134-022-06793-z
PLOT-ICU Investigators and the Nine-I Study Group 2022, 'Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT-ICU)', Acta Anaesthesiologica Scandinavica, vol. 66, no. 9, pp. 1146-1155. https://doi.org/10.1111/aas.14124
Meert, AP, Toffart, AC, Picard, M, Jaubert, P, Gibelin, A, Bauer, P, Mokart, D, Van De Louw, A, Hatzl, S, Moreno-Gonzales, G, Rousseau-Bussac, G, Bruneel, F, Montini, L, Moreau, AS, Carpentier, D, Seguin, A, Hemelaar, P, Azoulay, E & Lemiale, V 2022, 'When targeted therapy for cancer leads to ICU admission. RETRO-TARGETICU multicentric study', Bulletin du Cancer, vol. 109, no. 9, pp. 916-924. https://doi.org/10.1016/j.bulcan.2022.04.014

2021

for the Efraim investigators and the Nine-I study group 2021, 'Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort', Journal of Critical Care, vol. 64, pp. 114-119. https://doi.org/10.1016/j.jcrc.2021.03.014
Guck, D, Ismail-Sayed, I & Van de Louw, A 2021, 'Characteristics and prognosis of patients with myelodysplastic syndromes admitted to the intensive care unit', Leukemia and Lymphoma, vol. 62, no. 12, pp. 3057-3059. https://doi.org/10.1080/10428194.2021.1948039
Van de Louw, A, Cohrs, A & Leslie, D 2021, 'Effects of statins on the incidence and mortality of sepsis in patients with new cancer diagnosis', Journal of Clinical Medicine, vol. 10, no. 15, 3427. https://doi.org/10.3390/jcm10153427
Horn, J, Mullholand, JB, Ashraf, S, Shore, D & Van de Louw, A 2021, 'Herpes simplex virus meningoencephalitis following pulse-dose methylprednisolone: A case report and literature review', American Journal of Case Reports, vol. 22, no. 1, e933847. https://doi.org/10.12659/AJCR.933847
Van de Louw, A 2021, 'Kinetics of blood neutrophil and lymphocyte count in critically ill neutropenic patients with hematological malignancies', Critical Care, vol. 25, no. 1, 321. https://doi.org/10.1186/s13054-021-03740-0
Van De Louw, A, Mariotte, E, Darmon, M, Cohrs, A, Leslie, D & Azoulay, E 2021, 'Outcomes in 1096 patients with severe thrombotic thrombocytopenic purpura before the Caplacizumab era', PloS one, vol. 16, no. 8 August, e0256024. https://doi.org/10.1371/journal.pone.0256024
Nine-I investigators 2021, 'Outcomes in patients treated with chimeric antigen receptor T-cell therapy who were admitted to intensive care (CARTTAS): an international, multicentre, observational cohort study', The Lancet Haematology, vol. 8, no. 5, pp. e355-e364. https://doi.org/10.1016/S2352-3026(21)00060-0
Guck, D, Hernandez, R, Moore, S, Van De Louw, A & Haouzi, P 2021, 'Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion', Case Reports in Nephrology, vol. 2021, 4723092. https://doi.org/10.1155/2021/4723092

2020

for the Efraim investigators and the Nine-I study group 2020, 'Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status', Annals of Intensive Care, vol. 10, no. 1, 146. https://doi.org/10.1186/s13613-020-00764-7
Lopez, R, Rello, J, Taccone, FS, Salem, OBH, Bauer, PR, Séguin, A, Van De Louw, A, Metaxa, V, Klouche, K, Martin Loeches, I, Montini, L, Mehta, S, Bruneel, F, Lisboa, T, Viana, W, Pickkers, P, Russell, L, Rusinova, K, Kouatchet, A, Barbier, F, Mokart, D, Azoulay, E & Darmon, M 2020, 'Aminoglycosides in Immunocompromised Critically Ill Patients With Bacterial Pneumonia and Septic Shock: A Post-Hoc Analysis of a Prospective Multicenter Multinational Cohort', Shock, vol. 54, no. 6, pp. 731-737. https://doi.org/10.1097/SHK.0000000000001553
Van De Louw, A, Cohrs, A & Leslie, D 2021, 'Clinical Features and Outcome of Thrombotic Microangiopathies: Comparison between Patients with and without Malignancy', Thrombosis and Haemostasis, vol. 121, no. 5, pp. 565-572. https://doi.org/10.1055/s-0040-1720974
the Nine-i Investigators 2020, 'Correction to: Expert statement on the ICU management of patients with thrombotic thrombocytopenic purpura (Intensive Care Medicine, (2019), 45, 11, (1518-1539), 10.1007/s00134-019-05736-5)', Intensive Care Medicine, vol. 46, no. 3, pp. 570-571. https://doi.org/10.1007/s00134-019-05904-7
the Nine-i Investigators 2020, 'Diagnosis of severe respiratory infections in immunocompromised patients', Intensive Care Medicine, vol. 46, no. 2, pp. 298-314. https://doi.org/10.1007/s00134-019-05906-5
Efraim investigators and the Nine-I study group 2020, 'Etiologies and Outcomes of Acute Respiratory Failure in Solid Organ Transplant Recipients: Insight Into the EFRAIM Multicenter Cohort', Transplantation proceedings, vol. 52, no. 10, pp. 2980-2987. https://doi.org/10.1016/j.transproceed.2020.02.170
Van de Louw, A, Zhu, X & Frankenfield, D 2020, 'How obesity and malnutrition interplay to affect mortality in critically ill patients with hematological malignancies: a retrospective cohort study', Leukemia and Lymphoma, vol. 61, no. 8, pp. 2027-2029. https://doi.org/10.1080/10428194.2020.1759053
Efraim investigators and the Nine-I study group 2021, 'ICU-acquired pneumonia in immunosuppressed patients with acute hypoxemic respiratory failure: A post-hoc analysis of a prospective international cohort study', Journal of Critical Care, vol. 63, pp. 243-245. https://doi.org/10.1016/j.jcrc.2020.09.027
Van De Louw, A, Cohrs, A & Leslie, D 2020, 'Incidence of sepsis and associated mortality within the first year after cancer diagnosis in middle aged adults: A US population based study', PloS one, vol. 15, no. 12 December, e0243449. https://doi.org/10.1371/journal.pone.0243449
Van de Louw, A, Zhu, X & Frankenfield, D 2020, 'Obesity and malnutrition in critically ill patients with acute myeloid leukemia: prevalence and impact on mortality', Nutrition, vol. 79-80, 110956. https://doi.org/10.1016/j.nut.2020.110956
Van de Louw, A, Twomey, K, Habecker, N & Rakszawski, K 2021, 'Prevalence of acute liver dysfunction and impact on outcome in critically ill patients with hematological malignancies: a single-center retrospective cohort study', Annals of Hematology, vol. 100, no. 1, pp. 229-237. https://doi.org/10.1007/s00277-020-04197-x
Demoule, A, Antonelli, M, Schellongowski, P, Pickkers, P, Soares, M, Meyhoff, T, Rello, J, Bauer, PR, van de Louw, A, Lemiale, V, Grimaldi, D, Martin-Loeches, I, Balik, M, Mehta, S, Kouatchet, A, Barratt-Due, A, Valkonen, M, Reignier, J, Metaxa, V, Moreau, AS, Burghi, G, Mokart, D, Mayaux, J, Darmon, M, Azoulay, E, Amrein, K, Staundinger, T, Heinz, G, Sengölge, G, Zauner, C, Jaksch, P, Taccone, FS, Meert, AP, Benoît, D, Silva, UVA, Pierre de Moraes, AP, Lishoa, T, Salluh, J, Viana, W, Moralez, G, Correa, TD, Shah, U, Karvunidis, T, Martin, B, Russinova, K, Perner, A, Meyhoff, TS, Jonas, N, Bukan, RB, Moeller, AM, Nielsen, LB, Seguin, A, Chermak, A, Terzi, N, Vinatier, I, Wallet, F, Klouche, K, Platon, L, Gaborit, B, Barbier, F, Pène, F, Rabbat, A, Lemiale, V, N'Yunga, M, Girault, C, Lemaitre, C, Artaud-Macari, E, Bruneel, F, Moreau, AS, Kuitunen, A, Marsh, B, Misericordia, M, Mahon, AM, Cinnella, G, Cotoia, A, Riuniti, O, Montini, L, Spoelstra de Man, A, Landburg, PP, Bergmans, D, Hemelaar, P, Kaufmann, T, Barrat-Due, A, Klepstad, P, Encina, B, Moreno, G, Crespi, LS, Rodriguez-Ruiz, E, Bauer, P & Hemang, Y 2020, 'Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS: A Secondary Analysis of the EFRAIM Study', CHEST, vol. 158, no. 5, pp. 1947-1957. https://doi.org/10.1016/j.chest.2020.05.602