Arati Sharma, PhD - Penn State Cancer Institute
Researcher Profile
Arati Sharma, PhD
Professor, Department of Pharmacology
Associate Professor, Department of Pharmacology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Associate Professor, Department of Pharmacology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Next-Generation Therapies
Research Interests
Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.
To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.
Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.
- Melanoma
- Neoplasms
- Therapeutics
- Acute Myeloid Leukemia
- Pharmaceutical Preparations
- Apoptosis
- Growth
- Proteins
- Ceramides
- Genes
- Neoplasm Metastasis
- Leukemia
Recent Publications
2024
Paudel, BB, Tan, SF, Fox, TE, Ung, J, Golla, U, Shaw, JJP, Dunton, W, Lee, I, Fares, WA, Patel, S, Sharma, A, Viny, AD, Barth, BM, Tallman, MS, Cabot, M, Garrett-Bakelman, FE, Levine, RL, Kester, M, Feith, DJ, Claxton, D, Janes, KA & Loughran, TP 2024, 'Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes', Blood Advances, vol. 8, no. 5, pp. 1137-1142. https://doi.org/10.1182/bloodadvances.2023010535
2023
Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Taori, M, Horton, BJ, Golla, U, Sharma, A, Szulc, ZM, Wang, H-G, Chalfant, CE, Cabot, MC, Claxton, DF, Loughran, TP & Feith, DJ 2023, 'Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia', Cancers, vol. 15, no. 24, 5866. https://doi.org/10.3390/cancers15245866
Qian, F, Nettleford, SK, Zhou, J, Arner, BE, Hall, MA, Sharma, A, Annageldiyev, C, Rossi, RM, Tukaramrao, DB, Sarkar, D, Hegde, S, Gandhi, UH, Finch, ER, Goodfield, L, Quickel, MD, Claxton, DF, Paulson, RF & Prabhu, KS 2023, 'Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells', Cell Reports, vol. 42, no. 7, 112794. https://doi.org/10.1016/j.celrep.2023.112794
Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060. https://doi.org/10.3390/ph16081060
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571. https://doi.org/10.1038/s41388-023-02671-0
Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942. https://doi.org/10.1016/j.jbior.2022.100942
Fisher-Wellman, KH, Kassai, M, Hagen, JT, Neufer, PD, Kester, M, Loughran, TP, Chalfant, CE, Feith, DJ, Tan, SF, Fox, TE, Ung, J, Fabrias, G, Abad, JL, Sharma, A, Golla, U, Claxton, DF, Shaw, JJP, Bhowmick, D & Cabot, MC 2023, 'Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia', Cancers, vol. 15, no. 6, 1883. https://doi.org/10.3390/cancers15061883
2022
Singh, AP, Luo, H, Matur, M, Eshelman, MA, Hamamoto, K, Sharma, A, Lesperance, J & Huang, S 2022, 'A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling', Oncogene, vol. 41, no. 5, pp. 718-731. https://doi.org/10.1038/s41388-021-02127-3
Long, NA, Golla, U, Sharma, A & Claxton, DF 2022, 'Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications', Stem Cell Reviews and Reports, vol. 18, no. 4, pp. 1211-1226. https://doi.org/10.1007/s12015-021-10308-6
Khokhlatchev, AV, Sharma, A, Deering, TG, Shaw, JJP, Costa-Pinheiro, P, Golla, U, Annageldiyev, C, Cabot, MC, Conaway, MR, Tan, SF, Ung, J, Feith, DJ, Loughran, TP, Claxton, DF, Fox, TE & Kester, M 2022, 'Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia', FASEB Journal, vol. 36, no. 10, e22514. https://doi.org/10.1096/fj.202200765R
Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Vass, LR, Costa-Pinheiro, P, Garrett-Bakelman, FE, Keng, MK, Sharma, A, Claxton, DF, Levine, RL, Tallman, MS, Cabot, MC, Kester, M, Feith, DJ & Loughran, TP 2022, 'Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia', Blood Reviews, vol. 55, 100950. https://doi.org/10.1016/j.blre.2022.100950
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972
2021
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889. https://doi.org/10.3390/cancers13194889
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956. https://doi.org/10.1038/s41467-021-22095-2
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21. https://doi.org/10.3390/cancers13051127
Dovat, E, Song, C, Hu, T, Rahman, MA, Dhanyamraju, PK, Klink, M, Bogush, D, Soliman, M, Kane, S, McGrath, M, Ding, Y, Desai, D, Sharma, A & Gowda, C 2021, 'Transcriptional regulation of PIK3CD and PIKFYVE in T-cell acute lymphoblastic leukemia by IKAROS and protein kinase CK2', International journal of molecular sciences, vol. 22, no. 2, 819, pp. 1-14. https://doi.org/10.3390/ijms22020819
2020
Pearson, JM, Tan, SF, Sharma, A, Annageldiyev, C, Fox, TE, Abad, JL, Fabrias, G, Desai, D, Amin, S, Wang, HG, Cabot, MC, Claxton, DF, Kester, M, Feith, DJ & Loughran, TP 2020, 'Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia', Molecular Cancer Research, vol. 18, no. 3, pp. 352-363. https://doi.org/10.1158/1541-7786.MCR-19-0619
Gebru, MT, Atkinson, JM, Young, MM, Zhang, L, Tang, Z, Liu, Z, Lu, P, Dower, CM, Chen, L, Annageldiyev, C, Sharma, A, Kawasawa, YI, Zhao, Z, Miller, BA, Claxton, DF & Wang, HG 2020, 'Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia', Blood, vol. 136, no. 9, pp. 1067-1079. https://doi.org/10.1182/blood.2019003124
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718. https://doi.org/10.3390/ijms21051718
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393. https://doi.org/10.3389/fonc.2020.00393
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696. https://doi.org/10.3324/haematol.2018.212886