Researcher Profile

Researcher Profile

Arati Sharma, PhD

Arati Sharma, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
aks12@psu.edu

Research Interests

Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.

To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.

Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.

  • Melanoma
  • Neoplasms
  • Therapeutics
  • Apoptosis
  • Growth
  • Acute Myeloid Leukemia
  • Pharmaceutical Preparations
  • Small Interfering RNA
  • Neoplasm Metastasis
  • Animals
  • Proteins
  • Ceramides

Recent Publications

2020

Pearson, JM, Tan, SF, Sharma, A, Annageldiyev, C, Fox, TE, Abad, JL, Fabrias, G, Desai, D, Amin, S, Wang, HG, Cabot, MC, Claxton, DF, Kester, M, Feith, DJ & Loughran, TP 2020, 'Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia', Molecular Cancer Research, vol. 18, no. 3, pp. 352-363. https://doi.org/10.1158/1541-7786.MCR-19-0619
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718. https://doi.org/10.3390/ijms21051718
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393. https://doi.org/10.3389/fonc.2020.00393
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696. https://doi.org/10.3324/haematol.2018.212886

2019

Madhunapantula, SRV, Patel, TN, Annageldiyev, C & Sharma, A 2019, Animal (mouse) models of melanoma. in A Azmi & RM Mohammad (eds), Animal Models in Cancer Drug Discovery. Academic Press, pp. 401-417. <https://www.sciencedirect.com/science/article/pii/B9780128147047000179?via%3Dihub#!>
Patel, TN, Madhunapantula, SRV, Annageldiyev, C, Claxton, D & Sharma, A 2019, Animal mouse models of acute myeloid leukemia. in A Azmi & RM Mohammad (eds), Animal Models in Cancer Drug Discovery. Academic Press, pp. 419-438. <https://www.sciencedirect.com/book/9780128147047/animal-models-in-cancer-drug-discovery>
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Kim, S, Zhang, Y, Tang, S, Qin, C, Karelia, D, Sharma, A, Jiang, C & Lu, J 2019, 'Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice', Prostate, vol. 79, no. 9, pp. 949-960. https://doi.org/10.1002/pros.23802
Barth, BM, Wang, W, Toran, PT, Fox, TE, Annageldiyev, C, Ondrasik, RM, Keasey, NR, Brown, TJ, Devine, VG, Sullivan, EC, Cote, AL, Papakotsi, V, Tan, SF, Shanmugavelandy, SS, Deering, TG, Needle, DB, Stern, ST, Zhu, J, Liao, J, Viny, AD, Feith, DJ, Levine, RL, Wang, HG, Loughran, TP, Sharma, A, Kester, M & Claxton, DF 2019, 'Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia', Blood Advances, vol. 3, no. 17, pp. 2598-2603. https://doi.org/10.1182/bloodadvances.2018021295

2018

Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, DF, Helm, KF, Drabick, JJ, Robertson, GP, Neighbors, JD, Hohl, RJ & Schell, TD 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614

2017

Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Kardos, G, Madhunapantula, SRV, Drabick, JJ & Robertson, GP 2018, 'Identification of WEE1 as a target to make AKT inhibition more effective in melanoma', Cancer Biology and Therapy, vol. 19, no. 1, pp. 53-62. https://doi.org/10.1080/15384047.2017.1360446
Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Dinavahi, SS, Kardos, G, Drabick, JJ & Robertson, GP 2017, 'Improving pharmacological targeting of AKT in melanoma', Cancer Letters, vol. 404, pp. 29-36. https://doi.org/10.1016/j.canlet.2017.07.001
Gowda, R, Kardos, G, Sharma, A, Singh, S & Robertson, GP 2017, 'Nanoparticle-based celecoxib and plumbagin for the synergistic treatment of melanoma', Molecular cancer therapeutics, vol. 16, no. 3, pp. 440-452. https://doi.org/10.1158/1535-7163.MCT-16-0285
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models', Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.
Gowda, R, Sharma, A & Robertson, GP 2017, 'Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth', Cancer Letters, vol. 385, pp. 243-250. https://doi.org/10.1016/j.canlet.2016.10.016

2016

Tan, SF, Liu, X, Fox, TE, Barth, BM, Sharma, A, Turner, SD, Awwad, A, Dewey, A, Doi, K, Spitzer, B, Shah, MV, Morad, SAF, Desai, D, Amin, S, Zhu, J, Liao, J, Yun, J, Kester, M, Claxton, DF, Wang, HG, Cabot, MC, Schuchman, EH, Levine, RL, Feith, DJ & Loughran, TP 2016, 'Acid ceramidase is upregulated in AML and represents a novel therapeutic target', Oncotarget, vol. 7, no. 50, pp. 83208-83222. https://doi.org/10.18632/oncotarget.13079

Clinical Trials Search


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