Researcher Profile

Researcher Profile

Arati Sharma, PhD

Arati Sharma, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Experimental Therapeutics
aks12@psu.edu

Research Interests

Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.

To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.

Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.

  • Melanoma
  • Neoplasms
  • Therapeutics
  • Growth
  • Apoptosis
  • Pharmaceutical Preparations
  • Neoplasm Metastasis
  • Small Interfering RNA
  • Proteins
  • Nanoparticles
  • Mitogen-Activated Protein Kinases
  • Lung

Recent Publications

2019

Kong, Y, Jia, B, Zhao, C, Claxton, D, Sharma, A, Annageldiyev, C, Fotos, J, Zeng, H, Paulson, R, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients' Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Kim, S, Zhang, Y, Tang, S, Qin, C, Karelia, D, Sharma, A, Jiang, C & Lu, J 2019, 'Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice', Prostate, vol. 79, no. 9, pp. 949-960. https://doi.org/10.1002/pros.23802

2018

Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, D, Helm, K, Drabick, J, Robertson, G, Neighbors, J, Hohl, R & Schell, T 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614

2017

Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Kardos, G, Madhunapantula, SRV, Drabick, J & Robertson, G 2018, 'Identification of WEE1 as a target to make AKT inhibition more effective in melanoma', Cancer Biology and Therapy, vol. 19, no. 1, pp. 53-62. https://doi.org/10.1080/15384047.2017.1360446
Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Dinavahi, SS, Kardos, G, Drabick, J & Robertson, G 2017, 'Improving pharmacological targeting of AKT in melanoma', Cancer Letters, vol. 404, pp. 29-36. https://doi.org/10.1016/j.canlet.2017.07.001
Gowda, R, Kardos, G, Sharma, A, Singh, S & Robertson, G 2017, 'Nanoparticle-based celecoxib and plumbagin for the synergistic treatment of melanoma', Molecular cancer therapeutics, vol. 16, no. 3, pp. 440-452. https://doi.org/10.1158/1535-7163.MCT-16-0285
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models' Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.
Gowda, R, Sharma, A & Robertson, G 2017, 'Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth', Cancer Letters, vol. 385, pp. 243-250. https://doi.org/10.1016/j.canlet.2016.10.016

2016

Tan, SF, Liu, X, Fox, TE, Barth, BM, Sharma, A, Turner, SD, Awwad, A, Dewey, A, Doi, K, Spitzer, B, Shah, MV, Morad, SAF, Desai, D, Amin, S, Zhu, J, Liao, JJ, Yun, J, Kester, M, Claxton, D, Wang, H-G, Cabot, MC, Schuchman, EH, Levine, RL, Feith, DJ & Loughran, TP 2016, 'Acid ceramidase is upregulated in AML and represents a novel therapeutic target', Oncotarget, vol. 7, no. 50, pp. 83208-83222. https://doi.org/10.18632/oncotarget.13079

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)