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Arati Sharma, PhD

Arati Sharma, PhD

Professor, Department of Pharmacology
Associate Professor, Department of Pharmacology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Next-Generation Therapies

Research Interests

Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.

To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.

Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.

  • Melanoma
  • Neoplasms
  • Therapeutics
  • Acute Myeloid Leukemia
  • Pharmaceutical Preparations
  • Apoptosis
  • Growth
  • Proteins
  • Ceramides
  • Genes
  • Neoplasm Metastasis
  • Leukemia

Recent Publications


Paudel, BB, Tan, SF, Fox, TE, Ung, J, Golla, U, Shaw, JJP, Dunton, W, Lee, I, Fares, WA, Patel, S, Sharma, A, Viny, AD, Barth, BM, Tallman, MS, Cabot, M, Garrett-Bakelman, FE, Levine, RL, Kester, M, Feith, DJ, Claxton, D, Janes, KA & Loughran, TP 2024, 'Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes', Blood Advances, vol. 8, no. 5, pp. 1137-1142.


Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Taori, M, Horton, BJ, Golla, U, Sharma, A, Szulc, ZM, Wang, H-G, Chalfant, CE, Cabot, MC, Claxton, DF, Loughran, TP & Feith, DJ 2023, 'Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia', Cancers, vol. 15, no. 24, 5866.
Qian, F, Nettleford, SK, Zhou, J, Arner, BE, Hall, MA, Sharma, A, Annageldiyev, C, Rossi, RM, Tukaramrao, DB, Sarkar, D, Hegde, S, Gandhi, UH, Finch, ER, Goodfield, L, Quickel, MD, Claxton, DF, Paulson, RF & Prabhu, KS 2023, 'Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells', Cell Reports, vol. 42, no. 7, 112794.
Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060.
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516.
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571.
Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942.
Fisher-Wellman, KH, Kassai, M, Hagen, JT, Neufer, PD, Kester, M, Loughran, TP, Chalfant, CE, Feith, DJ, Tan, SF, Fox, TE, Ung, J, Fabrias, G, Abad, JL, Sharma, A, Golla, U, Claxton, DF, Shaw, JJP, Bhowmick, D & Cabot, MC 2023, 'Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia', Cancers, vol. 15, no. 6, 1883.


Singh, AP, Luo, H, Matur, M, Eshelman, MA, Hamamoto, K, Sharma, A, Lesperance, J & Huang, S 2022, 'A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling', Oncogene, vol. 41, no. 5, pp. 718-731.
Long, NA, Golla, U, Sharma, A & Claxton, DF 2022, 'Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications', Stem Cell Reviews and Reports, vol. 18, no. 4, pp. 1211-1226.
Khokhlatchev, AV, Sharma, A, Deering, TG, Shaw, JJP, Costa-Pinheiro, P, Golla, U, Annageldiyev, C, Cabot, MC, Conaway, MR, Tan, SF, Ung, J, Feith, DJ, Loughran, TP, Claxton, DF, Fox, TE & Kester, M 2022, 'Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia', FASEB Journal, vol. 36, no. 10, e22514.
Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Vass, LR, Costa-Pinheiro, P, Garrett-Bakelman, FE, Keng, MK, Sharma, A, Claxton, DF, Levine, RL, Tallman, MS, Cabot, MC, Kester, M, Feith, DJ & Loughran, TP 2022, 'Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia', Blood Reviews, vol. 55, 100950.
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328.
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972.


Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889.
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278.
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956.
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21.
Dovat, E, Song, C, Hu, T, Rahman, MA, Dhanyamraju, PK, Klink, M, Bogush, D, Soliman, M, Kane, S, McGrath, M, Ding, Y, Desai, D, Sharma, A & Gowda, C 2021, 'Transcriptional regulation of PIK3CD and PIKFYVE in T-cell acute lymphoblastic leukemia by IKAROS and protein kinase CK2', International journal of molecular sciences, vol. 22, no. 2, 819, pp. 1-14.


Pearson, JM, Tan, SF, Sharma, A, Annageldiyev, C, Fox, TE, Abad, JL, Fabrias, G, Desai, D, Amin, S, Wang, HG, Cabot, MC, Claxton, DF, Kester, M, Feith, DJ & Loughran, TP 2020, 'Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia', Molecular Cancer Research, vol. 18, no. 3, pp. 352-363.
Gebru, MT, Atkinson, JM, Young, MM, Zhang, L, Tang, Z, Liu, Z, Lu, P, Dower, CM, Chen, L, Annageldiyev, C, Sharma, A, Kawasawa, YI, Zhao, Z, Miller, BA, Claxton, DF & Wang, HG 2020, 'Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia', Blood, vol. 136, no. 9, pp. 1067-1079.
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718.
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393.
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696.