Researcher Profile

Researcher Profile

Arun Sharma, PhD

Arun Sharma, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies

Research Interests

The major focus of Dr. Arun Sharma’s lab is the design and development of novel small drug-like molecules as potential cancer therapeutic and preventive agents, and testing them in various in vitro and in vivo cancer models.

This effort has resulted in the development of some potent anti-cancer agents and understanding of their efficacy, toxicity, pharmacokinetics, and mechanisms of action. The main strategies adapted for designing new agents include optimization of

  • naturally occurring agents;
  • existing drugs or agents that fail in clinical trials; and
  • lead compounds obtained from chemical library screening, to enhance potency, bioavailability and therapeutic/chemopreventive index.

An example of natural product optimization includes the development of ISC-4, an isosteric selenium analog of isothiocyanates that occur naturally in cruciferous vegetables. ISC-4 was shown to be a PI3K/Akt pathway inhibitor that effectively inhibited tumor growth in melanoma and colon cancer xenograft models, alone and in combination with standard of care. Further optimization of ISC-4 structure has now led to a dual Akt pathway/topoisomerase II inhibitor NISC-6 as a potential melanoma therapeutic.

Through extensive structure-activity studies based on Selenium-NSAID hybrid molecules, Dr. Sharma’s lab has recently discovered two potent small molecules: Se-Aspirin, published recently and already commercially available; and AS-10, a bis-aspirinyl-selenazolidine analog which has shown great potential as a cancer therapeutic, particularly for pancreatic cancer. p-XS-Asp, another Se-aspirin hybrid molecule developed recently, is orally bioavailable and effective in preventing against NNK induced lung tumorigenesis.

Apart from developing anti-cancer compounds, Dr. Sharma’s lab is also focusing on developing "smart antibiotics." The emphasis is on designing and synthesizing cationic bolaamphiphiles (CABs) as carrier compounds that can transport antisense oligonucleotide (ASO) into C. difficile to selectively target the genetic material in C. difficile.

  • Neoplasms
  • Cell Line
  • Growth
  • Apoptosis
  • Melanoma
  • Cycloaddition Reaction
  • In Vitro Techniques
  • Colorectal Neoplasms
  • Selenium
  • dibenzo(a,l)pyrene
  • Peroxisome Proliferator-Activated Receptors
  • Ligands

Recent Publications


Chen, YC, Dinavahi, SS, Feng, Q, Gowda, R, Ramisetti, S, Xia, X, LaPenna, KB, Chirasani, VR, Cho, SH, Hafenstein, SL, Battu, MB, Berg, A, Sharma, AK, Kirchhausen, T, Dokholyan, NV, Amin, S, He, P & Robertson, GP 2021, 'Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis', Cancer Letters, vol. 506, pp. 107-119.
Lee, S, Slagle-Webb, B, Sharma, AK & Connor, JR 2021, 'Biological activity of a thiobarbituric acid compound in neuroblastomas', Anticancer Research, vol. 41, no. 3, pp. 1171-1181.
Bapat, P, Sewell, DG, Boylan, M, Sharma, AK & Spallholz, JE 2021, 'In vitro cytotoxicity of trastuzumab (Tz) and se-trastuzumab (se-tz) against the her/2 breast cancer cell lines jimt-1 and bt-474', International journal of molecular sciences, vol. 22, no. 9, 4655.
Karelia, DN, Kim, S, Pandey, MK, Plano, D, Amin, S, Lu, J & Sharma, AK 2021, 'Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity', International journal of molecular sciences, vol. 22, no. 9, 4966.


Tyagi, A, Sharma, AK & Damodaran, C 2020, 'A Review on Notch Signaling and Colorectal Cancer', Cells, vol. 9, no. 6.
Tyagi, A, Kolluru, V, Chandrasekaran, B, Saran, U, Sharma, AK, Ankem, MK & Damodaran, C 2020, 'ASR488, a novel small molecule, activates an mRNA binding protein, CPEB1, and inhibits the growth of bladder cancer', Oncology Letters, vol. 20, no. 1, pp. 850-860.
Tyagi, A, Chandrasekaran, B, Kolluru, V, Baby, BV, Sripathi, CA, Ankem, MK, Ramisetti, SR, Chirasani, VR, Dokholyan, NV, Sharma, AK & Damodaran, C 2020, 'ASR490, a small molecule, overrides aberrant expression of notch1 in colorectal cancer', Molecular cancer therapeutics, vol. 19, no. 12, pp. 2422-2431.
Gütschow, M, Eynde, JJV, Jampilek, J, Kang, CB, Mangoni, AA, Fossa, P, Karaman, R, Trabocchi, A, Scott, PJH, Reynisson, J, Rapposelli, S, Galdier, S, Winum, JY, Brullo, C, Prokai-Tatrai, K, Sharma, AK, Schapira, M, Azuma, YT, Cerchia, L, Spete, M, Torri, G, Collina, S, Geronikaki, A, García-Sosa, AT, Helena Vasconcelos, M, Sousa, ME, Kosalec, I, Tuccinardi, T, Duarte, IF, Salvador, JAR, Bertinaria, M, Pellecchia, M, Amato, J, Rastelli, G, Gomes, PAC, Guedes, RC, Sabatier, JM, Estévez-Braun, A, Pagano, B, Mangani, S, Ragno, R, Kokotos, G, Brindisi, M, González, FV, Borges, F, Miloso, M, Rautio, J & Muñoz-Torrero, D 2020, 'Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7', Molecules, vol. 25, no. 13, 2968.
Lee, SY, Slagle-Webb, B, Sharma, AK & Connor, JR 2020, 'Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment', Anticancer Research, vol. 40, no. 11, pp. 6039-6049.
Ruberte, AC, González-Gaitano, G, Sharma, AK, Aydillo, C, Encío, I, Sanmartín, C & Plano, D 2020, 'New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer', International journal of molecular sciences, vol. 21, no. 23, 9017, pp. 1-17.
Gummidi, L, Kerru, N, Awolade, P, Raza, A, Sharma, AK & Singh, P 2020, 'Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents', Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 22, 127544.
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393.
Ruberte, AC, Aydillo, C, Sharma, AK, Sanmartín, C & Plano, D 2020, 'Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity', RSC Advances, vol. 10, no. 63, pp. 38404-38408.


Narayan, S, Ramisetti, S, Jaiswal, AS, Law, BK, Singh-Pillay, A, Singh, P, Amin, S & Sharma, AK 2019, 'ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells', European Journal of Medicinal Chemistry, vol. 161, pp. 456-467.
Ruberte, AC, Sanmartin, C, Aydillo, C, Sharma, AK & Plano, D 2020, 'Development and Therapeutic Potential of Selenazo Compounds', Journal of Medicinal Chemistry, vol. 63, no. 4, pp. 1473-1489.
Frieben, EE, Amin, S & Sharma, AK 2019, 'Development of Isoselenocyanate Compounds' Syntheses and Biological Applications', Journal of Medicinal Chemistry, vol. 62, no. 11, pp. 5261-5275.
Alcolea, V, Karelia, DN, Pandey, MK, Plano, D, Singh, P, Palop, JA, Amin, S, Sanmartín, C & Sharma, AK 2019, 'Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic', International journal of molecular sciences, vol. 20, no. 3, 521.
Fernández-Rubio, C, Larrea, E, Guerrero, JP, Herrero, ES, Gamboa, I, Berrio, C, Plano, D, Amin, S, Sharma, AK & Nguewa, PA 2019, 'Leishmanicidal activity of isoselenocyanate derivatives', Antimicrobial agents and chemotherapy, vol. 63, no. 2, e00904-18.


Sharma, AK, Krzeminski, J, Weissig, V, Hegarty, JP & Stewart, DB 2018, 'Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile', Journal of Antibiotics, vol. 71, no. 8, pp. 713-721.
Ruberte, AC, Plano, D, Encío, I, Aydillo, C, Sharma, AK & Sanmartín, C 2018, 'Novel selenadiazole derivatives as selective antitumor and radical scavenging agents', European Journal of Medicinal Chemistry, vol. 157, pp. 14-27.
Wu, W, Karelia, D, Pramanik, K, Amin, S, Sharma, A, Jiang, C & Lu, J 2018, 'Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells', Molecular Carcinogenesis, vol. 57, no. 8, pp. 1055-1066.
Pal, D, Tyagi, A, Chandrasekaran, B, Alattasi, H, Ankem, MK, Sharma, AK & Damodaran, C 2018, 'Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer', Cell Death and Disease, vol. 9, no. 8, 798.
Chandrasekaran, B, Pal, D, Kolluru, V, Tyagi, A, Baby, B, Dahiya, NR, Youssef, K, Alatassi, H, Ankem, MK, Sharma, AK & Damodaran, C 2018, 'The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models', Carcinogenesis, vol. 39, no. 12, pp. 1537-1547.


Ramisetti, SR, Oña-Ruales, JO, Wise, SA, Amin, S & Sharma, AK 2020, 'An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract', Polycyclic Aromatic Compounds, vol. 40, no. 1, pp. 88-98.
Ramisetti, SR, Pandey, MK, Lee, S, Karelia, D, Narayan, S, Amin, S & Sharma, A 2018, 'Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells', European Journal of Medicinal Chemistry, vol. 143, pp. 1919-1930.
Karelia, DN, Sk, UH, Singh, P, Gowda, ASP, Pandey, MK, Ramisetti, SR, Amin, S & Sharma, A 2017, 'Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity', European Journal of Medicinal Chemistry, vol. 135, pp. 282-295.
Plano, D, Alcolea, V, Sanmartín, C & Sharma, AK 2017, 'Methods of selecting combination therapy for colorectal cancer patients: a patent evaluation of US20160025730A1', Expert Opinion on Therapeutic Patents, vol. 27, no. 5, pp. 527-538.
Chandrasekaran, B, Tyagi, A, Sharma, AK, Cai, L, Ankem, M & Damodaran, C 2017, 'Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer', Genes and Cancer, vol. 8, no. 9-10, pp. 713-724.
Narayan, S, Jaiswal, AS, Sharma, R, Nawab, A, Duckworth, LV, Law, BK, Zajac-Kaye, M, George, TJ, Sharma, J, Sharma, AK & Hromas, RA 2017, 'NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations', Oncotarget, vol. 8, no. 34, pp. 57246-57264.
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models', Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121. <;year=2017;volume=3;issue=4;spage=109;epage=121;aulast=Hengst;type=0>

Clinical Trials Search

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Adults (age >= 18 years)