Researcher Profile

Researcher Profile

Andrew Fraser Read, PhD

Andrew Fraser Read, PhD

Center for Infectious Disease Dynamics
Evan Pugh Professor of Biology and Entomology, Biology
Professor of Biotechnology, Eberly College of Science
Scientific Program:Next-Generation Therapies
afr3@psu.edu

Research Interests

  • Malaria
  • Parasites
  • Infection
  • Virulence
  • Culicidae
  • Rodentia
  • Plasmodium chabaudi
  • Pharmaceutical Preparations
  • Population
  • Clone Cells
  • Drug Resistance
  • Immunity

Recent Publications

2020

Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9. https://doi.org/10.7554/eLife.58147
Hansen, E, Karslake, J, Woods, RJ, Read, AF & Wood, KB 2020, 'Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations', PLoS biology, vol. 18, no. 5, e3000713. https://doi.org/10.1371/journal.pbio.3000713
Hansen, E & Read, AF 2020, 'Cancer therapy: Attempt cure or manage drug resistance?', Evolutionary Applications, vol. 13, no. 7, pp. 1660-1672. https://doi.org/10.1111/eva.12994
Kinnear, CL, Hansen, E, Morley, VJ, Tracy, KC, Forstchen, M, Read, AF & Woods, RJ 2020, 'Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium', PLoS biology, vol. 18, no. 12, pp. e3000987. https://doi.org/10.1371/journal.pbio.3000987
Greischar, MA, Alexander, HK, Bashey, F, Bento, AI, Bhattacharya, A, Bushman, M, Childs, LM, Daversa, DR, Day, T, Faust, CL, Gallagher, ME, Gandon, S, Glidden, CK, Halliday, FW, Hanley, KA, Kamiya, T, Read, AF, Schwabl, P, Sweeny, AR, Tate, AT, Thompson, RN, Wale, N, Wearing, HJ, Yeh, PJ & Mideo, N 2020, 'Evolutionary consequences of feedbacks between within-host competition and disease control', Evolution, Medicine and Public Health, vol. 2020, no. 1, pp. 30-34. https://doi.org/10.1093/emph/eoaa004
Morley, VJ, Firgens, EPC, Vanderbilt, RR, Zhou, Y, Zook, M, Read, AF & MacGeorge, EL 2020, 'Factors associated with antibiotic prescribing for acute bronchitis at a university health center', BMC Infectious Diseases, vol. 20, no. 1, 177. https://doi.org/10.1186/s12879-020-4825-2
Hansen, E & Read, AF 2020, 'Modifying adaptive therapy to enhance competitive suppression', Cancers, vol. 12, no. 12, 3556, pp. 1-13. https://doi.org/10.3390/cancers12123556
Sutcliffe, J, McLaughlin, R, Webster, G, Read, AF, Drlica, K, Elliott, R & Stuart, I 2020, 'Susceptibility of Cutibacterium acnes to topical minocycline foam', Anaerobe, vol. 62, 102169. https://doi.org/10.1016/j.anaerobe.2020.102169

2019

Morley, VJ, Woods, RJ & Read, AF 2019, 'Bystander Selection for Antimicrobial Resistance: Implications for Patient Health', Trends in Microbiology, vol. 27, no. 10, pp. 864-877. https://doi.org/10.1016/j.tim.2019.06.004
Kinnear, CL, Patel, TS, Young, CL, Marshall, V, Newton, DW, Read, AF & Woods, RJ 2019, 'Impact of an antimicrobial stewardship intervention on within- and between-patient daptomycin resistance evolution in vancomycin-resistant enterococcus faecium', Antimicrobial agents and chemotherapy, vol. 63, no. 4, e01800-18. https://doi.org/10.1128/AAC.01800-18
Kerr, PJ, Eden, JS, Di Giallonardo, F, Peacock, D, Liu, J, Strive, T, Read, AF & Holmes, EC 2019, 'Punctuated evolution of myxoma virus: Rapid and disjunct evolution of a recent viral lineage in Australia', Journal of virology, vol. 93, no. 8, Y. https://doi.org/10.1128/JVI.01994-18
Wale, N, Jones, MJ, Sim, DG, Read, AF & King, AA 2019, 'The contribution of host cell-directed vs. Parasite-directed immunity to the disease and dynamics of malaria infections', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 44, pp. 22386-22392. https://doi.org/10.1073/pnas.1908147116
Richardson, LA, Schmid, SL, Bhandoola, A, Harly, C, Hedenström, A, Laub, MT, Mace, GM, Sengupta, P, Stock, AM, Read, AF, Malik, HS, Estelle, M, Lowell, S & Kimmelman, J 2019, 'The plos biology xv collection: 15 years of exceptional science highlighted across 12 months', PLoS biology, vol. 17, no. 2, e3000180. https://doi.org/10.1371/journal.pbio.3000180
Chanderraj, R, Millar, JA, Patel, TS, Read, AF, Washer, L, Kaye, KS & Woods, RJ 2019, 'Vancomycin-resistant enterococcus acquisition in a tertiary care hospital: Testing the roles of antibiotic use, proton pump inhibitor use, and colonization pressure', Open Forum Infectious Diseases, vol. 6, no. 4. https://doi.org/10.1093/ofid/ofz139

2018

Woods, RJ, Patel, TS, Nagel, JL, Newton, DW & Read, AF 2018, 'Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections', Infection Control and Hospital Epidemiology, vol. 39, no. 2, pp. 226-228. https://doi.org/10.1017/ice.2017.279
Kennedy, DA, Dunn, PA & Read, AF 2018, 'Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution', Epidemics, vol. 23, pp. 85-95. https://doi.org/10.1016/j.epidem.2018.01.001
Huijben, S, Chan, BHK, Nelson, WA & Read, AF 2018, 'The impact of within-host ecology on the fitness of a drug-resistant parasite', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137. https://doi.org/10.1093/emph/eoy016
De Moraes, CM, Wanjiku, C, Stanczyk, NM, Pulido, H, Sims, JW, Betz, HS, Read, AF, Torto, B & Mescher, MC 2018, 'Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5780-5785. https://doi.org/10.1073/pnas.1801512115
Kennedy, DA & Read, AF 2018, 'Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12878-12886. https://doi.org/10.1073/pnas.1717159115

2017

Ssentongo, P, Robuccio, AE, Thuku, G, Sim, DG, Nabi, A, Bahari, F, Shanmugasundaram, B, Billard, MW, Geronimo, A, Short, KW, Drew, PJ, Baccon, J, Weinstein, SL, Gilliam, FG, Stoute, JA, Chinchilli, VM, Read, AF, Gluckman, BJ & Schiff, SJ 2017, 'A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection', Scientific reports, vol. 7, 43652. https://doi.org/10.1038/srep43652
Wale, N, Sim, DG & Read, AF 2017, 'A nutrient mediates intraspecific competition between rodent malaria parasites in vivo', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1859, 20171067. https://doi.org/10.1098/rspb.2017.1067
Read, AF & Kerr, PJ 2017, 'Do pathogens gain virulence as hosts become more resistant?', Scientist, vol. 31, no. 10.
Read, AF 2017, Ecology, Evolution, and the Cancer Patient. in Ecology and Evolution of Cancer. Elsevier Inc., pp. 255-257. https://doi.org/10.1016/B978-0-12-804310-3.00023-5
Kerr, PJ, Cattadori, IM, Rogers, MB, Fitch, A, Geber, A, Liu, J, Sim, DG, Boag, B, Eden, JS, Ghedin, E, Read, AF & Holmes, EC 2017, 'Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia', PLoS pathogens, vol. 13, no. 3, e1006252. https://doi.org/10.1371/journal.ppat.1006252
Hansen, E, Woods, RJ & Read, AF 2017, 'How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient', PLoS biology, vol. 15, no. 2, e2001110. https://doi.org/10.1371/journal.pbio.2001110
Kennedy, DA, Cairns, C, Jones, MJ, Bell, AS, Salathé, RM, Baigent, SJ, Nair, VK, Dunn, PA & Read, AF 2017, 'Industry-Wide Surveillance of Marek's Disease Virus on Commercial Poultry Farms', Avian diseases, vol. 61, no. 2, pp. 153-164. https://doi.org/10.1637/11525-110216-Reg.1
Kerr, PJ, Cattadori, IM, Liu, J, Sim, DG, Dodds, JW, Brooks, JW, Kennett, MJ, Holmes, EC & Read, AF 2017, 'Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9397-9402. https://doi.org/10.1073/pnas.1710336114
Wale, N, Sim, DG, Jones, MJ, Salathe, R, Day, T & Read, AF 2017, 'Resource limitation prevents the emergence of drug resistance by intensifying within-host competition', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 52, pp. 13774-13779. https://doi.org/10.1073/pnas.1715874115
Liu, J, Cattadori, IM, Sim, DG, Eden, JS, Holmes, EC, Read, AF & Kerr, PJ 2017, 'Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field', Journal of virology, vol. 91, no. 20, e01289-17. https://doi.org/10.1128/JVI.01289-17
Beck-Johnson, LM, Nelson, WA, Paaijmans, KP, Read, A, Thomas, MB & Bjørnstad, ON 2017, 'The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk', Royal Society Open Science, vol. 4, no. 3, 160969. https://doi.org/10.1098/rsos.160969
Read, AF 2017, 'The selfish germ', PLoS biology, vol. 15, no. 7, e2003250. https://doi.org/10.1371/journal.pbio.2003250
Kennedy, DA & Read, AF 2017, 'Why does drug resistance readily evolve but vaccine resistance does not?', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1851, 20162562. https://doi.org/10.1098/rspb.2016.2562

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