Researcher Profile

Researcher Profile

Andrew Fraser Read, PhD

Andrew Fraser Read, PhD

Evan Pugh Professor of Biology and Entomology, Biology
Professor of Biotechnology, Eberly College of Science
Scientific Program:Next-Generation Therapies

Research Interests

  • Malaria
  • Parasites
  • Infection
  • Virulence
  • Culicidae
  • Rodentia
  • Plasmodium chabaudi
  • Pharmaceutical Preparations
  • Population
  • Clone Cells
  • Drug Resistance
  • Immunity

Recent Publications


Hansen, E, Karslake, J, Woods, RJ, Read, AF & Wood, KB 2020, 'Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations', PLoS biology, vol. 18, no. 5, e3000713.
Greischar, MA, Alexander, HK, Bashey, F, Bento, AI, Bhattacharya, A, Bushman, M, Childs, LM, Daversa, DR, Day, T, Faust, CL, Gallagher, ME, Gandon, S, Glidden, CK, Halliday, FW, Hanley, KA, Kamiya, T, Read, AF, Schwabl, P, Sweeny, AR, Tate, AT, Thompson, RN, Wale, N, Wearing, HJ, Yeh, PJ & Mideo, N 2020, 'Evolutionary consequences of feedbacks between within-host competition and disease control', Evolution, Medicine and Public Health, vol. 2020, no. 1, pp. 30-34.
Morley, VJ, Firgens, EPC, Vanderbilt, RR, Zhou, Y, Zook, M, Read, AF & MacGeorge, EL 2020, 'Factors associated with antibiotic prescribing for acute bronchitis at a university health center', BMC Infectious Diseases, vol. 20, no. 1, 177.
Sutcliffe, J, McLaughlin, R, Webster, G, Read, AF, Drlica, K, Elliott, R & Stuart, I 2020, 'Susceptibility of Cutibacterium acnes to topical minocycline foam', Anaerobe, vol. 62, 102169.


Morley, VJ, Woods, RJ & Read, AF 2019, 'Bystander Selection for Antimicrobial Resistance: Implications for Patient Health', Trends in Microbiology, vol. 27, no. 10, pp. 864-877.
Kinnear, CL, Patel, TS, Young, CL, Marshall, V, Newton, DW, Read, AF & Woods, RJ 2019, 'Impact of an antimicrobial stewardship intervention on within- and between-patient daptomycin resistance evolution in vancomycin-resistant enterococcus faecium', Antimicrobial agents and chemotherapy, vol. 63, no. 4, e01800-18.
Kerr, PJ, Eden, JS, Di Giallonardo, F, Peacock, D, Liu, J, Strive, T, Read, AF & Holmes, EC 2019, 'Punctuated evolution of myxoma virus: Rapid and disjunct evolution of a recent viral lineage in Australia', Journal of virology, vol. 93, no. 8, Y.
Wale, N, Jones, MJ, Sim, DG, Read, AF & King, AA 2019, 'The contribution of host cell-directed vs. Parasite-directed immunity to the disease and dynamics of malaria infections', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 44, pp. 22386-22392.
Richardson, LA, Schmid, SL, Bhandoola, A, Harly, C, Hedenström, A, Laub, MT, Mace, GM, Sengupta, P, Stock, AM, Read, AF, Malik, HS, Estelle, M, Lowell, S & Kimmelman, J 2019, 'The plos biology xv collection: 15 years of exceptional science highlighted across 12 months', PLoS biology, vol. 17, no. 2, e3000180.
Chanderraj, R, Millar, JA, Patel, TS, Read, AF, Washer, L, Kaye, KS & Woods, RJ 2019, 'Vancomycin-resistant enterococcus acquisition in a tertiary care hospital: Testing the roles of antibiotic use, proton pump inhibitor use, and colonization pressure', Open Forum Infectious Diseases, vol. 6, no. 4.


Woods, RJ, Patel, TS, Nagel, JL, Newton, DW & Read, AF 2018, 'Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections', Infection Control and Hospital Epidemiology, vol. 39, no. 2, pp. 226-228.
Kennedy, DA, Dunn, PA & Read, AF 2018, 'Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution', Epidemics, vol. 23, pp. 85-95.
Huijben, S, Chan, BHK, Nelson, WA & Read, AF 2018, 'The impact of within-host ecology on the fitness of a drug-resistant parasite', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137.
De Moraes, CM, Wanjiku, C, Stanczyk, NM, Pulido, H, Sims, JW, Betz, HS, Read, AF, Torto, B & Mescher, MC 2018, 'Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5780-5785.
Kennedy, DA & Read, AF 2018, 'Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12878-12886.


Ssentongo, P, Robuccio, AE, Thuku, G, Sim, DG, Nabi, A, Bahari, F, Shanmugasundaram, B, Billard, MW, Geronimo, A, Short, KW, Drew, PJ, Baccon, J, Weinstein, SL, Gilliam, FG, Stoute, JA, Chinchilli, VM, Read, AF, Gluckman, BJ & Schiff, SJ 2017, 'A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection', Scientific reports, vol. 7, 43652.
Wale, N, Sim, DG & Read, AF 2017, 'A nutrient mediates intraspecific competition between rodent malaria parasites in vivo', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1859, 20171067.
Read, AF & Kerr, PJ 2017, 'Do pathogens gain virulence as hosts become more resistant?', Scientist, vol. 31, no. 10.
Read, AF 2017, Ecology, Evolution, and the Cancer Patient. in Ecology and Evolution of Cancer. Elsevier Inc., pp. 255-257.
Kerr, PJ, Cattadori, IM, Rogers, MB, Fitch, A, Geber, A, Liu, J, Sim, DG, Boag, B, Eden, JS, Ghedin, E, Read, AF & Holmes, EC 2017, 'Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia', PLoS pathogens, vol. 13, no. 3, e1006252.
Hansen, E, Woods, RJ & Read, AF 2017, 'How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient', PLoS biology, vol. 15, no. 2, e2001110.
Kennedy, DA, Cairns, C, Jones, MJ, Bell, AS, Salathé, RM, Baigent, SJ, Nair, VK, Dunn, PA & Read, AF 2017, 'Industry-Wide Surveillance of Marek's Disease Virus on Commercial Poultry Farms', Avian diseases, vol. 61, no. 2, pp. 153-164.
Kerr, PJ, Cattadori, IM, Liu, J, Sim, DG, Dodds, JW, Brooks, JW, Kennett, MJ, Holmes, EC & Read, AF 2017, 'Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9397-9402.
Wale, N, Sim, DG, Jones, MJ, Salathe, R, Day, T & Read, AF 2017, 'Resource limitation prevents the emergence of drug resistance by intensifying within-host competition', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 52, pp. 13774-13779.
Liu, J, Cattadori, IM, Sim, DG, Eden, JS, Holmes, EC, Read, AF & Kerr, PJ 2017, 'Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field', Journal of virology, vol. 91, no. 20, e01289-17.
Beck-Johnson, LM, Nelson, WA, Paaijmans, KP, Read, A, Thomas, MB & Bjørnstad, ON 2017, 'The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk', Royal Society Open Science, vol. 4, no. 3, 160969.
Read, AF 2017, 'The selfish germ', PLoS biology, vol. 15, no. 7, e2003250.
Kennedy, DA & Read, AF 2017, 'Why does drug resistance readily evolve but vaccine resistance does not?', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1851, 20162562.


Mideo, N, Bailey, JA, Hathaway, NJ, Ngasala, B, Saunders, DL, Lon, C, Kharabora, O, Jamnik, A, Balasubramanian, S, Bj�rkman, A, M�rtensson, A, Meshnick, SR, Read, AF & Juliano, JJ 2016, 'A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections', Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 21-36.
Pandey, U, Bell, AS, Renner, DW, Kennedy, DA, Shreve, JT, Cairns, CL, Jones, MJ, Dunn, PA, Read, AF & Szpara, ML 2016, 'DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples', mSphere, vol. 1, no. 5, e00132-16.
Day, T & Read, AF 2016, 'Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?', PLoS computational biology, vol. 12, no. 1, e1004689.
Ohm, JR, Teeple, J, Nelson, WA, Thomas, MB, Read, AF & Cator, LJ 2016, 'Fitness consequences of altered feeding behavior in immune-challenged mosquitoes', Parasites and Vectors, vol. 9, no. 1, 113.
Read, AF, Bentley, GR & Haig, D 2016, 'George C Williams Prize 2015', Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 212-213.
Kennedy, DA, Kurath, G, Brito, IL, Purcell, MK, Read, AF, Winton, JR & Wargo, AR 2016, 'Potential drivers of virulence evolution in aquaculture', Evolutionary Applications, vol. 9, no. 2, pp. 344-354.
Greischar, MA, Mideo, N, Read, AF & Bjørnstad, ON 2016, 'Predicting optimal transmission investment in malaria parasites', Evolution; international journal of organic evolution, vol. 70, no. 7, pp. 1542-1558.
Greischar, MA, Mideo, N, Read, AF & Bjørnstad, ON 2016, 'Quantifying Transmission Investment in Malaria Parasites', PLoS computational biology, vol. 12, no. 2, e1004718.
Thomas, MB & Read, AF 2016, 'The threat (or not) of insecticide resistance for malaria control', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 32, pp. 8900-8902.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)