Researcher Profile

Researcher Profile

Andrew Fraser Read, PhD

Andrew Fraser Read, PhD

Evan Pugh Professor of Biology and Entomology, Biology
Professor of Biotechnology, Eberly College of Science
Scientific Program:Experimental Therapeutics

Research Interests

  • Malaria
  • Parasites
  • Infection
  • Virulence
  • Culicidae
  • Plasmodium chabaudi
  • Rodentia
  • Pharmaceutical Preparations
  • Population
  • Clone Cells
  • Drug Resistance
  • Immunity

Recent Publications


Morley, VJ, Woods, RJ & Read, AF 2019, 'Bystander Selection for Antimicrobial Resistance: Implications for Patient Health', Trends in Microbiology.
Kinnear, CL, Patel, TS, Young, CL, Marshall, V, Newton, DW, Read, AF & Woods, RJ 2019, 'Impact of an antimicrobial stewardship intervention on within- and between-patient daptomycin resistance evolution in vancomycin-resistant enterococcus faecium' Antimicrobial agents and chemotherapy.
Kerr, PJ, Eden, JS, Di Giallonardo, F, Peacock, D, Liu, J, Strive, T, Read, AF & Holmes, EC 2019, 'Punctuated evolution of myxoma virus: Rapid and disjunct evolution of a recent viral lineage in Australia', Journal of virology, vol. 93, no. 8, Y.
Richardson, LA, Schmid, SL, Bhandoola, A, Harly, C, Hedenström, A, Laub, MT, Mace, GM, Sengupta, P, Stock, AM, Read, AF, Malik, HS, Estelle, M, Lowell, S & Kimmelman, J 2019, 'The plos biology xv collection: 15 years of exceptional science highlighted across 12 months', PLoS biology, vol. 17, no. 2, e3000180.
Chanderraj, R, Millar, JA, Patel, TS, Read, AF, Washer, L, Kaye, KS & Woods, RJ 2019, 'Vancomycin-resistant enterococcus acquisition in a tertiary care hospital: Testing the roles of antibiotic use, proton pump inhibitor use, and colonization pressure', Open Forum Infectious Diseases, vol. 6, no. 4.


Woods, RJ, Patel, TS, Nagel, JL, Newton, DW & Read, AF 2018, 'Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections', Infection Control and Hospital Epidemiology, vol. 39, no. 2, pp. 226-228.
Kennedy, DA, Dunn, P & Read, AF 2018, 'Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution', Epidemics, vol. 23, pp. 85-95.
Huijben, S, Chan, BHK, Nelson, WA & Read, AF 2018, 'The impact of within-host ecology on the fitness of a drug-resistant parasite', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137.
De Moraes, CM, Wanjiku, C, Stanczyk, NM, Pulido, H, Sims, JW, Betz, HS, Read, AF, Torto, B & Mescher, MC 2018, 'Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5780-5785.
Kennedy, DA & Read, AF 2018, 'Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12878-12886.


Ssentongo, P, Robuccio, AE, Thuku, G, Sim, DG, Nabi, A, Bahari, F, Shanmugasundaram, B, Billard, MW, Geronimo, A, Short, KW, Drew, PJ, Baccon, J, Weinstein, SL, Gilliam, FG, Stoute, J, Chinchilli, V, Read, AF, Gluckman, B & Schiff, S 2017, 'A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection', Scientific reports, vol. 7, 43652.
Wale, N, Sim, DG & Read, AF 2017, 'A nutrient mediates intraspecific competition between rodent malaria parasites in vivo', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1859, 20171067.
Read, AF & Kerr, PJ 2017, 'Do pathogens gain virulence as hosts become more resistant?' Scientist, vol. 31, no. 10.
Read, AF 2017, Ecology, Evolution, and the Cancer Patient. in Ecology and Evolution of Cancer. Elsevier Inc., pp. 255-257.
Kerr, PJ, Cattadori, I, Rogers, MB, Fitch, A, Geber, A, Liu, J, Sim, DG, Boag, B, Eden, JS, Ghedin, E, Read, AF & Holmes, EC 2017, 'Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia', PLoS pathogens, vol. 13, no. 3, e1006252.
Hansen, EK, Woods, RJ & Read, AF 2017, 'How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient', PLoS Biology, vol. 15, no. 2, e2001110.
Kennedy, DA, Cairns, C, Jones, MJ, Bell, AS, Salathé, RM, Baigent, SJ, Nair, VK, Dunn, P & Read, AF 2017, 'Industry-Wide Surveillance of Marek's Disease Virus on Commercial Poultry Farms', Avian diseases, vol. 61, no. 2, pp. 153-164.
Kerr, PJ, Cattadori, I, Liu, J, Sim, DG, Dodds, J, Brooks, JW, Kennett, MJ, Holmes, EC & Read, AF 2017, 'Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9397-9402.
Wale, N, Sim, DG, Jones, MJ, Salathe, R, Day, T & Read, AF 2017, 'Resource limitation prevents the emergence of drug resistance by intensifying within-host competition', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 52, pp. 13774-13779.
Liu, J, Cattadori, I, Sim, DG, Eden, JS, Holmes, EC, Read, AF & Kerr, PJ 2017, 'Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field', Journal of virology, vol. 91, no. 20, e01289-17.
Beck-Johnson, LM, Nelson, WA, Paaijmans, KP, Read, AF, Thomas, MB & Bjornstad, ON 2017, 'The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk', Royal Society Open Science, vol. 4, no. 3, 160969.
Read, AF 2017, 'The selfish germ' PLoS Biology, vol. 15, no. 7, e2003250.
Kennedy, DA & Read, AF 2017, 'Why does drug resistance readily evolve but vaccine resistance does not?', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1851, 20162562.


Mideo, N, Bailey, JA, Hathaway, NJ, Ngasala, B, Saunders, DL, Lon, C, Kharabora, O, Jamnik, A, Balasubramanian, S, Bj�rkman, A, M�rtensson, A, Meshnick, SR, Read, AF & Juliano, JJ 2016, 'A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections', Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 21-36.
Pandey, U, Bell, AS, Renner, DW, Kennedy, DA, Shreve, JT, Cairns, CL, Jones, MJ, Dunn, P, Read, AF & Szpara, ML 2016, 'DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples', mSphere, vol. 1, no. 5, e00132-16.
Day, T & Read, AF 2016, 'Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?', PLoS computational biology, vol. 12, no. 1, e1004689.
Ohm, JR, Teeple, J, Nelson, WA, Thomas, MB, Read, AF & Cator, LJ 2016, 'Fitness consequences of altered feeding behavior in immune-challenged mosquitoes', Parasites and Vectors, vol. 9, no. 1, 113.
Read, AF, Bentley, GR & Haig, D 2016, 'George C Williams Prize 2015' Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 212-213.
Kennedy, DA, Kurath, G, Brito, IL, Purcell, MK, Read, AF, Winton, JR & Wargo, AR 2016, 'Potential drivers of virulence evolution in aquaculture', Evolutionary Applications, vol. 9, no. 2, pp. 344-354.
Greischar, MA, Mideo, N, Read, AF & Bjornstad, ON 2016, 'Predicting optimal transmission investment in malaria parasites', Evolution; international journal of organic evolution, vol. 70, no. 7, pp. 1542-1558.
Greischar, MA, Mideo, N, Read, AF & Bjornstad, ON 2016, 'Quantifying Transmission Investment in Malaria Parasites', PLoS computational biology, vol. 12, no. 2, e1004718.
Thomas, MB & Read, AF 2016, 'The threat (or not) of insecticide resistance for malaria control', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 32, pp. 8900-8902.


Kennedy, DA, Dunn, JR, Dunn, P & Read, AF 2015, 'An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America', Preventive Veterinary Medicine, vol. 120, no. 3-4, pp. 328-335.
Smith, RA, M’ikanatha, NM & Read, AF 2015, 'Antibiotic Resistance: A Primer and Call to Action', Health Communication, vol. 30, no. 3, pp. 309-314.
Woods, RJ & Read, AF 2015, 'Clinical management of resistance evolution in a bacterial infection: A case study', Evolution, Medicine and Public Health, vol. 2015, no. 1, eov025, pp. 281-288.
Pollitt, LC, Bram, JT, Blanford, S, Jones, MJ & Read, AF 2015, 'Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector', PLoS pathogens, vol. 11, no. 7, e1005003.
Cator, LJ, Pietri, JE, Murdock, CC, Ohm, JR, Lewis, EE, Read, AF, Luckhart, S & Thomas, MB 2015, 'Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential' Scientific reports, vol. 5, 11947.
Read, AF, Baigent, SJ, Powers, C, Kgosana, LB, Blackwell, L, Smith, LP, Kennedy, DA, Walkden-Brown, SW & Nair, VK 2015, 'Imperfect vaccination can enhance the transmission of highly virulent pathogens', PLoS Biology, vol. 13, no. 7.
Day, T, Huijben, S & Read, AF 2015, 'Is selection relevant in the evolutionary emergence of drug resistance?', Trends in Microbiology, vol. 23, no. 3, pp. 126-133.
Kerr, PJ, Liu, J, Cattadori, I, Ghedin, E, Read, AF & Holmes, EC 2015, 'Myxoma virus and the leporipoxviruses: An evolutionary paradigm', Viruses, vol. 7, no. 3, pp. 1020-1061.
Carlton, JM, Volkman, SK, Uplekar, S, Hupalo, DN, Pereira Alves, JM, Cui, L, Donnelly, M, Roos, DS, Harb, OS, Acosta, M, Read, AF, Ribolla, PEM, Singh, OP, Valecha, N, Wassmer, SC, Ferreira, M & Escalante, AA 2015, 'Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research' The American journal of tropical medicine and hygiene, vol. 93, no. 3, pp. 87-98.
Huijben, S, Chan, BHK & Read, AF 2015, 'Relevance of undetectably rare resistant malaria parasites in treatment failure: Experimental evidence from Plasmodium chabaudi', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 6, pp. 1214-1221.
Pollitt, LC, Sim, DG, Salathé, R & Read, AF 2015, 'Understanding genetic variation in in vivo tolerance to artesunate: Implications for treatment efficacy and resistance monitoring' Evolutionary Applications, vol. 8, no. 3, pp. 296-304.

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