Researcher Profile

Researcher Profile

Andrew Fraser Read, PhD

Andrew Fraser Read, PhD

Professor of Biotechnology, Eberly College of Science
Evan Pugh Professor of Biology and Entomology, Eberly Professor of Biotechnology, Biology
Center for Infectious Disease Dynamics
Scientific Program:Next-Generation Therapies
afr3@psu.edu

Research Interests

  • Malaria
  • Parasites
  • Infections
  • Virulence
  • Culicidae
  • Rodentia
  • Plasmodium chabaudi
  • Pharmaceutical Preparations
  • Population
  • Clone Cells
  • Drug Resistance
  • Vaccines

Recent Publications

2021

Day, T, Kennedy, DA, Read, AF & McAdams, D 2021, 'The economics of managing evolution', PLoS biology, vol. 19, no. 11, e3001409. https://doi.org/10.1371/journal.pbio.3001409

2020

Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17. https://doi.org/10.7554/eLife.58147
Hansen, E, Karslake, J, Woods, RJ, Read, AF & Wood, KB 2020, 'Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations', PLoS biology, vol. 18, no. 5, e3000713. https://doi.org/10.1371/journal.pbio.3000713
Hansen, E & Read, AF 2020, 'Cancer therapy: Attempt cure or manage drug resistance?', Evolutionary Applications, vol. 13, no. 7, pp. 1660-1672. https://doi.org/10.1111/eva.12994
Kinnear, CL, Hansen, E, Morley, VJ, Tracy, KC, Forstchen, M, Read, AF & Woods, RJ 2020, 'Daptomycin treatment impacts resistance in off-target populations of vancomycin-resistant Enterococcus faecium', PLoS biology, vol. 18, no. 12, pp. e3000987. https://doi.org/10.1371/journal.pbio.3000987
Acosta, MM, Bram, JT, Sim, D & Read, AF 2020, 'Effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model', Evolution, Medicine and Public Health, vol. 2020, no. 1, pp. 196-210. https://doi.org/10.1093/EMPH/EOAA016
Greischar, MA, Alexander, HK, Bashey, F, Bento, AI, Bhattacharya, A, Bushman, M, Childs, LM, Daversa, DR, Day, T, Faust, CL, Gallagher, ME, Gandon, S, Glidden, CK, Halliday, FW, Hanley, KA, Kamiya, T, Read, AF, Schwabl, P, Sweeny, AR, Tate, AT, Thompson, RN, Wale, N, Wearing, HJ, Yeh, PJ & Mideo, N 2020, 'Evolutionary consequences of feedbacks between within-host competition and disease control', Evolution, Medicine and Public Health, vol. 2020, no. 1, pp. 30-34. https://doi.org/10.1093/emph/eoaa004
Morley, VJ, Firgens, EPC, Vanderbilt, RR, Zhou, Y, Zook, M, Read, AF & MacGeorge, EL 2020, 'Factors associated with antibiotic prescribing for acute bronchitis at a university health center', BMC Infectious Diseases, vol. 20, no. 1, 177. https://doi.org/10.1186/s12879-020-4825-2
Dujon, AM, Aktipis, A, Alix-Panabières, C, Amend, SR, Boddy, AM, Brown, JS, Capp, JP, DeGregori, J, Ewald, P, Gatenby, R, Gerlinger, M, Giraudeau, M, Hamede, RK, Hansen, E, Kareva, I, Maley, CC, Marusyk, A, McGranahan, N, Metzger, MJ, Nedelcu, AM, Noble, R, Nunney, L, Pienta, KJ, Polyak, K, Pujol, P, Read, AF, Roche, B, Sebens, S, Solary, E, Staňková, K, Swain Ewald, H, Thomas, F & Ujvari, B 2020, 'Identifying key questions in the ecology and evolution of cancer', Evolutionary Applications, vol. 14, no. 4, pp. 877-892. https://doi.org/10.1111/eva.13190
Hansen, E & Read, AF 2020, 'Modifying adaptive therapy to enhance competitive suppression', Cancers, vol. 12, no. 12, 3556, pp. 1-13. https://doi.org/10.3390/cancers12123556
Kennedy, DA, Read, AF & Kennedy, DA 2020, 'Monitor for COVID-19 vaccine resistance evolution during clinical trials', PLoS biology, vol. 18, no. 11, e3001000. https://doi.org/10.1371/journal.pbio.3001000
Sutcliffe, J, McLaughlin, R, Webster, G, Read, AF, Drlica, K, Elliott, R & Stuart, I 2020, 'Susceptibility of Cutibacterium acnes to topical minocycline foam', Anaerobe, vol. 62, 102169. https://doi.org/10.1016/j.anaerobe.2020.102169

2019

Morley, VJ, Woods, RJ & Read, AF 2019, 'Bystander Selection for Antimicrobial Resistance: Implications for Patient Health', Trends in Microbiology, vol. 27, no. 10, pp. 864-877. https://doi.org/10.1016/j.tim.2019.06.004
Kinnear, CL, Patel, TS, Young, CL, Marshall, V, Newton, DW, Read, AF & Woods, RJ 2019, 'Impact of an antimicrobial stewardship intervention on within- and between-patient daptomycin resistance evolution in vancomycin-resistant enterococcus faecium', Antimicrobial agents and chemotherapy, vol. 63, no. 4, e01800-18. https://doi.org/10.1128/AAC.01800-18
Bell, AS, Kennedy, DA, Jones, MJ, Cairns, CL, Pandey, U, Dunn, PA, Szpara, ML & Read, AF 2019, 'Molecular epidemiology of Marek’s disease virus in central Pennsylvania, USA', Virus Evolution, vol. 5, no. 1, vey042. https://doi.org/10.1093/ve/vey042
Kerr, PJ, Eden, JS, Di Giallonardo, F, Peacock, D, Liu, J, Strive, T, Read, AF & Holmes, EC 2019, 'Punctuated evolution of myxoma virus: Rapid and disjunct evolution of a recent viral lineage in Australia', Journal of virology, vol. 93, no. 8, Y. https://doi.org/10.1128/JVI.01994-18
Wale, N, Jones, MJ, Sim, DG, Read, AF & King, AA 2019, 'The contribution of host cell-directed vs. Parasite-directed immunity to the disease and dynamics of malaria infections', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 44, pp. 22386-22392. https://doi.org/10.1073/pnas.1908147116
Richardson, LA, Schmid, SL, Bhandoola, A, Harly, C, Hedenström, A, Laub, MT, Mace, GM, Sengupta, P, Stock, AM, Read, AF, Malik, HS, Estelle, M, Lowell, S & Kimmelman, J 2019, 'The plos biology xv collection: 15 years of exceptional science highlighted across 12 months', PLoS biology, vol. 17, no. 2, e3000180. https://doi.org/10.1371/journal.pbio.3000180
Chanderraj, R, Millar, JA, Patel, TS, Read, AF, Washer, L, Kaye, KS & Woods, RJ 2019, 'Vancomycin-resistant enterococcus acquisition in a tertiary care hospital: Testing the roles of antibiotic use, proton pump inhibitor use, and colonization pressure', Open Forum Infectious Diseases, vol. 6, no. 4. https://doi.org/10.1093/ofid/ofz139

2018

Woods, RJ, Patel, TS, Nagel, JL, Newton, DW & Read, AF 2018, 'Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections', Infection Control and Hospital Epidemiology, vol. 39, no. 2, pp. 226-228. https://doi.org/10.1017/ice.2017.279
Kennedy, DA, Dunn, PA & Read, AF 2018, 'Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution', Epidemics, vol. 23, pp. 85-95. https://doi.org/10.1016/j.epidem.2018.01.001
Huijben, S, Chan, BHK, Nelson, WA & Read, AF 2018, 'The impact of within-host ecology on the fitness of a drug-resistant parasite', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137. https://doi.org/10.1093/emph/eoy016
De Moraes, CM, Wanjiku, C, Stanczyk, NM, Pulido, H, Sims, JW, Betz, HS, Read, AF, Torto, B & Mescher, MC 2018, 'Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5780-5785. https://doi.org/10.1073/pnas.1801512115
Kennedy, DA & Read, AF 2018, 'Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12878-12886. https://doi.org/10.1073/pnas.1717159115

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)