Researcher Profile

Researcher Profile

Andrew Fraser Read, PhD

Andrew Fraser Read, PhD

Evan Pugh Professor of Biology and Entomology, Biology
Professor of Biotechnology, Eberly College of Science
Scientific Program:Experimental Therapeutics
afr3@psu.edu

Research Interests

  • Malaria
  • Parasites
  • Infection
  • Virulence
  • Culicidae
  • Plasmodium chabaudi
  • Rodentia
  • Pharmaceutical Preparations
  • Population
  • Clone Cells
  • Drug Resistance
  • Immunity

Recent Publications

2019

Morley, VJ, Woods, RJ & Read, AF 2019, 'Bystander Selection for Antimicrobial Resistance: Implications for Patient Health', Trends in Microbiology. https://doi.org/10.1016/j.tim.2019.06.004
Kinnear, CL, Patel, TS, Young, CL, Marshall, V, Newton, DW, Read, AF & Woods, RJ 2019, 'Impact of an antimicrobial stewardship intervention on within- and between-patient daptomycin resistance evolution in vancomycin-resistant enterococcus faecium' Antimicrobial agents and chemotherapy. https://doi.org/10.1128/AAC.01800-18
Kerr, PJ, Eden, JS, Di Giallonardo, F, Peacock, D, Liu, J, Strive, T, Read, AF & Holmes, EC 2019, 'Punctuated evolution of myxoma virus: Rapid and disjunct evolution of a recent viral lineage in Australia', Journal of virology, vol. 93, no. 8, Y. https://doi.org/10.1128/JVI.01994-18
Richardson, LA, Schmid, SL, Bhandoola, A, Harly, C, Hedenström, A, Laub, MT, Mace, GM, Sengupta, P, Stock, AM, Read, AF, Malik, HS, Estelle, M, Lowell, S & Kimmelman, J 2019, 'The plos biology xv collection: 15 years of exceptional science highlighted across 12 months', PLoS biology, vol. 17, no. 2, e3000180. https://doi.org/10.1371/journal.pbio.3000180
Chanderraj, R, Millar, JA, Patel, TS, Read, AF, Washer, L, Kaye, KS & Woods, RJ 2019, 'Vancomycin-resistant enterococcus acquisition in a tertiary care hospital: Testing the roles of antibiotic use, proton pump inhibitor use, and colonization pressure', Open Forum Infectious Diseases, vol. 6, no. 4. https://doi.org/10.1093/ofid/ofz139

2018

Woods, RJ, Patel, TS, Nagel, JL, Newton, DW & Read, AF 2018, 'Institution-wide and Within-Patient Evolution of Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium Bloodstream Infections', Infection Control and Hospital Epidemiology, vol. 39, no. 2, pp. 226-228. https://doi.org/10.1017/ice.2017.279
Kennedy, DA, Dunn, P & Read, AF 2018, 'Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution', Epidemics, vol. 23, pp. 85-95. https://doi.org/10.1016/j.epidem.2018.01.001
Huijben, S, Chan, BHK, Nelson, WA & Read, AF 2018, 'The impact of within-host ecology on the fitness of a drug-resistant parasite', Evolution, Medicine and Public Health, vol. 2018, no. 1, pp. 127-137. https://doi.org/10.1093/emph/eoy016
De Moraes, CM, Wanjiku, C, Stanczyk, NM, Pulido, H, Sims, JW, Betz, HS, Read, AF, Torto, B & Mescher, MC 2018, 'Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. 5780-5785. https://doi.org/10.1073/pnas.1801512115
Kennedy, DA & Read, AF 2018, 'Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. 12878-12886. https://doi.org/10.1073/pnas.1717159115

2017

Ssentongo, P, Robuccio, AE, Thuku, G, Sim, DG, Nabi, A, Bahari, F, Shanmugasundaram, B, Billard, MW, Geronimo, A, Short, KW, Drew, PJ, Baccon, J, Weinstein, SL, Gilliam, FG, Stoute, J, Chinchilli, V, Read, AF, Gluckman, B & Schiff, S 2017, 'A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection', Scientific reports, vol. 7, 43652. https://doi.org/10.1038/srep43652
Wale, N, Sim, DG & Read, AF 2017, 'A nutrient mediates intraspecific competition between rodent malaria parasites in vivo', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1859, 20171067. https://doi.org/10.1098/rspb.2017.1067
Read, AF & Kerr, PJ 2017, 'Do pathogens gain virulence as hosts become more resistant?' Scientist, vol. 31, no. 10.
Read, AF 2017, Ecology, Evolution, and the Cancer Patient. in Ecology and Evolution of Cancer. Elsevier Inc., pp. 255-257. https://doi.org/10.1016/B978-0-12-804310-3.00023-5
Kerr, PJ, Cattadori, I, Rogers, MB, Fitch, A, Geber, A, Liu, J, Sim, DG, Boag, B, Eden, JS, Ghedin, E, Read, AF & Holmes, EC 2017, 'Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia', PLoS pathogens, vol. 13, no. 3, e1006252. https://doi.org/10.1371/journal.ppat.1006252
Hansen, EK, Woods, RJ & Read, AF 2017, 'How to Use a Chemotherapeutic Agent When Resistance to It Threatens the Patient', PLoS Biology, vol. 15, no. 2, e2001110. https://doi.org/10.1371/journal.pbio.2001110
Kennedy, DA, Cairns, C, Jones, MJ, Bell, AS, Salathé, RM, Baigent, SJ, Nair, VK, Dunn, P & Read, AF 2017, 'Industry-Wide Surveillance of Marek's Disease Virus on Commercial Poultry Farms', Avian diseases, vol. 61, no. 2, pp. 153-164. https://doi.org/10.1637/11525-110216-Reg.1
Kerr, PJ, Cattadori, I, Liu, J, Sim, DG, Dodds, J, Brooks, JW, Kennett, MJ, Holmes, EC & Read, AF 2017, 'Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. 9397-9402. https://doi.org/10.1073/pnas.1710336114
Wale, N, Sim, DG, Jones, MJ, Salathe, R, Day, T & Read, AF 2017, 'Resource limitation prevents the emergence of drug resistance by intensifying within-host competition', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 52, pp. 13774-13779. https://doi.org/10.1073/pnas.1715874115
Liu, J, Cattadori, I, Sim, DG, Eden, JS, Holmes, EC, Read, AF & Kerr, PJ 2017, 'Reverse engineering field isolates of myxoma virus demonstrates that some gene disruptions or losses of function do not explain virulence changes observed in the field', Journal of virology, vol. 91, no. 20, e01289-17. https://doi.org/10.1128/JVI.01289-17
Beck-Johnson, LM, Nelson, WA, Paaijmans, KP, Read, AF, Thomas, MB & Bjornstad, ON 2017, 'The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk', Royal Society Open Science, vol. 4, no. 3, 160969. https://doi.org/10.1098/rsos.160969
Read, AF 2017, 'The selfish germ' PLoS Biology, vol. 15, no. 7, e2003250. https://doi.org/10.1371/journal.pbio.2003250
Kennedy, DA & Read, AF 2017, 'Why does drug resistance readily evolve but vaccine resistance does not?', Proceedings of the Royal Society B: Biological Sciences, vol. 284, no. 1851, 20162562. https://doi.org/10.1098/rspb.2016.2562

2016

Mideo, N, Bailey, JA, Hathaway, NJ, Ngasala, B, Saunders, DL, Lon, C, Kharabora, O, Jamnik, A, Balasubramanian, S, Bj�rkman, A, M�rtensson, A, Meshnick, SR, Read, AF & Juliano, JJ 2016, 'A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections', Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 21-36. https://doi.org/10.1093/EMPH/EOV036
Pandey, U, Bell, AS, Renner, DW, Kennedy, DA, Shreve, JT, Cairns, CL, Jones, MJ, Dunn, P, Read, AF & Szpara, ML 2016, 'DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples', mSphere, vol. 1, no. 5, e00132-16. https://doi.org/10.1128/mSphere.00132-16
Day, T & Read, AF 2016, 'Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?', PLoS computational biology, vol. 12, no. 1, e1004689. https://doi.org/10.1371/journal.pcbi.1004689
Ohm, JR, Teeple, J, Nelson, WA, Thomas, MB, Read, AF & Cator, LJ 2016, 'Fitness consequences of altered feeding behavior in immune-challenged mosquitoes', Parasites and Vectors, vol. 9, no. 1, 113. https://doi.org/10.1186/s13071-016-1392-x
Read, AF, Bentley, GR & Haig, D 2016, 'George C Williams Prize 2015' Evolution, Medicine and Public Health, vol. 2016, no. 1, pp. 212-213. https://doi.org/10.1093/EMPH/EOW017
Kennedy, DA, Kurath, G, Brito, IL, Purcell, MK, Read, AF, Winton, JR & Wargo, AR 2016, 'Potential drivers of virulence evolution in aquaculture', Evolutionary Applications, vol. 9, no. 2, pp. 344-354. https://doi.org/10.1111/eva.12342
Greischar, MA, Mideo, N, Read, AF & Bjornstad, ON 2016, 'Predicting optimal transmission investment in malaria parasites', Evolution; international journal of organic evolution, vol. 70, no. 7, pp. 1542-1558. https://doi.org/10.1111/evo.12969
Greischar, MA, Mideo, N, Read, AF & Bjornstad, ON 2016, 'Quantifying Transmission Investment in Malaria Parasites', PLoS computational biology, vol. 12, no. 2, e1004718. https://doi.org/10.1371/journal.pcbi.1004718
Thomas, MB & Read, AF 2016, 'The threat (or not) of insecticide resistance for malaria control', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 32, pp. 8900-8902. https://doi.org/10.1073/pnas.1609889113

2015

Kennedy, DA, Dunn, JR, Dunn, P & Read, AF 2015, 'An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America', Preventive Veterinary Medicine, vol. 120, no. 3-4, pp. 328-335. https://doi.org/10.1016/j.prevetmed.2015.04.013
Smith, RA, M’ikanatha, NM & Read, AF 2015, 'Antibiotic Resistance: A Primer and Call to Action', Health Communication, vol. 30, no. 3, pp. 309-314. https://doi.org/10.1080/10410236.2014.943634
Woods, RJ & Read, AF 2015, 'Clinical management of resistance evolution in a bacterial infection: A case study', Evolution, Medicine and Public Health, vol. 2015, no. 1, eov025, pp. 281-288. https://doi.org/10.1093/emph/eov025
Pollitt, LC, Bram, JT, Blanford, S, Jones, MJ & Read, AF 2015, 'Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector', PLoS pathogens, vol. 11, no. 7, e1005003. https://doi.org/10.1371/journal.ppat.1005003
Cator, LJ, Pietri, JE, Murdock, CC, Ohm, JR, Lewis, EE, Read, AF, Luckhart, S & Thomas, MB 2015, 'Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential' Scientific reports, vol. 5, 11947. https://doi.org/10.1038/srep11947
Read, AF, Baigent, SJ, Powers, C, Kgosana, LB, Blackwell, L, Smith, LP, Kennedy, DA, Walkden-Brown, SW & Nair, VK 2015, 'Imperfect vaccination can enhance the transmission of highly virulent pathogens', PLoS Biology, vol. 13, no. 7. https://doi.org/10.5061/dryad.4tn48
Day, T, Huijben, S & Read, AF 2015, 'Is selection relevant in the evolutionary emergence of drug resistance?', Trends in Microbiology, vol. 23, no. 3, pp. 126-133. https://doi.org/10.1016/j.tim.2015.01.005
Kerr, PJ, Liu, J, Cattadori, I, Ghedin, E, Read, AF & Holmes, EC 2015, 'Myxoma virus and the leporipoxviruses: An evolutionary paradigm', Viruses, vol. 7, no. 3, pp. 1020-1061. https://doi.org/10.3390/v7031020
Carlton, JM, Volkman, SK, Uplekar, S, Hupalo, DN, Pereira Alves, JM, Cui, L, Donnelly, M, Roos, DS, Harb, OS, Acosta, M, Read, AF, Ribolla, PEM, Singh, OP, Valecha, N, Wassmer, SC, Ferreira, M & Escalante, AA 2015, 'Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research' The American journal of tropical medicine and hygiene, vol. 93, no. 3, pp. 87-98. https://doi.org/10.4269/ajtmh.15-0049
Huijben, S, Chan, BHK & Read, AF 2015, 'Relevance of undetectably rare resistant malaria parasites in treatment failure: Experimental evidence from Plasmodium chabaudi', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 6, pp. 1214-1221. https://doi.org/10.4269/ajtmh.15-0036
Pollitt, LC, Sim, DG, Salathé, R & Read, AF 2015, 'Understanding genetic variation in in vivo tolerance to artesunate: Implications for treatment efficacy and resistance monitoring' Evolutionary Applications, vol. 8, no. 3, pp. 296-304. https://doi.org/10.1111/eva.12194

Clinical Trials Search


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