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Researcher Profile

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Aron Lukacher, MD, PhD

Aron Lukacher, MD, PhD

Professor and Chair, Department of Microbiology and Immunology
Professor, Department of Pathology and Laboratory Medicine
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • T-Lymphocytes
  • Polyomavirus
  • Infections
  • Viruses
  • Antiviral Agents
  • Virus Diseases
  • Neoplasms
  • Polyomavirus Infections
  • Peptides
  • Immunity
  • Antigens
  • Brain

Recent Publications


Pham, AM, Ortiz, LE, Lukacher, AE & Kwun, HJ 2023, 'Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain', Cells, vol. 12, no. 3, 380.


Lauver, MD, Jin, G, Ayers, KN, Carey, SN, Specht, CS, Abendroth, CS & Lukacher, AE 2022, 'T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus', eLife, vol. 11, e83030.


Netherby-Winslow, CS, Ayers, KN & Lukacher, AE 2021, 'Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TRM Formation and Function', Frontiers in immunology, vol. 11, 624144.
Ren, HM, Lukacher, AE, Rahman, ZSM & Olsen, NJ 2021, 'New developments implicating IL-21 in autoimmune disease', Journal of Autoimmunity, vol. 122, 102689.
Ayers, KN, Carey, SN & Lukacher, AE 2022, 'Understanding polyomavirus CNS disease – a perspective from mouse models', FEBS Journal, vol. 289, no. 19, pp. 5744-5761.


Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68.
Mockus, TE, Netherby-Winslow, CS, Atkins, HM, Lauver, MD, Jin, G, Ren, HM & Lukacher, AE 2020, 'CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy', Journal of virology, vol. 94, no. 8, e02038-19.
Ren, HM, Kolawole, EM, Ren, M, Jin, G, Netherby-Winslow, CS, Wade, Q, Shwetank, , Rahman, ZSM, Evavold, BD & Lukacher, AE 2020, 'IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection', Science Immunology, vol. 5, no. 51, A1.
Ren, HM & Lukacher, AE 2020, 'Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection', International journal of molecular sciences, vol. 21, no. 18, 6966, pp. 1-16.
Lauver, MD & Lukacher, AE 2020, 'JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?', Viruses, vol. 12, no. 10, 1156.
Chodisetti, SB, Fike, AJ, Domeier, PP, Schell, SL, Mockus, TE, Choi, NM, Corradetti, C, Hou, B, Atkins, HM, Caricchio, R, Decker, T, Lukacher, AE, Olsen, N & Rahman, ZSM 2020, 'Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development', Journal of Immunology, vol. 204, no. 10, pp. 2641-2650.


Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors', Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803.
Shwetank, Frost, EL, Mockus, TE, Ren, HM, Toprak, M, Lauver, MD, Netherby-Winslow, CS, Jin, G, Cosby, JM, Evavold, BD & Lukacher, AE 2019, 'PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis', Frontiers in immunology, vol. 10, no. MAR, 783.
Shwetank 2019, 'To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections', Viruses, vol. 11, no. 9.