Researcher Profile

Researcher Profile

Aron Lukacher, MD, PhD

Aron Lukacher, MD, PhD

Professor and Chair, Department of Microbiology and Immunology
Professor, Department of Pathology and Laboratory Medicine
Scientific Program:Mechanisms of Carcinogenesis
ael17@psu.edu

Research Interests

  • T-Lymphocytes
  • Polyomavirus
  • Infections
  • Viruses
  • Antiviral Agents
  • Virus Diseases
  • Neoplasms
  • Polyomavirus Infections
  • Peptides
  • Antigens
  • Immunity
  • Brain

Recent Publications

2021

Netherby-Winslow, CS, Ayers, KN & Lukacher, AE 2021, 'Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TRM Formation and Function', Frontiers in immunology, vol. 11, 624144. https://doi.org/10.3389/fimmu.2020.624144
Ren, HM, Lukacher, A, Rahman, ZSM & Olsen, NJ 2021, 'New developments implicating IL-21 in autoimmune disease', Journal of Autoimmunity, vol. 122, 102689. https://doi.org/10.1016/j.jaut.2021.102689

2020

Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Mockus, TE, Netherby-Winslow, CS, Atkins, HM, Lauver, MD, Jin, G, Ren, HM & Lukacher, AE 2020, 'CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy', Journal of virology, vol. 94, no. 8, e02038-19. https://doi.org/10.1128/JVI.02038-19
Ren, HM, Kolawole, EM, Ren, M, Jin, G, Netherby-Winslow, CS, Wade, Q, Shwetank, , Rahman, ZSM, Evavold, BD & Lukacher, AE 2020, 'IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection', Science Immunology, vol. 5, no. 51, A1. https://doi.org/10.1126/SCIIMMUNOL.ABB5590
Ren, HM & Lukacher, AE 2020, 'Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection', International journal of molecular sciences, vol. 21, no. 18, 6966, pp. 1-16. https://doi.org/10.3390/ijms21186966
Lauver, MD & Lukacher, AE 2020, 'JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?', Viruses, vol. 12, no. 10, 1156. https://doi.org/10.3390/v12101156
Chodisetti, SB, Fike, AJ, Domeier, PP, Schell, SL, Mockus, TE, Choi, NM, Corradetti, C, Hou, B, Atkins, HM, Caricchio, R, Decker, T, Lukacher, AE, Olsen, N & Rahman, ZSM 2020, 'Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development', Journal of Immunology, vol. 204, no. 10, pp. 2641-2650. https://doi.org/10.4049/jimmunol.2000170

2019

Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors', Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803. https://doi.org/10.1016/j.bmc.2019.03.026
Shwetank, Frost, EL, Mockus, TE, Ren, HM, Toprak, M, Lauver, MD, Netherby-Winslow, CS, Jin, G, Cosby, JM, Evavold, BD & Lukacher, AE 2019, 'PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis', Frontiers in immunology, vol. 10, no. MAR, 783. https://doi.org/10.3389/fimmu.2019.00783
Shwetank 2019, 'To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections', Viruses, vol. 11, no. 9. https://doi.org/10.3390/v11090842

2018

Mockus, TE, Shwetank, Lauver, MD, Ren, HM, Netherby, CS, Salameh, T, Kawasawa, YI, Yue, F, Broach, JR & Lukacher, AE 2018, 'CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection', PLoS pathogens, vol. 14, no. 10, e1007365. https://doi.org/10.1371/journal.ppat.1007365
Ward-Kavanagh, LK, Kokolus, KM, Cooper, TK, Lukacher, AE & Schell, TD 2018, 'Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors', Cancer Immunology, Immunotherapy, vol. 67, no. 4, pp. 639-652. https://doi.org/10.1007/s00262-018-2115-2
Braciale, TJ, Lukacher, AE, Sweetser, MT & Braciale, VL 2018, Cytolytic T lymphocyte clones in anti-viral immunity: Effector function in vivo and mechanism of action. in Cytolytic Lymphocytes and Complement Effectors of the Immune System. vol. 2, CRC Press, pp. 161-174. https://doi.org/10.1201/9781351071291

2017

Maru, S, Jin, G, Desai, D, Amin, S, Shwetank, Lauver, MD & Lukacher, AE 2017, 'Inhibition of retrograde transport limits polyomavirus infection in vivo', mSphere, vol. 2, no. 6, e00494-17. https://doi.org/10.1128/mSphere.00494-17
Shwetank, Abdelsamed, HA, Frost, EL, Schmitz, HM, Mockus, TE, Youngblood, BA & Lukacher, AE 2017, 'Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent', Immunology and Cell Biology, vol. 95, no. 10, pp. 953-959. https://doi.org/10.1038/icb.2017.62
Qin, Q, Lauver, M, Maru, S, Lin, E & Lukacher, AE 2017, 'Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells', Virology, vol. 502, pp. 198-205. https://doi.org/10.1016/j.virol.2016.12.028
Maru, S, Jin, G, Schell, TD & Lukacher, AE 2017, 'TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection', PLoS pathogens, vol. 13, no. 4, e1006318. https://doi.org/10.1371/journal.ppat.1006318

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)