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Aron Lukacher, MD, PhD

Aron Lukacher, MD, PhD

Professor and Chair, Department of Microbiology and Immunology
Professor, Department of Pathology and Laboratory Medicine
Scientific Program:Mechanisms of Carcinogenesis
AEL17@psu.edu

Research Interests

  • T-Lymphocytes
  • Polyomavirus
  • Infections
  • Viruses
  • Antiviral Agents
  • Virus Diseases
  • Neoplasms
  • Polyomavirus Infections
  • Peptides
  • Immunity
  • Antigens
  • Brain

Recent Publications

2023

Pham, AM, Ortiz, LE, Lukacher, AE & Kwun, HJ 2023, 'Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain', Cells, vol. 12, no. 3, 380. https://doi.org/10.3390/cells12030380
Butic, AB, Spencer, SA, Shaheen, SK & Lukacher, AE 2023, 'Polyomavirus Wakes Up and Chooses Neurovirulence', Viruses, vol. 15, no. 10, 2112. https://doi.org/10.3390/v15102112

2022

Lauver, MD, Jin, G, Ayers, KN, Carey, SN, Specht, CS, Abendroth, CS & Lukacher, AE 2022, 'T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus', eLife, vol. 11, e83030. https://doi.org/10.7554/ELIFE.83030

2021

Netherby-Winslow, CS, Ayers, KN & Lukacher, AE 2021, 'Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TRM Formation and Function', Frontiers in immunology, vol. 11, 624144. https://doi.org/10.3389/fimmu.2020.624144
Ren, HM, Lukacher, AE, Rahman, ZSM & Olsen, NJ 2021, 'New developments implicating IL-21 in autoimmune disease', Journal of Autoimmunity, vol. 122, 102689. https://doi.org/10.1016/j.jaut.2021.102689
Ayers, KN, Carey, SN & Lukacher, AE 2022, 'Understanding polyomavirus CNS disease – a perspective from mouse models', FEBS Journal, vol. 289, no. 19, pp. 5744-5761. https://doi.org/10.1111/febs.16083

2020

Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Mockus, TE, Netherby-Winslow, CS, Atkins, HM, Lauver, MD, Jin, G, Ren, HM & Lukacher, AE 2020, 'CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy', Journal of virology, vol. 94, no. 8, e02038-19. https://doi.org/10.1128/JVI.02038-19
Ren, HM, Kolawole, EM, Ren, M, Jin, G, Netherby-Winslow, CS, Wade, Q, Shwetank, , Rahman, ZSM, Evavold, BD & Lukacher, AE 2020, 'IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection', Science Immunology, vol. 5, no. 51, A1. https://doi.org/10.1126/SCIIMMUNOL.ABB5590
Ren, HM & Lukacher, AE 2020, 'Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection', International journal of molecular sciences, vol. 21, no. 18, 6966, pp. 1-16. https://doi.org/10.3390/ijms21186966
Lauver, MD & Lukacher, AE 2020, 'JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?', Viruses, vol. 12, no. 10, 1156. https://doi.org/10.3390/v12101156
Chodisetti, SB, Fike, AJ, Domeier, PP, Schell, SL, Mockus, TE, Choi, NM, Corradetti, C, Hou, B, Atkins, HM, Caricchio, R, Decker, T, Lukacher, AE, Olsen, N & Rahman, ZSM 2020, 'Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development', Journal of Immunology, vol. 204, no. 10, pp. 2641-2650. https://doi.org/10.4049/jimmunol.2000170