Researcher Profile

Researcher Profile

Aron Lukacher, MD, PhD

Aron Lukacher, MD, PhD

Professor and Chair, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
ael17@psu.edu

Research Interests

  • T-Lymphocytes
  • Polyomavirus
  • Viruses
  • Antiviral Agents
  • Infection
  • Virus Diseases
  • Neoplasms
  • Polyomavirus Infections
  • Peptides
  • Clone Cells
  • Antigens
  • Immunity

Recent Publications

2019

Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors' Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803. https://doi.org/10.1016/j.bmc.2019.03.026
Shwetank, Frost, EL, Mockus, TE, Ren, HM, Toprak, M, Lauver, MD, Netherby-Winslow, CS, Jin, G, Cosby, JM, Evavold, BD & Lukacher, A 2019, 'PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis' Frontiers in immunology, vol. 10, no. MAR, 783. https://doi.org/10.3389/fimmu.2019.00783

2018

Mockus, TE, Shwetank, Lauver, MD, Ren, HM, Netherby, CS, Salameh, T, Imamura, Y, Yue, F, Broach, J & Lukacher, A 2018, 'CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection', PLoS Pathogens, vol. 14, no. 10, e1007365. https://doi.org/10.1371/journal.ppat.1007365
Ward-Kavanagh, LK, Kokolus, KM, Cooper, TK, Lukacher, A & Schell, T 2018, 'Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors', Cancer Immunology, Immunotherapy, vol. 67, no. 4, pp. 639-652. https://doi.org/10.1007/s00262-018-2115-2
Braciale, TJ, Lukacher, A, Sweetser, MT & Braciale, VL 2018, Cytolytic T lymphocyte clones in anti-viral immunity: Effector function in vivo and mechanism of action. in Cytolytic Lymphocytes and Complement Effectors of the Immune System. vol. 2, CRC Press, pp. 161-174. https://doi.org/10.1201/9781351071291

2017

Maru, S, Jin, G, Desai, D, Amin, S, Shwetank, Lauver, MD & Lukacher, A 2017, 'Inhibition of retrograde transport limits polyomavirus infection in vivo', mSphere, vol. 2, no. 6, e00494-17. https://doi.org/10.1128/mSphere.00494-17
Shwetank, Abdelsamed, HA, Frost, EL, Schmitz, HM, Mockus, TE, Youngblood, BA & Lukacher, A 2017, 'Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent', Immunology and Cell Biology, vol. 95, no. 10, pp. 953-959. https://doi.org/10.1038/icb.2017.62
Qin, Q, Lauver, M, Maru, S, Lin, E & Lukacher, A 2017, 'Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells', Virology, vol. 502, pp. 198-205. https://doi.org/10.1016/j.virol.2016.12.028
Maru, S, Jin, G, Schell, T & Lukacher, A 2017, 'TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection', PLoS Pathogens, vol. 13, no. 4, e1006318. https://doi.org/10.1371/journal.ppat.1006318

2016

Qin, Q, Shwetank, Frost, EL, Maru, S & Lukacher, A 2016, 'Type I interferons regulate the magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a virus strain- dependent manner', Journal of virology, vol. 90, no. 10, pp. 5187-5199. https://doi.org/10.1128/JVI.00199-16

2015

Frost, EL, Kersh, AE, Evavold, BD & Lukacher, A 2015, 'Cutting edge: Resident memory CD8 T cells express high-affinity TCRs', Journal of Immunology, vol. 195, no. 8, pp. 3520-3524. https://doi.org/10.4049/jimmunol.1501521
Soni, C, Domeier, PP, Wong, EB, Shwetank, Khan, TN, Elias, MJ, Schell, SL, Lukacher, A, Cooper, T & Rahman, Z 2015, 'Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity', Journal of Autoimmunity, vol. 63, pp. 31-46. https://doi.org/10.1016/j.jaut.2015.06.011
Badell, IR, Kitchens, WH, Wagener, ME, Lukacher, A, Larsen, CP & Ford, ML 2015, 'Pathogen stimulation history impacts donor-specific CD8+ T cell susceptibility to costimulation/integrin blockade-based therapy' American Journal of Transplantation, vol. 15, no. 12, pp. 3081-3094. https://doi.org/10.1111/ajt.13399
Frost, EL & Lukacher, A 2015, 'The importance of mouse models to define immunovirologic determinants of progressive multifocal leukoencephalopathy' Frontiers in immunology, vol. 6, no. JAN, 00646. https://doi.org/10.3389/fimmu.2014.00646

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