Aron Lukacher, MD, PhD - Penn State Cancer Institute
Researcher Profile
Aron Lukacher, MD, PhD
Professor and Chair, Department of Microbiology and Immunology
Professor, Department of Pathology and Laboratory Medicine
One Health Microbiome Center
Professor, Department of Pathology and Laboratory Medicine
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Butic, AB, Katz, ZE, Jin, G, Fukushima, K, Hazama, M, Lukacher, AE & Lauver, MD 2024, 'Brincidofovir inhibits polyomavirus infection in vivo', mBio, vol. 15, no. 8. https://doi.org/10.1128/mbio.01049-24
2023
Pham, AM, Ortiz, LE, Lukacher, AE & Kwun, HJ 2023, 'Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain', Cells, vol. 12, no. 3, 380. https://doi.org/10.3390/cells12030380
Butic, AB, Spencer, SA, Shaheen, SK & Lukacher, AE 2023, 'Polyomavirus Wakes Up and Chooses Neurovirulence', Viruses, vol. 15, no. 10, 2112. https://doi.org/10.3390/v15102112
2022
Lauver, MD, Jin, G, Ayers, KN, Carey, SN, Specht, CS, Abendroth, CS & Lukacher, AE 2022, 'T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus', eLife, vol. 11, e83030. https://doi.org/10.7554/ELIFE.83030
2021
Netherby-Winslow, CS, Ayers, KN & Lukacher, AE 2021, 'Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TRM Formation and Function', Frontiers in immunology, vol. 11, 624144. https://doi.org/10.3389/fimmu.2020.624144
Ren, HM, Lukacher, AE, Rahman, ZSM & Olsen, NJ 2021, 'New developments implicating IL-21 in autoimmune disease', Journal of Autoimmunity, vol. 122, 102689. https://doi.org/10.1016/j.jaut.2021.102689
Ayers, KN, Carey, SN & Lukacher, AE 2022, 'Understanding polyomavirus CNS disease – a perspective from mouse models', FEBS Journal, vol. 289, no. 19, pp. 5744-5761. https://doi.org/10.1111/febs.16083
2020
Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Mockus, TE, Netherby-Winslow, CS, Atkins, HM, Lauver, MD, Jin, G, Ren, HM & Lukacher, AE 2020, 'CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy', Journal of virology, vol. 94, no. 8, e02038-19. https://doi.org/10.1128/JVI.02038-19
Ren, HM, Kolawole, EM, Ren, M, Jin, G, Netherby-Winslow, CS, Wade, Q, Shwetank, , Rahman, ZSM, Evavold, BD & Lukacher, AE 2020, 'IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection', Science Immunology, vol. 5, no. 51, A1. https://doi.org/10.1126/SCIIMMUNOL.ABB5590
Ren, HM & Lukacher, AE 2020, 'Il-21 in homeostasis of resident memory and exhausted cd8 t cells during persistent infection', International journal of molecular sciences, vol. 21, no. 18, 6966, pp. 1-16. https://doi.org/10.3390/ijms21186966
Lauver, MD & Lukacher, AE 2020, 'JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?', Viruses, vol. 12, no. 10, 1156. https://doi.org/10.3390/v12101156
Chodisetti, SB, Fike, AJ, Domeier, PP, Schell, SL, Mockus, TE, Choi, NM, Corradetti, C, Hou, B, Atkins, HM, Caricchio, R, Decker, T, Lukacher, AE, Olsen, N & Rahman, ZSM 2020, 'Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development', Journal of Immunology, vol. 204, no. 10, pp. 2641-2650. https://doi.org/10.4049/jimmunol.2000170