Aron Lukacher, MD, PhD - Penn State Cancer Institute
Researcher Profile
Aron Lukacher, MD, PhD
Professor, Department of Cell and Biological Systems
Professor, Department of Pathology and Laboratory Medicine
One Health Microbiome Center
Professor, Department of Pathology and Laboratory Medicine
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Alexander, KM, Afanasiev, E, Butic, AB, Jin, G, Abdelmageed, M, Paul, A, Stratton, JA, Lukacher, AE & Spencer, SA 2025, 'CXCR4 and CXCR6 dually limit T cell entry into the polyomavirus-infected brain', Journal of neuroinflammation, vol. 22, no. 1, 169. https://doi.org/10.1186/s12974-025-03496-2
Alexander, KM, Ayers, KN & Lukacher, AE 2025, 'Live long and persist: polyomavirus immune evasion in the brain and kidney', Future Virology, vol. 20, no. 9, pp. 313-321. https://doi.org/10.1080/17460794.2025.2530832
Stoltzfus, KC, Deal, TJ, Heuvel, JPV, Lukacher, AE, Simkins, S, Dokholyan, NV & Kraschnewski, JL 2025, 'Pilot wrap-around support initiative: Enhanced support for internally funded CTSA pilot awards', Journal of Clinical and Translational Science, vol. 9, no. 1, e140. https://doi.org/10.1017/cts.2025.10071
Lauver, MD, Katz, ZE, Markus, H, Derosia, NM, Jin, G, Ayers, KN, Butic, AB, Bushey, K, Abendroth, CS, Liu, DJ & Lukacher, AE 2025, 'The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney', PLoS pathogens, vol. 21, no. 3, e1012969. https://doi.org/10.1371/journal.ppat.1012969
2024
Butic, AB, Katz, ZE, Jin, G, Fukushima, K, Hazama, M, Lukacher, AE & Lauver, MD 2024, 'Brincidofovir inhibits polyomavirus infection in vivo', mBio, vol. 15, no. 8. https://doi.org/10.1128/mbio.01049-24
2023
Pham, AM, Ortiz, LE, Lukacher, AE & Kwun, HJ 2023, 'Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain', Cells, vol. 12, no. 3, 380. https://doi.org/10.3390/cells12030380
Butic, AB, Spencer, SA, Shaheen, SK & Lukacher, AE 2023, 'Polyomavirus Wakes Up and Chooses Neurovirulence', Viruses, vol. 15, no. 10, 2112. https://doi.org/10.3390/v15102112
2022
Lauver, MD, Jin, G, Ayers, KN, Carey, SN, Specht, CS, Abendroth, CS & Lukacher, AE 2022, 'T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus', eLife, vol. 11, e83030. https://doi.org/10.7554/ELIFE.83030
2021
Netherby-Winslow, CS, Ayers, KN & Lukacher, AE 2021, 'Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain TRM Formation and Function', Frontiers in immunology, vol. 11, 624144. https://doi.org/10.3389/fimmu.2020.624144
Ren, HM, Lukacher, AE, Rahman, ZSM & Olsen, NJ 2021, 'New developments implicating IL-21 in autoimmune disease', Journal of Autoimmunity, vol. 122, 102689. https://doi.org/10.1016/j.jaut.2021.102689
Ayers, KN, Carey, SN & Lukacher, AE 2022, 'Understanding polyomavirus CNS disease – a perspective from mouse models', FEBS Journal, vol. 289, no. 19, pp. 5744-5761. https://doi.org/10.1111/febs.16083