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Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Professor, Veterinary and Biomedical Sciences
One Health Microbiome Center
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Mechanisms of Carcinogenesis
ADP117@psu.edu

Research Interests

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  • Metabolomics
  • Gastrointestinal Microbiome
  • Microbiota
  • Liver
  • Diet
  • Bile Acids and Salts
  • Aryl Hydrocarbon Receptors
  • Mass Spectrometry
  • Neoplasms
  • Homeostasis
  • Serum
  • Genes
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Recent Publications

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2024

Zhu, B, Zhu, X, Borland, MG, Ralph, DH, Chiaro, CR, Krausz, KW, Ntambi, JM, Glick, AB, Patterson, AD, Perdew, GH, Gonzalez, FJ & Peters, JM 2024, 'Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids', Biomolecules, vol. 14, no. 6, 606. https://doi.org/10.3390/biom14060606
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Van Syoc, E, Nixon, MP, Silverman, JD, Luo, Y, Gonzalez, FJ, Elbere, I, Klovins, J, Patterson, AD, Rogers, CJ & Ganda, E 2024, 'Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations', mBio, vol. 15, no. 6. https://doi.org/10.1128/mbio.00169-24
Hecht, AL, Harling, LC, Friedman, ES, Tanes, C, Lee, J, Firrman, J, Hao, F, Tu, V, Liu, LS, Patterson, AD, Bittinger, K, Goulian, M & Wu, GD 2024, 'Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae', Journal of Clinical Investigation, vol. 134, no. 9, e174726. https://doi.org/10.1172/JCI174726
Paudel, D, Nair, DVT, Tian, S, Hao, F, Goand, UK, Joseph, G, Prodes, E, Chai, Z, Robert, CEM, Chassaing, B, Patterson, AD & Singh, V 2024, 'Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation', Gut microbes, vol. 16, no. 1, 2341457. https://doi.org/10.1080/19490976.2024.2341457
Daniel, N, Wu, GD, Walters, W, Compher, C, Ni, J, Delaroque, C, Albenberg, L, Ley, RE, Patterson, AD, Lewis, JD, Gewirtz, AT & Chassaing, B 2024, 'Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption', CMGH, vol. 17, no. 2, pp. 315-318. https://doi.org/10.1016/j.jcmgh.2023.11.001
Chakraborty, D, Coslo, DM, Murray, IA, Vijay, A, Patterson, AD & Perdew, GH 2024, 'Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine', FASEB Journal, vol. 38, no. 4, e23471. https://doi.org/10.1096/fj.202302319R
Bonazzi, E, Bretin, A, Vigué, L, Hao, F, Patterson, AD, Gewirtz, AT & Chassaing, B 2024, 'Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity', Microbiome, vol. 12, no. 1, 5. https://doi.org/10.1186/s40168-023-01724-6
Karan, SK, Hosur, S, Kashani, Z, Leng, H, Vijay, A, Sriramdas, R, Wang, K, Poudel, B, Patterson, AD, Kiani, M & Priya, S 2024, 'Magnetic field and ultrasound induced simultaneous wireless energy harvesting', Energy and Environmental Science, vol. 17, no. 6, pp. 2129-2144. https://doi.org/10.1039/d3ee03889k
Gentry, EC, Collins, SL, Panitchpakdi, M, Belda-Ferre, P, Stewart, AK, Carrillo Terrazas, M, Lu, HH, Zuffa, S, Yan, T, Avila-Pacheco, J, Plichta, DR, Aron, AT, Wang, M, Jarmusch, AK, Hao, F, Syrkin-Nikolau, M, Vlamakis, H, Ananthakrishnan, AN, Boland, BS, Hemperly, A, Vande Casteele, N, Gonzalez, FJ, Clish, CB, Xavier, RJ, Chu, H, Baker, ES, Patterson, AD, Knight, R, Siegel, D & Dorrestein, PC 2024, 'Reverse metabolomics for the discovery of chemical structures from humans', Nature, vol. 626, no. 7998, pp. 419-426. https://doi.org/10.1038/s41586-023-06906-8
Golonka, RM, Yeoh, BS, Saha, P, Tian, Y, Chiang, JYL, Patterson, AD, Gewirtz, AT, Joe, B & Kumar, MV 2024, 'Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice', CMGH, vol. 17, no. 5, pp. 719-735. https://doi.org/10.1016/j.jcmgh.2024.01.011
Mohanty, I, Mannochio-Russo, H, Schweer, JV, El Abiead, Y, Bittremieux, W, Xing, S, Schmid, R, Zuffa, S, Vasquez, F, Muti, VB, Zemlin, J, Tovar-Herrera, OE, Moraïs, S, Desai, D, Amin, S, Koo, I, Turck, CW, Mizrahi, I, Kris-Etherton, PM, Petersen, K, Fleming, JA, Huan, T, Patterson, AD, Siegel, D, Hagey, LR, Wang, M, Aron, AT & Dorrestein, PC 2024, 'The underappreciated diversity of bile acid modifications', Cell, vol. 187, no. 7, pp. 1801-1818.e20. https://doi.org/10.1016/j.cell.2024.02.019
Zuffa, S, Schmid, R, Bauermeister, A, Paulo, PW, Caraballo-Rodriguez, AM, El Abiead, Y, Aron, AT, Gentry, EC, Zemlin, J, Meehan, MJ, Avalon, NE, Cichewicz, RH, Buzun, E, Terrazas, MC, Hsu, CY, Oles, R, Ayala, AV, Zhao, J, Chu, H, Kuijpers, MCM, Jackrel, SL, Tugizimana, F, Nephali, LP, Dubery, IA, Madala, NE, Moreira, EA, Costa-Lotufo, LV, Lopes, NP, Rezende-Teixeira, P, Jimenez, PC, Rimal, B, Patterson, AD, Traxler, MF, Pessotti, RDC, Alvarado-Villalobos, D, Tamayo-Castillo, G, Chaverri, P, Escudero-Leyva, E, Quiros-Guerrero, LM, Bory, AJ, Joubert, J, Rutz, A, Wolfender, JL, Allard, PM, Sichert, A, Pontrelli, S, Pullman, BS, Bandeira, N, Gerwick, WH, Gindro, K, Massana-Codina, J, Wagner, BC, Forchhammer, K, Petras, D, Aiosa, N, Garg, N, Liebeke, M, Bourceau, P, Kang, KB, Gadhavi, H, de Carvalho, LPS, Silva dos Santos, M, Pérez-Lorente, AI, Molina-Santiago, C, Romero, D, Franke, R, Brönstrup, M, Vera Ponce de León, A, Pope, PB, La Rosa, SL, La Barbera, G, Roager, HM, Laursen, MF, Hammerle, F, Siewert, B, Peintner, U, Licona-Cassani, C, Rodriguez-Orduña, L, Rampler, E, Hildebrand, F, Koellensperger, G, Schoeny, H, Hohenwallner, K, Panzenboeck, L, Gregor, R, O’Neill, EC, Roxborough, ET, Odoi, J, Bale, NJ, Ding, S, Sinninghe Damsté, JS, Guan, XL, Cui, JJ, Ju, KS, Silva, DB, Silva, FMR, da Silva, GF, Koolen, HHF, Grundmann, C, Clement, JA, Mohimani, H, Broders, K, McPhail, KL, Ober-Singleton, SE, Rath, CM, McDonald, D, Knight, R, Wang, M & Dorrestein, PC 2024, 'microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data', Nature Microbiology, vol. 9, no. 2, pp. 336-345. https://doi.org/10.1038/s41564-023-01575-9

2023

Zhu, X, Liu, Q, Patterson, AD, Sharma, AK, Amin, SG, Cohen, SM, Gonzalez, FJ & Peters, JM 2023, 'Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice', Metabolites, vol. 13, no. 8, 936. https://doi.org/10.3390/metabo13080936
Zhou, X, Chakraborty, D, Murray, IA, Coslo, D, Kehs, Z, Vijay, A, Ton, C, Desai, D, Amin, SG, Patterson, AD & Perdew, GH 2023, 'Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming', Laboratory Investigation, vol. 103, no. 2, 100012. https://doi.org/10.1016/j.labinv.2022.100012
Vijay, A, Boyle, NR, Kumar, SM, Perdew, GH, Srinivasan, S & Patterson, AD 2023, 'Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice', Toxicological Sciences, vol. 192, no. 1, pp. 117-128. https://doi.org/10.1093/toxsci/kfad014
Sun, L, Zhang, Y, Cai, J, Rimal, B, Rocha, ER, Coleman, JP, Zhang, C, Nichols, RG, Luo, Y, Kim, B, Chen, Y, Krausz, KW, Harris, CC, Patterson, AD, Zhang, Z, Takahashi, S & Gonzalez, FJ 2023, 'Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer', Nature communications, vol. 14, no. 1, 755. https://doi.org/10.1038/s41467-023-36089-9
Bass, R, Tanes, C, Bittinger, K, Li, Y, Lee, H, Friedman, ES, Koo, I, Patterson, AD, Liu, Q, Wu, GD & Stallings, VA 2024, 'Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids', Journal of Cystic Fibrosis, vol. 23, no. 3, pp. 481-489. https://doi.org/10.1016/j.jcf.2023.09.010
Hwang, S, Koo, I, Patterson, AD & Lambert, JD 2023, 'Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate', Food and Function, vol. 14, no. 20, pp. 9434-9445. https://doi.org/10.1039/d3fo02710d
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010. https://doi.org/10.1096/fj.202300703R
Morgan, EW, Dong, F, Annalora, AJ, Murray, IA, Wolfe, T, Erickson, R, Gowda, K, Amin, SG, Petersen, KS, Kris-Etherton, PM, Marcus, CB, Walk, ST, Patterson, AD & Perdew, GH 2023, 'Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182510
Dong, F, Annalora, AJ, Murray, IA, Tian, Y, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182508
Young, JA, Duran-Ortiz, S, Bell, S, Funk, K, Tian, Y, Liu, Q, Patterson, AD, List, EO, Berryman, DE & Kopchick, JJ 2023, 'Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice', Metabolites, vol. 13, no. 2, 191. https://doi.org/10.3390/metabo13020191
Patel, D, Murray, IA, Dong, F, Annalora, AJ, Gowda, K, Coslo, DM, Krzeminski, J, Koo, I, Hao, F, Amin, SG, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites', Metabolites, vol. 13, no. 9, 985. https://doi.org/10.3390/metabo13090985
Misra, S, Lee, TJ, Sebastian, A, McGuigan, J, Liao, C, Koo, I, Patterson, AD, Rossi, RM, Hall, MA, Albert, I & Prabhu, KS 2023, 'Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation', Redox Biology, vol. 59, 102571. https://doi.org/10.1016/j.redox.2022.102571
Chen, X, Patterson, AD, Perdew, GH, Murray, IA & Kellogg, JJ 2023, 'Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)', Journal of Functional Foods, vol. 106, 105602. https://doi.org/10.1016/j.jff.2023.105602
Shalon, D, Culver, RN, Grembi, JA, Folz, J, Treit, PV, Shi, H, Rosenberger, FA, Dethlefsen, L, Meng, X, Yaffe, E, Aranda-Díaz, A, Geyer, PE, Mueller-Reif, JB, Spencer, S, Patterson, AD, Triadafilopoulos, G, Holmes, SP, Mann, M, Fiehn, O, Relman, DA & Huang, KC 2023, 'Profiling the human intestinal environment under physiological conditions', Nature, vol. 617, no. 7961, pp. 581-591. https://doi.org/10.1038/s41586-023-05989-7
Bretin, A, Zou, J, San Yeoh, B, Ngo, VL, Winer, S, Winer, DA, Reddivari, L, Pellizzon, M, Walters, WA, Patterson, AD, Ley, R, Chassaing, B, Vijay-Kumar, M & Gewirtz, AT 2023, 'Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor', CMGH, vol. 15, no. 6, pp. 1421-1442. https://doi.org/10.1016/j.jcmgh.2023.02.007
Tian, S, Paudel, D, Hao, F, Neupane, R, Castro, R, Patterson, AD, Tiwari, AK, Prabhu, KS & Singh, V 2023, 'Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production', Cancer Reports, vol. 6, no. 11, e1863. https://doi.org/10.1002/cnr2.1863
Perdew, GH, Esser, C, Snyder, M, Sherr, DH, van den Bogaard, EH, McGovern, K, Fernández-Salguero, PM, Coumoul, X & Patterson, AD 2023, 'The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022', International journal of molecular sciences, vol. 24, no. 6, 5550. https://doi.org/10.3390/ijms24065550
Yeoh, BS, Golonka, RM, Saha, P, Kandalgaonkar, MR, Tian, Y, Osman, I, Patterson, AD, Gewirtz, AT, Joe, B & Vijay-Kumar, M 2023, 'Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice', Function, vol. 4, no. 5, zqad040. https://doi.org/10.1093/function/zqad040

2022

Dohnalová, L, Lundgren, P, Carty, JRE, Goldstein, N, Wenski, SL, Nanudorn, P, Thiengmag, S, Huang, KP, Litichevskiy, L, Descamps, HC, Chellappa, K, Glassman, A, Kessler, S, Kim, J, Cox, TO, Dmitrieva-Posocco, O, Wong, AC, Allman, EL, Ghosh, S, Sharma, N, Sengupta, K, Cornes, B, Dean, N, Churchill, GA, Khurana, TS, Sellmyer, MA, FitzGerald, GA, Patterson, AD, Baur, JA, Alhadeff, AL, Helfrich, EJN, Levy, M, Betley, JN & Thaiss, CA 2022, 'A microbiome-dependent gut–brain pathway regulates motivation for exercise', Nature, vol. 612, no. 7941, pp. 739-747. https://doi.org/10.1038/s41586-022-05525-z
Granados, JC, Falah, K, Koo, I, Morgan, EW, Perdew, GH, Patterson, AD, Jamshidi, N & Nigam, SK 2022, 'AHR is a master regulator of diverse pathways in endogenous metabolism', Scientific reports, vol. 12, no. 1, 16625. https://doi.org/10.1038/s41598-022-20572-2
Alrehaili, BD, Lee, M, Takahashi, S, Novak, R, Rimal, B, Boehme, S, Trammell, SAJ, Grevengoed, TJ, Kumar, D, Alnouti, Y, Chiti, K, Wang, X, Patterson, AD, Chiang, JYL, Gonzalez, FJ & Lee, YK 2022, 'Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice', Hepatology Communications, vol. 6, no. 10, pp. 2765-2780. https://doi.org/10.1002/hep4.2041
Cai, J, Rimal, B, Jiang, C, Chiang, JYL & Patterson, AD 2022, 'Bile acid metabolism and signaling, the microbiota, and metabolic disease', Pharmacology and Therapeutics, vol. 237, 108238. https://doi.org/10.1016/j.pharmthera.2022.108238
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Mohammed, AD, Mohammed, Z, Roland, MM, Chatzistamou, I, Jolly, A, Schoettmer, LM, Arroyo, M, Kakar, K, Tian, Y, Patterson, A, Nagarkatti, M, Nagarkatti, P & Kubinak, JL 2022, 'Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel', Nature communications, vol. 13, no. 1, 525. https://doi.org/10.1038/s41467-022-28126-w
Delaroque, C, Wu, GD, Compher, C, Ni, J, Albenberg, L, Liu, Q, Tian, Y, Patterson, AD, Lewis, JD, Gewirtz, AT & Chassaing, B 2022, 'Diet standardization reduces intra-individual microbiome variation', Gut microbes, vol. 14, no. 1, pp. 2149047. https://doi.org/10.1080/19490976.2022.2149047
Tian, Y, Rimal, B, Gui, W, Koo, I, Smith, PB, Yokoyama, S & Patterson, AD 2022, 'Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood', Metabolites, vol. 12, no. 10, 894. https://doi.org/10.3390/metabo12100894
Tian, Y, Rimal, B, Gui, W, Koo, I, Yokoyama, S, Perdew, GH & Patterson, AD 2022, 'Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood', International journal of molecular sciences, vol. 23, no. 15, 8220. https://doi.org/10.3390/ijms23158220
Baldin, M, Garcia, D, Zanton, GI, Hao, F, Patterson, AD & Harvatine, KJ 2022, 'Effect of 2-hydroxy-4-(methylthio)butanoate (HMTBa) on milk fat, rumen environment and biohydrogenation, and rumen protozoa in lactating cows fed diets with increased risk for milk fat depression', Journal of dairy science, vol. 105, no. 9, pp. 7446-7461. https://doi.org/10.3168/jds.2022-21910
Seemiller, LR, Goldberg, LR, Smith, PB, Dennis, J, Patterson, AD & Gould, TJ 2022, 'Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains', Neuropharmacology, vol. 221, 109279. https://doi.org/10.1016/j.neuropharm.2022.109279
Jiang, J, Ma, Y, Liu, Y, Lu, D, Gao, X, Krausz, KW, Desai, D, Amin, SG, Patterson, AD, Gonzalez, FJ & Xie, C 2022, 'Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice', Hepatology Communications, vol. 6, no. 12, pp. 3363-3378. https://doi.org/10.1002/hep4.2099
Matamoros, C, Hao, F, Tian, Y, Patterson, AD & Harvatine, KJ 2022, 'Interaction of sodium acetate supplementation and dietary fiber level on feeding behavior, digestibility, milk synthesis, and plasma metabolites', Journal of dairy science, vol. 105, no. 11, pp. 8824-8838. https://doi.org/10.3168/jds.2022-21911
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological Sciences, vol. 187, no. 2, pp. 189-213. https://doi.org/10.1093/toxsci/kfac029
Chassaing, B, Compher, C, Bonhomme, B, Liu, Q, Tian, Y, Walters, W, Nessel, L, Delaroque, C, Hao, F, Gershuni, V, Chau, L, Ni, J, Bewtra, M, Albenberg, L, Bretin, A, McKeever, L, Ley, RE, Patterson, AD, Wu, GD, Gewirtz, AT & Lewis, JD 2022, 'Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome', Gastroenterology, vol. 162, no. 3, pp. 743-756. https://doi.org/10.1053/j.gastro.2021.11.006
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056. https://doi.org/10.1016/j.tox.2021.153056
Chalmers, FE, Mogre, S, Rimal, B, Son, J, Patterson, AD, Stairs, DB & Glick, AB 2022, 'The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus', Developmental biology, vol. 492, pp. 59-70. https://doi.org/10.1016/j.ydbio.2022.09.009

2021

von Schwartzenberg, RJ, Bisanz, JE, Lyalina, S, Spanogiannopoulos, P, Ang, QY, Cai, J, Dickmann, S, Friedrich, M, Liu, SY, Collins, SL, Ingebrigtsen, D, Miller, S, Turnbaugh, JA, Patterson, AD, Pollard, KS, Mai, K, Spranger, J & Turnbaugh, PJ 2021, 'Caloric restriction disrupts the microbiota and colonization resistance', Nature, vol. 595, no. 7866, pp. 272-277. https://doi.org/10.1038/s41586-021-03663-4
Matamoros, C, Cai, J, Patterson, AD & Harvatine, KJ 2021, 'Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production', Journal of dairy science, vol. 104, no. 7, pp. 7572-7582. https://doi.org/10.3168/jds.2020-19526
Collins, SL, Koo, I, Peters, JM, Smith, PB & Patterson, AD 2021, 'Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics', Annual Review of Analytical Chemistry, vol. 14, pp. 467-487. https://doi.org/10.1146/annurev-anchem-091620-015205
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology, vol. 19, no. 8, pp. 1723-1725. https://doi.org/10.1016/j.cgh.2020.08.063
Shi, Z, Lei, H, Chen, G, Yuan, P, Cao, Z, Ser, HL, Zhu, X, Wu, F, Liu, C, Dong, M, Song, Y, Guo, Y, Chen, C, Hu, K, Zhu, Y, Zeng, XA, Zhou, J, Lu, Y, Patterson, AD & Zhang, L 2021, 'Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice', mSystems, vol. 6, no. 1, e00985-20. https://doi.org/10.1128/MSYSTEMS.00985-20
Nandy, D, Craig, SJC, Cai, J, Tian, Y, Paul, IM, Savage, JS, Marini, ME, Hohman, EE, Reimherr, ML, Patterson, AD, Makova, KD & Chiaromonte, F 2022, 'Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes', Pediatric Obesity, vol. 17, no. 1, e12833. https://doi.org/10.1111/ijpo.12833
Nayak, RR, Alexander, M, Deshpande, I, Stapleton-Gray, K, Rimal, B, Patterson, AD, Ubeda, C, Scher, JU & Turnbaugh, PJ 2021, 'Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation', Cell Host and Microbe, vol. 29, no. 3, pp. 362-377.e11. https://doi.org/10.1016/j.chom.2020.12.008
Tian, Y, Cai, J, Allman, EL, Smith, PB & Patterson, AD 2021, Quantitative analysis of bile acid with UHPLC-MS/MS. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2194, Humana Press Inc., pp. 291-300. https://doi.org/10.1007/978-1-0716-0849-4_15
Czernik, PJ, Golonka, RM, Chakraborty, S, Yeoh, BS, Abokor, AA, Saha, P, Yeo, JY, Mell, B, Cheng, X, Baroi, S, Tian, Y, Patterson, AD, Joe, B, Vijay-Kumar, M & Lecka-Czernik, B 2021, 'Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content', Physiological genomics, vol. 53, no. 12, pp. 518-533. https://doi.org/10.1152/physiolgenomics.00017.2021
Rimal, B & Patterson, AD 2021, 'Role of bile acids and gut bacteria in healthy ageing of centenarians', Nature, vol. 599, no. 7885, pp. 380-381. https://doi.org/10.1038/d41586-021-02196-0
Mal, TK, Tian, Y & Patterson, AD 2021, Sample preparation and data analysis for NMR-based metabolomics. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2194, Humana Press Inc., pp. 301-313. https://doi.org/10.1007/978-1-0716-0849-4_16
Winston, JA, Rivera, A, Cai, J, Patterson, AD & Theriot, CM 2021, 'Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice', PloS one, vol. 16, no. 2 Febuary, e0246161. https://doi.org/10.1371/journal.pone.0246161
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410. https://doi.org/10.1016/j.jbc.2021.100410
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831. https://doi.org/10.1016/j.tox.2021.152831
Ang, QY, Alba, DL, Upadhyay, V, Bisanz, JE, Cai, J, Lee, HL, Barajas, E, Wei, G, Noecker, C, Patterson, AD, Koliwad, SK & Turnbaugh, PJ 2021, 'The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health', eLife, vol. 10, e70349. https://doi.org/10.7554/eLife.70349

2020

Man, K, Bowman, C, Braverman, KN, Escalante, V, Tian, Y, Bisanz, JE, Ganeshan, K, Wang, B, Patterson, A, Bayrer, JR, Turnbaugh, PJ & Chawla, A 2020, 'A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 50, pp. 32029-32037. https://doi.org/10.1073/pnas.2012003117
Bittinger, K, Zhao, C, Li, Y, Ford, E, Friedman, ES, Ni, J, Kulkarni, CV, Cai, J, Tian, Y, Liu, Q, Patterson, AD, Sarkar, D, Chan, SHJ, Maranas, C, Saha-Shah, A, Lund, P, Garcia, BA, Mattei, LM, Gerber, JS, Elovitz, MA, Kelly, A, DeRusso, P, Kim, D, Hofstaedter, CE, Goulian, M, Li, H, Bushman, FD, Zemel, BS & Wu, GD 2020, 'Bacterial colonization reprograms the neonatal gut metabolome', Nature Microbiology, vol. 5, no. 6, pp. 838-847. https://doi.org/10.1038/s41564-020-0694-0
McMullen, JG, Peters-Schulze, G, Cai, J, Patterson, AD & Douglas, AE 2020, 'How gut microbiome interactions affect nutritional traits of Drosophila melanogaster', Journal of Experimental Biology, vol. 223, no. 19, jeb227843. https://doi.org/10.1242/jeb.227843
Blow, F, Ankrah, NYD, Clark, N, Koo, I, Allman, EL, Liu, Q, Anitha, M, Patterson, AD & Douglas, AE 2020, 'Impact of facultative bacteria on the metabolic function of an obligate insect-bacterial symbiosis', mBio, vol. 11, no. 4, e00402-20, pp. 1-12. https://doi.org/10.1128/mBio.00402-20
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24. https://doi.org/10.1080/19490976.2020.1788899
Ang, QY, Alexander, M, Newman, JC, Tian, Y, Cai, J, Upadhyay, V, Turnbaugh, JA, Verdin, E, Hall, KD, Leibel, RL, Ravussin, E, Rosenbaum, M, Patterson, AD & Turnbaugh, PJ 2020, 'Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells', Cell, vol. 181, no. 6, pp. 1263-1275.e16. https://doi.org/10.1016/j.cell.2020.04.027
Singh, V, Galla, S, Golonka, RM, Patterson, AD, Chassaing, B, Joe, B & Vijay-Kumar, M 2020, 'Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice', Physiological genomics, vol. 52, no. 8, pp. 314-321. https://doi.org/10.1152/physiolgenomics.00118.2019
Patt, A, Demoret, B, Stets, C, Bill, KL, Smith, P, Vijay, A, Patterson, A, Hays, J, Hoang, M, Chen, JL & Mathé, EA 2020, 'Mdm2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models', Cancers, vol. 12, no. 8, 2157, pp. 1-14. https://doi.org/10.3390/cancers12082157
Tian, Y, Gui, W, Rimal, B, Koo, I, Smith, PB, Nichols, RG, Cai, J, Liu, Q & Patterson, AD 2020, 'Metabolic impact of persistent organic pollutants on gut microbiota', Gut microbes, vol. 12, no. 1, pp. 1-16. https://doi.org/10.1080/19490976.2020.1848209
Allen, JN, Dey, A, Cai, J, Zhang, J, Tian, Y, Kennett, M, Ma, Y, Liang, TJ, Patterson, AD & Hankey-Giblin, PA 2020, 'Metabolic profiling reveals aggravated non-alcoholic steatohepatitis in high-fat high-cholesterol diet-fed apolipoprotein e-deficient mice lacking ron receptor signaling', Metabolites, vol. 10, no. 8, 326, pp. 1-24. https://doi.org/10.3390/metabo10080326
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Das, NK, Schwartz, AJ, Barthel, G, Inohara, N, Liu, Q, Sankar, A, Hill, DR, Ma, X, Lamberg, O, Schnizlein, MK, Arqués, JL, Spence, JR, Nunez, G, Patterson, AD, Sun, D, Young, VB & Shah, YM 2020, 'Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis', Cell Metabolism, vol. 31, no. 1, pp. 115-130.e6. https://doi.org/10.1016/j.cmet.2019.10.005
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560. https://doi.org/10.1016/j.conctc.2020.100560
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365. https://doi.org/10.1016/j.tox.2020.152365
Noel, OF, Chu, X, Patterson, AD, Edwards, MA, Still, CD & Gerhard, GS 2021, 'Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein', Obesity Surgery, vol. 31, no. 2, pp. 773-780. https://doi.org/10.1007/s11695-020-04993-4
Artacho, A, Isaac, S, Nayak, R, Flor-Duro, A, Alexander, M, Koo, I, Manasson, J, Smith, PB, Rosenthal, P, Homsi, Y, Gulko, P, Pons, J, Puchades-Carrasco, L, Izmirly, P, Patterson, A, Abramson, SB, Pineda-Lucena, A, Turnbaugh, PJ, Ubeda, C & Scher, JU 2021, 'The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis', Arthritis and Rheumatology, vol. 73, no. 6, pp. 931-942. https://doi.org/10.1002/art.41622
Collins, SL & Patterson, AD 2020, 'The gut microbiome: an orchestrator of xenobiotic metabolism', Acta Pharmaceutica Sinica B, vol. 10, no. 1, pp. 19-32. https://doi.org/10.1016/j.apsb.2019.12.001
Tian, Y, Gui, W, Koo, I, Smith, PB, Allman, EL, Nichols, RG, Rimal, B, Cai, J, Liu, Q & Patterson, AD 2020, 'The microbiome modulating activity of bile acids', Gut microbes, vol. 11, no. 4, pp. 979-996. https://doi.org/10.1080/19490976.2020.1732268
Winston, JA, Rivera, AJ, Cai, J, Thanissery, R, Montgomery, SA, Patterson, AD & Theriot, CM 2020, 'Ursodeoxycholic acid (udca) mitigates the host inflammatory response during clostridioides difficile infection by altering gut bile acids', Infection and Immunity, vol. 88, no. 6, e00045. https://doi.org/10.1128/IAI.00045-20
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes, vol. 11, no. 4, pp. 1077-1091. https://doi.org/10.1080/19490976.2020.1743492
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