Researcher Profile

Researcher Profile

Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Associate Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Metabolomics
  • Liver
  • Microbiota
  • Gastrointestinal Microbiome
  • Neoplasms
  • Mass Spectrometry
  • Diet
  • Homeostasis
  • Bile Acids and Salts
  • Biomarkers
  • Serum
  • Aryl Hydrocarbon Receptors

Recent Publications


Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1.
Das, NK, Schwartz, AJ, Barthel, G, Inohara, N, Liu, Q, Sankar, A, Hill, DR, Ma, X, Lamberg, O, Schnizlein, MK, Arqués, JL, Spence, JR, Nunez, G, Patterson, AD, Sun, D, Young, VB & Shah, YM 2020, 'Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis', Cell Metabolism, vol. 31, no. 1, pp. 115-130.e6.
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560.
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365.
Collins, SL & Patterson, AD 2020, 'The gut microbiome: an orchestrator of xenobiotic metabolism', Acta Pharmaceutica Sinica B, vol. 10, no. 1, pp. 19-32.
Tian, Y, Gui, W, Koo, I, Smith, PB, Allman, EL, Nichols, RG, Rimal, B, Cai, J, Liu, Q & Patterson, AD 2020, 'The microbiome modulating activity of bile acids', Gut microbes.
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes.


Dutta, M, Cai, J, Gui, W & Patterson, AD 2019, 'A review of analytical platforms for accurate bile acid measurement', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4541-4549.
Tian, Y, Cai, J, Gui, W, Nichols, RG, Koo, I, Zhang, J, Anitha, M & Patterson, AD 2019, 'Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 86-93.
Zheng, X, Smith, FB, Aly, NA, Cai, J, Smith, RD, Patterson, AD & Baker, ES 2019, 'Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4673-4682.
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217.
Alwerdt, J, Patterson, AD & Sliwinski, MJ 2019, 'Gender differences in phytoestrogens and the relationship with speed of processing in older adults: A cross-sectional analysis of NHANES, 1999–2002', Nutrients, vol. 11, no. 8, 1780.
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome', Nature Medicine, vol. 25, no. 8, pp. 1225-1233.
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1.
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294.
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724.
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812.
Chagwedera, DN, Ang, QY, Bisanz, JE, Leong, YA, Ganeshan, K, Cai, J, Patterson, AD, Turnbaugh, PJ & Chawla, A 2019, 'Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass', Cell Metabolism, vol. 30, no. 2, pp. 364-373.e7.
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (Nature Medicine, (2019), 25, 8, (1225-1233), 10.1038/s41591-019-0509-0)', Nature Medicine, vol. 25, no. 9.
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Catharine Ross, A & Cantorna, MT 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN.
Zheng, S, Loreto, R, Smith, P, Patterson, A, Hughes, D & Wang, L 2019, 'Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host', International journal of molecular sciences, vol. 20, no. 18, 4589.
Bao, L, Festa, F, Freet, CS, Lee, JP, Hirschler-Laszkiewicz, IM, Chen, SJ, Keefer, KA, Wang, HG, Patterson, AD, Cheung, JY & Miller, BA 2019, 'The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2', Scientific reports, vol. 9, no. 1, 14132.
Cantorna, MT, Lin, YD, Arora, J, Bora, S, Tian, Y, Nichols, RG & Patterson, AD 2019, 'Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon', Frontiers in immunology, vol. 10.


Waghulde, H, Cheng, X, Galla, S, Mell, B, Cai, J, Pruett-Miller, SM, Vazquez, G, Patterson, A, Kumar, MV & Joe, B 2018, 'Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1', Hypertension, vol. 72, no. 5, pp. 1125-1132.
Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22.
Sun, L, Xie, C, Wang, G, Wu, Y, Wu, Q, Wang, X, Liu, J, Deng, Y, Xia, J, Chen, B, Zhang, S, Yun, C, Lian, G, Zhang, X, Zhang, H, Bisson, WH, Shi, J, Gao, X, Ge, P, Liu, C, Krausz, KW, Nichols, RG, Cai, J, Rimal, B, Patterson, AD, Wang, X, Gonzalez, FJ & Jiang, C 2018, 'Gut microbiota and intestinal FXR mediate the clinical benefits of metformin', Nature Medicine, vol. 24, no. 12, pp. 1919-1929.
Pathak, P, Xie, C, Nichols, RG, Ferrell, JM, Boehme, S, Krausz, KW, Patterson, AD, Gonzalez, FJ & Chiang, JYL 2018, 'Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism', Hepatology, vol. 68, no. 4, pp. 1574-1588.
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589.
Chen, F, Coslo, DM, Chen, T, Zhang, L, Tian, Y, Smith, PB, Patterson, AD & Omiecinski, CJ 2019, 'Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism', Journal of Proteome Research, vol. 18, no. 1, pp. 239-251.
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382.
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283.
Cai, J, Nichols, RG, Koo, I, Kalikow, ZA, Zhang, L, Tian, Y, Zhang, J, Smith, PB & Patterson, AD 2018, 'Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity', mSystems, vol. 3, no. 6, e00123.
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513.
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232.
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73.
Allen, J, Zhang, J, Quickel, MD, Kennett, M, Patterson, AD & Hankey-Giblin, PA 2018, 'Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model', Journal of Proteome Research, vol. 17, no. 9, pp. 3268-3280.
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54.
Cheema, M, Smith, PB, Patterson, AD, Hristov, A & Harte, FM 2018, 'The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size', Journal of dairy science, vol. 101, no. 10, pp. 8672-8687.
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408.
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34.


Xie, C, Yagai, T, Luo, Y, Liang, X, Chen, T, Wang, Q, Sun, D, Zhao, J, Ramakrishnan, SK, Sun, L, Jiang, C, Xue, X, Tian, Y, Krausz, KW, Patterson, AD, Shah, YM, Wu, Y, Jiang, C & Gonzalez, FJ 2017, 'Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis', Nature Medicine, vol. 23, no. 11, pp. 1298-1308.
Xie, C, Jiang, C, Shi, J, Gao, X, Sun, D, Sun, L, Wang, T, Takahashi, S, Anitha, M, Krausz, KW, Patterson, AD & Gonzalez, FJ 2017, 'An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice', Diabetes, vol. 66, no. 3, pp. 613-626.
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, P, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698.
Corresponding author 2017, 'Erratum: Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (Cell Metabolism (2017) 26(4) (672–685.e4) (S1550413117305041) (10.1016/j.cmet.2017.08.019))', Cell Metabolism, vol. 26, no. 5.
DiMarzio, M, Rusconi, B, Yennawar, NH, Eppinger, M, Patterson, AD & Dudley, EG 2017, 'Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA', PloS one, vol. 12, no. 9, e0183564.
Li, G, Xie, C, Lu, S, Nichols, RG, Tian, Y, Li, L, Patel, D, Ma, Y, Brocker, CN, Yan, T, Krausz, KW, Xiang, R, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2017, 'Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota', Cell Metabolism, vol. 26, no. 4, pp. 672-685.e4.
Gonzalez, FJ, Jiang, C, Xie, C & Patterson, AD 2017, 'Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease', Digestive Diseases, vol. 35, no. 3, pp. 178-184.
Huang, KH, Hao, L, Smith, PB, Rogers, CJ, Patterson, AD & Ross, AC 2017, 'Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice', Journal of Nutrition, vol. 147, no. 5, pp. 746-753.
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Vijay-Kumar, M 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33.
Cai, J, Zhang, J, Tian, Y, Zhang, L, Hatzakis, E, Krausz, KW, Smith, PB, Gonzalez, FJ & Patterson, AD 2017, 'Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation', Analytical chemistry, vol. 89, no. 15, pp. 7900-7906.
Zhang, L, Nichols, RG & Patterson, AD 2017, 'The aryl hydrocarbon receptor as a moderator of host-microbiota communication', Current Opinion in Toxicology, vol. 2, pp. 30-35.


Gonzalez, FJ, Jiang, C & Patterson, AD 2016, 'An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease', Gastroenterology, vol. 151, no. 5, pp. 845-859.
Cai, J, Zhang, L, Jones, RA, Correll, JB, Hatzakis, E, Smith, PB, Gonzalez, FJ & Patterson, AD 2016, 'Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota', Journal of Proteome Research, vol. 15, no. 2, pp. 563-571.
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969.
Zhang, L, Xie, C, Nichols, RG, Chan, SHJ, Jiang, C, Hao, R, Smith, PB, Cai, J, Simons, MN, Hatzakis, E, Maranas, CD, Gonzalez, FJ & Patterson, AD 2016, 'Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism', mSystems, vol. 1, no. 5, e00070.
Phillips, BE, Geletzke, AK, Smith, PB, Podany, AB, Chacon, A, Kelleher, SL, Patterson, AD & Soybel, DI 2016, 'Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction', Molecular Nutrition and Food Research, vol. 60, no. 3, pp. 672-681.
Cook, JA, Chandramouli, GVR, Anver, MR, Sowers, AL, Thetford, A, Krausz, KW, Gonzalez, FJ, Mitchell, JB & Patterson, AD 2016, 'Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer', Cancer Research, vol. 76, no. 6, pp. 1569-1577.
Dutta, M, Anitha, M, Smith, PB, Chiaro, CR, Maan, M, Chaudhury, K & Patterson, AD 2016, 'Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis', Journal of Proteome Research, vol. 15, no. 8, pp. 2626-2633.
Zhang, L, Hatzakis, E & Patterson, AD 2016, 'NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research', Current Pharmacology Reports, vol. 2, no. 5, pp. 231-240.
Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical research in toxicology, vol. 29, no. 12, pp. 1987-1997.
Zhang, L, Krishnan, P, Ehresman, DJ, Smith, PB, Dutta, M, Bagley, BD, Chang, SC, Butenhoff, JL, Patterson, AD & Peters, JM 2016, 'Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice', Toxicological Sciences, vol. 153, no. 1, kfw120, pp. 186-197.
Soo, VWC, McAnulty, MJ, Tripathi, A, Zhu, F, Zhang, L, Hatzakis, E, Smith, PB, Agrawal, S, Nazem-Bokaee, H, Gopalakrishnan, S, Salis, HM, Ferry, JG, Maranas, CD, Patterson, AD & Wood, TK 2016, 'Reversing methanogenesis to capture methane for liquid biofuel precursors', Microbial Cell Factories, vol. 15, no. 1, 11.
Yu, S, Allen, JN, Dey, A, Zhang, L, Balandaram, G, Kennett, MJ, Xia, M, Xiong, N, Peters, JM, Patterson, AD & Giblin, PH 2016, 'The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis', Journal of Immunology, vol. 197, no. 1, pp. 256-265.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)