Researcher Profile

Researcher Profile

Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
adp117@psu.edu

Research Interests

  • Metabolomics
  • Gastrointestinal Microbiome
  • Microbiota
  • Liver
  • Bile Acids and Salts
  • Diet
  • Neoplasms
  • Mass Spectrometry
  • Aryl Hydrocarbon Receptors
  • Homeostasis
  • Serum
  • Biomarkers

Recent Publications

2022

Mohammed, AD, Mohammed, Z, Roland, MM, Chatzistamou, I, Jolly, A, Schoettmer, LM, Arroyo, M, Kakar, K, Tian, Y, Patterson, A, Nagarkatti, M, Nagarkatti, P & Kubinak, JL 2022, 'Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel', Nature communications, vol. 13, no. 1, 525. https://doi.org/10.1038/s41467-022-28126-w
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological sciences : an official journal of the Society of Toxicology, vol. 187, no. 2, pp. 189-213. https://doi.org/10.1093/toxsci/kfac029
Chassaing, B, Compher, C, Bonhomme, B, Liu, Q, Tian, Y, Walters, W, Nessel, L, Delaroque, C, Hao, F, Gershuni, V, Chau, L, Ni, J, Bewtra, M, Albenberg, L, Bretin, A, McKeever, L, Ley, RE, Patterson, AD, Wu, GD, Gewirtz, AT & Lewis, JD 2022, 'Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome', Gastroenterology, vol. 162, no. 3, pp. 743-756. https://doi.org/10.1053/j.gastro.2021.11.006
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056. https://doi.org/10.1016/j.tox.2021.153056

2021

von Schwartzenberg, RJ, Bisanz, JE, Lyalina, S, Spanogiannopoulos, P, Ang, QY, Cai, J, Dickmann, S, Friedrich, M, Liu, SY, Collins, SL, Ingebrigtsen, D, Miller, S, Turnbaugh, JA, Patterson, AD, Pollard, KS, Mai, K, Spranger, J & Turnbaugh, PJ 2021, 'Caloric restriction disrupts the microbiota and colonization resistance', Nature, vol. 595, no. 7866, pp. 272-277. https://doi.org/10.1038/s41586-021-03663-4
Matamoros, C, Cai, J, Patterson, AD & Harvatine, KJ 2021, 'Comparison of the effects of short-term feeding of sodium acetate and sodium bicarbonate on milk fat production', Journal of dairy science, vol. 104, no. 7, pp. 7572-7582. https://doi.org/10.3168/jds.2020-19526
Collins, SL, Koo, I, Peters, JM, Smith, PB & Patterson, AD 2021, 'Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics', Annual Review of Analytical Chemistry, vol. 14, pp. 467-487. https://doi.org/10.1146/annurev-anchem-091620-015205
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology, vol. 19, no. 8, pp. 1723-1725. https://doi.org/10.1016/j.cgh.2020.08.063
Shi, Z, Lei, H, Chen, G, Yuan, P, Cao, Z, Ser, HL, Zhu, X, Wu, F, Liu, C, Dong, M, Song, Y, Guo, Y, Chen, C, Hu, K, Zhu, Y, Zeng, XA, Zhou, J, Lu, Y, Patterson, AD & Zhang, L 2021, 'Impaired intestinal akkermansia muciniphila and aryl hydrocarbon receptor ligands contribute to nonalcoholic fatty liver disease in mice', mSystems, vol. 6, no. 1, e00985-20. https://doi.org/10.1128/MSYSTEMS.00985-20
Nandy, D, Craig, SJC, Cai, J, Tian, Y, Paul, IM, Savage, JS, Marini, ME, Hohman, EE, Reimherr, ML, Patterson, AD, Makova, KD & Chiaromonte, F 2022, 'Metabolomic profiling of stool of two-year old children from the INSIGHT study reveals links between butyrate and child weight outcomes', Pediatric Obesity, vol. 17, no. 1, e12833. https://doi.org/10.1111/ijpo.12833
Nayak, RR, Alexander, M, Deshpande, I, Stapleton-Gray, K, Rimal, B, Patterson, AD, Ubeda, C, Scher, JU & Turnbaugh, PJ 2021, 'Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation', Cell Host and Microbe, vol. 29, no. 3, pp. 362-377.e11. https://doi.org/10.1016/j.chom.2020.12.008
Tian, Y, Cai, J, Allman, EL, Smith, PB & Patterson, AD 2021, Quantitative analysis of bile acid with UHPLC-MS/MS. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2194, Humana Press Inc., pp. 291-300. https://doi.org/10.1007/978-1-0716-0849-4_15
Czernik, PJ, Golonka, RM, Chakraborty, S, Yeoh, BS, Abokor, AA, Saha, P, Yeo, JY, Mell, B, Cheng, X, Baroi, S, Tian, Y, Patterson, AD, Joe, B, Vijay-Kumar, M & Lecka-Czernik, B 2021, 'Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content', Physiological genomics, vol. 53, no. 12, pp. 518-533. https://doi.org/10.1152/physiolgenomics.00017.2021
Mal, TK, Tian, Y & Patterson, AD 2021, Sample preparation and data analysis for NMR-based metabolomics. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2194, Humana Press Inc., pp. 301-313. https://doi.org/10.1007/978-1-0716-0849-4_16
Winston, JA, Rivera, A, Cai, J, Patterson, AD & Theriot, CM 2021, 'Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice', PloS one, vol. 16, no. 2 Febuary, e0246161. https://doi.org/10.1371/journal.pone.0246161
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410. https://doi.org/10.1016/j.jbc.2021.100410
Liu, Q, Zhang, L, Allman, EL, Hubbard, TD, Murray, IA, Hao, F, Tian, Y, Gui, W, Nichols, RG, Smith, PB, Anitha, M, Perdew, GH & Patterson, AD 2021, 'The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis', Toxicology, vol. 458, 152831. https://doi.org/10.1016/j.tox.2021.152831
Ang, QY, Alba, DL, Upadhyay, V, Bisanz, JE, Cai, J, Lee, HL, Barajas, E, Wei, G, Noecker, C, Patterson, AD, Koliwad, SK & Turnbaugh, PJ 2021, 'The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health', eLife, vol. 10, e70349. https://doi.org/10.7554/eLife.70349

2020

Man, K, Bowman, C, Braverman, KN, Escalante, V, Tian, Y, Bisanz, JE, Ganeshan, K, Wang, B, Patterson, A, Bayrer, JR, Turnbaugh, PJ & Chawla, A 2020, 'A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 50, pp. 32029-32037. https://doi.org/10.1073/pnas.2012003117
Bittinger, K, Zhao, C, Li, Y, Ford, E, Friedman, ES, Ni, J, Kulkarni, CV, Cai, J, Tian, Y, Liu, Q, Patterson, AD, Sarkar, D, Chan, SHJ, Maranas, C, Saha-Shah, A, Lund, P, Garcia, BA, Mattei, LM, Gerber, JS, Elovitz, MA, Kelly, A, DeRusso, P, Kim, D, Hofstaedter, CE, Goulian, M, Li, H, Bushman, FD, Zemel, BS & Wu, GD 2020, 'Bacterial colonization reprograms the neonatal gut metabolome', Nature Microbiology, vol. 5, no. 6, pp. 838-847. https://doi.org/10.1038/s41564-020-0694-0
McMullen, JG, Peters-Schulze, G, Cai, J, Patterson, AD & Douglas, AE 2020, 'How gut microbiome interactions affect nutritional traits of Drosophila melanogaster', Journal of Experimental Biology, vol. 223, no. 19, jeb227843. https://doi.org/10.1242/jeb.227843
Blow, F, Ankrah, NYD, Clark, N, Koo, I, Allman, EL, Liu, Q, Anitha, M, Patterson, AD & Douglas, AE 2020, 'Impact of facultative bacteria on the metabolic function of an obligate insect-bacterial symbiosis', mBio, vol. 11, no. 4, e00402-20, pp. 1-12. https://doi.org/10.1128/mBio.00402-20
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24. https://doi.org/10.1080/19490976.2020.1788899
Ang, QY, Alexander, M, Newman, JC, Tian, Y, Cai, J, Upadhyay, V, Turnbaugh, JA, Verdin, E, Hall, KD, Leibel, RL, Ravussin, E, Rosenbaum, M, Patterson, AD & Turnbaugh, PJ 2020, 'Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells', Cell, vol. 181, no. 6, pp. 1263-1275.e16. https://doi.org/10.1016/j.cell.2020.04.027
Singh, V, Galla, S, Golonka, RM, Patterson, AD, Chassaing, B, Joe, B & Vijay-Kumar, M 2020, 'Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice', Physiological genomics, vol. 52, no. 8, pp. 314-321. https://doi.org/10.1152/physiolgenomics.00118.2019
Patt, A, Demoret, B, Stets, C, Bill, KL, Smith, P, Vijay, A, Patterson, A, Hays, J, Hoang, M, Chen, JL & Mathé, EA 2020, 'Mdm2-dependent rewiring of metabolomic and lipidomic profiles in dedifferentiated liposarcoma models', Cancers, vol. 12, no. 8, 2157, pp. 1-14. https://doi.org/10.3390/cancers12082157
Tian, Y, Gui, W, Rimal, B, Koo, I, Smith, PB, Nichols, RG, Cai, J, Liu, Q & Patterson, AD 2020, 'Metabolic impact of persistent organic pollutants on gut microbiota', Gut microbes, vol. 12, no. 1, pp. 1-16. https://doi.org/10.1080/19490976.2020.1848209
Allen, JN, Dey, A, Cai, J, Zhang, J, Tian, Y, Kennett, M, Ma, Y, Liang, TJ, Patterson, AD & Hankey-Giblin, PA 2020, 'Metabolic profiling reveals aggravated non-alcoholic steatohepatitis in high-fat high-cholesterol diet-fed apolipoprotein e-deficient mice lacking ron receptor signaling', Metabolites, vol. 10, no. 8, 326, pp. 1-24. https://doi.org/10.3390/metabo10080326
Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Das, NK, Schwartz, AJ, Barthel, G, Inohara, N, Liu, Q, Sankar, A, Hill, DR, Ma, X, Lamberg, O, Schnizlein, MK, Arqués, JL, Spence, JR, Nunez, G, Patterson, AD, Sun, D, Young, VB & Shah, YM 2020, 'Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis', Cell Metabolism, vol. 31, no. 1, pp. 115-130.e6. https://doi.org/10.1016/j.cmet.2019.10.005
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560. https://doi.org/10.1016/j.conctc.2020.100560
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365. https://doi.org/10.1016/j.tox.2020.152365
Noel, OF, Chu, X, Patterson, AD, Edwards, MA, Still, CD & Gerhard, GS 2021, 'Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein', Obesity Surgery, vol. 31, no. 2, pp. 773-780. https://doi.org/10.1007/s11695-020-04993-4
Artacho, A, Isaac, S, Nayak, R, Flor-Duro, A, Alexander, M, Koo, I, Manasson, J, Smith, PB, Rosenthal, P, Homsi, Y, Gulko, P, Pons, J, Puchades-Carrasco, L, Izmirly, P, Patterson, A, Abramson, SB, Pineda-Lucena, A, Turnbaugh, PJ, Ubeda, C & Scher, JU 2021, 'The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis', Arthritis and Rheumatology, vol. 73, no. 6, pp. 931-942. https://doi.org/10.1002/art.41622
Collins, SL & Patterson, AD 2020, 'The gut microbiome: an orchestrator of xenobiotic metabolism', Acta Pharmaceutica Sinica B, vol. 10, no. 1, pp. 19-32. https://doi.org/10.1016/j.apsb.2019.12.001
Tian, Y, Gui, W, Koo, I, Smith, PB, Allman, EL, Nichols, RG, Rimal, B, Cai, J, Liu, Q & Patterson, AD 2020, 'The microbiome modulating activity of bile acids', Gut microbes, vol. 11, no. 4, pp. 979-996. https://doi.org/10.1080/19490976.2020.1732268
Winston, JA, Rivera, AJ, Cai, J, Thanissery, R, Montgomery, SA, Patterson, AD & Theriot, CM 2020, 'Ursodeoxycholic acid (udca) mitigates the host inflammatory response during clostridioides difficile infection by altering gut bile acids', Infection and Immunity, vol. 88, no. 6, e00045. https://doi.org/10.1128/IAI.00045-20
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes, vol. 11, no. 4, pp. 1077-1091. https://doi.org/10.1080/19490976.2020.1743492

2019

Dutta, M, Cai, J, Gui, W & Patterson, AD 2019, 'A review of analytical platforms for accurate bile acid measurement', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4541-4549. https://doi.org/10.1007/s00216-019-01890-3
Tian, Y, Cai, J, Gui, W, Nichols, RG, Koo, I, Zhang, J, Anitha, M & Patterson, AD 2019, 'Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 86-93. https://doi.org/10.1124/dmd.118.083691
Zheng, X, Smith, FB, Aly, NA, Cai, J, Smith, RD, Patterson, AD & Baker, ES 2019, 'Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4673-4682. https://doi.org/10.1007/s00216-019-01869-0
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Alwerdt, J, Patterson, AD & Sliwinski, MJ 2019, 'Gender differences in phytoestrogens and the relationship with speed of processing in older adults: A cross-sectional analysis of NHANES, 1999–2002', Nutrients, vol. 11, no. 8, 1780. https://doi.org/10.3390/nu11081780
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome', Nature Medicine, vol. 25, no. 8, pp. 1225-1233. https://doi.org/10.1038/s41591-019-0509-0
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1. https://doi.org/10.1186/s40246-019-0211-9
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812. https://doi.org/10.1136/gutjnl-2018-316250
Chagwedera, DN, Ang, QY, Bisanz, JE, Leong, YA, Ganeshan, K, Cai, J, Patterson, AD, Turnbaugh, PJ & Chawla, A 2019, 'Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass', Cell Metabolism, vol. 30, no. 2, pp. 364-373.e7. https://doi.org/10.1016/j.cmet.2019.05.002
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (Nature Medicine, (2019), 25, 8, (1225-1233), 10.1038/s41591-019-0509-0)', Nature Medicine, vol. 25, no. 9, pp. 1459. https://doi.org/10.1038/s41591-019-0562-8
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Catharine Ross, A & Cantorna, MT 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN, 3090. https://doi.org/10.3389/fimmu.2018.03090
Zheng, S, Loreto, R, Smith, P, Patterson, A, Hughes, D & Wang, L 2019, 'Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host', International journal of molecular sciences, vol. 20, no. 18, 4589. https://doi.org/10.3390/ijms20184589
Bao, L, Festa, F, Freet, CS, Lee, JP, Hirschler-Laszkiewicz, IM, Chen, SJ, Keefer, KA, Wang, HG, Patterson, AD, Cheung, JY & Miller, BA 2019, 'The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2', Scientific reports, vol. 9, no. 1, 14132. https://doi.org/10.1038/s41598-019-50661-8
Peters, JM, Walter, V, Patterson, AD & Gonzalez, FJ 2019, 'Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis', npj Precision Oncology, vol. 3, no. 1, 26. https://doi.org/10.1038/s41698-019-0098-x
Cantorna, MT, Lin, YD, Arora, J, Bora, S, Tian, Y, Nichols, RG & Patterson, AD 2019, 'Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon', Frontiers in immunology, vol. 10, pp. 1772. https://doi.org/10.3389/fimmu.2019.01772

2018

Waghulde, H, Cheng, X, Galla, S, Mell, B, Cai, J, Pruett-Miller, SM, Vazquez, G, Patterson, A, Kumar, MV & Joe, B 2018, 'Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1', Hypertension, vol. 72, no. 5, pp. 1125-1132. https://doi.org/10.1161/HYPERTENSIONAHA.118.11175
Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22. https://doi.org/10.1016/j.cell.2018.09.004
Sun, L, Xie, C, Wang, G, Wu, Y, Wu, Q, Wang, X, Liu, J, Deng, Y, Xia, J, Chen, B, Zhang, S, Yun, C, Lian, G, Zhang, X, Zhang, H, Bisson, WH, Shi, J, Gao, X, Ge, P, Liu, C, Krausz, KW, Nichols, RG, Cai, J, Rimal, B, Patterson, AD, Wang, X, Gonzalez, FJ & Jiang, C 2018, 'Gut microbiota and intestinal FXR mediate the clinical benefits of metformin', Nature Medicine, vol. 24, no. 12, pp. 1919-1929. https://doi.org/10.1038/s41591-018-0222-4
Pathak, P, Xie, C, Nichols, RG, Ferrell, JM, Boehme, S, Krausz, KW, Patterson, AD, Gonzalez, FJ & Chiang, JYL 2018, 'Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism', Hepatology, vol. 68, no. 4, pp. 1574-1588. https://doi.org/10.1002/hep.29857
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589. https://doi.org/10.1016/j.bbrc.2018.02.097
Chen, F, Coslo, DM, Chen, T, Zhang, L, Tian, Y, Smith, PB, Patterson, AD & Omiecinski, CJ 2019, 'Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism', Journal of Proteome Research, vol. 18, no. 1, pp. 239-251. https://doi.org/10.1021/acs.jproteome.8b00566
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Cai, J, Nichols, RG, Koo, I, Kalikow, ZA, Zhang, L, Tian, Y, Zhang, J, Smith, PB & Patterson, AD 2018, 'Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity', mSystems, vol. 3, no. 6, e00123. https://doi.org/10.1128/mSystems.00123-18
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232. https://doi.org/10.1016/j.jff.2018.04.008
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73. https://doi.org/10.1016/j.jnutbio.2018.01.011
Allen, J, Zhang, J, Quickel, MD, Kennett, M, Patterson, AD & Hankey-Giblin, PA 2018, 'Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model', Journal of Proteome Research, vol. 17, no. 9, pp. 3268-3280. https://doi.org/10.1021/acs.jproteome.8b00379
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Cheema, M, Smith, PB, Patterson, AD, Hristov, A & Harte, FM 2018, 'The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size', Journal of dairy science, vol. 101, no. 10, pp. 8672-8687. https://doi.org/10.3168/jds.2017-14137
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408. https://doi.org/10.3389/fimmu.2018.00408
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2017.10.011

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