Andrew David Patterson, PhD - Penn State Cancer Institute
Researcher Profile
Andrew David Patterson, PhD
Biochemistry & Molecular Biology
Professor, Veterinary and Biomedical Sciences
One Health Microbiome Center
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Professor, Veterinary and Biomedical Sciences
One Health Microbiome Center
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Cao, Z, Zhang, C, Lei, H, Lin, W, Yu, W, Gao, X, He, Y, Li, X, Xiang, Q, Zhang, Z, Luo, W, Patterson, AD, Zhang, L & Chen, G 2026, 'Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging', Advanced Science, vol. 13, no. 4, e15794. https://doi.org/10.1002/advs.202515794
Bonazzi, E, Hao, F, Patterson, AD, Peyrin-Biroulet, L, Jensen, BAH & Chassaing, B 2026, 'Microbiota modulation by a human Paneth cell α-defensin fragment protects against DSS-induced colitis', iScience, vol. 29, no. 1, 114310. https://doi.org/10.1016/j.isci.2025.114310
Yokoyama, S, Kido, T, Yoneda, M, Springer, DA, Awasthi, PP, Chari, R, Patterson, AD & Kimura, S 2026, 'Secretoglobin 3A1 in activated muscle satellite cells contributes to myosin heavy chain IIX and IIB fiber differentiation', Cellular and Molecular Life Sciences, vol. 83, no. 1, 52. https://doi.org/10.1007/s00018-025-06045-5
2025
Tian, S, Kim, MS, Zhao, J, Heber, K, Hao, F, Koslicki, D, Tian, S, Singh, V, Patterson, AD & Bisanz, JE 2025, 'A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance', Cell Host and Microbe, vol. 33, no. 3, pp. 373-387.e9. https://doi.org/10.1016/j.chom.2025.02.007
Koo, H, Heber, K, Tian, S, Connolly, ST, Hao, F, Zhao, J, Swencki-Underwood, B, Patterson, AD, Townsend, GE & Bisanz, JE 2025, 'A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage', mBio, vol. 16, no. 12, pp. 1-19. https://doi.org/10.1128/mbio.02341-25
Park, G, Johnson, K, Miller, K, Kadyan, S, Singar, S, Patoine, C, Hao, F, Lee, Y, Patterson, AD, Arjmandi, B, Kris-Etherton, PM, Berryman, CE & Nagpal, R 2025, 'Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers', npj Science of Food, vol. 9, no. 1, 35. https://doi.org/10.1038/s41538-025-00403-0
Crockett, AM, Vélez Colόn, MC, Kebir, H, Smith, FM, Iascone, DM, Ciesielski, B, Koshkin, S, Patterson, AD, Rossano, AJ, Sehgal, A, Anderson, SA & Alvarez, JI 2025, 'Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome', Science Translational Medicine, vol. 17, no. 812, eads2116. https://doi.org/10.1126/scitranslmed.ads2116
Khan, Y, Schmidt, AM, Oldro, KJ, Zhu, X, Kramer, AR, Hamilton, SR, Bleil, KO, Krisko, RM, Zitzow, JD, Tian, Y, Chang, SC, Walter, V, Cohen, SM, Gonzalez, FJ, Patterson, AD & Peters, JM 2025, 'Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate', Toxicological Sciences, vol. 205, no. 1, pp. 47-52. https://doi.org/10.1093/toxsci/kfaf026
El Abiead, Y, Rutz, A, Zuffa, S, Amer, B, Xing, S, Brungs, C, Schmid, R, Correia, MSP, Caraballo-Rodriguez, AM, Zarrinpar, A, Mannochio-Russo, H, Witting, M, Mohanty, I, Pluskal, T, Bittremieux, W, Knight, R, Patterson, AD, van der Hooft, JJJ, Böcker, S, Dunn, WB, Linington, RG, Wishart, DS, Wolfender, JL, Fiehn, O, Zamboni, N & Dorrestein, PC 2025, 'Discovery of metabolites prevails amid in-source fragmentation', Nature Metabolism, vol. 7, no. 3, 3832, pp. 435-437. https://doi.org/10.1038/s42255-025-01239-4
DiMattia, ZS, Zhao, J, Hao, F, Koshkin, S, Bisanz, JE, Patterson, AD, Fleming, JA, Kris-Etherton, PM & Petersen, KS 2025, 'Effect of Varying Quantities of Lean Beef as Part of a Mediterranean-Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial', Journal of the American Heart Association, vol. 14, no. 19, e041063. https://doi.org/10.1161/JAHA.125.041063
Huang, W, Zhang, Y, Das, NK, Solanki, S, Jain, C, El-Derany, MO, Koo, I, Bell, HN, Aabed, N, Singhal, R, Castillo, C, Buscher, K, Ying, Y, Dimitroff, J, Sharma, A, Shi, J, Hogan, SP, Dame, MK, Higgins, PDR, Colacino, JA, Oh, TG, Spence, JR, Patterson, AD, Greenberg, AS, Greenson, JK, Nusrat, A & Shah, YM 2025, 'Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD', Nature Metabolism, vol. 7, no. 7, pp. 1358-1374. https://doi.org/10.1038/s42255-025-01313-x
Hwang, S, Koo, I, Patterson, AD & Lambert, JD 2025, 'High-fat diet-induced obesity alters the dose-dependent metabolism of (–)-epigallocatechin-3-gallate in mice', Nutrition Research, vol. 143, pp. 16-28. https://doi.org/10.1016/j.nutres.2025.09.009
Li, Y, Leung, PSC, Zhang, W, Zhang, S, Liu, Z, Kurth, M, Patterson, AD, Gershwin, ME & Song, J 2025, 'Immunobiology of bile and cholangiocytes', Journal of Autoimmunity, vol. 151, 103376. https://doi.org/10.1016/j.jaut.2025.103376
Rytter, H, Naimi, S, Wu, G, Lewis, J, Duquesnoy, M, Vigué, L, Tenaillon, O, Belda, E, Vazquez-Gomez, M, Touly, N, Arnone, D, Hao, F, Ley, RE, Clément, K, Peyrin-Biroulet, L, Patterson, AD, Gewirtz, AT & Chassaing, B 2025, 'In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier', Gut, vol. 74, no. 5, pp. 761-774. https://doi.org/10.1136/gutjnl-2024-333925
Delaroque, C, Rytter, H, Bonazzi, E, Huillet, M, Ellero-Simatos, S, Chatonnat, E, Hao, F, Patterson, A & Chassaing, B 2025, 'Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility', Nature communications, vol. 16, no. 1, 6954. https://doi.org/10.1038/s41467-025-62397-3
Katona, BW, Shukla, A, Hu, W, Nyul, T, Dudzik, C, Arvanitis, A, Clay, D, Dungan, M, Weber, M, Tu, V, Hao, F, Gan, S, Chau, L, Buchner, AM, Falk, GW, Jaffe, DL, Ginsberg, G, Palmer, SN, Zhan, X, Patterson, AD, Bittinger, K & Ni, J 2025, 'Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver', Gut microbes, vol. 17, no. 1, 2474141. https://doi.org/10.1080/19490976.2025.2474141
Dong, F, Annalora, AJ, Murray, IA, Chakraborty, D, Coslo, DM, Marcus, C, Patterson, AD & Perdew, GH 2025, 'Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context', Nutrients, vol. 17, no. 5, 876. https://doi.org/10.3390/nu17050876
Mogre, S, Robinson, L, Sethia, K, Rimal, B, Son, J, Pacifico, C, Santy, L, Patterson, A & Glick, AB 2025, 'Somatic mutations in IRE1α regulate keratinocyte migration and survival by differentially activating Rho GTPases', Journal of Cell Science, vol. 138, no. 16, jcs263790. https://doi.org/10.1242/jcs.263790
2024
Alexander, M, Upadhyay, V, Rock, R, Ramirez, L, Trepka, K, Puchalska, P, Orellana, D, Ang, QY, Whitty, C, Turnbaugh, JA, Tian, Y, Dumlao, D, Nayak, R, Patterson, A, Newman, JC, Crawford, PA & Turnbaugh, PJ 2024, 'A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity', Cell Reports, vol. 43, no. 11, 114891. https://doi.org/10.1016/j.celrep.2024.114891
Zhu, B, Zhu, X, Borland, MG, Ralph, DH, Chiaro, CR, Krausz, KW, Ntambi, JM, Glick, AB, Patterson, AD, Perdew, GH, Gonzalez, FJ & Peters, JM 2024, 'Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids', Biomolecules, vol. 14, no. 6, 606. https://doi.org/10.3390/biom14060606
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Van Syoc, E, Nixon, MP, Silverman, JD, Luo, Y, Gonzalez, FJ, Elbere, I, Klovins, J, Patterson, AD, Rogers, CJ & Ganda, E 2024, 'Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations', mBio, vol. 15, no. 6. https://doi.org/10.1128/mbio.00169-24
Nichols, RG, Rimal, B, Hao, F, Peters, JM, Davenport, ER & Patterson, AD 2024, 'Chlorpyrifos modulates the mouse gut microbiota and metabolic activity', Environment international, vol. 192, 109022. https://doi.org/10.1016/j.envint.2024.109022
Hecht, AL, Harling, LC, Friedman, ES, Tanes, C, Lee, J, Firrman, J, Hao, F, Tu, V, Liu, LS, Patterson, AD, Bittinger, K, Goulian, M & Wu, GD 2024, 'Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae', Journal of Clinical Investigation, vol. 134, no. 9, e174726. https://doi.org/10.1172/JCI174726
Paudel, D, Nair, DVT, Tian, S, Hao, F, Goand, UK, Joseph, G, Prodes, E, Chai, Z, Robert, CEM, Chassaing, B, Patterson, AD & Singh, V 2024, 'Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation', Gut microbes, vol. 16, no. 1, 2341457. https://doi.org/10.1080/19490976.2024.2341457
Tian, Y, Rimal, B, Bisanz, JE, Gui, W, Wolfe, TM, Koo, I, Murray, IA, Nettleford, SK, Yokoyama, S, Dong, F, Koshkin, S, Prabhu, KS, Turnbaugh, PJ, Walk, ST, Perdew, GH & Patterson, AD 2024, 'Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice', Environmental health perspectives, vol. 132, no. 8, 087005. https://doi.org/10.1289/EHP13356
Paudel, D, Hao, F, Goand, UK, Tian, S, Koehle, AM, Nguyen, LV, Tian, Y, Patterson, AD & Singh, V 2024, 'Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease', iScience, vol. 27, no. 10, 110940. https://doi.org/10.1016/j.isci.2024.110940
Ntambi, JN, Kalyesubula, M, Cootway, D, Lewis, SA, Phang, YX, Liu, Z, O'Neill, LM, Lefers, L, Huff, H, Miller, JR, Pegkou Christofi, V, Anderson, E, Aljohani, A, Mutebi, F, Dutta, M, Patterson, A & Ntambi, JM 2024, 'Hepatic stearoyl-CoA desaturase-1 deficiency induces fibrosis and hepatocellular carcinoma-related gene activation under a high carbohydrate low fat diet', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1869, no. 7, 159538. https://doi.org/10.1016/j.bbalip.2024.159538
Daniel, N, Wu, GD, Walters, W, Compher, C, Ni, J, Delaroque, C, Albenberg, L, Ley, RE, Patterson, AD, Lewis, JD, Gewirtz, AT & Chassaing, B 2024, 'Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption', CMGH, vol. 17, no. 2, pp. 315-318. https://doi.org/10.1016/j.jcmgh.2023.11.001
Chakraborty, D, Coslo, DM, Murray, IA, Vijay, A, Patterson, AD & Perdew, GH 2024, 'Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine', FASEB Journal, vol. 38, no. 4, e23471. https://doi.org/10.1096/fj.202302319R
Bonazzi, E, Bretin, A, Vigué, L, Hao, F, Patterson, AD, Gewirtz, AT & Chassaing, B 2024, 'Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity', Microbiome, vol. 12, no. 1, 5. https://doi.org/10.1186/s40168-023-01724-6
Tung, HC, Kim, JW, Zhu, J, Li, S, Yan, J, Liu, Q, Koo, I, Koshkin, SA, Hao, F, Zhong, G, Xu, M, Wang, Z, Wang, J, Huang, Y, Xi, Y, Cai, X, Xu, P, Ren, S, Higashiyama, T, Gonzalez, FJ, Li, S, Isoherranen, N, Yang, D, Ma, X, Patterson, AD & Xie, W 2024, 'Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose', Science Translational Medicine, vol. 16, no. 766, eadk8446. https://doi.org/10.1126/scitranslmed.adk8446
Karan, SK, Hosur, S, Kashani, Z, Leng, H, Vijay, A, Sriramdas, R, Wang, K, Poudel, B, Patterson, AD, Kiani, M & Priya, S 2024, 'Magnetic field and ultrasound induced simultaneous wireless energy harvesting', Energy and Environmental Science, vol. 17, no. 6, pp. 2129-2144. https://doi.org/10.1039/d3ee03889k
Anitha, M, Kumar, SM, Koo, I, Perdew, GH, Srinivasan, S & Patterson, AD 2024, 'Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress', International journal of molecular sciences, vol. 25, no. 16, 8581. https://doi.org/10.3390/ijms25168581
Gray, JL, Tian, Y, Ning, G, Cutler, T, Zheng, Y & Patterson, AD 2024, 'Optimization of Conventionally Processed Biological Samples for STEM-EDS Elemental Quantification', Microscopy and Microanalysis, vol. 30, no. 2024, pp. 878-880. https://doi.org/10.1093/mam/ozae044.428
Gentry, EC, Collins, SL, Panitchpakdi, M, Belda-Ferre, P, Stewart, AK, Carrillo Terrazas, M, Lu, HH, Zuffa, S, Yan, T, Avila-Pacheco, J, Plichta, DR, Aron, AT, Wang, M, Jarmusch, AK, Hao, F, Syrkin-Nikolau, M, Vlamakis, H, Ananthakrishnan, AN, Boland, BS, Hemperly, A, Vande Casteele, N, Gonzalez, FJ, Clish, CB, Xavier, RJ, Chu, H, Baker, ES, Patterson, AD, Knight, R, Siegel, D & Dorrestein, PC 2024, 'Reverse metabolomics for the discovery of chemical structures from humans', Nature, vol. 626, no. 7998, pp. 419-426. https://doi.org/10.1038/s41586-023-06906-8
Golonka, RM, Yeoh, BS, Saha, P, Tian, Y, Chiang, JYL, Patterson, AD, Gewirtz, AT, Joe, B & Kumar, MV 2024, 'Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice', CMGH, vol. 17, no. 5, pp. 719-735. https://doi.org/10.1016/j.jcmgh.2024.01.011
Yokoyama, S, Koo, I, Aibara, D, Tian, Y, Murray, IA, Collins, SL, Coslo, DM, Kono, M, Peters, JM, Proia, RL, Gonzalez, FJ, Perdew, GH & Patterson, AD 2024, 'Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation', Advanced Science, vol. 11, no. 40, 2400794. https://doi.org/10.1002/advs.202400794
DINE-CD & SPARC IBD Investigators 2024, 'Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts', CMGH, vol. 18, no. 3, 101357. https://doi.org/10.1016/j.jcmgh.2024.05.005
Mohanty, I, Mannochio-Russo, H, Schweer, JV, El Abiead, Y, Bittremieux, W, Xing, S, Schmid, R, Zuffa, S, Vasquez, F, Muti, VB, Zemlin, J, Tovar-Herrera, OE, Moraïs, S, Desai, D, Amin, S, Koo, I, Turck, CW, Mizrahi, I, Kris-Etherton, PM, Petersen, K, Fleming, JA, Huan, T, Patterson, AD, Siegel, D, Hagey, LR, Wang, M, Aron, AT & Dorrestein, PC 2024, 'The underappreciated diversity of bile acid modifications', Cell, vol. 187, no. 7, pp. 1801-1818.e20. https://doi.org/10.1016/j.cell.2024.02.019
Mbah, NE, Myers, AL, Sajjakulnukit, P, Chung, C, Thompson, JK, Hong, HS, Giza, H, Dang, D, Nwosu, ZC, Shan, M, Sweha, SR, Maydan, DD, Chen, B, Zhang, L, Magnuson, B, Zhu, Z, Radyk, M, Lavoie, B, Yadav, VN, Koo, I, Patterson, AD, Wahl, DR, Franchi, L, Agnihotri, S, Koschmann, CJ, Venneti, S & Lyssiotis, CA 2024, 'Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma', Nature communications, vol. 15, no. 1, 8983. https://doi.org/10.1038/s41467-024-52973-4
Zuffa, S, Schmid, R, Bauermeister, A, Paulo, PW, Caraballo-Rodriguez, AM, El Abiead, Y, Aron, AT, Gentry, EC, Zemlin, J, Meehan, MJ, Avalon, NE, Cichewicz, RH, Buzun, E, Terrazas, MC, Hsu, CY, Oles, R, Ayala, AV, Zhao, J, Chu, H, Kuijpers, MCM, Jackrel, SL, Tugizimana, F, Nephali, LP, Dubery, IA, Madala, NE, Moreira, EA, Costa-Lotufo, LV, Lopes, NP, Rezende-Teixeira, P, Jimenez, PC, Rimal, B, Patterson, AD, Traxler, MF, Pessotti, RDC, Alvarado-Villalobos, D, Tamayo-Castillo, G, Chaverri, P, Escudero-Leyva, E, Quiros-Guerrero, LM, Bory, AJ, Joubert, J, Rutz, A, Wolfender, JL, Allard, PM, Sichert, A, Pontrelli, S, Pullman, BS, Bandeira, N, Gerwick, WH, Gindro, K, Massana-Codina, J, Wagner, BC, Forchhammer, K, Petras, D, Aiosa, N, Garg, N, Liebeke, M, Bourceau, P, Kang, KB, Gadhavi, H, de Carvalho, LPS, Silva dos Santos, M, Pérez-Lorente, AI, Molina-Santiago, C, Romero, D, Franke, R, Brönstrup, M, Vera Ponce de León, A, Pope, PB, La Rosa, SL, La Barbera, G, Roager, HM, Laursen, MF, Hammerle, F, Siewert, B, Peintner, U, Licona-Cassani, C, Rodriguez-Orduña, L, Rampler, E, Hildebrand, F, Koellensperger, G, Schoeny, H, Hohenwallner, K, Panzenboeck, L, Gregor, R, O’Neill, EC, Roxborough, ET, Odoi, J, Bale, NJ, Ding, S, Sinninghe Damsté, JS, Guan, XL, Cui, JJ, Ju, KS, Silva, DB, Silva, FMR, da Silva, GF, Koolen, HHF, Grundmann, C, Clement, JA, Mohimani, H, Broders, K, McPhail, KL, Ober-Singleton, SE, Rath, CM, McDonald, D, Knight, R, Wang, M & Dorrestein, PC 2024, 'microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data', Nature Microbiology, vol. 9, no. 2, pp. 336-345. https://doi.org/10.1038/s41564-023-01575-9
2023
Zhu, X, Liu, Q, Patterson, AD, Sharma, AK, Amin, SG, Cohen, SM, Gonzalez, FJ & Peters, JM 2023, 'Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice', Metabolites, vol. 13, no. 8, 936. https://doi.org/10.3390/metabo13080936
Zhou, X, Chakraborty, D, Murray, IA, Coslo, D, Kehs, Z, Vijay, A, Ton, C, Desai, D, Amin, SG, Patterson, AD & Perdew, GH 2023, 'Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming', Laboratory Investigation, vol. 103, no. 2, 100012. https://doi.org/10.1016/j.labinv.2022.100012
Vijay, A, Boyle, NR, Kumar, SM, Perdew, GH, Srinivasan, S & Patterson, AD 2023, 'Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice', Toxicological Sciences, vol. 192, no. 1, pp. 117-128. https://doi.org/10.1093/toxsci/kfad014
Sun, L, Zhang, Y, Cai, J, Rimal, B, Rocha, ER, Coleman, JP, Zhang, C, Nichols, RG, Luo, Y, Kim, B, Chen, Y, Krausz, KW, Harris, CC, Patterson, AD, Zhang, Z, Takahashi, S & Gonzalez, FJ 2023, 'Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer', Nature communications, vol. 14, no. 1, 755. https://doi.org/10.1038/s41467-023-36089-9
Bass, R, Tanes, C, Bittinger, K, Li, Y, Lee, H, Friedman, ES, Koo, I, Patterson, AD, Liu, Q, Wu, GD & Stallings, VA 2024, 'Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids', Journal of Cystic Fibrosis, vol. 23, no. 3, pp. 481-489. https://doi.org/10.1016/j.jcf.2023.09.010
Hwang, S, Koo, I, Patterson, AD & Lambert, JD 2023, 'Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate', Food and Function, vol. 14, no. 20, pp. 9434-9445. https://doi.org/10.1039/d3fo02710d
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010. https://doi.org/10.1096/fj.202300703R
Morgan, EW, Dong, F, Annalora, AJ, Murray, IA, Wolfe, T, Erickson, R, Gowda, K, Amin, SG, Petersen, KS, Kris-Etherton, PM, Marcus, CB, Walk, ST, Patterson, AD & Perdew, GH 2023, 'Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182510
Dong, F, Annalora, AJ, Murray, IA, Tian, Y, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182508
Young, JA, Duran-Ortiz, S, Bell, S, Funk, K, Tian, Y, Liu, Q, Patterson, AD, List, EO, Berryman, DE & Kopchick, JJ 2023, 'Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice', Metabolites, vol. 13, no. 2, 191. https://doi.org/10.3390/metabo13020191
Patel, D, Murray, IA, Dong, F, Annalora, AJ, Gowda, K, Coslo, DM, Krzeminski, J, Koo, I, Hao, F, Amin, SG, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites', Metabolites, vol. 13, no. 9, 985. https://doi.org/10.3390/metabo13090985
Misra, S, Lee, TJ, Sebastian, A, McGuigan, J, Liao, C, Koo, I, Patterson, AD, Rossi, RM, Hall, MA, Albert, I & Prabhu, KS 2023, 'Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation', Redox Biology, vol. 59, 102571. https://doi.org/10.1016/j.redox.2022.102571
Chen, X, Patterson, AD, Perdew, GH, Murray, IA & Kellogg, JJ 2023, 'Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)', Journal of Functional Foods, vol. 106, 105602. https://doi.org/10.1016/j.jff.2023.105602
Shalon, D, Culver, RN, Grembi, JA, Folz, J, Treit, PV, Shi, H, Rosenberger, FA, Dethlefsen, L, Meng, X, Yaffe, E, Aranda-Díaz, A, Geyer, PE, Mueller-Reif, JB, Spencer, S, Patterson, AD, Triadafilopoulos, G, Holmes, SP, Mann, M, Fiehn, O, Relman, DA & Huang, KC 2023, 'Profiling the human intestinal environment under physiological conditions', Nature, vol. 617, no. 7961, pp. 581-591. https://doi.org/10.1038/s41586-023-05989-7
Bretin, A, Zou, J, San Yeoh, B, Ngo, VL, Winer, S, Winer, DA, Reddivari, L, Pellizzon, M, Walters, WA, Patterson, AD, Ley, R, Chassaing, B, Vijay-Kumar, M & Gewirtz, AT 2023, 'Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor', CMGH, vol. 15, no. 6, pp. 1421-1442. https://doi.org/10.1016/j.jcmgh.2023.02.007
Tian, S, Paudel, D, Hao, F, Neupane, R, Castro, R, Patterson, AD, Tiwari, AK, Prabhu, KS & Singh, V 2023, 'Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production', Cancer Reports, vol. 6, no. 11, e1863. https://doi.org/10.1002/cnr2.1863
Perdew, GH, Esser, C, Snyder, M, Sherr, DH, van den Bogaard, EH, McGovern, K, Fernández-Salguero, PM, Coumoul, X & Patterson, AD 2023, 'The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022', International journal of molecular sciences, vol. 24, no. 6, 5550. https://doi.org/10.3390/ijms24065550
Yeoh, BS, Golonka, RM, Saha, P, Kandalgaonkar, MR, Tian, Y, Osman, I, Patterson, AD, Gewirtz, AT, Joe, B & Vijay-Kumar, M 2023, 'Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice', Function, vol. 4, no. 5, zqad040. https://doi.org/10.1093/function/zqad040
2022
Dohnalová, L, Lundgren, P, Carty, JRE, Goldstein, N, Wenski, SL, Nanudorn, P, Thiengmag, S, Huang, KP, Litichevskiy, L, Descamps, HC, Chellappa, K, Glassman, A, Kessler, S, Kim, J, Cox, TO, Dmitrieva-Posocco, O, Wong, AC, Allman, EL, Ghosh, S, Sharma, N, Sengupta, K, Cornes, B, Dean, N, Churchill, GA, Khurana, TS, Sellmyer, MA, FitzGerald, GA, Patterson, AD, Baur, JA, Alhadeff, AL, Helfrich, EJN, Levy, M, Betley, JN & Thaiss, CA 2022, 'A microbiome-dependent gut–brain pathway regulates motivation for exercise', Nature, vol. 612, no. 7941, pp. 739-747. https://doi.org/10.1038/s41586-022-05525-z
Granados, JC, Falah, K, Koo, I, Morgan, EW, Perdew, GH, Patterson, AD, Jamshidi, N & Nigam, SK 2022, 'AHR is a master regulator of diverse pathways in endogenous metabolism', Scientific reports, vol. 12, no. 1, 16625. https://doi.org/10.1038/s41598-022-20572-2
Alrehaili, BD, Lee, M, Takahashi, S, Novak, R, Rimal, B, Boehme, S, Trammell, SAJ, Grevengoed, TJ, Kumar, D, Alnouti, Y, Chiti, K, Wang, X, Patterson, AD, Chiang, JYL, Gonzalez, FJ & Lee, YK 2022, 'Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice', Hepatology Communications, vol. 6, no. 10, pp. 2765-2780. https://doi.org/10.1002/hep4.2041
Cai, J, Rimal, B, Jiang, C, Chiang, JYL & Patterson, AD 2022, 'Bile acid metabolism and signaling, the microbiota, and metabolic disease', Pharmacology and Therapeutics, vol. 237, 108238. https://doi.org/10.1016/j.pharmthera.2022.108238
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Mohammed, AD, Mohammed, Z, Roland, MM, Chatzistamou, I, Jolly, A, Schoettmer, LM, Arroyo, M, Kakar, K, Tian, Y, Patterson, A, Nagarkatti, M, Nagarkatti, P & Kubinak, JL 2022, 'Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel', Nature communications, vol. 13, no. 1, 525. https://doi.org/10.1038/s41467-022-28126-w
Delaroque, C, Wu, GD, Compher, C, Ni, J, Albenberg, L, Liu, Q, Tian, Y, Patterson, AD, Lewis, JD, Gewirtz, AT & Chassaing, B 2022, 'Diet standardization reduces intra-individual microbiome variation', Gut microbes, vol. 14, no. 1, pp. 2149047. https://doi.org/10.1080/19490976.2022.2149047
Tian, Y, Rimal, B, Gui, W, Koo, I, Smith, PB, Yokoyama, S & Patterson, AD 2022, 'Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood', Metabolites, vol. 12, no. 10, 894. https://doi.org/10.3390/metabo12100894
Tian, Y, Rimal, B, Gui, W, Koo, I, Yokoyama, S, Perdew, GH & Patterson, AD 2022, 'Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood', International journal of molecular sciences, vol. 23, no. 15, 8220. https://doi.org/10.3390/ijms23158220
Baldin, M, Garcia, D, Zanton, GI, Hao, F, Patterson, AD & Harvatine, KJ 2022, 'Effect of 2-hydroxy-4-(methylthio)butanoate (HMTBa) on milk fat, rumen environment and biohydrogenation, and rumen protozoa in lactating cows fed diets with increased risk for milk fat depression', Journal of dairy science, vol. 105, no. 9, pp. 7446-7461. https://doi.org/10.3168/jds.2022-21910
Seemiller, LR, Goldberg, LR, Smith, PB, Dennis, J, Patterson, AD & Gould, TJ 2022, 'Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains', Neuropharmacology, vol. 221, 109279. https://doi.org/10.1016/j.neuropharm.2022.109279
Jiang, J, Ma, Y, Liu, Y, Lu, D, Gao, X, Krausz, KW, Desai, D, Amin, SG, Patterson, AD, Gonzalez, FJ & Xie, C 2022, 'Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice', Hepatology Communications, vol. 6, no. 12, pp. 3363-3378. https://doi.org/10.1002/hep4.2099
Matamoros, C, Hao, F, Tian, Y, Patterson, AD & Harvatine, KJ 2022, 'Interaction of sodium acetate supplementation and dietary fiber level on feeding behavior, digestibility, milk synthesis, and plasma metabolites', Journal of dairy science, vol. 105, no. 11, pp. 8824-8838. https://doi.org/10.3168/jds.2022-21911
Morgan, EW, Perdew, GH & Patterson, AD 2022, 'Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research', Toxicological Sciences, vol. 187, no. 2, pp. 189-213. https://doi.org/10.1093/toxsci/kfac029
Chassaing, B, Compher, C, Bonhomme, B, Liu, Q, Tian, Y, Walters, W, Nessel, L, Delaroque, C, Hao, F, Gershuni, V, Chau, L, Ni, J, Bewtra, M, Albenberg, L, Bretin, A, McKeever, L, Ley, RE, Patterson, AD, Wu, GD, Gewirtz, AT & Lewis, JD 2022, 'Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome', Gastroenterology, vol. 162, no. 3, pp. 743-756. https://doi.org/10.1053/j.gastro.2021.11.006
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056. https://doi.org/10.1016/j.tox.2021.153056
Chalmers, FE, Mogre, S, Rimal, B, Son, J, Patterson, AD, Stairs, DB & Glick, AB 2022, 'The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus', Developmental biology, vol. 492, pp. 59-70. https://doi.org/10.1016/j.ydbio.2022.09.009