Researcher Profile

Researcher Profile

Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Associate Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
adp117@psu.edu

Research Interests

  • Metabolomics
  • Liver
  • Mass Spectrometry
  • Neoplasms
  • Microbiota
  • Diet
  • Biomarkers
  • Obesity
  • Serum
  • Bile Acids and Salts
  • Aryl Hydrocarbon Receptors
  • Homeostasis

Recent Publications

2019

Dutta, M, Cai, J, Gui, W & Patterson, AD 2019, 'A review of analytical platforms for accurate bile acid measurement', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4541-4549. https://doi.org/10.1007/s00216-019-01890-3
Tian, Y, Cai, J, Gui, W, Nichols, RG, Koo, I, Zhang, J, Anitha, M & Patterson, AD 2019, 'Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 86-93. https://doi.org/10.1124/dmd.118.083691
Zheng, X, Smith, FB, Aly, NA, Cai, J, Smith, RD, Patterson, AD & Baker, ES 2019, 'Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4673-4682. https://doi.org/10.1007/s00216-019-01869-0
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, Z & Paulson, R 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline' Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut. https://doi.org/10.1136/gutjnl-2018-316250
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Ross, AC & Cantorna, MT-A 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN. https://doi.org/10.3389/fimmu.2018.03090

2018

Waghulde, H, Cheng, X, Galla, S, Mell, B, Cai, J, Pruett-Miller, SM, Vazquez, G, Patterson, AD, Kumar, MV & Joe, B 2018, 'Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1', Hypertension, vol. 72, no. 5, pp. 1125-1132. https://doi.org/10.1161/HYPERTENSIONAHA.118.11175
Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, W, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22. https://doi.org/10.1016/j.cell.2018.09.004
Sun, L, Xie, C, Wang, G, Wu, Y, Wu, Q, Wang, X, Liu, J, Deng, Y, Xia, J, Chen, B, Zhang, S, Yun, C, Lian, G, Zhang, X, Zhang, H, Bisson, WH, Shi, J, Gao, X, Ge, P, Liu, C, Krausz, KW, Nichols, RG, Cai, J, Rimal, B, Patterson, AD, Wang, X, Gonzalez, FJ & Jiang, C 2018, 'Gut microbiota and intestinal FXR mediate the clinical benefits of metformin', Nature Medicine, vol. 24, no. 12, pp. 1919-1929. https://doi.org/10.1038/s41591-018-0222-4
Pathak, P, Xie, C, Nichols, RG, Ferrell, JM, Boehme, S, Krausz, KW, Patterson, AD, Gonzalez, FJ & Chiang, JYL 2018, 'Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism', Hepatology, vol. 68, no. 4, pp. 1574-1588. https://doi.org/10.1002/hep.29857
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589. https://doi.org/10.1016/j.bbrc.2018.02.097
Chen, F, Coslo, DM, Chen, T, Zhang, L, Tian, Y, Smith, PB, Patterson, AD & Omiecinski, CJ 2019, 'Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism' Journal of Proteome Research, vol. 18, no. 1, pp. 239-251. https://doi.org/10.1021/acs.jproteome.8b00566
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Cai, J, Nichols, RG, Koo, I, Kalikow, ZA, Zhang, L, Tian, Y, Zhang, J, Smith, PB & Patterson, AD 2018, 'Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity' mSystems, vol. 3, no. 6, e00123. https://doi.org/10.1128/mSystems.00123-18
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, R, Patterson, AD, Cantorna, MT-A & Giblin, PH 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232. https://doi.org/10.1016/j.jff.2018.04.008
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73. https://doi.org/10.1016/j.jnutbio.2018.01.011
Allen, J, Zhang, J, Quickel, MD, Kennett, MJ, Patterson, AD & Giblin, PH 2018, 'Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model' Journal of Proteome Research, vol. 17, no. 9, pp. 3268-3280. https://doi.org/10.1021/acs.jproteome.8b00379
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists' Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408. https://doi.org/10.3389/fimmu.2018.00408
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2017.10.011

2017

Cai, J, Zhang, J, Tian, Y, Zhang, L, Hatzakis, E, Krausz, KW, Smith, PB, Gonzalez, FJ & Patterson, AD 2017, ' Orthogonal Comparison of GC-MS and 1 H NMR Spectroscopy for Short Chain Fatty Acid Quantitation ', Analytical Chemistry, vol. 89, no. 15, pp. 7900-7906. https://doi.org/10.1021/acs.analchem.7b00848
Xie, C, Yagai, T, Luo, Y, Liang, X, Chen, T, Wang, Q, Sun, D, Zhao, J, Ramakrishnan, SK, Sun, L, Jiang, C, Xue, X, Tian, Y, Krausz, KW, Patterson, AD, Shah, YM, Wu, Y, Jiang, C & Gonzalez, FJ 2017, 'Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis', Nature Medicine, vol. 23, no. 11, pp. 1298-1308. https://doi.org/10.1038/nm.4412
Xie, C, Jiang, C, Shi, J, Gao, X, Sun, D, Sun, L, Wang, T, Takahashi, S, Anitha, M, Krausz, KW, Patterson, AD & Gonzalez, FJ 2017, 'An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice', Diabetes, vol. 66, no. 3, pp. 613-626. https://doi.org/10.2337/db16-0663
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, PB, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698. https://doi.org/10.1016/j.jff.2017.08.038
Corresponding author 2017, 'Erratum: Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (Cell Metabolism (2017) 26(4) (672–685.e4) (S1550413117305041) (10.1016/j.cmet.2017.08.019))', Cell Metabolism, vol. 26, no. 5. https://doi.org/10.1016/j.cmet.2017.10.007
DiMarzio, M, Rusconi, B, Yennawar, N, Eppinger, M, Patterson, AD & Dudley, EG 2017, 'Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA', PLoS One, vol. 12, no. 9, e0183564. https://doi.org/10.1371/journal.pone.0183564
Li, G, Xie, C, Lu, S, Nichols, RG, Tian, Y, Li, L, Patel, D, Ma, Y, Brocker, CN, Yan, T, Krausz, KW, Xiang, R, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2017, 'Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota', Cell Metabolism, vol. 26, no. 4, pp. 672-685.e4. https://doi.org/10.1016/j.cmet.2017.08.019
Gonzalez, FJ, Jiang, C, Xie, C & Patterson, AD 2017, 'Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease', Digestive Diseases, vol. 35, no. 3, pp. 178-184. https://doi.org/10.1159/000450908
Huang, KH, Hao, L, Smith, PB, Rogers, CJ, Patterson, AD & Ross, AC 2017, 'Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice', Journal of Nutrition, vol. 147, no. 5, pp. 746-753. https://doi.org/10.3945/jn.116.245951
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Kumar, MV 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33. https://doi.org/10.1016/j.jnutbio.2016.11.014
Zhang, L, Nichols, RG & Patterson, AD 2017, 'The aryl hydrocarbon receptor as a moderator of host-microbiota communication', Current Opinion in Toxicology, vol. 2, pp. 30-35. https://doi.org/10.1016/j.cotox.2017.02.001

2016

Gonzalez, FJ, Jiang, C & Patterson, AD 2016, 'An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease', Gastroenterology, vol. 151, no. 5, pp. 845-859. https://doi.org/10.1053/j.gastro.2016.08.057
Cai, J, Zhang, L, Jones, RA, Correll, JB, Hatzakis, E, Smith, PB, Gonzalez, FJ & Patterson, AD 2016, 'Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota', Journal of Proteome Research, vol. 15, no. 2, pp. 563-571. https://doi.org/10.1021/acs.jproteome.5b00957
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969. https://doi.org/10.1038/srep33969
Zhang, L, Xie, C, Nichols, RG, Chan, SHJ, Jiang, C, Hao, R, Smith, PB, Cai, J, Simons, MN, Hatzakis, E, Maranas, CD, Gonzalez, FJ & Patterson, AD 2016, 'Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism', mSystems, vol. 1, no. 5, e00070. https://doi.org/10.1128/mSystems.00070-16
Phillips, BE, Geletzke, AK, Smith, PB, Podany, AB, Chacon, A, Kelleher, S, Patterson, AD & Soybel, D 2016, 'Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction', Molecular Nutrition and Food Research, vol. 60, no. 3, pp. 672-681. https://doi.org/10.1002/mnfr.201500688
Cook, JA, Chandramouli, GVR, Anver, MR, Sowers, AL, Thetford, A, Krausz, KW, Gonzalez, FJ, Mitchell, JB & Patterson, AD 2016, 'Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer', Cancer Research, vol. 76, no. 6, pp. 1569-1577. https://doi.org/10.1158/0008-5472.CAN-15-2416
Dutta, M, Anitha, M, Smith, PB, Chiaro, CR, Maan, M, Chaudhury, K & Patterson, AD 2016, 'Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis', Journal of Proteome Research, vol. 15, no. 8, pp. 2626-2633. https://doi.org/10.1021/acs.jproteome.6b00197
Zhang, L, Hatzakis, E & Patterson, AD 2016, 'NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research', Current Pharmacology Reports, vol. 2, no. 5, pp. 231-240. https://doi.org/10.1007/s40495-016-0067-9
Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical Research in Toxicology, vol. 29, no. 12, pp. 1987-1997. https://doi.org/10.1021/acs.chemrestox.6b00236
Zhang, L, Krishnan, P, Ehresman, DJ, Smith, PB, Dutta, M, Bagley, BD, Chang, SC, Butenhoff, JL, Patterson, AD & Peters, JM 2016, 'Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice', Toxicological Sciences, vol. 153, no. 1, kfw120, pp. 186-197. https://doi.org/10.1093/toxsci/kfw120
Soo, VWC, McAnulty, MJ, Tripathi, A, Zhu, F, Zhang, L, Hatzakis, E, Smith, PB, Agrawal, S, Nazem-Bokaee, H, Gopalakrishnan, S, Salis, HM, Ferry, JG, Maranas, CD, Patterson, AD & Wood, TK 2016, 'Reversing methanogenesis to capture methane for liquid biofuel precursors', Microbial Cell Factories, vol. 15, no. 1, 11. https://doi.org/10.1186/s12934-015-0397-z
Yu, S, Allen, JN, Dey, A, Zhang, L, Balandaram, G, Kennett, MJ, Xia, M, Xiong, N, Peters, JM, Patterson, AD & Giblin, PH 2016, 'The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis', Journal of Immunology, vol. 197, no. 1, pp. 256-265. https://doi.org/10.4049/jimmunol.1600450

2015

Hubbard, TD, Murray, IA, Bisson, WH, Lahoti, TS, Gowda, K, Amin, S, Patterson, AD & Perdew, GH 2015, 'Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles', Scientific reports, vol. 5, 12689. https://doi.org/10.1038/srep12689
Gonzalez, FJ, Jiang, C, Bisson, WH & Patterson, AD 2015, 'Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity' Journal of Hepatology, vol. 62, no. 6, 5593, pp. 1234-1236. https://doi.org/10.1016/j.jhep.2015.02.043
Jiang, C, Xie, C, Li, F, Zhang, L, Nichols, RG, Krausz, KW, Cai, J, Qi, Y, Fang, ZZ, Takahashi, S, Tanaka, N, Desai, D, Amin, S, Albert, I, Patterson, AD & Gonzalez, FJ 2015, 'Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease', Journal of Clinical Investigation, vol. 125, no. 1, pp. 386-402. https://doi.org/10.1172/JCI76738
Jiang, C, Xie, C, Lv, Y, Li, J, Krausz, KW, Shi, J, Brocker, CN, Desai, D, Amin, S, Bisson, WH, Liu, Y, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2015, 'Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction', Nature communications, vol. 6, 10166. https://doi.org/10.1038/ncomms10166
Zhan, X, Patterson, AD & Ghosh, D 2015, 'Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data' BMC bioinformatics, vol. 16, no. 1, 77. https://doi.org/10.1186/s12859-015-0506-3
Chassaing, B, Miles-Brown, J, Pellizzon, M, Ulman, E, Ricci, M, Zhang, L, Patterson, AD, Kumar, MV & Gewirtz, AT 2015, 'Lack of soluble fiber drives diet-induced adiposity in mice', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 309, no. 7, pp. G528-G541. https://doi.org/10.1152/ajpgi.00172.2015
Zhang, L, Hatzakis, E, Nichols, RG, Hao, R, Correll, J, Smith, PB, Chiaro, CR, Perdew, GH & Patterson, AD 2015, 'Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice', Environmental Science and Technology, vol. 49, no. 13, pp. 8067-8077. https://doi.org/10.1021/acs.est.5b01389
Singh, V, Chassaing, B, Zhang, L, San Yeoh, B, Xiao, X, Kumar, M, Baker, MT, Cai, J, Walker, R, Borkowski, K, Harvatine, KJ, Singh, N, Shearer, GC, Ntambi, JM, Joe, B, Patterson, AD, Gewirtz, AT & Kumar, MV 2015, 'Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice', Cell Metabolism, vol. 22, no. 6, pp. 983-996. https://doi.org/10.1016/j.cmet.2015.09.028
Li, F, Yang, XW, Krausz, KW, Nichols, RG, Xu, W, Patterson, AD & Gonzalez, FJ 2015, 'Modulation of colon cancer by nutmeg', Journal of Proteome Research, vol. 14, no. 4, pp. 1937-1946. https://doi.org/10.1021/pr5013152
Zhang, L, Nichols, RG, Correll, J, Murray, IA, Tanaka, N, Smith, PB, Hubbard, TD, Sebastian, A, Albert, I, Hatzakis, E, Gonzalez, FJ, Perdew, GH & Patterson, AD 2015, 'Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation', Environmental health perspectives, vol. 123, no. 7, pp. 679-688. https://doi.org/10.1289/ehp.1409055
Zhao, H, Chiaro, CR, Zhang, L, Smith, PB, Chan, CY, Pedley, AM, Pugh, RJ, French, JB, Patterson, AD & Benkovic, S 2015, 'Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis', Journal of Biological Chemistry, vol. 290, no. 11, pp. 6705-6713. https://doi.org/10.1074/jbc.M114.628701
Tanaka, N, Takahashi, S, Zhang, Y, Krausz, KW, Smith, PB, Patterson, AD & Gonzalez, FJ 2015, 'Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1852, no. 7, pp. 1242-1252. https://doi.org/10.1016/j.bbadis.2015.02.012

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