Researcher Profile

Researcher Profile

Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Associate Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
adp117@psu.edu

Research Interests

  • Metabolomics
  • Liver
  • Gastrointestinal Microbiome
  • Microbiota
  • Neoplasms
  • Mass Spectrometry
  • Diet
  • Homeostasis
  • Biomarkers
  • Serum
  • Aryl Hydrocarbon Receptors
  • Obesity

Recent Publications

2020

Nichols, RG, Zhang, J, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2020, 'Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran', Metabolites, vol. 10, no. 1, 1. https://doi.org/10.3390/metabo10010001
Das, NK, Schwartz, AJ, Barthel, G, Inohara, N, Liu, Q, Sankar, A, Hill, DR, Ma, X, Lamberg, O, Schnizlein, MK, Arqués, JL, Spence, JR, Nunez, G, Patterson, AD, Sun, D, Young, VB & Shah, YM 2020, 'Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis', Cell Metabolism, vol. 31, no. 1, pp. 115-130.e6. https://doi.org/10.1016/j.cmet.2019.10.005
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365. https://doi.org/10.1016/j.tox.2020.152365
Collins, SL & Patterson, AD 2020, 'The gut microbiome: an orchestrator of xenobiotic metabolism', Acta Pharmaceutica Sinica B, vol. 10, no. 1, pp. 19-32. https://doi.org/10.1016/j.apsb.2019.12.001

2019

Dutta, M, Cai, J, Gui, W & Patterson, AD 2019, 'A review of analytical platforms for accurate bile acid measurement', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4541-4549. https://doi.org/10.1007/s00216-019-01890-3
Tian, Y, Cai, J, Gui, W, Nichols, RG, Koo, I, Zhang, J, Anitha, M & Patterson, AD 2019, 'Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 86-93. https://doi.org/10.1124/dmd.118.083691
Zheng, X, Smith, FB, Aly, NA, Cai, J, Smith, RD, Patterson, AD & Baker, ES 2019, 'Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4673-4682. https://doi.org/10.1007/s00216-019-01869-0
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Alwerdt, J, Patterson, AD & Sliwinski, MJ 2019, 'Gender differences in phytoestrogens and the relationship with speed of processing in older adults: A cross-sectional analysis of NHANES, 1999–2002', Nutrients, vol. 11, no. 8, 1780. https://doi.org/10.3390/nu11081780
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome', Nature Medicine, vol. 25, no. 8, pp. 1225-1233. https://doi.org/10.1038/s41591-019-0509-0
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1. https://doi.org/10.1186/s40246-019-0211-9
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline', Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812. https://doi.org/10.1136/gutjnl-2018-316250
Chagwedera, DN, Ang, QY, Bisanz, JE, Leong, YA, Ganeshan, K, Cai, J, Patterson, AD, Turnbaugh, PJ & Chawla, A 2019, 'Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass', Cell Metabolism, vol. 30, no. 2, pp. 364-373.e7. https://doi.org/10.1016/j.cmet.2019.05.002
Qi, X, Yun, C, Sun, L, Xia, J, Wu, Q, Wang, Y, Wang, L, Zhang, Y, Liang, X, Wang, L, Gonzalez, FJ, Patterson, AD, Liu, H, Mu, L, Zhou, Z, Zhao, Y, Li, R, Liu, P, Zhong, C, Pang, Y, Jiang, C & Qiao, J 2019, 'Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (Nature Medicine, (2019), 25, 8, (1225-1233), 10.1038/s41591-019-0509-0)', Nature Medicine, vol. 25, no. 9. https://doi.org/10.1038/s41591-019-0562-8
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Catharine Ross, A & Cantorna, MT 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN. https://doi.org/10.3389/fimmu.2018.03090
Zheng, S, Loreto, R, Smith, P, Patterson, A, Hughes, D & Wang, L 2019, 'Specialist and generalist fungal parasites induce distinct biochemical changes in the mandible muscles of their host', International journal of molecular sciences, vol. 20, no. 18, 4589. https://doi.org/10.3390/ijms20184589
Bao, L, Festa, F, Freet, CS, Lee, JP, Hirschler-Laszkiewicz, IM, Chen, SJ, Keefer, KA, Wang, HG, Patterson, AD, Cheung, JY & Miller, BA 2019, 'The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2', Scientific reports, vol. 9, no. 1, 14132. https://doi.org/10.1038/s41598-019-50661-8
Cantorna, MT, Lin, YD, Arora, J, Bora, S, Tian, Y, Nichols, RG & Patterson, AD 2019, 'Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon', Frontiers in immunology, vol. 10. https://doi.org/10.3389/fimmu.2019.01772

2018

Waghulde, H, Cheng, X, Galla, S, Mell, B, Cai, J, Pruett-Miller, SM, Vazquez, G, Patterson, A, Kumar, MV & Joe, B 2018, 'Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1', Hypertension, vol. 72, no. 5, pp. 1125-1132. https://doi.org/10.1161/HYPERTENSIONAHA.118.11175
Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22. https://doi.org/10.1016/j.cell.2018.09.004
Sun, L, Xie, C, Wang, G, Wu, Y, Wu, Q, Wang, X, Liu, J, Deng, Y, Xia, J, Chen, B, Zhang, S, Yun, C, Lian, G, Zhang, X, Zhang, H, Bisson, WH, Shi, J, Gao, X, Ge, P, Liu, C, Krausz, KW, Nichols, RG, Cai, J, Rimal, B, Patterson, AD, Wang, X, Gonzalez, FJ & Jiang, C 2018, 'Gut microbiota and intestinal FXR mediate the clinical benefits of metformin', Nature Medicine, vol. 24, no. 12, pp. 1919-1929. https://doi.org/10.1038/s41591-018-0222-4
Pathak, P, Xie, C, Nichols, RG, Ferrell, JM, Boehme, S, Krausz, KW, Patterson, AD, Gonzalez, FJ & Chiang, JYL 2018, 'Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism', Hepatology, vol. 68, no. 4, pp. 1574-1588. https://doi.org/10.1002/hep.29857
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589. https://doi.org/10.1016/j.bbrc.2018.02.097
Chen, F, Coslo, DM, Chen, T, Zhang, L, Tian, Y, Smith, PB, Patterson, AD & Omiecinski, CJ 2019, 'Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism', Journal of Proteome Research, vol. 18, no. 1, pp. 239-251. https://doi.org/10.1021/acs.jproteome.8b00566
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382. https://doi.org/10.1021/acs.jproteome.7b00709
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Cai, J, Nichols, RG, Koo, I, Kalikow, ZA, Zhang, L, Tian, Y, Zhang, J, Smith, PB & Patterson, AD 2018, 'Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity', mSystems, vol. 3, no. 6, e00123. https://doi.org/10.1128/mSystems.00123-18
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232. https://doi.org/10.1016/j.jff.2018.04.008
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73. https://doi.org/10.1016/j.jnutbio.2018.01.011
Allen, J, Zhang, J, Quickel, MD, Kennett, M, Patterson, AD & Hankey-Giblin, PA 2018, 'Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model', Journal of Proteome Research, vol. 17, no. 9, pp. 3268-3280. https://doi.org/10.1021/acs.jproteome.8b00379
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists', Current Protocols in Toxicology, vol. 78, no. 1, e54. https://doi.org/10.1002/cptx.54
Cheema, M, Smith, PB, Patterson, AD, Hristov, A & Harte, FM 2018, 'The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size', Journal of dairy science, vol. 101, no. 10, pp. 8672-8687. https://doi.org/10.3168/jds.2017-14137
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408. https://doi.org/10.3389/fimmu.2018.00408
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2017.10.011

2017

Xie, C, Yagai, T, Luo, Y, Liang, X, Chen, T, Wang, Q, Sun, D, Zhao, J, Ramakrishnan, SK, Sun, L, Jiang, C, Xue, X, Tian, Y, Krausz, KW, Patterson, AD, Shah, YM, Wu, Y, Jiang, C & Gonzalez, FJ 2017, 'Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis', Nature Medicine, vol. 23, no. 11, pp. 1298-1308. https://doi.org/10.1038/nm.4412
Xie, C, Jiang, C, Shi, J, Gao, X, Sun, D, Sun, L, Wang, T, Takahashi, S, Anitha, M, Krausz, KW, Patterson, AD & Gonzalez, FJ 2017, 'An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice', Diabetes, vol. 66, no. 3, pp. 613-626. https://doi.org/10.2337/db16-0663
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, P, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698. https://doi.org/10.1016/j.jff.2017.08.038
Corresponding author 2017, 'Erratum: Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (Cell Metabolism (2017) 26(4) (672–685.e4) (S1550413117305041) (10.1016/j.cmet.2017.08.019))', Cell Metabolism, vol. 26, no. 5. https://doi.org/10.1016/j.cmet.2017.10.007
DiMarzio, M, Rusconi, B, Yennawar, NH, Eppinger, M, Patterson, AD & Dudley, EG 2017, 'Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA', PloS one, vol. 12, no. 9, e0183564. https://doi.org/10.1371/journal.pone.0183564
Li, G, Xie, C, Lu, S, Nichols, RG, Tian, Y, Li, L, Patel, D, Ma, Y, Brocker, CN, Yan, T, Krausz, KW, Xiang, R, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2017, 'Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota', Cell Metabolism, vol. 26, no. 4, pp. 672-685.e4. https://doi.org/10.1016/j.cmet.2017.08.019
Gonzalez, FJ, Jiang, C, Xie, C & Patterson, AD 2017, 'Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease', Digestive Diseases, vol. 35, no. 3, pp. 178-184. https://doi.org/10.1159/000450908
Huang, KH, Hao, L, Smith, PB, Rogers, CJ, Patterson, AD & Ross, AC 2017, 'Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice', Journal of Nutrition, vol. 147, no. 5, pp. 746-753. https://doi.org/10.3945/jn.116.245951
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Vijay-Kumar, M 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33. https://doi.org/10.1016/j.jnutbio.2016.11.014
Cai, J, Zhang, J, Tian, Y, Zhang, L, Hatzakis, E, Krausz, KW, Smith, PB, Gonzalez, FJ & Patterson, AD 2017, 'Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation', Analytical chemistry, vol. 89, no. 15, pp. 7900-7906. https://doi.org/10.1021/acs.analchem.7b00848
Zhang, L, Nichols, RG & Patterson, AD 2017, 'The aryl hydrocarbon receptor as a moderator of host-microbiota communication', Current Opinion in Toxicology, vol. 2, pp. 30-35. https://doi.org/10.1016/j.cotox.2017.02.001

2016

Gonzalez, FJ, Jiang, C & Patterson, AD 2016, 'An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease', Gastroenterology, vol. 151, no. 5, pp. 845-859. https://doi.org/10.1053/j.gastro.2016.08.057
Cai, J, Zhang, L, Jones, RA, Correll, JB, Hatzakis, E, Smith, PB, Gonzalez, FJ & Patterson, AD 2016, 'Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota', Journal of Proteome Research, vol. 15, no. 2, pp. 563-571. https://doi.org/10.1021/acs.jproteome.5b00957
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969. https://doi.org/10.1038/srep33969
Zhang, L, Xie, C, Nichols, RG, Chan, SHJ, Jiang, C, Hao, R, Smith, PB, Cai, J, Simons, MN, Hatzakis, E, Maranas, CD, Gonzalez, FJ & Patterson, AD 2016, 'Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism', mSystems, vol. 1, no. 5, e00070. https://doi.org/10.1128/mSystems.00070-16
Phillips, BE, Geletzke, AK, Smith, PB, Podany, AB, Chacon, A, Kelleher, SL, Patterson, AD & Soybel, DI 2016, 'Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction', Molecular Nutrition and Food Research, vol. 60, no. 3, pp. 672-681. https://doi.org/10.1002/mnfr.201500688
Cook, JA, Chandramouli, GVR, Anver, MR, Sowers, AL, Thetford, A, Krausz, KW, Gonzalez, FJ, Mitchell, JB & Patterson, AD 2016, 'Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer', Cancer Research, vol. 76, no. 6, pp. 1569-1577. https://doi.org/10.1158/0008-5472.CAN-15-2416
Dutta, M, Anitha, M, Smith, PB, Chiaro, CR, Maan, M, Chaudhury, K & Patterson, AD 2016, 'Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis', Journal of Proteome Research, vol. 15, no. 8, pp. 2626-2633. https://doi.org/10.1021/acs.jproteome.6b00197
Zhang, L, Hatzakis, E & Patterson, AD 2016, 'NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research', Current Pharmacology Reports, vol. 2, no. 5, pp. 231-240. https://doi.org/10.1007/s40495-016-0067-9
Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical Research in Toxicology, vol. 29, no. 12, pp. 1987-1997. https://doi.org/10.1021/acs.chemrestox.6b00236
Zhang, L, Krishnan, P, Ehresman, DJ, Smith, PB, Dutta, M, Bagley, BD, Chang, SC, Butenhoff, JL, Patterson, AD & Peters, JM 2016, 'Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice', Toxicological Sciences, vol. 153, no. 1, kfw120, pp. 186-197. https://doi.org/10.1093/toxsci/kfw120
Soo, VWC, McAnulty, MJ, Tripathi, A, Zhu, F, Zhang, L, Hatzakis, E, Smith, PB, Agrawal, S, Nazem-Bokaee, H, Gopalakrishnan, S, Salis, HM, Ferry, JG, Maranas, CD, Patterson, AD & Wood, TK 2016, 'Reversing methanogenesis to capture methane for liquid biofuel precursors', Microbial Cell Factories, vol. 15, no. 1, 11. https://doi.org/10.1186/s12934-015-0397-z
Yu, S, Allen, JN, Dey, A, Zhang, L, Balandaram, G, Kennett, MJ, Xia, M, Xiong, N, Peters, JM, Patterson, AD & Giblin, PH 2016, 'The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis', Journal of Immunology, vol. 197, no. 1, pp. 256-265. https://doi.org/10.4049/jimmunol.1600450

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