Researcher Profile

Researcher Profile

Andrew David Patterson, PhD

Andrew David Patterson, PhD

Biochemistry & Molecular Biology
Associate Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Metabolomics
  • Liver
  • Mass Spectrometry
  • Neoplasms
  • Microbiota
  • Diet
  • Biomarkers
  • Obesity
  • Serum
  • Bile Acids and Salts
  • Aryl Hydrocarbon Receptors
  • Homeostasis

Recent Publications


Dutta, M, Cai, J, Gui, W & Patterson, AD 2019, 'A review of analytical platforms for accurate bile acid measurement', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4541-4549.
Tian, Y, Cai, J, Gui, W, Nichols, RG, Koo, I, Zhang, J, Anitha, M & Patterson, AD 2019, 'Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation', Drug Metabolism and Disposition, vol. 47, no. 2, pp. 86-93.
Zheng, X, Smith, FB, Aly, NA, Cai, J, Smith, RD, Patterson, AD & Baker, ES 2019, 'Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry', Analytical and Bioanalytical Chemistry, vol. 411, no. 19, pp. 4673-4682.
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, Z & Paulson, R 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217.
Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline' Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724.
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut.
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Ross, AC & Cantorna, MT-A 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN.


Waghulde, H, Cheng, X, Galla, S, Mell, B, Cai, J, Pruett-Miller, SM, Vazquez, G, Patterson, AD, Kumar, MV & Joe, B 2018, 'Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1', Hypertension, vol. 72, no. 5, pp. 1125-1132.
Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, W, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22.
Sun, L, Xie, C, Wang, G, Wu, Y, Wu, Q, Wang, X, Liu, J, Deng, Y, Xia, J, Chen, B, Zhang, S, Yun, C, Lian, G, Zhang, X, Zhang, H, Bisson, WH, Shi, J, Gao, X, Ge, P, Liu, C, Krausz, KW, Nichols, RG, Cai, J, Rimal, B, Patterson, AD, Wang, X, Gonzalez, FJ & Jiang, C 2018, 'Gut microbiota and intestinal FXR mediate the clinical benefits of metformin', Nature Medicine, vol. 24, no. 12, pp. 1919-1929.
Pathak, P, Xie, C, Nichols, RG, Ferrell, JM, Boehme, S, Krausz, KW, Patterson, AD, Gonzalez, FJ & Chiang, JYL 2018, 'Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism', Hepatology, vol. 68, no. 4, pp. 1574-1588.
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589.
Chen, F, Coslo, DM, Chen, T, Zhang, L, Tian, Y, Smith, PB, Patterson, AD & Omiecinski, CJ 2019, 'Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism' Journal of Proteome Research, vol. 18, no. 1, pp. 239-251.
Belton, KR, Tian, Y, Zhang, L, Anitha, M, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice', Journal of Proteome Research, vol. 17, no. 4, pp. 1375-1382.
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283.
Cai, J, Nichols, RG, Koo, I, Kalikow, ZA, Zhang, L, Tian, Y, Zhang, J, Smith, PB & Patterson, AD 2018, 'Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity' mSystems, vol. 3, no. 6, e00123.
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, R, Patterson, AD, Cantorna, MT-A & Giblin, PH 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513.
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232.
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73.
Allen, J, Zhang, J, Quickel, MD, Kennett, MJ, Patterson, AD & Giblin, PH 2018, 'Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model' Journal of Proteome Research, vol. 17, no. 9, pp. 3268-3280.
Nichols, RG, Cai, J, Murray, IA, Koo, I, Smith, PB, Perdew, GH & Patterson, AD 2018, 'Structural and Functional Analysis of the Gut Microbiome for Toxicologists' Current Protocols in Toxicology, vol. 78, no. 1, e54.
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408.
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34.


Cai, J, Zhang, J, Tian, Y, Zhang, L, Hatzakis, E, Krausz, KW, Smith, PB, Gonzalez, FJ & Patterson, AD 2017, ' Orthogonal Comparison of GC-MS and 1 H NMR Spectroscopy for Short Chain Fatty Acid Quantitation ', Analytical Chemistry, vol. 89, no. 15, pp. 7900-7906.
Xie, C, Yagai, T, Luo, Y, Liang, X, Chen, T, Wang, Q, Sun, D, Zhao, J, Ramakrishnan, SK, Sun, L, Jiang, C, Xue, X, Tian, Y, Krausz, KW, Patterson, AD, Shah, YM, Wu, Y, Jiang, C & Gonzalez, FJ 2017, 'Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis', Nature Medicine, vol. 23, no. 11, pp. 1298-1308.
Xie, C, Jiang, C, Shi, J, Gao, X, Sun, D, Sun, L, Wang, T, Takahashi, S, Anitha, M, Krausz, KW, Patterson, AD & Gonzalez, FJ 2017, 'An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice', Diabetes, vol. 66, no. 3, pp. 613-626.
Hubbard, TD, Murray, IA, Nichols, RG, Cassel, K, Podolsky, M, Kuzu, G, Tian, Y, Smith, PB, Kennett, MJ, Patterson, AD & Perdew, GH 2017, 'Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner', Journal of Functional Foods, vol. 37, pp. 685-698.
Corresponding author 2017, 'Erratum: Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (Cell Metabolism (2017) 26(4) (672–685.e4) (S1550413117305041) (10.1016/j.cmet.2017.08.019))', Cell Metabolism, vol. 26, no. 5.
DiMarzio, M, Rusconi, B, Yennawar, N, Eppinger, M, Patterson, AD & Dudley, EG 2017, 'Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA', PLoS One, vol. 12, no. 9, e0183564.
Li, G, Xie, C, Lu, S, Nichols, RG, Tian, Y, Li, L, Patel, D, Ma, Y, Brocker, CN, Yan, T, Krausz, KW, Xiang, R, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2017, 'Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota', Cell Metabolism, vol. 26, no. 4, pp. 672-685.e4.
Gonzalez, FJ, Jiang, C, Xie, C & Patterson, AD 2017, 'Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease', Digestive Diseases, vol. 35, no. 3, pp. 178-184.
Huang, KH, Hao, L, Smith, PB, Rogers, CJ, Patterson, AD & Ross, AC 2017, 'Lipid emulsion added to a liquid high-carbohydrate diet and voluntary running exercise reduce lipogenesis and ameliorate early-stage hepatic steatosis in mice', Journal of Nutrition, vol. 147, no. 5, pp. 746-753.
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Kumar, MV 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33.
Zhang, L, Nichols, RG & Patterson, AD 2017, 'The aryl hydrocarbon receptor as a moderator of host-microbiota communication', Current Opinion in Toxicology, vol. 2, pp. 30-35.


Gonzalez, FJ, Jiang, C & Patterson, AD 2016, 'An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease', Gastroenterology, vol. 151, no. 5, pp. 845-859.
Cai, J, Zhang, L, Jones, RA, Correll, JB, Hatzakis, E, Smith, PB, Gonzalez, FJ & Patterson, AD 2016, 'Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota', Journal of Proteome Research, vol. 15, no. 2, pp. 563-571.
Murray, IA, Nichols, RG, Zhang, L, Patterson, AD & Perdew, GH 2016, 'Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice', Scientific reports, vol. 6, 33969.
Zhang, L, Xie, C, Nichols, RG, Chan, SHJ, Jiang, C, Hao, R, Smith, PB, Cai, J, Simons, MN, Hatzakis, E, Maranas, CD, Gonzalez, FJ & Patterson, AD 2016, 'Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism', mSystems, vol. 1, no. 5, e00070.
Phillips, BE, Geletzke, AK, Smith, PB, Podany, AB, Chacon, A, Kelleher, S, Patterson, AD & Soybel, D 2016, 'Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction', Molecular Nutrition and Food Research, vol. 60, no. 3, pp. 672-681.
Cook, JA, Chandramouli, GVR, Anver, MR, Sowers, AL, Thetford, A, Krausz, KW, Gonzalez, FJ, Mitchell, JB & Patterson, AD 2016, 'Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer', Cancer Research, vol. 76, no. 6, pp. 1569-1577.
Dutta, M, Anitha, M, Smith, PB, Chiaro, CR, Maan, M, Chaudhury, K & Patterson, AD 2016, 'Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis', Journal of Proteome Research, vol. 15, no. 8, pp. 2626-2633.
Zhang, L, Hatzakis, E & Patterson, AD 2016, 'NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research', Current Pharmacology Reports, vol. 2, no. 5, pp. 231-240.
Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical Research in Toxicology, vol. 29, no. 12, pp. 1987-1997.
Zhang, L, Krishnan, P, Ehresman, DJ, Smith, PB, Dutta, M, Bagley, BD, Chang, SC, Butenhoff, JL, Patterson, AD & Peters, JM 2016, 'Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice', Toxicological Sciences, vol. 153, no. 1, kfw120, pp. 186-197.
Soo, VWC, McAnulty, MJ, Tripathi, A, Zhu, F, Zhang, L, Hatzakis, E, Smith, PB, Agrawal, S, Nazem-Bokaee, H, Gopalakrishnan, S, Salis, HM, Ferry, JG, Maranas, CD, Patterson, AD & Wood, TK 2016, 'Reversing methanogenesis to capture methane for liquid biofuel precursors', Microbial Cell Factories, vol. 15, no. 1, 11.
Yu, S, Allen, JN, Dey, A, Zhang, L, Balandaram, G, Kennett, MJ, Xia, M, Xiong, N, Peters, JM, Patterson, AD & Giblin, PH 2016, 'The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis', Journal of Immunology, vol. 197, no. 1, pp. 256-265.


Hubbard, TD, Murray, IA, Bisson, WH, Lahoti, TS, Gowda, K, Amin, S, Patterson, AD & Perdew, GH 2015, 'Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles', Scientific reports, vol. 5, 12689.
Gonzalez, FJ, Jiang, C, Bisson, WH & Patterson, AD 2015, 'Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity' Journal of Hepatology, vol. 62, no. 6, 5593, pp. 1234-1236.
Jiang, C, Xie, C, Li, F, Zhang, L, Nichols, RG, Krausz, KW, Cai, J, Qi, Y, Fang, ZZ, Takahashi, S, Tanaka, N, Desai, D, Amin, S, Albert, I, Patterson, AD & Gonzalez, FJ 2015, 'Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease', Journal of Clinical Investigation, vol. 125, no. 1, pp. 386-402.
Jiang, C, Xie, C, Lv, Y, Li, J, Krausz, KW, Shi, J, Brocker, CN, Desai, D, Amin, S, Bisson, WH, Liu, Y, Gavrilova, O, Patterson, AD & Gonzalez, FJ 2015, 'Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction', Nature communications, vol. 6, 10166.
Zhan, X, Patterson, AD & Ghosh, D 2015, 'Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data' BMC bioinformatics, vol. 16, no. 1, 77.
Chassaing, B, Miles-Brown, J, Pellizzon, M, Ulman, E, Ricci, M, Zhang, L, Patterson, AD, Kumar, MV & Gewirtz, AT 2015, 'Lack of soluble fiber drives diet-induced adiposity in mice', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 309, no. 7, pp. G528-G541.
Zhang, L, Hatzakis, E, Nichols, RG, Hao, R, Correll, J, Smith, PB, Chiaro, CR, Perdew, GH & Patterson, AD 2015, 'Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice', Environmental Science and Technology, vol. 49, no. 13, pp. 8067-8077.
Singh, V, Chassaing, B, Zhang, L, San Yeoh, B, Xiao, X, Kumar, M, Baker, MT, Cai, J, Walker, R, Borkowski, K, Harvatine, KJ, Singh, N, Shearer, GC, Ntambi, JM, Joe, B, Patterson, AD, Gewirtz, AT & Kumar, MV 2015, 'Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice', Cell Metabolism, vol. 22, no. 6, pp. 983-996.
Li, F, Yang, XW, Krausz, KW, Nichols, RG, Xu, W, Patterson, AD & Gonzalez, FJ 2015, 'Modulation of colon cancer by nutmeg', Journal of Proteome Research, vol. 14, no. 4, pp. 1937-1946.
Zhang, L, Nichols, RG, Correll, J, Murray, IA, Tanaka, N, Smith, PB, Hubbard, TD, Sebastian, A, Albert, I, Hatzakis, E, Gonzalez, FJ, Perdew, GH & Patterson, AD 2015, 'Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation', Environmental health perspectives, vol. 123, no. 7, pp. 679-688.
Zhao, H, Chiaro, CR, Zhang, L, Smith, PB, Chan, CY, Pedley, AM, Pugh, RJ, French, JB, Patterson, AD & Benkovic, S 2015, 'Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis', Journal of Biological Chemistry, vol. 290, no. 11, pp. 6705-6713.
Tanaka, N, Takahashi, S, Zhang, Y, Krausz, KW, Smith, PB, Patterson, AD & Gonzalez, FJ 2015, 'Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1852, no. 7, pp. 1242-1252.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)