Adam Bleier Glick, PhD - Penn State Cancer Institute
Researcher Profile
Adam Bleier Glick, PhD
Associate Professor, Veterinary and Biomedical Sciences
Associate Professor, Department of Dermatology
Associate Professor, Department of Dermatology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Neoplasms
- Skin
- Keratinocytes
- Transforming Growth Factors
- Carcinogenesis
- Genes
- Papilloma
- Growth
- Proteins
- Squamous Cell Carcinoma
- Oncogenes
- Phenotype
Recent Publications
2024
Zhu, B, Zhu, X, Borland, MG, Ralph, DH, Chiaro, CR, Krausz, KW, Ntambi, JM, Glick, AB, Patterson, AD, Perdew, GH, Gonzalez, FJ & Peters, JM 2024, 'Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids', Biomolecules, vol. 14, no. 6, 606. https://doi.org/10.3390/biom14060606
Alden, NA, Yeingst, TJ, Pfeiffer, HM, Celik, N, Arrizabalaga, JH, Helton, AM, Liu, Y, Stairs, DB, Glick, AB, Goyal, N & Hayes, DJ 2024, 'Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment', Advanced Healthcare Materials, vol. 13, no. 10, 2303593. https://doi.org/10.1002/adhm.202303593
Mercurio, L, Bailey, J, Glick, AB, Dellambra, E, Scarponi, C, Pallotta, S, Albanesi, C & Madonna, S 2024, 'RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis', Journal of Dermatological Science, vol. 115, no. 1, pp. 21-32. https://doi.org/10.1016/j.jdermsci.2024.03.002
2022
Alden, NA, Arrizabalaga, JH, Liu, Y, Amin, S, Gowda, K, Yao, S, Archetti, M, Glick, AB & Hayes, DJ 2022, 'Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells', Langmuir, vol. 38, no. 32, pp. 9833-9843. https://doi.org/10.1021/acs.langmuir.2c00913
Mogre, S, Blazanin, N, Walsh, H, Ibinson, J, Minnich, C, Andrew Hu, CC & Glick, AB 2022, 'TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes', Molecular Carcinogenesis, vol. 61, no. 10, pp. 958-971. https://doi.org/10.1002/mc.23453
Chalmers, FE, Dusold, JE, Shaik, JA, Walsh, HA & Glick, AB 2022, 'Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration', Developmental biology, vol. 485, pp. 9-23. https://doi.org/10.1016/j.ydbio.2022.02.009
Chalmers, FE, Mogre, S, Rimal, B, Son, J, Patterson, AD, Stairs, DB & Glick, AB 2022, 'The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus', Developmental biology, vol. 492, pp. 59-70. https://doi.org/10.1016/j.ydbio.2022.09.009
2021
Son, J, Mogre, S, Chalmers, FE, Ibinson, J, Worrell, S & Glick, AB 2022, 'The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis', Journal of Investigative Dermatology, vol. 142, no. 6, pp. 1682-1691.e7. https://doi.org/10.1016/j.jid.2021.11.010
2020
Liu, Y, Bailey, JT, Abu-Laban, M, Li, S, Chen, C, Glick, AB & Hayes, DJ 2020, 'Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice', Biomaterials, vol. 256, 120212. https://doi.org/10.1016/j.biomaterials.2020.120212
Aronson, MR, Dahl, ES, Halle, JA, Simonson, AW, Gogal, RA, Glick, AB, Aird, KM & Medina, SH 2020, 'Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers', Cellular and Molecular Bioengineering, vol. 13, no. 5, pp. 447-461. https://doi.org/10.1007/s12195-020-00626-z
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745