Takefumi Komiya, MD, PhD - Penn State Cancer Institute
Researcher Profile
Takefumi Komiya, MD, PhD
Associate Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Research Interests
- Neoplasms
- Non-Small Cell Lung Carcinoma
- Therapeutics
- Survival
- Lung Neoplasms
- Lung
- Drug Therapy
- Databases
- Small Cell Lung Carcinoma
- Thorax
- Genes
- Squamous Cell Carcinoma
Clinical Trials
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA
NRG HN009- Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
S1914 A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT versus SBRT Alone in High Risk, Early Stage NSCLC
A randomized phase II trial of adjuvant Pembrolizumab versus observation following curative resection for stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm: Big Ten Cancer Research Consortium BTCRC-LUN18-153
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
Recent Publications
2023
Takamori, S, Shimokawa, M & Komiya, T 2023, 'Efficacy of immune checkpoint inhibitors in younger patients with non-small cell lung cancer', Journal of Cancer Research and Clinical Oncology, vol. 149, no. 14, pp. 13175-13184. https://doi.org/10.1007/s00432-023-05167-2
Khan, SS & Komiya, T 2023, 'Exclusion of Patients with Autoimmune Disease in Lung Cancer Clinical Trials', Asian Pacific Journal of Cancer Prevention, vol. 24, no. 1, pp. 331-336. https://doi.org/10.31557/APJCP.2023.24.1.331
Komiya, T, Takamori, S & Shimokawa, M 2023, 'Impact of Liver Metastasis on First-Line Immunotherapy in Stage IV Non-Small Cell Lung Cancer', World Journal of Oncology, vol. 14, no. 4, pp. 234-245. https://doi.org/10.14740/wjon1625
Takamori, S, Komiya, T, Shimokawa, M & Powell, E 2023, 'Lymph node dissections and survival in sublobar resection of non-small cell lung cancer ≤ 20 mm', General Thoracic and Cardiovascular Surgery, vol. 71, no. 3, pp. 189-197. https://doi.org/10.1007/s11748-022-01876-6
2022
Komiya, T, Takamori, S & Wilding, G 2022, 'Adjuvant radiation therapy improves survival in stage IIIA (N2) non-small cell lung cancer with persistent N2 disease after neoadjuvant chemotherapy', Radiotherapy and Oncology, vol. 176, pp. 234-238. https://doi.org/10.1016/j.radonc.2022.07.018
Sama, S, Komiya, T & Guddati, AK 2022, 'Advances in the Treatment of Mucoepidermoid Carcinoma', World Journal of Oncology, vol. 13, no. 1. https://doi.org/10.14740/wjon1412
Takamori, S, Komiya, T & Powell, E 2022, 'Clinical impact of number of lymph nodes dissected on postoperative survival in node-negative small cell lung cancer', Frontiers in Oncology, vol. 12, 962282. https://doi.org/10.3389/fonc.2022.962282
Dasari, S & Komiya, T 2022, 'Induction Immunotherapy Followed by Thoracic Radiation without Chemotherapy in Unresectable Stage III Non-Small Cell Lung Cancer: A Case Series', Asian Pacific Journal of Cancer Prevention, vol. 23, no. 1, pp. 217-220. https://doi.org/10.31557/APJCP.2022.23.1.217
Komiya, T, Takamori, S & Wilding, G 2022, 'Response to Bao et al', Radiotherapy and Oncology, vol. 177, pp. 251. https://doi.org/10.1016/j.radonc.2022.10.031
2021
Jabbour, SK, Lee, KH, Frost, N, Breder, V, Kowalski, DM, Pollock, T, Levchenko, E, Reguart, N, Martinez-Marti, A, Houghton, B, Paoli, JB, Safina, S, Park, K, Komiya, T, Sanford, A, Boolell, V, Liu, H, Samkari, A, Keller, SM & Reck, M 2021, 'Pembrolizumab plus Concurrent Chemoradiation Therapy in Patients with Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer: The Phase 2 KEYNOTE-799 Nonrandomized Trial', JAMA Oncology, vol. 7, no. 9, pp. 1351-1359. https://doi.org/10.1001/jamaoncol.2021.2301
Komiya, T, Powell, E & Takamori, S 2021, 'Prognostic Impact of Single and Multiple Descriptors in Pathologically Staged T3N0M0 NSCLC', JTO Clinical and Research Reports, vol. 2, no. 3, 100111. https://doi.org/10.1016/j.jtocrr.2020.100111
Takamori, S, Shimokawa, M & Komiya, T 2021, 'Prognostic impact of chronological age on efficacy of immune checkpoint inhibitors in non-small-cell lung cancer: Real-world data from 86 173 patients', Thoracic Cancer, vol. 12, no. 21, pp. 2943-2948. https://doi.org/10.1111/1759-7714.14178
Komiya, T, Ravindra, N & Powell, E 2021, 'Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung', Asian Pacific Journal of Cancer Prevention, vol. 22, no. 2, pp. 365-370. https://doi.org/10.31557/APJCP.2021.22.2.365
Komiya, T, Powell, E & Takamori, S 2021, 'Role of thoracic radiation in extensive stage small cell lung cancer: a NCDB analysis', Medical Oncology, vol. 38, no. 4, 44. https://doi.org/10.1007/s12032-021-01489-8
Bardia, A, Messersmith, WA, Kio, EA, Berlin, JD, Vahdat, L, Masters, GA, Moroose, R, Santin, AD, Kalinsky, K, Picozzi, V, O'Shaughnessy, J, Gray, JE, Komiya, T, Lang, JM, Chang, JC, Starodub, A, Goldenberg, DM, Sharkey, RM, Maliakal, P, Hong, Q, Wegener, WA, Goswami, T & Ocean, AJ 2021, 'Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial', Annals of Oncology, vol. 32, no. 6, pp. 746-756. https://doi.org/10.1016/j.annonc.2021.03.005
Takamori, S, Komiya, T & Powell, E 2021, 'Survival benefit from immunocheckpoint inhibitors in stage IV non-small cell lung cancer patients with brain metastases: A National Cancer Database propensity-matched analysis', Cancer medicine, vol. 10, no. 3, pp. 923-932. https://doi.org/10.1002/cam4.3675
2020
Deshotels, L, Chaaya, G & Komiya, T 2020, 'An overview of lung and breast cancer using the national cancer database', Asian Pacific Journal of Cancer Prevention, vol. 21, no. 1, pp. 163-167. https://doi.org/10.31557/APJCP.2020.21.1.163
Komiya, T, Chaaya, G, Deshotels, L, Powell, E & Guddati, AK 2020, 'Brain metastasis as exclusion criteria in extensive-stage small cell lung cancer trials: a trend over decades', Journal of Cancer Metastasis and Treatment, vol. 6, 3356. https://doi.org/10.20517/2394-4722.2019.41
Komiya, T, Chaaya, G, Deshotels, L & Wang, A 2020, 'Difference of environment behind research and clinical practice between USA and Japan', Journal of Thoracic Disease, vol. 12, no. 7, pp. 3804-3808. https://doi.org/10.21037/jtd.2019.07.70
Guddati, AK, Komiya, T, Patel, SJ, Sharma, N & Powell, E 2020, 'Impact of immunotherapy use in patients with stage IV pancreatic carcinoma', Journal of Gastrointestinal Oncology, vol. 11, no. 4, pp. 654-662. https://doi.org/10.21037/jgo-20-191
Komiya, T, Powell, E & Guddati, AK 2020, 'Recent trends in use of adjuvant chemotherapy in elderly stage II- III non-small cell lung cancer', Translational Lung Cancer Research, vol. 9, no. 4, pp. 1180-1186. https://doi.org/10.21037/tlcr-19-564
Komiya, T, Powell, E, Vu, CC & Guddati, AK 2020, 'Role of T0 status in overall survival for unresectable stage III non-small cell lung cancer: A NCDB analysis', Radiotherapy and Oncology, vol. 148, pp. 8-13. https://doi.org/10.1016/j.radonc.2020.03.021