Dipanjan Pan - Penn State Cancer Institute
Researcher Profile
Dipanjan Pan
Professor, Ken and Mary Alice Lindquist Department of Nuclear Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Nanoparticles
- Therapeutics
- Carbon
- Neoplasms
- Pharmaceutical Preparations
- Molecular Imaging
- In Vitro Techniques
- Tomography
- Prodrugs
- Contrast Media
- Nanomedicine
- Theranostic Nanomedicine
Recent Publications
2024
Aditya, T, Moitra, P, Alafeef, M, Skrodzki, D & Pan, D 2024, 'Chiral Induction in 2D Borophene Nanoplatelets through Stereoselective Boron-Sulfur Conjugation', ACS nano, vol. 18, no. 18, pp. 11921-11932. https://doi.org/10.1021/acsnano.4c01792
Moitra, P, Skrodzki, D, Molinaro, M, Gunaseelan, N, Sar, D, Aditya, T, Dahal, D, Ray, P & Pan, D 2024, 'Context-Responsive Nanoparticle Derived from Synthetic Zwitterionic Ionizable Phospholipids in Targeted CRISPR/Cas9 Therapy for Basal-like Breast Cancer', ACS nano, vol. 18, no. 12, pp. 9199-9220. https://doi.org/10.1021/acsnano.4c01400
Tan, Y, De La Toba, E, Rubakhin, SS, Labriola, LT, Canfield, C, Pan, D & Sweedler, JV 2024, 'NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears', Journal of the American Society for Mass Spectrometry, vol. 35, no. 1, pp. 106-113. https://doi.org/10.1021/jasms.3c00331
Pan, D 2024, 'Nanomedicine and nanobiotechnology in India', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 1, e1939. https://doi.org/10.1002/wnan.1939
Skrodzki, D, Molinaro, M, Brown, R, Moitra, P & Pan, D 2024, 'Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium', ACS nano, vol. 18, no. 2, pp. 1289-1324. https://doi.org/10.1021/acsnano.3c08917
2023
Alafeef, M, Skrodzki, D, Moitra, P, Gunaseelan, N & Pan, D 2023, 'Binding-Induced Folding of DNA Oligonucleotides Targeted to the Nucleocapsid Gene Enables Electrochemical Sensing of SARS-CoV-2', ACS Applied Bio Materials, vol. 6, no. 3, pp. 1133-1145. https://doi.org/10.1021/acsabm.2c00984
Srivastava, I, Moitra, P, Brent, KM, Wang, K, Pandit, S, Altun, E & Pan, D 2023, 'Biodegradable and switchable near-infrared fluorescent probes for hypoxia detection', Nanomedicine, vol. 18, no. 16, pp. 1061-1073. https://doi.org/10.2217/nnm-2023-0095
Alafeef, M, Srivastava, I, Aditya, T & Pan, D 2024, 'Carbon Dots: From Synthesis to Unraveling the Fluorescence Mechanism', Small, vol. 20, no. 4, 2303937. https://doi.org/10.1002/smll.202303937
Pan, D 2023, 'Comment on the “Development of copper nanoparticles and their prospective use in the pharmaceutical sector.”', Precision Nanomedicine, vol. 6, no. 2, 1133. https://doi.org/10.33218/001c.90170
Moitra, M, Alafeef, M, Narasimhan, A, Kakaria, V, Moitra, P & Pan, D 2023, 'Diagnosis of COVID-19 with simultaneous accurate prediction of cardiac abnormalities from chest computed tomographic images', PloS one, vol. 18, no. 12 December, e0290494. https://doi.org/10.1371/journal.pone.0290494
Ostadhossein, F, Moitra, P, Alafeef, M, Sar, D, D'Souza, S, Benig, LF, Nelappana, M, Huang, X, Soares, J, Zhang, K & Pan, D 2023, 'Ensemble and single-particle level fluorescent fine-tuning of carbon dots via positional changes of amines toward "supervised" oral microbiome sensing', Journal of Biomedical Optics, vol. 28, no. 8, pp. 82807. https://doi.org/10.1117/1.JBO.28.8.082807
Dighe, K, Moitra, P, Gunaseelan, N, Alafeef, M, Jensen, T, Rafferty, C & Pan, D 2023, 'Highly-Specific Single-Stranded Oligonucleotides and Functional Nanoprobes for Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections', Advanced Science, vol. 10, no. 36, 2304009. https://doi.org/10.1002/advs.202304009
Moitra, P, Iftesum, M, Skrodzki, D, Paul, P, Sheikh, E, Gray, JL, Dighe, K, Sheffield, Z, Gartia, MR & Pan, D 2023, 'Nucleotide-Driven Molecular Sensing of Monkeypox Virus Through Hierarchical Self-Assembly of 2D Hafnium Disulfide Nanoplatelets and Gold Nanospheres', Advanced Functional Materials, vol. 33, no. 19, 2212569. https://doi.org/10.1002/adfm.202212569
Misra, SK, Ye, M, Moitra, P, Dighe, K, Sharma, A, Daza, EA, Schwartz-Duval, AS, Ostadhossein, F & Pan, D 2023, 'Synthesis of an enediyne carbon-allotrope surface for photo-thermal degradation of DNA', Chemical Communications, vol. 59, no. 90, pp. 13434-13437. https://doi.org/10.1039/d3cc03353h
2022
Ikponmwoba, E, Ukorigho, O, Moitra, P, Pan, D, Gartia, MR & Owoyele, O 2022, 'A Machine Learning Framework for Detecting COVID-19 Infection Using Surface-Enhanced Raman Scattering', Biosensors, vol. 12, no. 8, 589. https://doi.org/10.3390/bios12080589
Watt, MM, Moitra, P, Sheffield, Z, Ostadhossein, F, Maxwell, EA & Pan, D 2023, 'A narrative review on the role of carbon nanoparticles in oncology', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 15, no. 2, e1845. https://doi.org/10.1002/wnan.1845
Dighe, K, Moitra, P, Alafeef, M, Gunaseelan, N & Pan, D 2022, 'A rapid RNA extraction-free lateral flow assay for molecular point-of-care detection of SARS-CoV-2 augmented by chemical probes', Biosensors and Bioelectronics, vol. 200, 113900. https://doi.org/10.1016/j.bios.2021.113900
Alafeef, M & Pan, D 2022, 'Diagnostic Approaches for COVID-19: Lessons Learned and the Path Forward', ACS nano, vol. 16, no. 8, pp. 11545-11576. https://doi.org/10.1021/acsnano.2c01697
Ray, P, Moitra, P & Pan, D 2022, 'Emerging theranostic applications of carbon dots and its variants', VIEW, vol. 3, no. 2, 20200089. https://doi.org/10.1002/VIW.20200089
Mittal, N, Rogers, S, Dougherty, S, Wang, Q, Moitra, P, Brummet, M, Cornett, EM, Kaye, AD, Shekoohi, S, Buehler, P, Spinella, P, Pan, D & Doctor, A 2022, Erythromer (EM), a Nanoscale Bio-Synthetic Artificial Red Cell. in Blood Substitutes and Oxygen Biotherapeutics. Springer International Publishing, pp. 253-265. https://doi.org/10.1007/978-3-030-95975-3_24
Ostadhossein, F, Moitra, P, Gunaseelan, N, Nelappana, M, Lowe, C, Moghiseh, M, Butler, A, de Ruiter, N, Mandalika, H, Tripathi, I, Misra, SK & Pan, D 2022, 'Hitchhiking probiotic vectors to deliver ultra-small hafnia nanoparticles for ‘Color’ gastrointestinal tract photon counting X-ray imaging', Nanoscale Horizons, vol. 7, no. 5, pp. 533-542. https://doi.org/10.1039/d1nh00626f
Fathi, P, Roslend, A, Alafeef, M, Moitra, P, Dighe, K, Esch, MB & Pan, D 2022, 'In Situ Surface-Directed Assembly of 2D Metal Nanoplatelets for Drug-Free Treatment of Antibiotic-Resistant Bacteria', Advanced Healthcare Materials, vol. 11, no. 19, 2102567. https://doi.org/10.1002/adhm.202102567
Alafeef, M, Dighe, K, Moitra, P & Pan, D 2022, 'Monitoring the Viral Transmission of SARS-CoV-2 in Still Waterbodies Using a Lanthanide-Doped Carbon Nanoparticle-Based Sensor Array', ACS Sustainable Chemistry and Engineering, vol. 10, no. 1, pp. 245-258. https://doi.org/10.1021/acssuschemeng.1c06066
Sheffield, Z, Alafeef, M, Moitra, P, Ray, P & Pan, D 2022, 'N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA', Nanoscale, vol. 14, no. 13, pp. 5112-5120. https://doi.org/10.1039/d1nr07169f
Moitra, P, Chaichi, A, Abid Hasan, SM, Dighe, K, Alafeef, M, Prasad, A, Gartia, MR & Pan, D 2022, 'Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning', Biosensors and Bioelectronics, vol. 208, 114200. https://doi.org/10.1016/j.bios.2022.114200
Moitra, P, Alafeef, M, Dighe, K & Pan, D 2022, 'Single-gene diagnostic assay for rapid subclassification of basal like breast cancer with mRNA targeted antisense oligonucleotide capped molecular probe', Biosensors and Bioelectronics, vol. 207, 114178. https://doi.org/10.1016/j.bios.2022.114178
Sar, D, Ostadhossein, F, Moitra, P, Alafeef, M & Pan, D 2022, 'Small Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots', Advanced Science, vol. 9, no. 22, 2202414. https://doi.org/10.1002/advs.202202414
Zhang, X, Misra, SK, Moitra, P, Zhang, X, Jeong, SJ, Stitham, J, Rodriguez-Velez, A, Park, A, Yeh, YS, Gillanders, WE, Fan, D, Diwan, A, Cho, J, Epelman, S, Lodhi, IJ, Pan, D & Razani, B 2023, 'Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis', Autophagy, vol. 19, no. 3, pp. 886-903. https://doi.org/10.1080/15548627.2022.2108252
2021
Schwartz-Duval, AS, Wen, R, Srivastava, I, Moitra, P & Pan, D 2021, 'A Simplistic Single-Step Method for Preparing Biomimetic Nanoparticles from Endogenous Biomaterials', ACS Applied Materials and Interfaces, vol. 13, no. 39, pp. 46464-46477. https://doi.org/10.1021/acsami.1c17302
Ostadhossein, F, Moitra, P, Altun, E, Dutta, D, Sar, D, Tripathi, I, Hsiao, SH, Kravchuk, V, Nie, S & Pan, D 2021, 'Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance', Communications Biology, vol. 4, no. 1, 846. https://doi.org/10.1038/s42003-021-02372-y
Alafeef, M, Moitra, P, Dighe, K & Pan, D 2021, 'Hyperspectral Mapping for the Detection of SARS-CoV-2 Using Nanomolecular Probes with Yoctomole Sensitivity', ACS nano, vol. 15, no. 8, pp. 13742-13758. https://doi.org/10.1021/acsnano.1c05226
Srivastava, I, Moitra, P, Sar, D, Wang, K, Alafeef, M, Scott, J & Pan, D 2021, 'Luminescence switching in polymerically confined carbon nanoparticles triggered by UV-light', Nanoscale, vol. 13, no. 38, pp. 16288-16295. https://doi.org/10.1039/d1nr02786g
Fathi, P, Moitra, P, McDonald, MM, Esch, MB & Pan, D 2021, 'Near-infrared emitting dual-stimuli-responsive carbon dots from endogenous bile pigments', Nanoscale, vol. 13, no. 31, pp. 13487-13496. https://doi.org/10.1039/d1nr01295a
Alafeef, M, Moitra, P, Dighe, K & Pan, D 2021, 'RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19', Nature Protocols, vol. 16, no. 6, pp. 3141-3162. https://doi.org/10.1038/s41596-021-00546-w
Moitra, P, Alafeef, M, Dighe, K, Ray, P, Chang, J, Thole, A, Punshon-Smith, B, Tolosa, M, Ramamurthy, SS, Ge, X, Frey, DD, Pan, D & Rao, G 2021, 'Rapid and low-cost sampling for detection of airborne SARS-CoV-2 in dehumidifier condensate', Biotechnology and bioengineering, vol. 118, no. 8, pp. 3029-3036. https://doi.org/10.1002/bit.27812
Srivastava, I, Moitra, P, Fayyaz, M, Pandit, S, Kampert, TL, Fathi, P, Alanagh, HR, Dighe, K, Alafeef, M, Vuong, K, Jabeen, M, Nie, S, Irudayaraj, J & Pan, D 2021, 'Rational Design of Surface-State Controlled Multicolor Cross-Linked Carbon Dots with Distinct Photoluminescence and Cellular Uptake Properties', ACS Applied Materials and Interfaces, vol. 13, no. 50, pp. 59747-59760. https://doi.org/10.1021/acsami.1c19995
Moitra, P, Alafeef, M, Dighe, K, Sheffield, Z, Dahal, D & Pan, D 2021, 'Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2', Chemical Communications, vol. 57, no. 51, pp. 6229-6232. https://doi.org/10.1039/d1cc01410b
Fathi, P, Roslend, A, Mehta, K, Moitra, P, Zhang, K & Pan, D 2021, 'UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles', Nanoscale, vol. 13, no. 9, pp. 4785-4798. https://doi.org/10.1039/d0nr08485a
Dahal, D, Ray, P & Pan, D 2021, 'Unlocking the power of optical imaging in the second biological window: Structuring near-infrared II materials from organic molecules to nanoparticles', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 13, no. 6, e1734. https://doi.org/10.1002/wnan.1734
Fontana, F, Scott, MJ, Allen, JS, Yang, X, Cui, G, Pan, D, Yanaba, N, Fiala, MA, O'Neal, J, Schmieder-Atteberry, AH, Ritchey, J, Rettig, M, Simons, K, Fletcher, S, Vij, R, DiPersio, JF & Lanza, GM 2021, 'VLA4-Targeted nanoparticles hijack cell adhesion-mediated drug resistance to target refractory myeloma cells and prolong survival', Clinical Cancer Research, vol. 27, no. 7, pp. 1974-1986. https://doi.org/10.1158/1078-0432.CCR-20-2839
2020
Hamideh, RA, Akbari, B, Fathi, P, Misra, SK, Sutrisno, A, Lam, F & Pan, D 2020, 'Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks', Advanced Healthcare Materials, vol. 9, no. 14, 2000136. https://doi.org/10.1002/adhm.202000136
Srivastava, I, Misra, SK, Bangru, S, Boateng, KA, Soares, JANT, Schwartz-Duval, AS, Kalsotra, A & Pan, D 2020, 'Complementary Oligonucleotide Conjugated Multicolor Carbon Dots for Intracellular Recognition of Biological Events', ACS Applied Materials and Interfaces, vol. 12, no. 14, pp. 16137-16149. https://doi.org/10.1021/acsami.0c02463
Fathi, P, Capron, G, Tripathi, I, Misra, S, Ostadhossein, F, Selmic, L, Rowitz, B & Pan, D 2020, 'Computed tomography-guided additive manufacturing of Personalized Absorbable Gastrointestinal Stents for intestinal fistulae and perforations', Biomaterials, vol. 228, 119542. https://doi.org/10.1016/j.biomaterials.2019.119542
Fathi, P & Pan, DI 2020, 'Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications', Nanomedicine, vol. 15, no. 25, pp. 2493-2515. https://doi.org/10.2217/nnm-2020-0125
Huang, Z, Wang, D, Ayele, BA, Zhou, J, Srivastava, I, Pan, D, Wang, Z & Chen, Q 2020, 'Enhancement of auxiliary agent for washing efficiency of diesel contaminated soil with surfactants.', Chemosphere, vol. 252, 126494. https://doi.org/10.1016/j.chemosphere.2020.126494
Schwartz-Duval, AS, Konopka, CJ, Moitra, P, Daza, EA, Srivastava, I, Johnson, EV, Kampert, TL, Fayn, S, Haran, A, Dobrucki, LW & Pan, D 2020, 'Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold', Nature communications, vol. 11, no. 1, 4530. https://doi.org/10.1038/s41467-020-17595-6
Fathi, P, Holland, G, Pan, D & Esch, MB 2020, 'Lymphatic Vessel on a Chip with Capability for Exposure to Cyclic Fluidic Flow', ACS Applied Bio Materials, vol. 3, no. 10, pp. 6697-6707. https://doi.org/10.1021/acsabm.0c00609
Alafeef, M, Srivastava, I & Pan, D 2020, 'Machine Learning for Precision Breast Cancer Diagnosis and Prediction of the Nanoparticle Cellular Internalization', ACS Sensors, vol. 5, no. 6, pp. 1689-1698. https://doi.org/10.1021/acssensors.0c00329
Ostadhossein, F, Tripathi, I, Benig, L, LoBato, D, Moghiseh, M, Lowe, C, Raja, A, Butler, A, Panta, R, Anjomrouz, M, Chernoglazov, A & Pan, D 2020, 'Multi-“Color” Delineation of Bone Microdamages Using Ligand-Directed Sub-5 nm Hafnia Nanodots and Photon Counting CT Imaging', Advanced Functional Materials, vol. 30, no. 4, 1904936. https://doi.org/10.1002/adfm.201904936
Alafeef, M, Moitra, P & Pan, D 2020, 'Nano-enabled sensing approaches for pathogenic bacterial detection', Biosensors and Bioelectronics, vol. 165, 112276. https://doi.org/10.1016/j.bios.2020.112276
Ostadhossein, F, Sar, D, Tripathi, I, Soares, J, Remsen, EE & Pan, D 2020, 'Oligodots: Structurally Defined Fluorescent Nanoprobes for Multiscale Dual-Color Imaging in Vitro and in Vivo', ACS Applied Materials and Interfaces, vol. 12, no. 9, pp. 10183-10192. https://doi.org/10.1021/acsami.0c00705
Srivastava, I, Khan, MS, Dighe, K, Alafeef, M, Wang, Z, Banerjee, T, Ghonge, T, Grove, LM, Bashir, R & Pan, D 2020, 'On-Chip Electrical Monitoring of Real-Time “Soft” and “Hard” Protein Corona Formation on Carbon Nanoparticles', Small Methods, vol. 4, no. 7, 2000099. https://doi.org/10.1002/smtd.202000099
Patel, PR, Senyuk, V, Sweiss, K, Calip, GS, Pan, D, Rodriguez, N, Oh, A, Mahmud, N & Rondelli, D 2020, 'PARP Inhibition Synergizes with Melphalan but Does not Reverse Resistance Completely', Biology of Blood and Marrow Transplantation, vol. 26, no. 7, pp. 1273-1279. https://doi.org/10.1016/j.bbmt.2020.03.008
Alafeef, M, Dighe, K, Moitra, P & Pan, D 2020, 'Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip', ACS nano, vol. 14, no. 12, pp. 17028-17045. https://doi.org/10.1021/acsnano.0c06392
Moitra, P, Alafeef, M, Alafeef, M, Alafeef, M, Dighe, K, Frieman, MB, Pan, D, Pan, D & Pan, D 2020, 'Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles', ACS nano, vol. 14, no. 6, pp. 7617-7627. https://doi.org/10.1021/acsnano.0c03822
Nguyen, HA, Srivastava, I, Pan, D & Gruebele, M 2020, 'Unraveling the Fluorescence Mechanism of Carbon Dots with Sub-Single-Particle Resolution', ACS nano, vol. 14, no. 5, pp. 6127-6137. https://doi.org/10.1021/acsnano.0c01924