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Researcher Profile

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Dipanjan Pan

Dipanjan Pan

Professor, Ken and Mary Alice Lindquist Department of Nuclear Engineering
Scientific Program:Next-Generation Therapies

Research Interests

  • Nanoparticles
  • Therapeutics
  • Carbon
  • Neoplasms
  • Pharmaceutical Preparations
  • Molecular Imaging
  • In Vitro Techniques
  • Tomography
  • Prodrugs
  • Contrast Media
  • Nanomedicine
  • Theranostic Nanomedicine

Recent Publications


Moitra, P, Skrodzki, D, Molinaro, M, Gunaseelan, N, Sar, D, Aditya, T, Dahal, D, Ray, P & Pan, D 2024, 'Context-Responsive Nanoparticle Derived from Synthetic Zwitterionic Ionizable Phospholipids in Targeted CRISPR/Cas9 Therapy for Basal-like Breast Cancer', ACS nano, vol. 18, no. 12, pp. 9199-9220.
Tan, Y, De La Toba, E, Rubakhin, SS, Labriola, LT, Canfield, C, Pan, D & Sweedler, JV 2024, 'NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears', Journal of the American Society for Mass Spectrometry, vol. 35, no. 1, pp. 106-113.
Pan, D 2024, 'Nanomedicine and nanobiotechnology in India', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 1, e1939.
Skrodzki, D, Molinaro, M, Brown, R, Moitra, P & Pan, D 2024, 'Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium', ACS nano, vol. 18, no. 2, pp. 1289-1324.


Alafeef, M, Skrodzki, D, Moitra, P, Gunaseelan, N & Pan, D 2023, 'Binding-Induced Folding of DNA Oligonucleotides Targeted to the Nucleocapsid Gene Enables Electrochemical Sensing of SARS-CoV-2', ACS Applied Bio Materials, vol. 6, no. 3, pp. 1133-1145.
Srivastava, I, Moitra, P, Brent, KM, Wang, K, Pandit, S, Altun, E & Pan, D 2023, 'Biodegradable and switchable near-infrared fluorescent probes for hypoxia detection', Nanomedicine, vol. 18, no. 16, pp. 1061-1073.
Alafeef, M, Srivastava, I, Aditya, T & Pan, D 2024, 'Carbon Dots: From Synthesis to Unraveling the Fluorescence Mechanism', Small, vol. 20, no. 4, 2303937.
Moitra, M, Alafeef, M, Narasimhan, A, Kakaria, V, Moitra, P & Pan, D 2023, 'Diagnosis of COVID-19 with simultaneous accurate prediction of cardiac abnormalities from chest computed tomographic images', PloS one, vol. 18, no. 12 December, e0290494.
Ostadhossein, F, Moitra, P, Alafeef, M, Sar, D, D'Souza, S, Benig, LF, Nelappana, M, Huang, X, Soares, J, Zhang, K & Pan, D 2023, 'Ensemble and single-particle level fluorescent fine-tuning of carbon dots via positional changes of amines toward "supervised" oral microbiome sensing', Journal of Biomedical Optics, vol. 28, no. 8, pp. 82807.
Dighe, K, Moitra, P, Gunaseelan, N, Alafeef, M, Jensen, T, Rafferty, C & Pan, D 2023, 'Highly-Specific Single-Stranded Oligonucleotides and Functional Nanoprobes for Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections', Advanced Science, vol. 10, no. 36, 2304009.
Moitra, P, Iftesum, M, Skrodzki, D, Paul, P, Sheikh, E, Gray, JL, Dighe, K, Sheffield, Z, Gartia, MR & Pan, D 2023, 'Nucleotide-Driven Molecular Sensing of Monkeypox Virus Through Hierarchical Self-Assembly of 2D Hafnium Disulfide Nanoplatelets and Gold Nanospheres', Advanced Functional Materials, vol. 33, no. 19, 2212569.
Misra, SK, Ye, M, Moitra, P, Dighe, K, Sharma, A, Daza, EA, Schwartz-Duval, AS, Ostadhossein, F & Pan, D 2023, 'Synthesis of an enediyne carbon-allotrope surface for photo-thermal degradation of DNA', Chemical Communications, vol. 59, no. 90, pp. 13434-13437.


Ikponmwoba, E, Ukorigho, O, Moitra, P, Pan, D, Gartia, MR & Owoyele, O 2022, 'A Machine Learning Framework for Detecting COVID-19 Infection Using Surface-Enhanced Raman Scattering', Biosensors, vol. 12, no. 8, 589.
Watt, MM, Moitra, P, Sheffield, Z, Ostadhossein, F, Maxwell, EA & Pan, D 2023, 'A narrative review on the role of carbon nanoparticles in oncology', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 15, no. 2, e1845.
Dighe, K, Moitra, P, Alafeef, M, Gunaseelan, N & Pan, D 2022, 'A rapid RNA extraction-free lateral flow assay for molecular point-of-care detection of SARS-CoV-2 augmented by chemical probes', Biosensors and Bioelectronics, vol. 200, 113900.
Alafeef, M & Pan, D 2022, 'Diagnostic Approaches for COVID-19: Lessons Learned and the Path Forward', ACS nano, vol. 16, no. 8, pp. 11545-11576.
Ray, P, Moitra, P & Pan, D 2022, 'Emerging theranostic applications of carbon dots and its variants', VIEW, vol. 3, no. 2, 20200089.
Mittal, N, Rogers, S, Dougherty, S, Wang, Q, Moitra, P, Brummet, M, Cornett, EM, Kaye, AD, Shekoohi, S, Buehler, P, Spinella, P, Pan, D & Doctor, A 2022, Erythromer (EM), a Nanoscale Bio-Synthetic Artificial Red Cell. in Blood Substitutes and Oxygen Biotherapeutics. Springer International Publishing, pp. 253-265.
Ostadhossein, F, Moitra, P, Gunaseelan, N, Nelappana, M, Lowe, C, Moghiseh, M, Butler, A, de Ruiter, N, Mandalika, H, Tripathi, I, Misra, SK & Pan, D 2022, 'Hitchhiking probiotic vectors to deliver ultra-small hafnia nanoparticles for ‘Color’ gastrointestinal tract photon counting X-ray imaging', Nanoscale Horizons, vol. 7, no. 5, pp. 533-542.
Fathi, P, Roslend, A, Alafeef, M, Moitra, P, Dighe, K, Esch, MB & Pan, D 2022, 'In Situ Surface-Directed Assembly of 2D Metal Nanoplatelets for Drug-Free Treatment of Antibiotic-Resistant Bacteria', Advanced Healthcare Materials, vol. 11, no. 19, 2102567.
Alafeef, M, Dighe, K, Moitra, P & Pan, D 2022, 'Monitoring the Viral Transmission of SARS-CoV-2 in Still Waterbodies Using a Lanthanide-Doped Carbon Nanoparticle-Based Sensor Array', ACS Sustainable Chemistry and Engineering, vol. 10, no. 1, pp. 245-258.
Sheffield, Z, Alafeef, M, Moitra, P, Ray, P & Pan, D 2022, 'N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA', Nanoscale, vol. 14, no. 13, pp. 5112-5120.
Moitra, P, Chaichi, A, Abid Hasan, SM, Dighe, K, Alafeef, M, Prasad, A, Gartia, MR & Pan, D 2022, 'Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning', Biosensors and Bioelectronics, vol. 208, 114200.
Moitra, P, Alafeef, M, Dighe, K & Pan, D 2022, 'Single-gene diagnostic assay for rapid subclassification of basal like breast cancer with mRNA targeted antisense oligonucleotide capped molecular probe', Biosensors and Bioelectronics, vol. 207, 114178.
Sar, D, Ostadhossein, F, Moitra, P, Alafeef, M & Pan, D 2022, 'Small Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots', Advanced Science, vol. 9, no. 22, 2202414.
Zhang, X, Misra, SK, Moitra, P, Zhang, X, Jeong, SJ, Stitham, J, Rodriguez-Velez, A, Park, A, Yeh, YS, Gillanders, WE, Fan, D, Diwan, A, Cho, J, Epelman, S, Lodhi, IJ, Pan, D & Razani, B 2023, 'Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis', Autophagy, vol. 19, no. 3, pp. 886-903.


Schwartz-Duval, AS, Wen, R, Srivastava, I, Moitra, P & Pan, D 2021, 'A Simplistic Single-Step Method for Preparing Biomimetic Nanoparticles from Endogenous Biomaterials', ACS Applied Materials and Interfaces, vol. 13, no. 39, pp. 46464-46477.
Ostadhossein, F, Moitra, P, Altun, E, Dutta, D, Sar, D, Tripathi, I, Hsiao, SH, Kravchuk, V, Nie, S & Pan, D 2021, 'Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance', Communications Biology, vol. 4, no. 1, 846.
Alafeef, M, Moitra, P, Dighe, K & Pan, D 2021, 'Hyperspectral Mapping for the Detection of SARS-CoV-2 Using Nanomolecular Probes with Yoctomole Sensitivity', ACS nano, vol. 15, no. 8, pp. 13742-13758.
Srivastava, I, Moitra, P, Sar, D, Wang, K, Alafeef, M, Scott, J & Pan, D 2021, 'Luminescence switching in polymerically confined carbon nanoparticles triggered by UV-light', Nanoscale, vol. 13, no. 38, pp. 16288-16295.
Fathi, P, Moitra, P, McDonald, MM, Esch, MB & Pan, D 2021, 'Near-infrared emitting dual-stimuli-responsive carbon dots from endogenous bile pigments', Nanoscale, vol. 13, no. 31, pp. 13487-13496.
Alafeef, M, Moitra, P, Dighe, K & Pan, D 2021, 'RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19', Nature Protocols, vol. 16, no. 6, pp. 3141-3162.
Moitra, P, Alafeef, M, Dighe, K, Ray, P, Chang, J, Thole, A, Punshon-Smith, B, Tolosa, M, Ramamurthy, SS, Ge, X, Frey, DD, Pan, D & Rao, G 2021, 'Rapid and low-cost sampling for detection of airborne SARS-CoV-2 in dehumidifier condensate', Biotechnology and bioengineering, vol. 118, no. 8, pp. 3029-3036.
Srivastava, I, Moitra, P, Fayyaz, M, Pandit, S, Kampert, TL, Fathi, P, Alanagh, HR, Dighe, K, Alafeef, M, Vuong, K, Jabeen, M, Nie, S, Irudayaraj, J & Pan, D 2021, 'Rational Design of Surface-State Controlled Multicolor Cross-Linked Carbon Dots with Distinct Photoluminescence and Cellular Uptake Properties', ACS Applied Materials and Interfaces, vol. 13, no. 50, pp. 59747-59760.
Moitra, P, Alafeef, M, Dighe, K, Sheffield, Z, Dahal, D & Pan, D 2021, 'Synthesis and characterisation of N-gene targeted NIR-II fluorescent probe for selective localisation of SARS-CoV-2', Chemical Communications, vol. 57, no. 51, pp. 6229-6232.
Fathi, P, Roslend, A, Mehta, K, Moitra, P, Zhang, K & Pan, D 2021, 'UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles', Nanoscale, vol. 13, no. 9, pp. 4785-4798.
Dahal, D, Ray, P & Pan, D 2021, 'Unlocking the power of optical imaging in the second biological window: Structuring near-infrared II materials from organic molecules to nanoparticles', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 13, no. 6, e1734.
Fontana, F, Scott, MJ, Allen, JS, Yang, X, Cui, G, Pan, D, Yanaba, N, Fiala, MA, O'Neal, J, Schmieder-Atteberry, AH, Ritchey, J, Rettig, M, Simons, K, Fletcher, S, Vij, R, DiPersio, JF & Lanza, GM 2021, 'VLA4-Targeted nanoparticles hijack cell adhesion-mediated drug resistance to target refractory myeloma cells and prolong survival', Clinical Cancer Research, vol. 27, no. 7, pp. 1974-1986.


Hamideh, RA, Akbari, B, Fathi, P, Misra, SK, Sutrisno, A, Lam, F & Pan, D 2020, 'Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks', Advanced Healthcare Materials, vol. 9, no. 14, 2000136.
Srivastava, I, Misra, SK, Bangru, S, Boateng, KA, Soares, JANT, Schwartz-Duval, AS, Kalsotra, A & Pan, D 2020, 'Complementary Oligonucleotide Conjugated Multicolor Carbon Dots for Intracellular Recognition of Biological Events', ACS Applied Materials and Interfaces, vol. 12, no. 14, pp. 16137-16149.
Fathi, P, Capron, G, Tripathi, I, Misra, S, Ostadhossein, F, Selmic, L, Rowitz, B & Pan, D 2020, 'Computed tomography-guided additive manufacturing of Personalized Absorbable Gastrointestinal Stents for intestinal fistulae and perforations', Biomaterials, vol. 228, 119542.
Fathi, P & Pan, DI 2020, 'Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications', Nanomedicine, vol. 15, no. 25, pp. 2493-2515.
Huang, Z, Wang, D, Ayele, BA, Zhou, J, Srivastava, I, Pan, D, Wang, Z & Chen, Q 2020, 'Enhancement of auxiliary agent for washing efficiency of diesel contaminated soil with surfactants.', Chemosphere, vol. 252, 126494.
Schwartz-Duval, AS, Konopka, CJ, Moitra, P, Daza, EA, Srivastava, I, Johnson, EV, Kampert, TL, Fayn, S, Haran, A, Dobrucki, LW & Pan, D 2020, 'Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold', Nature communications, vol. 11, no. 1, 4530.
Fathi, P, Holland, G, Pan, D & Esch, MB 2020, 'Lymphatic Vessel on a Chip with Capability for Exposure to Cyclic Fluidic Flow', ACS Applied Bio Materials, vol. 3, no. 10, pp. 6697-6707.
Alafeef, M, Srivastava, I & Pan, D 2020, 'Machine Learning for Precision Breast Cancer Diagnosis and Prediction of the Nanoparticle Cellular Internalization', ACS Sensors, vol. 5, no. 6, pp. 1689-1698.
Ostadhossein, F, Tripathi, I, Benig, L, LoBato, D, Moghiseh, M, Lowe, C, Raja, A, Butler, A, Panta, R, Anjomrouz, M, Chernoglazov, A & Pan, D 2020, 'Multi-“Color” Delineation of Bone Microdamages Using Ligand-Directed Sub-5 nm Hafnia Nanodots and Photon Counting CT Imaging', Advanced Functional Materials, vol. 30, no. 4, 1904936.
Alafeef, M, Moitra, P & Pan, D 2020, 'Nano-enabled sensing approaches for pathogenic bacterial detection', Biosensors and Bioelectronics, vol. 165, 112276.
Ostadhossein, F, Sar, D, Tripathi, I, Soares, J, Remsen, EE & Pan, D 2020, 'Oligodots: Structurally Defined Fluorescent Nanoprobes for Multiscale Dual-Color Imaging in Vitro and in Vivo', ACS Applied Materials and Interfaces, vol. 12, no. 9, pp. 10183-10192.
Srivastava, I, Khan, MS, Dighe, K, Alafeef, M, Wang, Z, Banerjee, T, Ghonge, T, Grove, LM, Bashir, R & Pan, D 2020, 'On-Chip Electrical Monitoring of Real-Time “Soft” and “Hard” Protein Corona Formation on Carbon Nanoparticles', Small Methods, vol. 4, no. 7, 2000099.
Patel, PR, Senyuk, V, Sweiss, K, Calip, GS, Pan, D, Rodriguez, N, Oh, A, Mahmud, N & Rondelli, D 2020, 'PARP Inhibition Synergizes with Melphalan but Does not Reverse Resistance Completely', Biology of Blood and Marrow Transplantation, vol. 26, no. 7, pp. 1273-1279.
Alafeef, M, Dighe, K, Moitra, P & Pan, D 2020, 'Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip', ACS nano, vol. 14, no. 12, pp. 17028-17045.
Moitra, P, Alafeef, M, Alafeef, M, Alafeef, M, Dighe, K, Frieman, MB, Pan, D, Pan, D & Pan, D 2020, 'Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles', ACS nano, vol. 14, no. 6, pp. 7617-7627.
Nguyen, HA, Srivastava, I, Pan, D & Gruebele, M 2020, 'Unraveling the Fluorescence Mechanism of Carbon Dots with Sub-Single-Particle Resolution', ACS nano, vol. 14, no. 5, pp. 6127-6137.