Dipanjan Pan - Penn State Cancer Institute
Researcher Profile
Dipanjan Pan
Professor, Ken and Mary Alice Lindquist Department of Nuclear Engineering
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Natarajan, S, Dighe, K, Skrodzki, D, Ponnusamy, N & Pan, D 2026, 'A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox', Chemical Communications, vol. 62, no. 21, pp. 5895-5899. https://doi.org/10.1039/d5cc06114h
Saha, P, Krishnakumar, S, Yardim, A, Skrodzki, D, Griffiths, A, Aditya, T & Pan, D 2026, 'Catalytic Wiring of Enzymatic Cascades Using ROS-Flux-Regulated Biodegradable Borophene', Small, vol. 22, no. 22, e12858. https://doi.org/10.1002/smll.202512858
Molinaro, M, Saha, P, Skrodzki, D, Machtay, M & Pan, D 2026, 'Liposome-Encapsulated Carfilzomib as a Radiosensitizer in Solid Tumors', Molecular Pharmaceutics, vol. 23, no. 3, pp. 1810-1818. https://doi.org/10.1021/acs.molpharmaceut.5c01534
Natarajan, S, Skrodzki, D, Yennawar, NH, Gershenson, J & Pan, D 2026, 'Programmable PNA–nanoparticle hybrids as nanoscale recognition architectures for amplification-free nucleic acid recognition', Biosensors and Bioelectronics, vol. 297, 118380. https://doi.org/10.1016/j.bios.2026.118380
2025
Capron, G, Fathi, P, Jensen, TW, Milner, DJ, van der Vlies, AJ, Moody, RL, Bangert, EA, Rowitz, B, Pan, D & Wheeler, MB 2026, '3D-Printed Gastrointestinal Stents: In Vivo Evaluation in a Swine Small Bowel Perforation Model', Advanced Healthcare Materials, vol. 15, no. 11, e05169. https://doi.org/10.1002/adhm.202505169
Saha, P, van der Vlies, AJ, Aditya, T, Dighe, K, Hicks, SD & Pan, D 2025, 'Anti-miR oligo-mediated detection of human salivary microRNAs for mild traumatic brain injury', Biosensors and Bioelectronics, vol. 278, 117333. https://doi.org/10.1016/j.bios.2025.117333
Molinaro, M & Pan, D 2025, 'Cancer targeting carfilzomib nanomedicine: a comprehensive review of delivery vehicles and efficacy', Nanomedicine, vol. 20, no. 24, pp. 2993-3004. https://doi.org/10.1080/17435889.2025.2579621
Dighe, K, Colak, O, Moitra, P, Alafeef, M, Skrodzki, D, Aditya, T, Saha, P, Gunaseelan, N, Hural, J, Pinto, C & Pan, D 2025, 'Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants', Science Advances, vol. 11, no. 49, eadz5639. https://doi.org/10.1126/sciadv.adz5639
Wu, L, Lanza, GM, Xie, J & Pan, D 2025, 'Editorial: Emerging advances in exploiting pulmonary administration for treatment of thoracic diseases', Frontiers in Bioengineering and Biotechnology, vol. 13, 1612172. https://doi.org/10.3389/fbioe.2025.1612172
Misra, SK, Dighe, K, Saha, P, Aditya, T, Khan, MS, Alafeef, M, Moitra, P & Pan, D 2026, 'Electro-Stimulated Graphene-Polymer Nanocomposites Enable Wearable Patches With Feedback-Controlled Drug Release', Advanced Healthcare Materials, vol. 15, no. 15, e05894. https://doi.org/10.1002/adhm.202505894
Natarajan, S, Dighe, K, Aditya, T, Skrodzki, D, Gupta, P, Saha, P, Gunaseelan, N & Pan, D 2025, Fabrication of Immunobiosensors by 2D Borophene-Induced Covalent and Oriented Immobilization of Antibody for Ultrasensitive Antigen Detection: 2D Borophene to achieve oriented immobilization of an antibody for better antigen-binding in Menstrual effluent. in 2025 IEEE BioSensors Conference, BioSensors 2025 - Conferece Proceedings. 2025 IEEE BioSensors Conference, BioSensors 2025 - Conferece Proceedings, Institute of Electrical and Electronics Engineers Inc., 3rd Annual IEEE BioSensors Conference, BioSensors 2025, San Diego, United States, 8/2/25. https://doi.org/10.1109/BioSensors65002.2025.11239222
Sansalone, JM, Moitra, P, Doctor, A, Pan, D & Aluru, NR 2025, 'Phospholipid Bilayer Properties in pH-Responsive Hemoglobin-Based Oxygen Carriers', Journal of Physical Chemistry B, vol. 129, no. 10, pp. 2668-2677. https://doi.org/10.1021/acs.jpcb.4c07060
Natarajan, S, Dighe, K, Aditya, T, Saha, P, Skrodzki, D, Gupta, P, Gunaseelan, N, Krishnakumar, S & Pan, D 2025, 'Photoinduced Immobilization on Two-Dimensional Nano Borophene Spatially Orients Capture Antibody for Highly Sensitive Biological Interactions', ACS Central Science, vol. 11, no. 8, pp. 1492-1511. https://doi.org/10.1021/acscentsci.5c00474
Natarajan, S, Dighe, K, Skrodzki, D & Pan, D 2025, Point of care nucleic acid test using Single Stranded DNAs paper microfluidics for differential detection of Mpox Virus Clades under low resource setting: Development of a ssDNAs-based molecular assay for the simultaneous detection and differentiation of Mpox virus Clade I and II. in 2025 IEEE BioSensors Conference, BioSensors 2025 - Conferece Proceedings. 2025 IEEE BioSensors Conference, BioSensors 2025 - Conferece Proceedings, Institute of Electrical and Electronics Engineers Inc., 3rd Annual IEEE BioSensors Conference, BioSensors 2025, San Diego, United States, 8/2/25. https://doi.org/10.1109/BioSensors65002.2025.11239223
Frenia, K, Fu, Y, Beatty, MA, Garwood, KC, Kimmel, J, Raiji, V, Pan, D, Bartlett, D, Labriola, LT & Xiao, K 2025, 'Precision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection', Biomedicines, vol. 13, no. 2, 386. https://doi.org/10.3390/biomedicines13020386
Aditya, T, Saha, P, Misra, SK, Alafeef, M, Ray, P, Daza, EA, Schwartz-Duval, AS, Tripathi, I & Pan, D 2025, 'Spatio-temporal nano-biomineralization and pro-antibiotic release for synergistically combatting multidrug-resistant bacteria', Materials Today, vol. 88, pp. 64-77. https://doi.org/10.1016/j.mattod.2025.05.019
Saha, P, Skrodzki, D, Aditya, T, Moitra, P, Alafeef, M, Dighe, K, Molinaro, M, Hicks, SD & Pan, D 2025, 'Tailored Anti-miR Decorated Covalent Organic Framework Enables Electrochemical Detection of Salivary miRNAs for Mild Traumatic Brain Injury', Small, vol. 21, no. 14, 2412107. https://doi.org/10.1002/smll.202412107
2024
Molinaro, M, Skrodzki, D & Pan, D 2024, 'Chemoradiotherapy and nanomedicine: Drug mechanisms and delivery systems', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 4, e1984. https://doi.org/10.1002/wnan.1984
Aditya, T, Moitra, P, Alafeef, M, Skrodzki, D & Pan, D 2024, 'Chiral Induction in 2D Borophene Nanoplatelets through Stereoselective Boron-Sulfur Conjugation', ACS nano, vol. 18, no. 18, pp. 11921-11932. https://doi.org/10.1021/acsnano.4c01792
Moitra, P, Skrodzki, D, Molinaro, M, Gunaseelan, N, Sar, D, Aditya, T, Dahal, D, Ray, P & Pan, D 2024, 'Context-Responsive Nanoparticle Derived from Synthetic Zwitterionic Ionizable Phospholipids in Targeted CRISPR/Cas9 Therapy for Basal-like Breast Cancer', ACS nano, vol. 18, no. 12, pp. 9199-9220. https://doi.org/10.1021/acsnano.4c01400
Dighe, K, Moitra, P, Saha, P, Gunaseelan, N & Pan, D 2024, 'Cooperative effect of complementary antisense oligonucleotides and CRISPR effectors for universal DNA-based pathogen assay using nano-enabled colorimetry', Materials Today, vol. 80, pp. 374-394. https://doi.org/10.1016/j.mattod.2024.09.017
Sheffield, Z, Paul, P, Krishnakumar, S & Pan, D 2025, 'Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications', Advanced Science, vol. 12, no. 5, 2411339. https://doi.org/10.1002/advs.202411339
R. Alanagh, H, Fathi, P, Knox, HJ, Moitra, P, Chan, J & Pan, D 2024, 'Exploring Biliverdin’s Molecular Interactions with Cu- and Fe-Based MOFs: A Unified In Vitro Study with Photoacoustic Analysis', Langmuir, vol. 40, no. 35, pp. 18407-18417. https://doi.org/10.1021/acs.langmuir.3c03584
Tan, Y, De La Toba, E, Rubakhin, SS, Labriola, LT, Canfield, C, Pan, D & Sweedler, JV 2024, 'NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears', Journal of the American Society for Mass Spectrometry, vol. 35, no. 1, pp. 106-113. https://doi.org/10.1021/jasms.3c00331
Pan, D 2024, 'Nanomedicine and nanobiotechnology in India', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 1, e1939. https://doi.org/10.1002/wnan.1939
Gunaseelan, N, Saha, P, Maher, N & Pan, D 2024, 'Nanoparticles with “K-edge” Metals Bring “Color” in Multiscale Spectral Photon Counting X-ray Imaging', ACS nano, vol. 18, no. 51, pp. 34464-34491. https://doi.org/10.1021/acsnano.4c11724
Skrodzki, D, Molinaro, M, Brown, R, Moitra, P & Pan, D 2024, 'Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium', ACS nano, vol. 18, no. 2, pp. 1289-1324. https://doi.org/10.1021/acsnano.3c08917
Gunaseelan, N, Moitra, P, Saha, P, Aditya, T, Moghiseh, M, Jonker, K, Gieseg, S, Butler, A, Kamal, F & Pan, D 2024, 'Targeted K-Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT', Advanced Science, vol. 11, no. 46, 2408408. https://doi.org/10.1002/advs.202408408
2023
Alafeef, M, Skrodzki, D, Moitra, P, Gunaseelan, N & Pan, D 2023, 'Binding-Induced Folding of DNA Oligonucleotides Targeted to the Nucleocapsid Gene Enables Electrochemical Sensing of SARS-CoV-2', ACS Applied Bio Materials, vol. 6, no. 3, pp. 1133-1145. https://doi.org/10.1021/acsabm.2c00984
Srivastava, I, Moitra, P, Brent, KM, Wang, K, Pandit, S, Altun, E & Pan, D 2023, 'Biodegradable and switchable near-infrared fluorescent probes for hypoxia detection', Nanomedicine, vol. 18, no. 16, pp. 1061-1073. https://doi.org/10.2217/nnm-2023-0095
Alafeef, M, Srivastava, I, Aditya, T & Pan, D 2024, 'Carbon Dots: From Synthesis to Unraveling the Fluorescence Mechanism', Small, vol. 20, no. 4, 2303937. https://doi.org/10.1002/smll.202303937
Pan, D 2023, 'Comment on the “Development of copper nanoparticles and their prospective use in the pharmaceutical sector.”', Precision Nanomedicine, vol. 6, no. 2, 1133. https://doi.org/10.33218/001c.90170
Moitra, M, Alafeef, M, Narasimhan, A, Kakaria, V, Moitra, P & Pan, D 2023, 'Diagnosis of COVID-19 with simultaneous accurate prediction of cardiac abnormalities from chest computed tomographic images', PloS one, vol. 18, no. 12 December, e0290494. https://doi.org/10.1371/journal.pone.0290494
Ostadhossein, F, Moitra, P, Alafeef, M, Sar, D, D'Souza, S, Benig, LF, Nelappana, M, Huang, X, Soares, J, Zhang, K & Pan, D 2023, 'Ensemble and single-particle level fluorescent fine-tuning of carbon dots via positional changes of amines toward "supervised" oral microbiome sensing', Journal of Biomedical Optics, vol. 28, no. 8, pp. 82807. https://doi.org/10.1117/1.JBO.28.8.082807
Dighe, K, Moitra, P, Gunaseelan, N, Alafeef, M, Jensen, T, Rafferty, C & Pan, D 2023, 'Highly-Specific Single-Stranded Oligonucleotides and Functional Nanoprobes for Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections', Advanced Science, vol. 10, no. 36, 2304009. https://doi.org/10.1002/advs.202304009
Moitra, P, Iftesum, M, Skrodzki, D, Paul, P, Sheikh, E, Gray, JL, Dighe, K, Sheffield, Z, Gartia, MR & Pan, D 2023, 'Nucleotide-Driven Molecular Sensing of Monkeypox Virus Through Hierarchical Self-Assembly of 2D Hafnium Disulfide Nanoplatelets and Gold Nanospheres', Advanced Functional Materials, vol. 33, no. 19, 2212569. https://doi.org/10.1002/adfm.202212569
Misra, SK, Ye, M, Moitra, P, Dighe, K, Sharma, A, Daza, EA, Schwartz-Duval, AS, Ostadhossein, F & Pan, D 2023, 'Synthesis of an enediyne carbon-allotrope surface for photo-thermal degradation of DNA', Chemical Communications, vol. 59, no. 90, pp. 13434-13437. https://doi.org/10.1039/d3cc03353h
2022
Ikponmwoba, E, Ukorigho, O, Moitra, P, Pan, D, Gartia, MR & Owoyele, O 2022, 'A Machine Learning Framework for Detecting COVID-19 Infection Using Surface-Enhanced Raman Scattering', Biosensors, vol. 12, no. 8, 589. https://doi.org/10.3390/bios12080589
Watt, MM, Moitra, P, Sheffield, Z, Ostadhossein, F, Maxwell, EA & Pan, D 2023, 'A narrative review on the role of carbon nanoparticles in oncology', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 15, no. 2, e1845. https://doi.org/10.1002/wnan.1845
Dighe, K, Moitra, P, Alafeef, M, Gunaseelan, N & Pan, D 2022, 'A rapid RNA extraction-free lateral flow assay for molecular point-of-care detection of SARS-CoV-2 augmented by chemical probes', Biosensors and Bioelectronics, vol. 200, 113900. https://doi.org/10.1016/j.bios.2021.113900
Alafeef, M & Pan, D 2022, 'Diagnostic Approaches for COVID-19: Lessons Learned and the Path Forward', ACS nano, vol. 16, no. 8, pp. 11545-11576. https://doi.org/10.1021/acsnano.2c01697
Ray, P, Moitra, P & Pan, D 2022, 'Emerging theranostic applications of carbon dots and its variants', VIEW, vol. 3, no. 2, 20200089. https://doi.org/10.1002/VIW.20200089
Mittal, N, Rogers, S, Dougherty, S, Wang, Q, Moitra, P, Brummet, M, Cornett, EM, Kaye, AD, Shekoohi, S, Buehler, P, Spinella, P, Pan, D & Doctor, A 2022, Erythromer (EM), a Nanoscale Bio-Synthetic Artificial Red Cell. in Blood Substitutes and Oxygen Biotherapeutics. Springer International Publishing, pp. 253-265. https://doi.org/10.1007/978-3-030-95975-3_24
Ostadhossein, F, Moitra, P, Gunaseelan, N, Nelappana, M, Lowe, C, Moghiseh, M, Butler, A, de Ruiter, N, Mandalika, H, Tripathi, I, Misra, SK & Pan, D 2022, 'Hitchhiking probiotic vectors to deliver ultra-small hafnia nanoparticles for ‘Color’ gastrointestinal tract photon counting X-ray imaging', Nanoscale Horizons, vol. 7, no. 5, pp. 533-542. https://doi.org/10.1039/d1nh00626f
Fathi, P, Roslend, A, Alafeef, M, Moitra, P, Dighe, K, Esch, MB & Pan, D 2022, 'In Situ Surface-Directed Assembly of 2D Metal Nanoplatelets for Drug-Free Treatment of Antibiotic-Resistant Bacteria', Advanced Healthcare Materials, vol. 11, no. 19, 2102567. https://doi.org/10.1002/adhm.202102567
Alafeef, M, Dighe, K, Moitra, P & Pan, D 2022, 'Monitoring the Viral Transmission of SARS-CoV-2 in Still Waterbodies Using a Lanthanide-Doped Carbon Nanoparticle-Based Sensor Array', ACS Sustainable Chemistry and Engineering, vol. 10, no. 1, pp. 245-258. https://doi.org/10.1021/acssuschemeng.1c06066
Sheffield, Z, Alafeef, M, Moitra, P, Ray, P & Pan, D 2022, 'N-gene-complementary antisense-oligonucleotide directed molecular aggregation of dual-colour carbon dots, leading to efficient fluorometric sensing of SARS-COV-2 RNA', Nanoscale, vol. 14, no. 13, pp. 5112-5120. https://doi.org/10.1039/d1nr07169f
Moitra, P, Chaichi, A, Abid Hasan, SM, Dighe, K, Alafeef, M, Prasad, A, Gartia, MR & Pan, D 2022, 'Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning', Biosensors and Bioelectronics, vol. 208, 114200. https://doi.org/10.1016/j.bios.2022.114200
Moitra, P, Alafeef, M, Dighe, K & Pan, D 2022, 'Single-gene diagnostic assay for rapid subclassification of basal like breast cancer with mRNA targeted antisense oligonucleotide capped molecular probe', Biosensors and Bioelectronics, vol. 207, 114178. https://doi.org/10.1016/j.bios.2022.114178
Sar, D, Ostadhossein, F, Moitra, P, Alafeef, M & Pan, D 2022, 'Small Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots', Advanced Science, vol. 9, no. 22, 2202414. https://doi.org/10.1002/advs.202202414
Zhang, X, Misra, SK, Moitra, P, Zhang, X, Jeong, SJ, Stitham, J, Rodriguez-Velez, A, Park, A, Yeh, YS, Gillanders, WE, Fan, D, Diwan, A, Cho, J, Epelman, S, Lodhi, IJ, Pan, D & Razani, B 2023, 'Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis', Autophagy, vol. 19, no. 3, pp. 886-903. https://doi.org/10.1080/15548627.2022.2108252