Yasin Uzun, PhD, MSc - Penn State Cancer Institute
Researcher Profile
Yasin Uzun, PhD, MSc
Assistant Professor, Department of Pediatrics
Assistant Professor, Department of Molecular and Precision Medicine
Assistant Professor, Department of Molecular and Precision Medicine
Scientific Program:Next-Generation Therapies
Recent Publications
2024
Moeckel, C, Mouratidis, I, Chantzi, N, Uzun, Y & Georgakopoulos-Soares, I 2024, 'Advances in computational and experimental approaches for deciphering transcriptional regulatory networks: Understanding the roles of cis-regulatory elements is essential, and recent research utilizing MPRAs, STARR-seq, CRISPR-Cas9, and machine learning has yielded valuable insights', BioEssays, vol. 46, no. 7, 2300210. https://doi.org/10.1002/bies.202300210
Karamveer, & Uzun, Y 2024, 'Approaches for Benchmarking Single-Cell Gene Regulatory Network Methods', Bioinformatics and Biology Insights, vol. 18. https://doi.org/10.1177/11779322241287120
Grossmann, LD, Chen, CH, Uzun, Y, Thadi, A, Wolpaw, AJ, Louault, K, Goldstein, Y, Surrey, LF, Martinez, D, Calafatti, M, Gerelus, M, Gao, P, Lee, L, Patel, K, Kaufman, RS, Shani, G, Farrel, A, Moshitch-Moshkovitz, S, Grimaldi, P, Shapiro, M, Kendsersky, NM, Lindsay, JM, Casey, CE, Krytska, K, Scolaro, L, Tsang, M, Groff, D, Matkar, S, Kalna, JR, Mycek, E, McDevitt, J, Runbeck, E, Patel, T, Bernt, KM, Asgharzadeh, S, Declerck, YA, Mossé, YP, Tan, K & Maris, JM 2024, 'Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister Cells', Cancer Discovery, vol. 14, no. 12, pp. 2387-2406. https://doi.org/10.1158/2159-8290.CD-24-0046
2023
Hattori, T, Fundora, KA, Hamamoto, K, Opozda, DM, Liang, X, Liu, X, Zhang, J, Uzun, Y, Takahashi, Y & Wang, HG 2024, 'ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis', Autophagy, vol. 20, no. 2, pp. 349-364. https://doi.org/10.1080/15548627.2023.2258701
Uzun, Y, Wu, H & Tan, K 2023, Integrating Single-Cell Methylome and Transcriptome Data with MAPLE. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2624, Humana Press Inc., pp. 43-54. https://doi.org/10.1007/978-1-0716-2962-8_4
Morral, C, Ghinnagow, R, Karakasheva, T, Zhou, Y, Thadi, A, Li, N, Yoshor, B, Soto, GE, Chen, CH, Aleynick, D, Weinbrom, S, Fulton, MK, Uzun, Y, Bewtra, M, Kelsen, JR, Lengner, CJ, Tan, K, Minn, AJ & Hamilton, KE 2023, 'Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions', Bio-protocol, vol. 13, no. 18, e4825. https://doi.org/10.21769/BioProtoc.4825
2022
Yang, Y, Mumau, M, Tober, J, Zhu, Q, Bennett, L, Hong, C, Sung, D, Keller, T, Uzun, Y, Gao, P, Shewale, S, Chen, M, Yang, J, Chen, X, Thomas, SA, Tan, K, Speck, NA & Kahn, ML 2022, 'Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis', Blood, vol. 139, no. 19, pp. 2942-2957. https://doi.org/10.1182/blood.2021013934
Wolpaw, AJ, Grossmann, LD, Dessau, JL, Dong, MM, Aaron, BJ, Brafford, PA, Volgina, D, Pascual-Pasto, G, Rodriguez-Garcia, A, Uzun, Y, Arsenian-Henriksson, M, Powell, DJ, Bosse, KR, Kossenkov, A, Tan, K, Hogarty, MD, Maris, JM & Dang, CV 2022, 'Epigenetic state determines inflammatory sensing in neuroblastoma', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 6, e2102358119. https://doi.org/10.1073/pnas.2102358119
Human Tumor Atlas Network 2022, 'MITI minimum information guidelines for highly multiplexed tissue images', Nature methods, vol. 19, no. 3, pp. 262-267. https://doi.org/10.1038/s41592-022-01415-4
Chen, C, Yu, W, Alikarami, F, Qiu, Q, Chen, CH, Flournoy, J, Gao, P, Uzun, Y, Fang, L, Davenport, JW, Hu, Y, Zhu, Q, Wang, K, Libbrecht, C, Felmeister, A, Rozich, I, Ding, YY, Hunger, SP, Felix, CA, Wu, H, Brown, PA, Guest, EM, Barrett, DM, Bernt, KM & Tan, K 2022, 'Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia', Blood, vol. 139, no. 14, pp. 2198-2211. https://doi.org/10.1182/blood.2021013442
2021
Chen, GM, Chen, C, Das, RK, Gao, P, Chen, CH, Bandyopadhyay, S, Ding, YY, Uzun, Y, Yu, W, Zhu, Q, Myers, RM, Grupp, SA, Barrett, DM & Tan, K 2021, 'Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy', Cancer Discovery, vol. 11, no. 9, pp. 2186-2199. https://doi.org/10.1158/2159-8290.CD-20-1677
Uzun, Y, Wu, H & Tan, K 2021, 'Predictive modeling of single-cell DNA methylome data enhances integration with transcriptome data', Genome research, vol. 31, no. 1, pp. 101-109. https://doi.org/10.1101/gr.267047.120