Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Yasin Uzun, PhD, MSc

Yasin Uzun, PhD, MSc

Assistant Professor, Department of Pediatrics
Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies
View Website

Research Interests

Dr. Yasin Uzun uses bioinformatics and genomics methods to understand gene regulation at the molecular level. For this purpose, he employs Systems Biology approaches to utilize next generation sequencing data, with a particular emphasis on single-cell genomics for modeling epigenetic control. His studies in this field reveal the molecular mechanisms that switch the genes on and off during cell differentiation. In this way, he investigates how the dysregulation in these control mechanisms are associated with various genetic diseases with a particular focus on cancer and how this information can present novel therapeutic opportunities.

  • Population
  • Transcriptome
  • Epigenomics
  • Neoplasms
  • Epigenome
  • Hematopoietic Stem Cells
  • Gene Regulatory Networks
  • Hemangioblasts
  • Genes
  • Endothelium
  • T-Lymphocytes
  • Chromatin

Recent Publications


Hattori, T, Fundora, KA, Hamamoto, K, Opozda, DM, Liang, X, Liu, X, Zhang, J, Uzun, Y, Takahashi, Y & Wang, HG 2024, 'ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis', Autophagy, vol. 20, no. 2, pp. 349-364.
Uzun, Y, Wu, H & Tan, K 2023, Integrating Single-Cell Methylome and Transcriptome Data with MAPLE. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2624, Humana Press Inc., pp. 43-54.
Morral, C, Ghinnagow, R, Karakasheva, T, Zhou, Y, Thadi, A, Li, N, Yoshor, B, Soto, GE, Chen, CH, Aleynick, D, Weinbrom, S, Fulton, MK, Uzun, Y, Bewtra, M, Kelsen, JR, Lengner, CJ, Tan, K, Minn, AJ & Hamilton, KE 2023, 'Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions', Bio-protocol, vol. 13, no. 18, e4825.


Yang, Y, Mumau, M, Tober, J, Zhu, Q, Bennett, L, Hong, C, Sung, D, Keller, T, Uzun, Y, Gao, P, Shewale, S, Chen, M, Yang, J, Chen, X, Thomas, SA, Tan, K, Speck, NA & Kahn, ML 2022, 'Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis', Blood, vol. 139, no. 19, pp. 2942-2957.
Wolpaw, AJ, Grossmann, LD, Dessau, JL, Dong, MM, Aaron, BJ, Brafford, PA, Volgina, D, Pascual-Pasto, G, Rodriguez-Garcia, A, Uzun, Y, Arsenian-Henriksson, M, Powell, DJ, Bosse, KR, Kossenkov, A, Tan, K, Hogarty, MD, Maris, JM & Dang, CV 2022, 'Epigenetic state determines inflammatory sensing in neuroblastoma', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 6, e2102358119.
Human Tumor Atlas Network 2022, 'MITI minimum information guidelines for highly multiplexed tissue images', Nature methods, vol. 19, no. 3, pp. 262-267.
Chen, C, Yu, W, Alikarami, F, Qiu, Q, Chen, CH, Flournoy, J, Gao, P, Uzun, Y, Fang, L, Davenport, JW, Hu, Y, Zhu, Q, Wang, K, Libbrecht, C, Felmeister, A, Rozich, I, Ding, YY, Hunger, SP, Felix, CA, Wu, H, Brown, PA, Guest, EM, Barrett, DM, Bernt, KM & Tan, K 2022, 'Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia', Blood, vol. 139, no. 14, pp. 2198-2211.


Chen, GM, Chen, C, Das, RK, Gao, P, Chen, CH, Bandyopadhyay, S, Ding, YY, Uzun, Y, Yu, W, Zhu, Q, Myers, RM, Grupp, SA, Barrett, DM & Tan, K 2021, 'Integrative bulk and single-cell profiling of premanufacture t-cell populations reveals factors mediating long-term persistence of car t-cell therapy', Cancer Discovery, vol. 11, no. 9, pp. 2186-2199.
Uzun, Y, Wu, H & Tan, K 2021, 'Predictive modeling of single-cell DNA methylome data enhances integration with transcriptome data', Genome research, vol. 31, no. 1, pp. 101-109.


Zhu, Q, Gao, P, Tober, J, Bennett, L, Chen, C, Uzun, Y, Li, Y, Howell, ED, Mumau, M, Yu, W, He, B, Speck, NA & Tan, K 2020, 'Developmental trajectory of prehematopoietic stem cell formation from endothelium', Blood, vol. 136, no. 7, pp. 845-856.
Yu, W, Uzun, Y, Zhu, Q, Chen, C & Tan, K 2020, 'ScATAC-pro: A comprehensive workbench for single-cell chromatin accessibility sequencing data', Genome biology, vol. 21, no. 1, 94.
Human Tumor Atlas Network 2020, 'The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution', Cell, vol. 181, no. 2, pp. 236-249.
Gao, P, Chen, C, Howell, ED, Li, Y, Tober, J, Uzun, Y, He, B, Gao, L, Zhu, Q, Siekmann, AF, Speck, NA & Tan, K 2020, 'Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells', Genes and Development, vol. 34, no. 13-14.