Che-Yen "Joseph" Wang, PhD - Penn State Cancer Institute
Researcher Profile
Che-Yen "Joseph" Wang, PhD
Assistant Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2023
Hong, X, Bianchini, EN, Wang, JCY & Hu, J 2023, 'Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes', mBio, vol. 14, no. 1. https://doi.org/10.1128/mbio.03501-22
DiNunno, N, Bianchini, EN, Liu, H & Wang, JCY 2023, 'Protein Structure Predictions, Atomic Model Building, and Validation Using a Cryo-EM Density Map from Hepatitis B Virus Spherical Subviral Particle', Bio-protocol, vol. 13, no. 14, e4751. https://doi.org/10.21769/BioProtoc.4751
Kim, C, Schlicksup, CJ, Pérez-Segura, C, Hadden-Perilla, JA, Wang, JCY & Zlotnick, A 2023, 'Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit', Journal of Biological Chemistry, vol. 299, no. 9, 105104. https://doi.org/10.1016/j.jbc.2023.105104
2022
Kim, C, Barnes, LF, Schlicksup, CJ, Patterson, AJ, Bothner, B, Jarrold, MF, Wang, CYJ & Zlotnick, A 2022, 'Core Protein-Directed Antivirals and Importin b Can Synergistically Disrupt Hepatitis B Virus Capsids', Journal of virology, vol. 96, no. 2, A4. https://doi.org/10.1128/JVI.01395-21
Liu, H, Hong, X, Xi, J, Menne, S, Hu, J & Che-Yen Wang, J 2022, 'Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles', Science Advances, vol. 8, no. 31, eabo4184. https://doi.org/10.1126/sciadv.abo4184
Robins, LI, Clark, A, Gafken, PR, Alam, S, Milici, J, Hassan, R, Wang, CY, Williams, J & Meyers, C 2022, 'Hypochlorous acid as a disinfectant for high-risk HPV: Insight into the mechanism of action', Journal of Medical Virology, vol. 94, no. 7, pp. 3386-3393. https://doi.org/10.1002/jmv.27716
Ren, SC, Qazi, SA, Towell, B, Wang, JCY & Mukhopadhyay, S 2022, 'Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes', Journal of virology, vol. 96, no. 5, e02149-21. https://doi.org/10.1128/jvi.02149-21
Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8. https://doi.org/10.1128/jvi.00399-22
2021
Zhao, Z, Wang, JCY, Zhang, M, Lyktey, NA, Jarrold, MF, Jacobson, SC & Zlotnick, A 2021, 'Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry', Nature communications, vol. 12, no. 1, 589. https://doi.org/10.1038/s41467-020-20862-1
Goodall, CP, Schwarz, B, Selivanovitch, E, Avera, J, Wang, J, Miettinen, H & Douglas, T 2021, 'Controlled Modular Multivalent Presentation of the CD40 Ligand on P22 Virus-like Particles Leads to Tunable Amplification of CD40 Signaling', ACS Applied Bio Materials, vol. 4, no. 12, pp. 8205-8214. https://doi.org/10.1021/acsabm.1c00718
Wang, JCY & Chen, L 2021, 'Publisher Correction: Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60 (Scientific Reports, (2021), 11, 1, (14809), 10.1038/s41598-021-94236-y)', Scientific reports, vol. 11, no. 1, 17372. https://doi.org/10.1038/s41598-021-96945-w
Truong, CD, Williams, DR, Zhu, M, Wang, JCY & Chiu, PL 2021, 'Sample Preparation using a Lipid Monolayer Method for Electron Crystallographic Studies', Journal of Visualized Experiments, vol. 2021, no. 177, e63015. https://doi.org/10.3791/63015
Wang, JCY & Chen, L 2021, 'Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60', Scientific reports, vol. 11, no. 1, 14809. https://doi.org/10.1038/s41598-021-94236-y
Fukudome, A, Singh, J, Mishra, V, Reddem, E, Martinez-Marquez, F, Wenzel, S, Yan, R, Shiozaki, M, Yu, Z, Wang, JCY, Takagi, Y & Pikaard, CS 2021, 'Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 51, e2115899118. https://doi.org/10.1073/pnas.2115899118
2020
Zhou, W, Tahir, F, Wang, JCY, Woodson, M, Sherman, MB, Karim, S, Neelakanta, G & Sultana, H 2020, 'Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface', Frontiers in Cell and Developmental Biology, vol. 8, 554. https://doi.org/10.3389/fcell.2020.00554
Schlicksup, CJ, Laughlin, P, Dunkelbarger, S, Wang, JCY & Zlotnick, A 2020, 'Local Stabilization of Subunit-Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids', ACS chemical biology, vol. 15, no. 6, pp. 1708-1717. https://doi.org/10.1021/acschembio.0c00320
Button, JM, Qazi, SA, Wang, JCY & Mukhopadhyay, S 2020, 'Revisiting an old friend: new findings in alphavirus structure and assembly', Current Opinion in Virology, vol. 45, pp. 25-33. https://doi.org/10.1016/j.coviro.2020.06.005
Hadden-Perilla, JA, Zlotnick, A, Zhao, Z, Wang, JCY & Segura, CP 2020, 'The integrity of the intradimer interface of the hepatitis B virus capsid protein dimer regulates capsid self-assembly', ACS chemical biology, vol. 15, no. 12, pp. 3124-3132. https://doi.org/10.1021/acschembio.0c00277
Bond, K, Tsvetkova, IB, Wang, JCY, Jarrold, MF & Dragnea, B 2020, 'Virus Assembly Pathways: Straying Away but Not Too Far', Small, vol. 16, no. 51, 2004475. https://doi.org/10.1002/smll.202004475