Irina Elcheva, PhD - Penn State Cancer Institute
Researcher Profile
Irina Elcheva, PhD
Assistant Professor, Department of Pediatrics
Division of Hematology and Oncology
Assistant Professor, Department of Cell and Biological Systems
Penn State Neuroscience Institute
Division of Hematology and Oncology
Assistant Professor, Department of Cell and Biological Systems
Penn State Neuroscience Institute
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Palsa, K, Sahu, AP, Rye, DB, Trotti, LM, Elcheva, IA, Spiegelman, VS & Connor, JR 2026, 'Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors', Annals of Neurology, vol. 100, no. 1, pp. 48-58. https://doi.org/10.1002/ana.78221
Palsa, K, Helmuth, TB, Sahu, AP, Zhao, Y, Serpa, RO, Neely, EB, Elcheva, IA, Spiegelman, VS & Connor, JR 2026, 'Extracellular vesicles released from blood-brain barrier endothelial cells mediate brain iron accumulation during LPS-induced brain inflammation', Journal of Biological Chemistry, vol. 302, no. 5, 111399. https://doi.org/10.1016/j.jbc.2026.111399
Fajardo, AF, Gowda, CP, Johnson, E, Petroni, R, Tomar, VS, Liu, Z, Andres Blanco, M, Janssen, J, Elcheva, IA, Lanza, M, Fuchs, SY & Spiegelman, VS 2026, 'In vivo CRISPR knockout screen identifies Polr1a as a key driver and a potential therapeutic target for melanoma metastasis', Oncogene, vol. 45, no. 29, pp. 2978-2987. https://doi.org/10.1038/s41388-026-03851-4
2025
Chen, D, Liu, AJ, Sheng, L, Liu, Z & Elcheva, I 2025, 'A Five-Gene Signature for the Prediction of Event-Free Survival of Both Pediatric and Adult Acute Myeloid Leukemia', Diagnostics, vol. 15, no. 11, 1421. https://doi.org/10.3390/diagnostics15111421
Sullivan, R, Ahrens, Q, Mills-Huffnagle, SL, Elcheva, IA & Hicks, SD 2025, 'A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study', PloS one, vol. 20, no. 4 April, e0319418. https://doi.org/10.1371/journal.pone.0319418
2023
Singh, V, Walter, V, Elcheva, I, Imamura Kawasawa, Y & Spiegelman, VS 2023, 'Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells', Frontiers in Cell and Developmental Biology, vol. 11, 1236356. https://doi.org/10.3389/fcell.2023.1236356
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
2022
Liu, Z & Elcheva, I 2022, 'A six-gene prognostic signature for both adult and pediatric acute myeloid leukemia identified with machine learning', American Journal of Translational Research, vol. 14, no. 9, pp. 6210-6221. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556437/>
McLaughlin, C, Datta, P, Singh, YP, Lo, A, Horchler, S, Elcheva, IA, Ozbolat, IT, Ravnic, DJ & Koduru, SV 2022, 'Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications', Cells, no. 21, 3366. https://doi.org/10.3390/cells11213366