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Lindsay Fernandez-Rhodes, Assistant Professor of Biobehavioral Health

Lindsay Fernandez-Rhodes, Assistant Professor of Biobehavioral Health

Associate Professor, Biobehavioral Health
Assistant Professor, Biobehavioral Health
Scientific Program:Cancer Control
LEF5319@psu.edu

Research Interests

Dr. Fernández-Rhodes is a trained epidemiologist with experience in the areas of Genetic, Epigenetic, and Social Epidemiology. Her interdisciplinary research program seeks to 1) elucidate the complex etiology of chronic diseases, and 2) identify drivers of health disparities in the United States, both across the life course and across generations. To this aim, she leads a vibrant lab that conducts bio-psychosocially integrated studies of reproductive and cardiovascular traits in under-studied and marginalized populations, such as United States Hispanic/Latino immigrants and their families. They use a variety of traditional epidemiologic and family-based genetic methods to describe the intergenerational patterning of genetic, epigenetic and societal risk factors and their cumulative impact on health across the life course.

  • Hispanic Americans
  • Population
  • Public Health
  • Single Nucleotide Polymorphism
  • Body Mass Index
  • Genomics
  • Menarche
  • Obesity
  • Genome-Wide Association Study
  • Genes
  • Epidemiology
  • Genetic Loci

Recent Publications

2024

Martinez, RAM, Howard, AG, Fernández-Rhodes, L, Maselko, J, Pence, BW, Dhingra, R, Galea, S, Uddin, M, Wildman, DE & Aiello, AE 2024, 'Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study', Social Science and Medicine, vol. 340, 116440. https://doi.org/10.1016/j.socscimed.2023.116440

2023

Fernández-Rhodes, L, McArdle, CE, Rao, H, Wang, Y, Martinez-Miller, EE, Ward, JB, Cai, J, Sofer, T, Isasi, CR & North, KE 2023, 'A Gene-Acculturation Study of Obesity Among US Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos', Psychosomatic medicine, vol. 85, no. 4, pp. 358-365. https://doi.org/10.1097/PSY.0000000000001193
Anwar, MY, Graff, M, Highland, HM, Smit, R, Wang, Z, Buchanan, VL, Young, KL, Kenny, EE, Fernandez-Rhodes, L, Liu, S, Assimes, T, Garcia, DO, Daeeun, K, Gignoux, CR, Justice, AE, Haiman, CA, Buyske, S, Peters, U, Loos, RJF, Kooperberg, C & North, KE 2023, 'Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts', Human genetics, vol. 142, no. 10, pp. 1477-1489. https://doi.org/10.1007/s00439-023-02593-7
Fernández-Rhodes, L 2023, 'Beyond borders: A commentary on the benefit of promoting immigrant populations in genome-wide association studies', Human Genetics and Genomics Advances, vol. 4, no. 3, 100205. https://doi.org/10.1016/j.xhgg.2023.100205
Filigrana, P, Moon, JY, Gallo, LC, Fernández-Rhodes, L, Perreira, KM, Daviglus, ML, Thyagarajan, B, Garcia-Bedoya, OL, Cai, J, Lipton, RB, Kaplan, RC, Gonzalez, HM & Isasi, CR 2023, 'Childhood and Life-Course Socioeconomic Position and Cognitive Function in the Adult Population of the Hispanic Community Health Study/Study of Latinos', American journal of epidemiology, vol. 192, no. 12, pp. 2006-2017. https://doi.org/10.1093/aje/kwad157
Filigrana, P, Moon, J-Y, Gallo, LC, Fernández-Rhodes, L, Perreira, KM, Daviglus, ML, Thyagarajan, B, Garcia-Bedoya, OL, Cai, J, Lipton, RB, Kaplan, RC, Gonzalez, HM & Isasi, CR 2023, 'Childhood and life-course socioeconomic position and cognitive function in adult population of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)', American journal of epidemiology. https://doi.org/10.1093/aje/kwad157
Fernández-Rhodes, L, Graff, M, Buchanan, VL, Justice, AE, Highland, HM, Guo, X, Zhu, W, Chen, HH, Young, KL, Adhikari, K, Palmer, ND, Below, JE, Bradfield, J, Pereira, AC, Glover, L, Kim, D, Lilly, AG, Shrestha, P, Thomas, AG, Zhang, X, Chen, M, Chiang, CWK, Pulit, S, Horimoto, A, Krieger, JE, Guindo-Martínez, M, Preuss, M, Schumann, C, Smit, RAJ, Torres-Mejía, G, Acuña-Alonzo, V, Bedoya, G, Bortolini, MC, Canizales-Quinteros, S, Gallo, C, González-José, R, Poletti, G, Rothhammer, F, Hakonarson, H, Igo, R, Adler, SG, Iyengar, SK, Nicholas, SB, Gogarten, SM, Isasi, CR, Papnicolaou, G, Stilp, AM, Qi, Q, Kho, M, Smith, JA, Langefeld, CD, Wagenknecht, L, Mckean-Cowdin, R, Gao, XR, Nousome, D, Conti, DV, Feng, Y, Allison, MA, Arzumanyan, Z, Buchanan, TA, Chen, YDI, Genter, PM, Goodarzi, MO, Hai, Y, Hsueh, W, Ipp, E, Kandeel, FR, Lam, K, Li, X, Nadler, JL, Raffel, LJ, Roll, K, Sandow, K, Tan, J, Taylor, KD, Xiang, AH, Yao, J, Audirac-Chalifour, A, Peralta Romero, JDJ, Hartwig, F, Horta, B, Blangero, J, Curran, JE, Duggirala, R, Lehman, DE, Puppala, S, Fejerman, L, John, EM, Aguilar-Salinas, C, Burtt, NP, Florez, JC, García-Ortíz, H, González-Villalpando, C, Mercader, J, Orozco, L, Tusié-Luna, T, Blanco, E, Gahagan, S, Cox, NJ, Hanis, C, Butte, NF, Cole, SA, Comuzzie, AG, Voruganti, VS, Rohde, R, Wang, Y, Sofer, T, Ziv, E, Grant, SFA, Ruiz-Linares, A, Rotter, JI, Haiman, CA, Parra, EJ, Cruz, M, Loos, RJF & North, KE 2023, 'Erratum: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium', Human Genetics and Genomics Advances, vol. 4, no. 1, pp. 100149. https://doi.org/10.1016/j.xhgg.2022.100149
ABCTB Investigators 2023, 'Understanding the genetic complexity of puberty timing across the allele frequency spectrum', medRxiv. https://doi.org/10.1101/2023.06.14.23291322

2022

Fernández-Rhodes, L, Graff, M, Buchanan, VL, Justice, AE, Highland, HM, Guo, X, Zhu, W, Chen, HH, Young, KL, Adhikari, K, Palmer, ND, Below, JE, Bradfield, J, Pereira, AC, Glover, LS, Kim, D, Lilly, AG, Shrestha, P, Thomas, AG, Zhang, X, Chen, M, Chiang, CWK, Pulit, S, Horimoto, A, Krieger, JE, Guindo-Martínez, M, Preuss, M, Schumann, C, Smit, RAJ, Torres-Mejía, G, Acuña-Alonzo, V, Bedoya, G, Bortolini, MC, Canizales-Quinteros, S, Gallo, C, González-José, R, Poletti, G, Rothhammer, F, Hakonarson, H, Igo, R, Adler, SG, Iyengar, SK, Nicholas, SB, Gogarten, SM, Isasi, CR, Papnicolaou, G, Stilp, AM, Qi, Q, Kho, M & Smith, JA 2022, 'Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium', Human Genetics and Genomics Advances, vol. 3, no. 2, 100099. https://doi.org/10.1016/j.xhgg.2022.100099
TOPMed Anthropometry Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium 2022, 'Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data', Nature Genetics, vol. 54, no. 3, pp. 263-273. https://doi.org/10.1038/s41588-021-00997-7
Preudhomme, LK, Gellman, MD, Franceschini, N, Perreira, KM, Fernández-Rhodes, LE, Gallo, LC, Isasi, CR, Smoller, S, Castañeda, SF, Daviglus, M, Hutten, C, Cooper, RS, Cai, J, Schneiderman, N & Llabre, MM 2022, 'Genetic and stress influences on the prevalence of hypertension among hispanics/latinos in the hispanic community health study/study of latinos (HCHS/SOL)', Blood Pressure, vol. 31, no. 1, pp. 155-163. https://doi.org/10.1080/08037051.2022.2091977
LifeLines Cohort Study 2022, 'Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention', Nature Genetics. https://doi.org/10.1038/s41588-022-01165-1

2021

Fernández-Rhodes, L, Butera, NM, Lodge, EK, Franceschini, N, Llabre, MM, Arredondo, EM, Gallo, LC, Arguelles, W, Penedo, FJ, Daviglus, ML, Isasi, CR, Smokowski, P, Gordon-Larsen, P, Aiello, AE, Perreira, KM, Sotres-Alvarez, D & North, KE 2021, 'Demographic and sociocultural risk factors for adulthood weight gain in Hispanic/Latinos: results from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)', BMC Public Health, vol. 21, no. 1, 2064. https://doi.org/10.1186/s12889-021-11848-9
McArdle, CE, Bokhari, H, Rodell, CC, Buchanan, V, Preudhomme, LK, Isasi, CR, Graff, M, North, K, Gallo, LC, Pirzada, A, Daviglus, ML, Wojcik, G, Cai, J, Perreira, K & Fernandez-Rhodes, L 2021, 'Findings from the Hispanic Community Health Study/Study of Latinos on the Importance of Sociocultural Environmental Interactors: Polygenic Risk Score-by-Immigration and Dietary Interactions', Frontiers in Genetics, vol. 12, 720750. https://doi.org/10.3389/fgene.2021.720750
Crenshaw, EG, Fernández-Rhodes, L, Martin, CL, Gordon-Larsen, P, Haan, MN & Aiello, AE 2021, 'Intergenerational Educational Attainment and Cardiometabolic Health in Latino Individuals Living in the United States', Obesity, vol. 29, no. 7, pp. 1178-1185. https://doi.org/10.1002/oby.23156
Fernández-Rhodes, L, Ward, JB, Martin, CL, Zeki Al Hazzouri, A, Torres, J, Gordon-Larsen, P, Haan, MN & Aiello, AE 2022, 'Intergenerational educational mobility and type 2 diabetes in the Sacramento Area Latino Study on Aging', Annals of Epidemiology, vol. 65, pp. 93-100. https://doi.org/10.1016/j.annepidem.2021.07.006
Sarnowski, C, Cousminer, DL, Franceschini, N, Raffield, LM, Jia, G, Fernández-Rhodes, L, Grant, SFA, Hakonarson, H, Lange, LA, Long, J, Sofer, T, Tao, R, Wallace, RB, Wong, Q, Zirpoli, G, Boerwinkle, E, Bradfield, JP, Correa, A, Kooperberg, CL, North, KE, Palmer, JR, Zemel, BS, Zheng, W, Murabito, JM & Lunetta, KL 2021, 'Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche', Human reproduction (Oxford, England), vol. 36, no. 7, pp. 1999-2010. https://doi.org/10.1093/humrep/deab086
Fernández-Rhodes, L & White, MJ 2022, 'Local-Level Immigration Enforcement and Risk of Pediatric Hospitalization for Ambulatory Care Sensitive Conditions', Journal of Immigrant and Minority Health, vol. 24, no. 2, pp. 309-317. https://doi.org/10.1007/s10903-021-01163-1

2020

Stanhope, KK, Cammack, AL, Perreira, KM, Fernández-Rhodes, L, Cordero, C, Gallo, LC, Isasi, CR, Castañeda, SF, Daviglus, ML, Kominiarek, MA & Suglia, SS 2020, 'Adverse childhood experiences and lifetime adverse maternal outcomes (gestational diabetes and hypertensive disorders of pregnancy) in the Hispanic Community Health Study/Study of Latinos', Annals of Epidemiology, vol. 50, pp. 1-6. https://doi.org/10.1016/j.annepidem.2020.08.004
Fernández-Rhodes, L, Young, KL, Lilly, AG, Raffield, LM, Highland, HM, Wojcik, GL, Agler, C, Love, SAM, Okello, S, Petty, LE, Graff, M, Below, JE, Divaris, K & North, KE 2020, 'Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations', Circulation research, vol. 126, no. 12, pp. 1816-1840. https://doi.org/10.1161/CIRCRESAHA.120.315893
Justice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, CT, Cupples, LA, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA, Beilin, LJ, Huang, RC, Gordon-Larsen, P, Howard, AG & North, KE 2020, 'Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems', Epigenomics, vol. 12, no. 17, pp. 1483-1499. https://doi.org/10.2217/epi-2019-0276