Daniel J. Hayes - Penn State Cancer Institute
Researcher Profile
Daniel J. Hayes
Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Stem Cells
- Nanoparticles
- Stromal Cells
- In Vitro Techniques
- Adipose Tissue
- Bone and Bones
- MicroRNAs
- Tissue Engineering
- Osteogenesis
- Hydrogels
- Silver
- Extracellular Matrix
Recent Publications
2024
Alden, NA, Yeingst, TJ, Pfeiffer, HM, Celik, N, Arrizabalaga, JH, Helton, AM, Liu, Y, Stairs, DB, Glick, AB, Goyal, N & Hayes, DJ 2024, 'Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment', Advanced Healthcare Materials, vol. 13, no. 10, 2303593. https://doi.org/10.1002/adhm.202303593
2023
Yeingst, TJ, Arrizabalaga, JH, Rawnaque, FS, Stone, LP, Yeware, A, Helton, AM, Dhawan, A, Simon, JC & Hayes, DJ 2023, 'Controlled Degradation of Polycaprolactone Polymers through Ultrasound Stimulation', ACS Applied Materials and Interfaces, vol. 15, no. 29, pp. 34607-34616. https://doi.org/10.1021/acsami.3c06873
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068. https://doi.org/10.1016/j.bej.2023.109068
Bhanja, D, Wilding, H, Baroz, A, Trifoi, M, Shenoy, G, Slagle-Webb, B, Hayes, D, Soudagar, Y, Connor, J & Mansouri, A 2023, 'Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability', Cancers, vol. 15, no. 13, 3427. https://doi.org/10.3390/cancers15133427
2022
Alden, NA, Arrizabalaga, JH, Liu, Y, Amin, S, Gowda, K, Yao, S, Archetti, M, Glick, AB & Hayes, DJ 2022, 'Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells', Langmuir, vol. 38, no. 32, pp. 9833-9843. https://doi.org/10.1021/acs.langmuir.2c00913
Hayes, DJ & Gimble, JM 2022, 'Developing a clinical grade human adipose decellularized biomaterial', Biomaterials and Biosystems, vol. 7, 100053. https://doi.org/10.1016/j.bbiosy.2022.100053
Berntsen, L, Forghani, A & Hayes, DJ 2022, 'Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface', Tissue Engineering - Part A, vol. 28, no. 7-8, pp. 341-352. https://doi.org/10.1089/ten.tea.2021.0072
Yeingst, TJ, Arrizabalaga, JH & Hayes, DJ 2022, 'Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels', Gels, vol. 8, no. 9, 554. https://doi.org/10.3390/gels8090554
Arrizabalaga, JH, Smallcomb, M, Abu-Laban, M, Liu, Y, Yeingst, TJ, Dhawan, A, Simon, JC & Hayes, DJ 2022, 'Ultrasound-Responsive Hydrogels for On-Demand Protein Release', ACS Applied Bio Materials, vol. 5, no. 7, pp. 3212-3218. https://doi.org/10.1021/acsabm.2c00192
Celik, N, Kim, MH, Yeo, M, Kamal, F, Hayes, DJ & Ozbolat, IT 2022, 'miRNA induced 3D bioprinted-heterotypic osteochondral interface', Biofabrication, vol. 14, no. 4, 044104. https://doi.org/10.1088/1758-5090/ac7fbb
2021
Frazier, T, Williams, C, Henderson, M, Duplessis, T, Rogers, E, Wu, X, Hamel, K, Martin, EC, Mohiuddin, O, Shaik, S, Devireddy, R, Rowan, BG, Hayes, DJ & Gimble, JM 2021, 'Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System', Tissue Engineering - Part A, vol. 27, no. 7-8, pp. 479-488. https://doi.org/10.1089/ten.tea.2020.0372
Arrizabalaga, JH, Casey, JS, Becca, JC, Jensen, L & Hayes, DJ 2021, 'Comparison of thermoresponsive Diels-Alder linkers for the release of payloads from magnetic nanoparticles via hysteretic heating', JCIS Open, vol. 4, 100034. https://doi.org/10.1016/j.jciso.2021.100034
Li, S, Liu, Y, McCann, J, Ravnic, DJ, Gimble, JM & Hayes, DJ 2022, 'Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix', Journal of Biomedical Materials Research - Part A, vol. 110, no. 1, pp. 156-163. https://doi.org/10.1002/jbm.a.37273
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107. https://doi.org/10.1088/1758-5090/ac23ae
Shaik, S, Martin, E, Hayes, D, Gimble, J & Devireddy, R 2021, 'MicroRNA sequencing of CD34+ sorted adipose stem cells undergoing endotheliogenesis', Stem Cells and Development, vol. 30, no. 5, pp. 265-288. https://doi.org/10.1089/scd.2020.0173
2020
Casey, JS, Arrizabalaga, JH, Abu-Laban, M, Becca, JC, Rose, BJ, Strickland, KT, Bursavich, JB, McCann, JS, Pacheco, CN, Jessen, L, Attaluri, A & Hayes, DJ 2020, 'Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating', Journal of Colloid And Interface Science, vol. 571, pp. 348-355. https://doi.org/10.1016/j.jcis.2020.03.056
Mohiuddin, OA, Motherwell, JM, Rogers, E, Bratton, MR, Zhang, Q, Wang, G, Bunnell, B, Hayes, DJ & Gimble, JM 2020, 'Characterization and Proteomic Analysis of Decellularized Adipose Tissue Hydrogels Derived from Lean and Overweight/Obese Human Donors', Advanced Biosystems, vol. 4, no. 10, 2000124. https://doi.org/10.1002/adbi.202000124
Frazier, T, Alarcon, A, Wu, X, Mohiuddin, OA, Motherwell, JM, Carlsson, AH, Christy, RJ, Edwards, JV, Mackin, RT, Prevost, N, Gloster, E, Zhang, Q, Wang, G, Hayes, DJ & Gimble, JM 2020, 'Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels', Biomolecules, vol. 10, no. 10, 1373, pp. 1-21. https://doi.org/10.3390/biom10101373
Mohiuddin, OA, Campbell, B, Poche, JN, Thomas-Porch, C, Hayes, DA, Bunnell, BA & Gimble, JM 2020, Decellularized Adipose Tissue: Biochemical Composition, in vivo Analysis and Potential Clinical Applications. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1212, Springer, pp. 57-70. https://doi.org/10.1007/5584_2019_371
Forghani, A, Koduru, SV, Chen, C, Leberfinger, AN, Ravnic, DJ & Hayes, DJ 2020, 'Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro', Regenerative Engineering and Translational Medicine, vol. 6, no. 1, pp. 101-110. https://doi.org/10.1007/s40883-019-00093-7
Liu, Y, Bailey, JT, Abu-Laban, M, Li, S, Chen, C, Glick, AB & Hayes, DJ 2020, 'Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice', Biomaterials, vol. 256, 120212. https://doi.org/10.1016/j.biomaterials.2020.120212