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Daniel J. Hayes

Daniel J. Hayes

Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies

Research Interests

  • Stem Cells
  • Nanoparticles
  • Stromal Cells
  • In Vitro Techniques
  • Adipose Tissue
  • Bone and Bones
  • MicroRNAs
  • Tissue Engineering
  • Osteogenesis
  • Hydrogels
  • Silver
  • Extracellular Matrix

Recent Publications


Alden, NA, Yeingst, TJ, Pfeiffer, HM, Celik, N, Arrizabalaga, JH, Helton, AM, Liu, Y, Stairs, DB, Glick, AB, Goyal, N & Hayes, DJ 2024, 'Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment', Advanced Healthcare Materials, vol. 13, no. 10, 2303593.


Yeingst, TJ, Arrizabalaga, JH, Rawnaque, FS, Stone, LP, Yeware, A, Helton, AM, Dhawan, A, Simon, JC & Hayes, DJ 2023, 'Controlled Degradation of Polycaprolactone Polymers through Ultrasound Stimulation', ACS Applied Materials and Interfaces, vol. 15, no. 29, pp. 34607-34616.
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068.
Bhanja, D, Wilding, H, Baroz, A, Trifoi, M, Shenoy, G, Slagle-Webb, B, Hayes, D, Soudagar, Y, Connor, J & Mansouri, A 2023, 'Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability', Cancers, vol. 15, no. 13, 3427.


Alden, NA, Arrizabalaga, JH, Liu, Y, Amin, S, Gowda, K, Yao, S, Archetti, M, Glick, AB & Hayes, DJ 2022, 'Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells', Langmuir, vol. 38, no. 32, pp. 9833-9843.
Hayes, DJ & Gimble, JM 2022, 'Developing a clinical grade human adipose decellularized biomaterial', Biomaterials and Biosystems, vol. 7, 100053.
Berntsen, L, Forghani, A & Hayes, DJ 2022, 'Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface', Tissue Engineering - Part A, vol. 28, no. 7-8, pp. 341-352.
Yeingst, TJ, Arrizabalaga, JH & Hayes, DJ 2022, 'Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels', Gels, vol. 8, no. 9, 554.
Arrizabalaga, JH, Smallcomb, M, Abu-Laban, M, Liu, Y, Yeingst, TJ, Dhawan, A, Simon, JC & Hayes, DJ 2022, 'Ultrasound-Responsive Hydrogels for On-Demand Protein Release', ACS Applied Bio Materials, vol. 5, no. 7, pp. 3212-3218.
Celik, N, Kim, MH, Yeo, M, Kamal, F, Hayes, DJ & Ozbolat, IT 2022, 'miRNA induced 3D bioprinted-heterotypic osteochondral interface', Biofabrication, vol. 14, no. 4, 044104.


Frazier, T, Williams, C, Henderson, M, Duplessis, T, Rogers, E, Wu, X, Hamel, K, Martin, EC, Mohiuddin, O, Shaik, S, Devireddy, R, Rowan, BG, Hayes, DJ & Gimble, JM 2021, 'Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System', Tissue Engineering - Part A, vol. 27, no. 7-8, pp. 479-488.
Arrizabalaga, JH, Casey, JS, Becca, JC, Jensen, L & Hayes, DJ 2021, 'Comparison of thermoresponsive Diels-Alder linkers for the release of payloads from magnetic nanoparticles via hysteretic heating', JCIS Open, vol. 4, 100034.
Li, S, Liu, Y, McCann, J, Ravnic, DJ, Gimble, JM & Hayes, DJ 2022, 'Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix', Journal of Biomedical Materials Research - Part A, vol. 110, no. 1, pp. 156-163.
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107.
Shaik, S, Martin, E, Hayes, D, Gimble, J & Devireddy, R 2021, 'MicroRNA sequencing of CD34+ sorted adipose stem cells undergoing endotheliogenesis', Stem Cells and Development, vol. 30, no. 5, pp. 265-288.


Casey, JS, Arrizabalaga, JH, Abu-Laban, M, Becca, JC, Rose, BJ, Strickland, KT, Bursavich, JB, McCann, JS, Pacheco, CN, Jessen, L, Attaluri, A & Hayes, DJ 2020, 'Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating', Journal of Colloid And Interface Science, vol. 571, pp. 348-355.
Mohiuddin, OA, Motherwell, JM, Rogers, E, Bratton, MR, Zhang, Q, Wang, G, Bunnell, B, Hayes, DJ & Gimble, JM 2020, 'Characterization and Proteomic Analysis of Decellularized Adipose Tissue Hydrogels Derived from Lean and Overweight/Obese Human Donors', Advanced Biosystems, vol. 4, no. 10, 2000124.
Frazier, T, Alarcon, A, Wu, X, Mohiuddin, OA, Motherwell, JM, Carlsson, AH, Christy, RJ, Edwards, JV, Mackin, RT, Prevost, N, Gloster, E, Zhang, Q, Wang, G, Hayes, DJ & Gimble, JM 2020, 'Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels', Biomolecules, vol. 10, no. 10, 1373, pp. 1-21.
Mohiuddin, OA, Campbell, B, Poche, JN, Thomas-Porch, C, Hayes, DA, Bunnell, BA & Gimble, JM 2020, Decellularized Adipose Tissue: Biochemical Composition, in vivo Analysis and Potential Clinical Applications. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1212, Springer, pp. 57-70.
Forghani, A, Koduru, SV, Chen, C, Leberfinger, AN, Ravnic, DJ & Hayes, DJ 2020, 'Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro', Regenerative Engineering and Translational Medicine, vol. 6, no. 1, pp. 101-110.
Liu, Y, Bailey, JT, Abu-Laban, M, Li, S, Chen, C, Glick, AB & Hayes, DJ 2020, 'Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice', Biomaterials, vol. 256, 120212.