Yong Wang - Penn State Cancer Institute
Researcher Profile
Yong Wang
Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Yang, Y, Wu, X, Pan, Y, Wang, Y, Lian, X, Dong, C, Liu, W, Wang, S & Lei, Y 2026, 'Collagen hydrogel tube microbioreactors for cell and tissue manufacturing', Biofabrication, vol. 18, no. 1, 015013. https://doi.org/10.1088/1758-5090/ae2718
2025
Wen, C, Wang, Y & Wang, Y 2025, 'Aptamers in drug delivery development', Materials Today, vol. 88, pp. 855-870. https://doi.org/10.1016/j.mattod.2025.06.020
El-Mallah, JC, Wen, C, Waldron, O, Jikaria, NR, Asgardoon, MH, Schlidt, K, Goldenberg, D, Horchler, S, Landmesser, ME, Park, JH, Hasegawa, U, Wang, Y & Ravnic, DJ 2025, 'Current Modalities in Soft-Tissue Reconstruction and Vascularized Adipose Engineering', Biomolecules, vol. 15, no. 6, 780. https://doi.org/10.3390/biom15060780
Wen, C, Wang, Y, Lee, K, Wang, X & Wang, Y 2025, 'DNA-triggered activation of aptamer-neutralized enzyme for in situ formation of injectable hydrogel', Nanoscale Horizons, vol. 10, no. 8, pp. 1703-1716. https://doi.org/10.1039/d5nh00314h
Wen, C, Park, JH, Jikaria, NR, Landmesser, ME, Dawes, J, Wu, CW, Ravnic, D & Wang, Y 2025, 'Enhanced safety and potency in local angiogenic growth factor delivery via aptamer functionalization of hydrogels', Journal of Controlled Release, vol. 387, 114251. https://doi.org/10.1016/j.jconrel.2025.114251
Lee, K, Aviles Vargas, A, Bottino, R & Wang, Y 2025, 'Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 17, no. 3, e70016. https://doi.org/10.1002/wnan.70016
2024
Wen, C, Lee, K, Wang, Y, Wang, X & Wang, Y 2024, 'Bidirectional Enzyme Inhibition and Activation for In Situ Formation of Injectable Hydrogel Using a Bispecific Aptamer', Langmuir, vol. 40, no. 50, pp. 26751-26759. https://doi.org/10.1021/acs.langmuir.4c03925
Wang, X, Jia, B, Lee, K, Davis, B, Wen, C, Wang, Y, Zheng, H & Wang, Y 2024, 'Biomimetic Bacterial Capsule for Enhanced Aptamer Display and Cell Recognition', Journal of the American Chemical Society, vol. 146, no. 1, pp. 868-877. https://doi.org/10.1021/jacs.3c11208
Shaik, R, Brown, J, Xu, J, Lamichhane, R, Wang, Y, Hong, Y & Zhang, G 2024, 'Cardiac Matrix-Derived Granular Hydrogel Enhances Cell Function in 3D Culture', ACS Applied Materials and Interfaces, vol. 16, no. 43, pp. 58346-58356. https://doi.org/10.1021/acsami.4c12871
Waldron, OP, El-Mallah, JC, Lochan, D, Wen, C, Landmesser, ME, Asgardoon, M, Dawes, J, Horchler, SN, Schlidt, K, Agrawal, S, Wang, Y & Ravnic, DJ 2024, 'Ushering in the era of regenerative surgery', Minerva Surgery, vol. 79, no. 2, pp. 166-182. https://doi.org/10.23736/S2724-5691.23.10113-4
2023
Davis, B, Lee, K, Wang, X & Wang, Y 2023, 'Deoxyribonucleic Acid-Based Polyvalent Ligand-Receptor Binding for Engineering the Cell Surface with Nanoparticles', Biomacromolecules, vol. 24, no. 7, pp. 3193-3202. https://doi.org/10.1021/acs.biomac.3c00264
Wang, X, Wang, Y, Lee, K, Davis, B, Wen, C, Jia, B, Zheng, H, Dong, C & Wang, Y 2024, 'Display of Polyvalent Hybrid Antibodies on the Cell Surface for Enhanced Cell Recognition', Small Methods, vol. 8, no. 9, 2301331. https://doi.org/10.1002/smtd.202301331
Abune, L, Wen, C, Lee, K, Wang, X, Ravnic, D & Wang, Y 2024, 'Elastic Macroporous Matrix-Supported In Situ Formation of Injectable Extracellular Matrix-Like Hydrogel for Carrying Growth Factors and Living Cells', Macromolecular Bioscience, vol. 24, no. 3, 2300475. https://doi.org/10.1002/mabi.202300475
Wang, O, Han, L, Lin, H, Tian, M, Zhang, S, Duan, B, Chung, S, Zhang, C, Lian, X, Wang, Y & Lei, Y 2023, 'Fabricating 3-dimensional human brown adipose microtissues for transplantation studies', Bioactive Materials, vol. 22, pp. 518-534. https://doi.org/10.1016/j.bioactmat.2022.10.022
Singh, NK, Wang, Y, Wen, C, Davis, B, Wang, X, Lee, K & Wang, Y 2024, 'High-affinity one-step aptamer selection using a non-fouling porous hydrogel', Nature Biotechnology, vol. 42, no. 8, pp. 1224-1231. https://doi.org/10.1038/s41587-023-01973-8
Han, L, Wu, X, Wang, O, Luan, X, Velander, WH, Aynardi, M, Halstead, ES, Bonavia, AS, Jin, R, Li, G, Li, Y, Wang, Y, Dong, C & Lei, Y 2023, 'Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution', Theranostics, vol. 13, no. 9, pp. 2843-2862. https://doi.org/10.7150/thno.83942
Yang, J, Kamai, H, Wang, Y & Xu, Y 2023, 'Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations', Small, vol. 19, no. 43, 2301013. https://doi.org/10.1002/smll.202301013
Lee, K, Davis, B, Wang, X, Mirg, S, Wen, C, Abune, L, Peterson, BE, Han, L, Chen, H, Wang, H, Szczesny, SE, Lei, Y, Kothapalli, SR & Wang, Y 2023, 'Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation', Angewandte Chemie - International Edition, vol. 62, no. 31, e202306583. https://doi.org/10.1002/anie.202306583
2022
Davis, B, Shi, P, Gaddes, E, Lai, J & Wang, Y 2022, 'Bidirectional Supramolecular Display and Signal Amplification on the Surface of Living Cells', Biomacromolecules, vol. 23, no. 3, pp. 1403-1412. https://doi.org/10.1021/acs.biomac.1c01627
Davila, ML, Xu, M, Huang, C, Gaddes, ER, Winter, L, Cantorna, MT, Wang, Y & Xiong, N 2022, 'CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues', iScience, vol. 25, no. 6, 104426. https://doi.org/10.1016/j.isci.2022.104426
Abune, L, Lee, K & Wang, Y 2022, 'Development of a Biomimetic Extracellular Matrix with Functions of Protein Sequestration and Cell Attachment Using Dual Aptamer-Functionalized Hydrogels', ACS Biomaterials Science and Engineering, vol. 8, no. 3, pp. 1279-1289. https://doi.org/10.1021/acsbiomaterials.1c01544
Shaik, R, Xu, J, Wang, Y, Hong, Y & Zhang, G 2023, 'Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis', ACS Biomaterials Science and Engineering, vol. 9, no. 2, pp. 877-888. https://doi.org/10.1021/acsbiomaterials.2c01148
Watson, C, Abune, L, Saaid, H, Wen, C, Wang, Y & Manning, KB 2023, 'Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices', Cardiovascular Engineering and Technology, vol. 14, no. 2, pp. 239-251. https://doi.org/10.1007/s13239-022-00650-2
Wang, X, Wen, C, Davis, B, Shi, P, Abune, L, Lee, K, Dong, C & Wang, Y 2022, 'Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability', ACS Applied Materials and Interfaces, vol. 14, no. 3, pp. 3900-3909. https://doi.org/10.1021/acsami.1c22774
Xu, R, Abune, L, Davis, B, Ouyang, L, Zhang, G, Wang, Y & Zhe, J 2022, 'Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting', Biosensors and Bioelectronics, vol. 203, 114023. https://doi.org/10.1016/j.bios.2022.114023
Patel, S, Ershad, F, Zhao, M, Isseroff, RR, Duan, B, Zhou, Y, Wang, Y & Yu, C 2022, 'Wearable electronics for skin wound monitoring and healing', Soft Science, vol. 2, no. 2, 9. https://doi.org/10.20517/ss.2022.13