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Breast Cancer Research

Clinical Trial Disease Team

Research Breast Cancer Overview

Research into breast cancer at Penn State Cancer Institute is conducted by a dedicated breast cancer team. See current clinical trials and members of that team here.

Clinical Trials

CUFF Study: Characterization of Upper Limb Function following Mastectomy and Reconstruction for Breast Cancer
The COVID-19 and Cancer Consortium (CCC19) Registry
Pilot study to evaluate if contrast-enhanced ultrasound (CEUS) can predict treatment response in triple negative breast cancer (TNBC) patients receiving combined chemotherapy and Immune Checkpoint Inhibitors (ICI).
Prospective evaluation of potential effects of repeated gadoliniumbased contrast agent (GBCA) administrations of the same GBCA on motor and cognitive functions in neurologically normal adults in comparison to a non-GBCA exposed control group ODYSSEY
Trial Assessing Light-Intensity Exercise on the Health of Older Breast Cancer Survivors (TALIE-HO Breast Cancer Survivors)
NRG-BR007: A Phase III Clinical Trial Evaluating Deescalation of Breast Radiation for Conservative Treatment of Stage I, Hormone sensitive, HER2- Negative Oncotype recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
A Phase 3 Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Who Have Residual Invasive Disease in the Breast and/or Axillary Lymph Nodes at Surgical Resection Following Neoadjuvant Systemic Therapy(TROPION-Breast03)
CCTG MA.39:Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive and T3N0 Breast Cancer
A Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients with Hormone Receptor-Positive (HR+)/Human Epidermal Growth Factor Receptor 2-Negative (HER2-) (HER2 IHC0 or HER2-low [IHC 1+, IHC 2+/ISH-]) Inoperable, Locally Advanced, or Metastatic Breast Cancer and Have Received Endocrine Therapy
Attitudes towards cannabis use in the PSCI cancer population
An Open Label, Phase II Trial of Pre-operative Neratinib and Endocrine Therapy with Trastuzumab in Triple Positive Breast Cancers
NRG-BR009: A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score (OFSET)
NRG-BR008: A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO)

Research Breast Cancer Overview

Research into breast cancer at Penn State Cancer Institute is conducted by a dedicated breast cancer team. See current clinical trials and members of that team here.
CUFF Study: Characterization of Upper Limb Function following Mastectomy and Reconstruction for Breast Cancer
The COVID-19 and Cancer Consortium (CCC19) Registry
Pilot study to evaluate if contrast-enhanced ultrasound (CEUS) can predict treatment response in triple negative breast cancer (TNBC) patients receiving combined chemotherapy and Immune Checkpoint Inhibitors (ICI).
Prospective evaluation of potential effects of repeated gadoliniumbased contrast agent (GBCA) administrations of the same GBCA on motor and cognitive functions in neurologically normal adults in comparison to a non-GBCA exposed control group ODYSSEY
Trial Assessing Light-Intensity Exercise on the Health of Older Breast Cancer Survivors (TALIE-HO Breast Cancer Survivors)
NRG-BR007: A Phase III Clinical Trial Evaluating Deescalation of Breast Radiation for Conservative Treatment of Stage I, Hormone sensitive, HER2- Negative Oncotype recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
A Phase 3 Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Who Have Residual Invasive Disease in the Breast and/or Axillary Lymph Nodes at Surgical Resection Following Neoadjuvant Systemic Therapy(TROPION-Breast03)
CCTG MA.39:Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive and T3N0 Breast Cancer
A Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients with Hormone Receptor-Positive (HR+)/Human Epidermal Growth Factor Receptor 2-Negative (HER2-) (HER2 IHC0 or HER2-low [IHC 1+, IHC 2+/ISH-]) Inoperable, Locally Advanced, or Metastatic Breast Cancer and Have Received Endocrine Therapy
Attitudes towards cannabis use in the PSCI cancer population
An Open Label, Phase II Trial of Pre-operative Neratinib and Endocrine Therapy with Trastuzumab in Triple Positive Breast Cancers
NRG-BR009: A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score (OFSET)
NRG-BR008: A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO)