Jordan Bisanz - Penn State Cancer Institute
Researcher Profile
Jordan Bisanz
Assistant Professor, Biochemistry & Molecular Biology
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Microbiota
- Gastrointestinal Microbiome
- Probiotics
- Genes
- Bacteria
- Diet
- Yogurt
- Health
- Lactobacillus
- Pregnant Women
- Enzymes
- Bacteriophages
Recent Publications
2024
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
McCurry, MD, D'Agostino, GD, Walsh, JT, Bisanz, JE, Zalosnik, I, Dong, X, Morris, DJ, Korzenik, JR, Edlow, AG, Balskus, EP, Turnbaugh, PJ, Huh, JR & Devlin, AS 2024, 'Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas', Cell, vol. 187, no. 12, pp. 2952-2968.e13. https://doi.org/10.1016/j.cell.2024.05.005
Kyaw, TS, Zhang, C, Sandy, M, Trepka, K, Zhang, S, Ramirez Hernandez, LA, Ramirez, L, Goh, JJN, Yu, K, Dimassa, V, Bess, EN, Brockert, JG, Dumlao, DS, Bisanz, JE & Turnbaugh, PJ 2024, 'Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors', iScience, vol. 27, no. 6, 110122. https://doi.org/10.1016/j.isci.2024.110122
2023
Anderson, BD & Bisanz, JE 2023, 'Challenges and opportunities of strain diversity in gut microbiome research', Frontiers in Microbiology, vol. 14, 1117122. https://doi.org/10.3389/fmicb.2023.1117122
Kim, MS & Bisanz, JE 2023, 'Meta-organismal metabolism in cardiovascular disease', Cell Host and Microbe, vol. 31, no. 1, pp. 1-2. https://doi.org/10.1016/j.chom.2022.12.007
Upadhyay, V, Suryawanshi, RK, Tasoff, P, McCavitt-Malvido, M, Kumar, RG, Murray, VW, Noecker, C, Bisanz, JE, Hswen, Y, Ha, CWY, Sreekumar, B, Chen, IP, Lynch, SV, Ott, M, Lee, S & Turnbaugh, PJ 2023, 'Mild SARS-CoV-2 infection results in long-lasting microbiota instability', mBio, vol. 14, no. 4, pp. e0088923. https://doi.org/10.1128/mbio.00889-23
Carmody, RN & Bisanz, JE 2023, 'Roles of the gut microbiome in weight management', Nature Reviews Microbiology, vol. 21, no. 8, pp. 535-550. https://doi.org/10.1038/s41579-023-00888-0
Noecker, C, Sanchez, J, Bisanz, JE, Escalante, V, Alexander, M, Trepka, K, Heinken, A, Liu, Y, Dodd, D, Thiele, I, DeFelice, BC & Turnbaugh, PJ 2023, 'Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta', PLoS biology, vol. 21, no. 5, e3002125. https://doi.org/10.1371/journal.pbio.3002125
2022
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Sbierski-Kind, J, Grenkowitz, S, Schlickeiser, S, Sandforth, A, Friedrich, M, Kunkel, D, Glauben, R, Brachs, S, Mai, K, Thürmer, A, Radonić, A, Drechsel, O, Turnbaugh, PJ, Bisanz, JE, Volk, HD, Spranger, J & von Schwartzenberg, RJ 2022, 'Effects of caloric restriction on the gut microbiome are linked with immune senescence', Microbiome, vol. 10, no. 1, 57. https://doi.org/10.1186/s40168-022-01249-4
Paik, D, Yao, L, Zhang, Y, Bae, S, D’Agostino, GD, Zhang, M, Kim, E, Franzosa, EA, Avila-Pacheco, J, Bisanz, JE, Rakowski, CK, Vlamakis, H, Xavier, RJ, Turnbaugh, PJ, Longman, RS, Krout, MR, Clish, CB, Rastinejad, F, Huttenhower, C, Huh, JR & Devlin, AS 2022, 'Human gut bacteria produce ΤΗ17-modulating bile acid metabolites', Nature, vol. 603, no. 7903, pp. 907-912. https://doi.org/10.1038/s41586-022-04480-z
Tian, S & Bisanz, JE 2022, 'Making gut microbiomes from scratch', Cell Host and Microbe, vol. 30, no. 11, pp. 1508-1509. https://doi.org/10.1016/j.chom.2022.10.005
2021
von Schwartzenberg, RJ, Bisanz, JE, Lyalina, S, Spanogiannopoulos, P, Ang, QY, Cai, J, Dickmann, S, Friedrich, M, Liu, SY, Collins, SL, Ingebrigtsen, D, Miller, S, Turnbaugh, JA, Patterson, AD, Pollard, KS, Mai, K, Spranger, J & Turnbaugh, PJ 2021, 'Caloric restriction disrupts the microbiota and colonization resistance', Nature, vol. 595, no. 7866, pp. 272-277. https://doi.org/10.1038/s41586-021-03663-4
Lam, KN, Spanogiannopoulos, P, Soto-Perez, P, Alexander, M, Nalley, MJ, Bisanz, JE, Nayak, RR, Weakley, AM, Yu, FB & Turnbaugh, PJ 2021, 'Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome', Cell Reports, vol. 37, no. 5, 109930. https://doi.org/10.1016/j.celrep.2021.109930
Genomic Standards Consortium & Massive Analysis and Quality Control Society 2021, 'Reporting guidelines for human microbiome research: the STORMS checklist', Nature Medicine, vol. 27, no. 11, pp. 1885-1892. https://doi.org/10.1038/s41591-021-01552-x
Ang, QY, Alba, DL, Upadhyay, V, Bisanz, JE, Cai, J, Lee, HL, Barajas, E, Wei, G, Noecker, C, Patterson, AD, Koliwad, SK & Turnbaugh, PJ 2021, 'The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health', eLife, vol. 10, e70349. https://doi.org/10.7554/eLife.70349
2020
Bisanz, JE, Soto-Perez, P, Noecker, C, Aksenov, AA, Lam, KN, Kenney, GE, Bess, EN, Haiser, HJ, Kyaw, TS, Yu, FB, Rekdal, VM, Ha, CWY, Devkota, S, Balskus, EP, Dorrestein, PC, Allen-Vercoe, E & Turnbaugh, PJ 2020, 'A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria', Cell Host and Microbe, vol. 27, no. 6, pp. 1001-1013.e9. https://doi.org/10.1016/j.chom.2020.04.006
Man, K, Bowman, C, Braverman, KN, Escalante, V, Tian, Y, Bisanz, JE, Ganeshan, K, Wang, B, Patterson, A, Bayrer, JR, Turnbaugh, PJ & Chawla, A 2020, 'A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 50, pp. 32029-32037. https://doi.org/10.1073/pnas.2012003117
Rekdal, VM, Bernadino, PN, Luescher, MU, Kiamehr, S, Le, C, Bisanz, JE, Turnbaugh, PJ, Bess, EN & Balskus, EP 2020, 'A widely distributed metalloenzyme class enables gut microbial metabolism of host-and diet-derived catechols', eLife, vol. 9, e50845. https://doi.org/10.7554/eLife.50845
Greenstein, RA, Barrales, RR, Sanchez, NA, Bisanz, JE, Braun, S & Al-Sady, B 2020, 'Erratum: Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability (Genes Dev. (2020) 34 DOI: 10.1101/gad.342006.120)', Genes and Development, vol. 34, no. 15-16, pp. 1106. https://doi.org/10.1101/GAD.342006.120
Bess, EN, Bisanz, JE, Yarza, F, Bustion, A, Rich, BE, Li, X, Kitamura, S, Waligurski, E, Ang, QY, Alba, DL, Spanogiannopoulos, P, Nayfach, S, Koliwad, SK, Wolan, DW, Franke, AA & Turnbaugh, PJ 2020, 'Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria', Nature Microbiology, vol. 5, no. 1, pp. 56-66. https://doi.org/10.1038/s41564-019-0596-1
Pröbstel, AK, Zhou, X, Baumann, R, Wischnewski, S, Kutza, M, Rojas, OL, Sellrie, K, Bischof, A, Kim, K, Ramesh, A, Dandekar, R, Greenfield, AL, Schubert, RD, Bisanz, JE, Vistnes, S, Khaleghi, K, Landefeld, J, Kirkish, G, Liesche-Starnecker, F, Ramaglia, V, Singh, S, Tran, EB, Barba, P, Zorn, K, Oechtering, J, Forsberg, K, Shiow, LR, Henry, RG, Graves, J, Cree, BAC, Hauser, SL, Kuhle, J, Gelfand, JM, Andersen, PM, Schlegel, J, Turnbaugh, PJ, Seeberger, PH, Gommerman, JL, Wilson, MR, Schirmer, L & Baranzini, SE 2020, 'Gut microbiota–specific iga+ B cells traffic to the CNS in active multiple sclerosis', Science Immunology, vol. 5, no. 53, abc7191. https://doi.org/10.1126/SCIIMMUNOL.ABC7191
Greenstein, RA, Barrales, RR, Sanchez, NA, Bisanz, JE, Braun, S & Al-Sady, B 2020, 'Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability', Genes & development, vol. 34, no. 1-2, pp. 99-117. https://doi.org/10.1101/gad.328468.119