Scott H. Medina - Penn State Cancer Institute
Researcher Profile
Scott H. Medina
Associate Professor, Biomedical Engineering
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Glossop, HD, Gebretsadik, G, Sultana, S, Biswas, D, Schacht, NA, Yennawar, NH, Rather, MA, Baughn, AD & Medina, SH 2026, 'Retro-inversion imparts antimycobacterial specificity to host defense peptides', Nature communications, vol. 17, no. 1, 469. https://doi.org/10.1038/s41467-025-67162-0
Kim, I, Griffith, K, Brockway, DF, Crowley, NA & Medina, SH 2026, 'Ultrasound actuated neuropeptide delivery across cerebrovascular interfaces using phase-change peptide nanoemulsions', Journal of Colloid And Interface Science, vol. 705, 139466. https://doi.org/10.1016/j.jcis.2025.139466
2025
Cordeiro Gomes, FD, Ferreira Alves, MC, Alves Júnior, S & Medina, SH 2025, 'Bactericidal Metal-Organic Gallium Frameworks - Synthesis to Application', Molecular Pharmaceutics, vol. 22, no. 2, pp. 638-646. https://doi.org/10.1021/acs.molpharmaceut.4c01253
Biswas, D, Benson, S, Matunis, A, Gebretsadik, G, Wertz, A, StPierre, BJ, Schacht, N, Yan, Y, Gebremichael, HY, Wong, PK, Baughn, AD & Medina, SH 2025, 'Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides', Biomacromolecules, vol. 26, no. 5, pp. 3167-3179. https://doi.org/10.1021/acs.biomac.5c00244
Singh, H, Biswas, D, Park, JH, Landmesser, ME, Ravnic, DJ & Medina, SH 2025, 'Non-invasive ultrasonic debridement of implant biofilms via hydrogen-sulfide releasing peptide nanoemulsions', Biomaterials, vol. 321, 123337. https://doi.org/10.1016/j.biomaterials.2025.123337
Kim, I & Medina, SH 2025, 'Ultrasonic disruption of circulating amyloid β aggregates via phase-change peptide nanoemulsions', Biomaterials, vol. 318, 123146. https://doi.org/10.1016/j.biomaterials.2025.123146
2024
Singh, H, Lawanprasert, A, Utkarsh, N, Pimcharoen, S, Dewan, A, Rahoi, D, Kirimanjeswara, GS & Medina, SH 2024, 'Decoupling Fluorous Protein Coatings Yield Heat-Stable and Intrinsically Sterile Bioformulations', ACS Applied Materials and Interfaces, vol. 16, no. 30, pp. 38893-38904. https://doi.org/10.1021/acsami.4c03724
Lawanprasert, A, Singh, H, Pimcharoen, S, Vargas, MG, Dewan, A, Kirimanjeswara, GS & Medina, SH 2024, 'Heat stable and intrinsically sterile liquid protein formulations', Nature communications, vol. 15, no. 1, 10897. https://doi.org/10.1038/s41467-024-55304-9
Miller, MA & Medina, S 2024, 'Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 3, e1966. https://doi.org/10.1002/wnan.1966
Miller, MA & Medina, S 2024, 'Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids', Advanced Functional Materials, vol. 34, no. 38, 2402514. https://doi.org/10.1002/adfm.202402514
Kim, I, Elliott, JC, Lawanprasert, A, Koehle, AM, Wood, GM, Castro, R, Simon, JC & Medina, SH 2025, 'Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques', Advanced Functional Materials, vol. 35, no. 8, 2415609. https://doi.org/10.1002/adfm.202415609
2023
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159. https://doi.org/10.1002/cbic.202300159
Kim, I, Elliott, JC, Lawanprasert, A, Wood, GM, Simon, JC & Medina, SH 2023, 'Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions', Small, vol. 19, no. 46, 2301673. https://doi.org/10.1002/smll.202301673
Guadagno, AH & Medina, SH 2023, 'The manifold role of octapeptide repeats in prion protein assembly', Peptide Science, vol. 115, no. 2, e24303. https://doi.org/10.1002/pep2.24303
2022
Hale, MM & Medina, SH 2022, 'Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4453-4465. https://doi.org/10.1021/acs.molpharmaceut.2c00626
Lawanprasert, A, Pimcharoen, S, Sumner, SE, Watson, CT, Manning, KB, Kirimanjeswara, GS & Medina, SH 2022, 'Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation', Small, vol. 18, no. 46, 2203751. https://doi.org/10.1002/smll.202203751
Crowley, NA & Medina, SH 2023, 'Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions', Neuropsychopharmacology, vol. 48, no. 1, pp. 253-254. https://doi.org/10.1038/s41386-022-01380-8
Medina, SH 2022, 'Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4392. https://doi.org/10.1021/acs.molpharmaceut.2c00894