Mitchell Machtay, MD - Penn State Cancer Institute
Researcher Profile
Mitchell Machtay, MD
Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor and Endowed Chair in Cancer Clinical Research, Department of Radiation Oncology
Professor, Department of Medicine
Professor and Endowed Chair in Cancer Clinical Research, Department of Radiation Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Cancer Institute, Head and Neck Cancer Team
Cancer Institute, Thoracic Cancer Team
Cancer Institute, Head and Neck Cancer Team
Cancer Institute, Thoracic Cancer Team
Clinical Trials
NRG-BN013: Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
NRG-CC013: A Randomized, Masked, Placebo Controlled, Phase II Trial Of Concurrent Chemoradiation With Bmx-001 In Patients With Head And Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation
Consolidative Use Of Radiotherapy To Block (Curb2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer - A Randomized Phase 3 Trial (BR.38)
NRG-HN014:
Randomized Phase III Trial Of Neoadjuvant Immunotherapy With Response-Adapted Treatment Versus Standard-Of-Care Treatment For Resectable Stage Iii/Iv Cutaneous Squamous Cell Carcinoma
NRG-CC014: Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (PREEMPT)
Long-term Follow-up of AAV2-hAQP1 Gene Therapy in Participants with Radiation-Induced Late Xerostomia
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
NRG-LU008: Phase III Prospective Randomized Trial Of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed By Concurrent Mediastinal Chemoradiation For Locally Advanced Non-Small Cell Lung Cancer
TRANSPARENT: Single-Arm Study of Toripalimab in Combination with Cisplatin and Gemcitabine in Recurrent Metastatic Nasopharyngeal Carcinoma Systemic Treatment Naïve Participants
Recent Publications
2026
Miccio, JA, Potter, NJ & Machtay, M 2026, 'BID-ding wars: will dose-escalated twice daily radiotherapy for limited stage small cell lung cancer be the new standard of care? —critical analysis of the literature', Journal of Thoracic Disease, vol. 18, no. 1, 46. https://doi.org/10.21037/jtd-2025-aw-2218
Xiao, Y, Benedict, S, Cui, Y, Glide-Hurst, C, Graves, S, Jia, X, Kry, SF, Li, H, Lin, L, Matuszak, M, Newpower, M, Paganetti, H, Qi, XS, Roncali, E, Rong, Y, Sgouros, G, Simone, CB, Sunderland, JJ, Taylor, PA, Tchelebi, L, Weldon, M, Zou, JW, Wuthrick, EJ, Machtay, M, Le, QT & Buchsbaum, JC 2026, 'Erratum to Xiao Y, Benedict S, Cui Y, Glide-Hurst C, Graves S, Jia X, KryF S, Li H, Lin L, Matuszak M, Newpower M, Paganetti H, Qi XS, Roncali E, Rong Y, Sgouros G, Simone 2nd CB, Sunderland JJ, Taylor PA, Tchelebi L, Weldon M, Zou JW, Wuthrick EJ, Machtay M, Le QT, Buchsbaum JC. Embracing the future of clinical trials in radiation therapy: an NRG oncology CIRO technology retreat whitepaper on pioneering technologies and AI-driven solutions. Int J of Radiat Oncol Biol Phys 2025:122;443-457 (International Journal of Radiation Oncology, Biology, Physics (2025) 122(2) (443–457), (S0360301625000574), (10.1016/j.ijrobp.2025.01.006))', International Journal of Radiation Oncology Biology Physics, vol. 124, no. 2, pp. 560. https://doi.org/10.1016/j.ijrobp.2025.10.024
2025
Mansouri, A, Ozair, A, Bhanja, D, Wilding, H, Mashiach, E, Haque, W, Mikolajewicz, N, de Macedo Filho, L, Mahase, SS, Machtay, M, Metellus, P, Dhermain, F, Sheehan, J, Kondziolka, D, Lunsford, LD, Niranjan, A, Minniti, G, Li, J, Kalkanis, SN, Wen, PY, Kotecha, R, McDermott, MW, Bettegowda, C, Woodworth, GF, Brown, PD, Sahgal, A & Ahluwalia, MS 2025, 'Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care (Nature Reviews Clinical Oncology, (2025), 22, 5, (327-347), 10.1038/s41571-025-01013-1)', Nature Reviews Clinical Oncology, vol. 22, no. 12, pp. 996. https://doi.org/10.1038/s41571-025-01083-1
El-Bayoumy, K, Christensen, N, Broach, J, Meyers, C, Stairs, D, Machtay, M, Hu, J, Bitzer, ZT, Schell, TD, Chen, K-M, Sun, Y-W, Desai, D, Walter, V & Zhu, J 2025, 'Current challenges and potential opportunities for interception and prevention of head and neck cancer', Carcinogenesis, vol. 46, no. 2, bgaf025. https://doi.org/10.1093/carcin/bgaf025
Xiao, Y, Benedict, S, Cui, Y, Glide-Hurst, C, Graves, S, Jia, X, Kry, SF, Li, H, Lin, L, Matuszak, M, Newpower, M, Paganetti, H, Qi, XS, Roncali, E, Rong, Y, Sgouros, G, Simone, CB, Sunderland, JJ, Taylor, PA, Tchelebi, L, Weldon, M, Zou, JW, Wuthrick, EJ, Machtay, M, Le, QT & Buchsbaum, JC 2025, 'Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions', International Journal of Radiation Oncology Biology Physics, vol. 122, no. 2, pp. 443-457. https://doi.org/10.1016/j.ijrobp.2025.01.006
azquez-Urrutia, JR, Venugopal, N, Zhu, J, Miccio, JA, Machtay, M & Komiya, T 2025, 'Evaluating the role of consolidative chest radiotherapy after chemo-immunotherapy in extensive-stage small cell lung cancer: a retrospective study', Discover Oncology, vol. 16, no. 1, 813. https://doi.org/10.1007/s12672-025-02589-x
Lorenz, FJ, Kharouta, M, Mahase, SS, Goyal, N, Rezaee, R, Lavertu, P, Machtay, M & Yao, M 2025, 'Hospital-Based Registry Analysis of Staging Efficacy and Proposed Staging Subclassification for Stage I HPV-Associated Oropharyngeal Squamous Cell Carcinoma', Oral Oncology, vol. 163, 107251. https://doi.org/10.1016/j.oraloncology.2025.107251
NRG Oncology RTOG 0920 Collaborating Team 2025, 'Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer', Journal of Clinical Oncology, vol. 43, no. 12, pp. 1474-1487. https://doi.org/10.1200/JCO-24-01829
Zumsteg, ZS, Luu, M, Fortpied, C, Jang, JK, Chen, MM, Mallen-St. Clair, J, Walgama, E, Le, QT, Machtay, M, Tribius, S, Forastiere, A, Wong, S, Ozsahin, EM, Gregoire, V, Vermorken, JB, Ho, AS & Yom, SS 2025, 'Re-examining post-operative chemoradiotherapy in head and neck cancer: an updated long-term combined analysis of RTOG 9501/EORTC 22931', Annals of Oncology, vol. 36, no. 11, pp. 1379-1388. https://doi.org/10.1016/j.annonc.2025.07.004
Kong, FM, Hu, C, Bradley, JD & MacHtay, M 2025, 'Reply to: Mid-Treatment Positron Emission Tomography- Adaptive Radiotherapy in Stage III Non-Small Cell Lung Cancer: Another Attempt Toward Personalized Care', Journal of Clinical Oncology, vol. 43, no. 16, pp. 1936-1937. https://doi.org/10.1200/JCO-25-00069
Mansouri, A, Ozair, A, Bhanja, D, Wilding, H, Mashiach, E, Haque, W, Mikolajewicz, N, de Macedo Filho, L, Mahase, SS, Machtay, M, Metellus, P, Dhermain, F, Sheehan, J, Kondziolka, D, Lunsford, LD, Niranjan, A, Minniti, G, Li, J, Kalkanis, SN, Wen, PY, Kotecha, R, McDermott, MW, Bettegowda, C, Woodworth, GF, Brown, PD, Sahgal, A & Ahluwalia, MS 2025, 'Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care', Nature Reviews Clinical Oncology, vol. 22, no. 5, 101402, pp. 327-347. https://doi.org/10.1038/s41571-025-01013-1
2024
Bruno, DS, Mitchell, C, Dowlati, A, Shamp, S, Fu, P, Rindeau, J, Zheng, Y, Machtay, M & Biswas, T 2024, 'A Pilot Trial of Proton-Based Cardiac Sparing Accelerated Fractionated Radiation Therapy in Unresectable Non-small Cell Lung Cancer With Extended Durvalumab Therapy (PARTICLE-D)', Practical Radiation Oncology, vol. 14, no. 6, pp. e470-e479. https://doi.org/10.1016/j.prro.2024.06.007
Jin, JY, Yuan, J, Qin, X, Li, Y, Yan, H, Oleinick, NL, Yao, M, Pan, Q, Kong, FM & Machtay, M 2024, 'Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database', Frontiers in Oncology, vol. 14, 1415213. https://doi.org/10.3389/fonc.2024.1415213
Kozak, MM, Mahase, S, Traughber, B, Machtay, M & Buatti, J 2024, MR-Guided Radiotherapy in the Pediatric and Adolescent Patient. in A Practical Guide to MR-Linac: Technical Innovation and Clinical Implication. Springer International Publishing, pp. 355-373. https://doi.org/10.1007/978-3-031-48165-9_19
Chaung, KV, Kharouta, MZ, Gross, AJ, Fu, P, Machtay, M, Hodges, TR, Sloan, AE, Biswas, T, Dowlati, A & Choi, S 2024, 'Outcomes of initial therapy for synchronous brain metastases from small cell lung cancer: a single-institution retrospective analysis', Translational Lung Cancer Research, vol. 13, no. 5, pp. 1110-1120. https://doi.org/10.21037/tlcr-23-641
Kong, FM, Hu, C, Pryma, DA, Duan, F, Matuszak, M, Xiao, Y, Haken, RT, Siegel, MJ, Hanna, L, Curran, W, Dunphy, M, Gelblum, D, Piert, M, Jolly, S, Robinson, CG, Quon, A, Loo, BW, Srinivas, S, Videtic, GM, Faria, SL, Ferguson, C, Dunlap, NE, Kundapur, V, Paulus, R, Siegel, BA, Bradley, JD & Machtay, M 2024, 'Primary Results of NRG-RTOG1106/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using Midtreatment 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Stage III Non–Small Cell Lung Cancer', Journal of Clinical Oncology, vol. 42, no. 33, pp. 3935-3946. https://doi.org/10.1200/JCO.24.00022
Miccio, JA, Potter, NJ, Showkat, A, Yao, M, Mahase, S, Ferenci, M, Sisley, K, Dailey, A, Knipple, J, Blakely, A, Tuanquin, L & Machtay, M 2024, 'Single institution experience of MRI-guided radiotherapy for thoracic tumors and clinical characteristics impacting treatment duty cycle', Frontiers in Oncology, vol. 14, 1401703. https://doi.org/10.3389/fonc.2024.1401703
2023
Rosenberg, J, Le, QT & Machtay, M 2023, History of the Cooperative Group system (National Clinical Trials Network). in Translational Radiation Oncology. Elsevier, pp. 543-549. https://doi.org/10.1016/B978-0-323-88423-5.00037-6
Rogers, CL, Pugh, SL, Vogelbaum, MA, Perry, A, Ashby, LS, Modi, JM, Alleman, AM, Barani, IJ, Braunstein, S, Bovi, JA, de Groot, JF, Whitton, AC, Lindhorst, SM, Deb, N, Shrieve, DC, Shu, HK, Bloom, B, Machtay, M, Mishra, MV, Robinson, CG, Won, M & Mehta, MP 2023, 'Low-risk meningioma: Initial outcomes from NRG Oncology/RTOG 0539', Neuro-oncology, vol. 25, no. 1, pp. 137-145. https://doi.org/10.1093/neuonc/noac137
Gross, AJ, Sheikh, S, Kharouta, M, Chaung, K, Choi, S, Margevicius, S, Fu, P, Machtay, M, Bruno, DS, Dowlati, A & Biswas, T 2023, 'The Impact of Prophylactic Cranial Irradiation and Consolidative Thoracic Radiation Therapy for Extensive Stage Small-Cell Lung Cancer in the Transition to the Chemo-Immunotherapy Era: A Single Institution Series', Clinical Lung Cancer, vol. 24, no. 8, pp. 696-705. https://doi.org/10.1016/j.cllc.2023.08.009
2022
Deshpande, SR, Grubb, WR, Kharouta, M, Zhang, Y, Zheng, Y, Podder, TK, Towe, C, Young, B, Machtay, M & Biswas, T 2022, 'A Comparative Study of Patients With Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Using CyberKnife and Linear Accelerator–Based Volumetric Modulated Arc Therapy', Practical Radiation Oncology, vol. 12, no. 3, pp. 200-209. https://doi.org/10.1016/j.prro.2021.12.011
Oh, S, Awan, MJ, Monroe, JI, Liang, Y, Wegner, RE, Karlovits, S, Machtay, M, Lo, SS, Sloan, A & Sohn, JW 2022, 'A volume-independent conformity index for stereotactic radiosurgery', Medical Physics, vol. 49, no. 5, pp. 2931-2937. https://doi.org/10.1002/mp.15619
Biswas, T, Dowlati, A, Kunos, CA, Pink, JJ, Oleinick, NL, Malik, S, Fu, P, Cao, S, Bruno, DS, Bajor, DL, Patel, M, Gerson, SL & Machtay, M 2022, 'Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial', Clinical Cancer Research, vol. 28, no. 4, pp. 646-652. https://doi.org/10.1158/1078-0432.CCR-21-2025
Gillison, ML, Ferris, RL, Harris, J, Colevas, AD, Mell, LK, Kong, C, Jordan, RC, Moore, KL, Truong, MT, Kirsch, C, Chakravarti, A, Blakaj, DM, Clump, DA, Ohr, JP, Deeken, JF, Gensheimer, MF, Saba, NF, Dorth, JA, Rosenthal, DI, Leidner, RS, Kimple, RJ, Machtay, M, Curran, WJ, Torres-Saavedra, P & Le, QT 2023, 'Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: RTOG Foundation 3504', International Journal of Radiation Oncology Biology Physics, vol. 115, no. 4, pp. 847-860. https://doi.org/10.1016/j.ijrobp.2022.10.008
Damico, NJ, Deshane, A, Kharouta, M, Wu, A, Wang, GM, Machtay, MX, Kumar, A, Choi, S & Bhatt, AD 2022, 'Telemedicine Use and Satisfaction Among Radiation Oncologists During the COVID-19 Pandemic: Evaluation of Current Trends and Future Opportunities', Advances in Radiation Oncology, vol. 7, no. 2, 100835. https://doi.org/10.1016/j.adro.2021.100835