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Mitchell Machtay, MD

Mitchell Machtay, MD

Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor and Endowed Chair in Cancer Clinical Research, Department of Radiation Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Cancer Institute, Head and Neck Cancer Team
Cancer Institute, Thoracic Cancer Team

Research Interests

  • Radiotherapy
  • Therapeutics
  • Survival
  • Non-Small Cell Lung Carcinoma
  • Neoplasms
  • Head and Neck Neoplasms
  • Radiation
  • Radiation Oncology
  • Radiosurgery
  • Neoplasm Metastasis
  • Drug Therapy
  • Squamous Cell Carcinoma of Head and Neck

Clinical Trials

A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
Radiopaque Hydrogel Rectal Spacer for Prostate Cancer Radiation Image Guidance
NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
ACR 3518: Phase I Safety Assessment of Hypofractionated Postoperative Radiotherapy (H-PORT) for Intermediate-Risk Head and Neck Cancer
KEYSTROKE: A Randomized Phase II Study of Pembrolizumab (KEYTRUDA®) Plus Stereotactic Re-irradiation Versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma
NRG-LU008: Phase III Prospective Randomized Trial Of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed By Concurrent Mediastinal Chemoradiation For Locally Advanced Non-Small Cell Lung Cancer
The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing The Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients With Locally Advanced Rectal Cancer
A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA
NRG HN009- Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
S1914 A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT versus SBRT Alone in High Risk, Early Stage NSCLC
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial

Recent Publications


Chaung, KV, Kharouta, MZ, Gross, AJ, Fu, P, Machtay, M, Hodges, TR, Sloan, AE, Biswas, T, Dowlati, A & Choi, S 2024, 'Outcomes of initial therapy for synchronous brain metastases from small cell lung cancer: a single-institution retrospective analysis', Translational Lung Cancer Research, vol. 13, no. 5, pp. 1110-1120.
Miccio, JA, Potter, NJ, Showkat, A, Yao, M, Mahase, S, Ferenci, M, Sisley, K, Dailey, A, Knipple, J, Blakely, A, Tuanquin, L & Machtay, M 2024, 'Single institution experience of MRI-guided radiotherapy for thoracic tumors and clinical characteristics impacting treatment duty cycle', Frontiers in Oncology, vol. 14, 1401703.


Rosenberg, J, Le, QT & Machtay, M 2023, History of the Cooperative Group system (National Clinical Trials Network). in Translational Radiation Oncology. Elsevier, pp. 543-549.
Rogers, CL, Pugh, SL, Vogelbaum, MA, Perry, A, Ashby, LS, Modi, JM, Alleman, AM, Barani, IJ, Braunstein, S, Bovi, JA, de Groot, JF, Whitton, AC, Lindhorst, SM, Deb, N, Shrieve, DC, Shu, HK, Bloom, B, Machtay, M, Mishra, MV, Robinson, CG, Won, M & Mehta, MP 2023, 'Low-risk meningioma: Initial outcomes from NRG Oncology/RTOG 0539', Neuro-oncology, vol. 25, no. 1, pp. 137-145.
Gross, AJ, Sheikh, S, Kharouta, M, Chaung, K, Choi, S, Margevicius, S, Fu, P, Machtay, M, Bruno, DS, Dowlati, A & Biswas, T 2023, 'The Impact of Prophylactic Cranial Irradiation and Consolidative Thoracic Radiation Therapy for Extensive Stage Small-Cell Lung Cancer in the Transition to the Chemo-Immunotherapy Era: A Single Institution Series', Clinical Lung Cancer, vol. 24, no. 8, pp. 696-705.


Deshpande, SR, Grubb, WR, Kharouta, M, Zhang, Y, Zheng, Y, Podder, TK, Towe, C, Young, B, Machtay, M & Biswas, T 2022, 'A Comparative Study of Patients With Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Using CyberKnife and Linear Accelerator–Based Volumetric Modulated Arc Therapy', Practical Radiation Oncology, vol. 12, no. 3, pp. 200-209.
Oh, S, Awan, MJ, Monroe, JI, Liang, Y, Wegner, RE, Karlovits, S, Machtay, M, Lo, SS, Sloan, A & Sohn, JW 2022, 'A volume-independent conformity index for stereotactic radiosurgery', Medical Physics, vol. 49, no. 5, pp. 2931-2937.
Biswas, T, Dowlati, A, Kunos, CA, Pink, JJ, Oleinick, NL, Malik, S, Fu, P, Cao, S, Bruno, DS, Bajor, DL, Patel, M, Gerson, SL & Machtay, M 2022, 'Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial', Clinical Cancer Research, vol. 28, no. 4, pp. 646-652.
Gillison, ML, Ferris, RL, Harris, J, Colevas, AD, Mell, LK, Kong, C, Jordan, RC, Moore, KL, Truong, MT, Kirsch, C, Chakravarti, A, Blakaj, DM, Clump, DA, Ohr, JP, Deeken, JF, Gensheimer, MF, Saba, NF, Dorth, JA, Rosenthal, DI, Leidner, RS, Kimple, RJ, Machtay, M, Curran, WJ, Torres-Saavedra, P & Le, QT 2023, 'Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: RTOG Foundation 3504', International Journal of Radiation Oncology Biology Physics, vol. 115, no. 4, pp. 847-860.
Damico, NJ, Deshane, A, Kharouta, M, Wu, A, Wang, GM, Machtay, MX, Kumar, A, Choi, S & Bhatt, AD 2022, 'Telemedicine Use and Satisfaction Among Radiation Oncologists During the COVID-19 Pandemic: Evaluation of Current Trends and Future Opportunities', Advances in Radiation Oncology, vol. 7, no. 2, 100835.


Kang, KH, Efird, JT, Podder, TK, Zhang, Y, Dowlati, A, Machtay, M, Jindal, C & Biswas, T 2021, 'A pilot study examining the prognostic utility of tumor shrinkage on cone-beam computed tomography (Cbct) for stage iii locally advanced non-small cell lung cancer patients treated with definitive chemoradiation', International journal of environmental research and public health, vol. 18, no. 6, 3241, pp. 1-8.
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143.
Fredman, E, Traughber, B, Kharouta, M, Podder, T, Lo, S, Ponsky, L, MacLennan, G, Paspulati, R, Ellis, B, Machtay, M & Ellis, R 2021, 'Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning', Frontiers in Oncology, vol. 11, 744130.
Jin, JY, Hu, C, Xiao, Y, Zhang, H, Paulus, R, Ellsworth, SG, Schild, SE, Bogart, JA, Dobelbower, MC, Kavadi, VS, Narayan, S, Iyengar, P, Robinson, C, Greenberger, JS, Koprowski, C, Machtay, M, Curran, W, Choy, H, Bradley, JD & Kong, FM 2021, 'Higher radiation dose to the immune cells correlates with worse tumor control and overall survival in patients with stage iii nsclc: A secondary analysis of rtog0617', Cancers, vol. 13, no. 24, 6193.
Yu, Y, Fu, P, Jin, JY, Gao, S, Wang, W, Machtay, M, Wang, L, Kong, FM & Yu, J 2021, 'Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC', Radiotherapy and Oncology, vol. 162, pp. 26-33.
Patil, N, Somasundaram, E, Waite, KA, Lathia, JD, Machtay, M, Gilbert, MR, Connor, JR, Rubin, JB, Berens, ME, Buerki, RA, Choi, S, Sloan, AE, Penas-Prado, M, Ashby, LS, Blumenthal, DT, Werner-Wasik, M, Hunter, GK, Flickinger, JC, Wendland, MM, Panet-Raymond, V, Robins, HI, Pugh, SL, Mehta, MP & Barnholtz-Sloan, JS 2021, 'Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Journal of neuro-oncology, vol. 155, no. 3, pp. 363-372.
Yuan, J, Fredman, E, Jin, JY, Choi, S, Mansur, D, Sloan, A, Machtay, M & Zheng, Y 2021, 'Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery', Technology in Cancer Research and Treatment, vol. 20.
Biswas, T, Gawdi, R, Jindal, C, Iyer, S, Kang, KH, Bajor, D, Machtay, M, Choi, YM & Efird, JT 2021, 'Pretreatment neutrophil-to-lymphocyte ratio as an important prognostic marker in stage III locally advanced non-small cell lung cancer: Confirmatory results from the PROCLAIM phase III clinical trial', Journal of Thoracic Disease, vol. 13, no. 10, pp. 5617-5626.
Sheikh, S, Kharouta, MZ, Pidikiti, R, Damico, NJ, Choi, S, Dorth, JA, Mansur, DB, Machtay, MX, Yao, M & Bhatt, AD 2022, 'Proton Beam Therapy for Locally Advanced Head and Neck Tumors: An Analysis of Dosimetric and Clinical Outcomes', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 2, pp. 81-87.
Damico, NJ, Wu, AK, Kharouta, MZ, Eitan, T, Pidikiti, R, Jesseph, FB, Smith, M, Langmack, C, Mattson, DL, Dobbins, D, Mansur, DB, Machtay, MX, Dorth, JA, Choi, S, Yao, M & Bhatt, AD 2021, 'Proton beam therapy in the treatment of periorbital malignancies', International Journal of Particle Therapy, vol. 7, no. 4, pp. 42-51.
Tchelebi, LT, Batchelder, E, Wang, M, Lehrer, EJ, Drabick, JJ, Sharma, N, MacHtay, M, Trifiletti, DM & Zaorsky, NG 2021, 'Radiotherapy and Receptor Tyrosine Kinase Inhibition for Solid Cancers (ROCKIT): A Meta-Analysis of 13 Studies', JNCI Cancer Spectrum, vol. 5, no. 4, pkab050.
Awan, MJ, Gittleman, H, Barnholtz-Sloan, J, Machtay, M, Nguyen-Tan, PF, Rosenthal, DI, Schultz, C, Huth, BJ, Thorstad, WL, Frank, SJ, Kim, H, Foote, RL, Lango, MN, Shenouda, G, Suntharalingam, M, Harris, J, Zhang, Q, Le, QT & Yao, M 2021, 'Risk groups of laryngeal cancer treated with chemoradiation according to nomogram scores – A pooled analysis of RTOG 0129 and 0522', Oral Oncology, vol. 116, 105241.
Sheikh, S, Dey, A, Datta, S, Podder, TK, Jindal, C, Dowlati, A, Efird, JT, Machtay, M & Biswas, T 2021, 'Role of radiation in extensive stage small cell lung cancer: A National Cancer Database registry analysis', Future Oncology, vol. 17, no. 21, pp. 2713-2724.
Shamp, SJ, Sheikh, S, Chang, T, Damico, N, Linden, P, Dowlati, A, Machtay, M & Biswas, T 2021, 'Stereotactic body radiotherapy (SBRT) for T2N0 (>3 cm) non-small cell lung cancer: Outcomes and failure patterns', Journal of Radiosurgery and SBRT, vol. 7, no. 4, pp. 271-277.


Jin, JY, Mereniuk, T, Yalamanchali, A, Wang, W, Machtay, M, (Spring)Kong, FM & Ellsworth, S 2020, 'A framework for modeling radiation induced lymphopenia in radiotherapy', Radiotherapy and Oncology, vol. 144, pp. 105-113.
Wang, W, Huang, L, Jin, JY, Pi, W, Ellsworth, SG, Jolly, S, Mellor, AL, Machtay, M & Kong, FM 2020, 'A validation study on IDO immune biomarkers for survival prediction in non–small cell lung cancer: Radiation dose fractionation effect in early-stage disease', Clinical Cancer Research, vol. 26, no. 1, pp. 282-289.
Rogers, LR, Ostrom, QT, Schroer, J, Vengoechea, J, Li, L, Gerson, S, Nock, CJ, Machtay, M, Selman, W, Lo, S, Sloan, AE & Barnholtz-Sloan, JS 2020, 'Association of metabolic syndrome with glioblastoma: A retrospective cohort study and review', Neuro-Oncology Practice, vol. 7, no. 5, pp. 541-548.
Wang, W, Matuszak, MM, Hu, C, Huang, KC, Chen, E, Arenberg, D, Curtis, JL, Jolly, S, Jin, JY, Machtay, M, Ten Haken, RK & Kong, FM 2020, 'Central Airway Toxicity After High Dose Radiation: A Combined Analysis of Prospective Clinical Trials for Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 3, pp. 587-596.
Sohn, JW, Kim, H, Park, SB, Lee, S, Monroe, JI, Malone, TB, Kinsella, T, Yao, M, Kunos, C, Lo, SS, Shenk, R & Machtay, M 2020, 'Clinical Study of Using Biometrics to Identify Patient and Procedure', Frontiers in Oncology, vol. 10, 586232.
Worrell, SG, Towe, CW, A. Dorth, J, Machtay, M, Perry, Y & Linden, PA 2020, 'Higher Doses of Neoadjuvant Radiation for Esophageal Cancer Do Not Affect the Pathologic Complete Response Rate or Survival: A Propensity-Matched Analysis', Annals of Surgical Oncology, vol. 27, no. 2, pp. 500-508.
Eitz, KA, Lo, SS, Soliman, H, Sahgal, A, Theriault, A, Pinkham, MB, Foote, MC, Song, AJ, Shi, W, Redmond, KJ, Gui, C, Kumar, AMS, MacHtay, M, Meyer, B & Combs, SE 2020, 'Multi-institutional Analysis of Prognostic Factors and Outcomes after Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients with Brain Metastases', JAMA Oncology, vol. 6, no. 12, pp. 1901-1909.
Gensheimer, MF, Yom, SS, Soto, N, Dignam, JJ, Le, QT, Machtay, M & Curran, WJ 2020, 'Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 2, pp. 483-485.
Yu, Y, Wang, L, Cao, S, Gao, S, Wang, W, Mulvihill, L, Machtay, M, Fu, P, Yu, J & Kong, FM 2020, 'Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: Model development and validation', Translational Lung Cancer Research, vol. 9, no. 6, pp. 2315-2327.
Jin, JY, Gu, A, Wang, W, Oleinick, NL, Machtay, M & (Spring) Kong, FM 2020, 'Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?', Radiotherapy and Oncology, vol. 149, pp. 55-62.
Biswas, T, Kang, KH, Gawdi, R, Bajor, D, Machtay, M, Jindal, C & Efird, JT 2020, 'Using the systemic immune-inflammation index (SII) as a mid-treatment marker for survival among patients with stage-III locally advanced non-small cell lung cancer (NSCLC)', International journal of environmental research and public health, vol. 17, no. 21, 7995, pp. 1-13.