Vishal Singh - Penn State Cancer Institute
Researcher Profile
Vishal Singh
Assistant Professor, Nutritional Sciences
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Inflammation
- Lipocalin-2
- Microbiota
- Gastrointestinal Microbiome
- Diet
- Colitis
- Atherosclerosis
- Cholesterol
- Liver
- turmeric extract
- Interleukin-1
- Macrophages
Recent Publications
2024
Castro, R, Kalecký, K, Huang, NK, Petersen, K, Singh, V, Ross, AC, Neuberger, T & Bottiglieri, T 2024, 'A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and impacts systemic inflammation and experimental atherosclerosis', Journal of Nutritional Biochemistry, vol. 126, 109562. https://doi.org/10.1016/j.jnutbio.2023.109562
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Andrews, SG, Koehle, AM, Paudel, D, Neuberger, T, Ross, AC, Singh, V, Bottiglieri, T & Castro, R 2024, 'Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice', Nutrients, vol. 16, no. 3, 330. https://doi.org/10.3390/nu16030330
Paudel, D, Nair, DVT, Tian, S, Hao, F, Goand, UK, Joseph, G, Prodes, E, Chai, Z, Robert, CEM, Chassaing, B, Patterson, AD & Singh, V 2024, 'Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation', Gut microbes, vol. 16, no. 1, 2341457. https://doi.org/10.1080/19490976.2024.2341457
Paudel, D, Nair, DVT, Joseph, G, Castro, R, Tiwari, AK & Singh, V 2024, 'Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges', Gastroenterology Report, vol. 12, goae033. https://doi.org/10.1093/gastro/goae033
Bajaj, G, Singh, V, Sagar, P, Gupta, R & Singhal, NK 2024, 'Phosphoenolpyruvate carboxykinase-1 targeted siRNA promotes wound healing in type 2 diabetic mice by restoring glucose homeostasis', International Journal of Biological Macromolecules, vol. 270, 132504. https://doi.org/10.1016/j.ijbiomac.2024.132504
2023
Godbole, MS & Singh, V 2023, 'Deciphering the impacts of gut and tissue microbiome on human cancers', Cancer Reports, vol. 6, no. 11, e1924. https://doi.org/10.1002/cnr2.1924
Tian, S, Paudel, D, Hao, F, Neupane, R, Castro, R, Patterson, AD, Tiwari, AK, Prabhu, KS & Singh, V 2023, 'Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production', Cancer Reports, vol. 6, no. 11, e1863. https://doi.org/10.1002/cnr2.1863
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850. https://doi.org/10.3390/antiox12040850
Sharma, SK, Mohanty, BP, Singh, V, Bansal, MP, Singhal, NK, Sharma, SK & Sandhir, R 2023, 'Trace elements dyshomeostasis in liver and brain of weanling mice under altered dietary selenium conditions', Journal of Trace Elements in Medicine and Biology, vol. 80, 127305. https://doi.org/10.1016/j.jtemb.2023.127305
2022
Bachu, RD, Abou-Dahech, M, Balaji, S, Boddu, SHS, Amos, S, Singh, V, Babu, RJ & Tiwari, AK 2022, 'Oncology biosimilars: New developments and future directions', Cancer Reports, vol. 5, no. 11, e1720. https://doi.org/10.1002/cnr2.1720
Agarwal, H, Sukka, SR, Singh, V, Dikshit, M & Barthwal, MK 2022, 'Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation', Inflammation Research, vol. 71, no. 4, pp. 423-437. https://doi.org/10.1007/s00011-022-01549-3
Aggarwal, H, Pathak, P, Singh, V, Kumar, Y, Shankar, M, Das, B, Jagavelu, K & Dikshit, M 2022, 'Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice', Frontiers in Cellular and Infection Microbiology, vol. 11, 795333. https://doi.org/10.3389/fcimb.2021.795333
2021
Lee, LH, Wong, SH, Chin, SF, Singh, V & Ab Mutalib, NS 2021, 'Editorial: Human Microbiome: Symbiosis to Pathogenesis', Frontiers in Microbiology, vol. 12, 605783. https://doi.org/10.3389/fmicb.2021.605783
Sagar, P, Singh, V, Gupta, R, Kaul, S, Sharma, S, Kaur, S, Bhunia, RK, Kondepudi, KK & Singhal, NK 2021, 'PH-Triggered, Synbiotic Hydrogel Beads for in Vivo Therapy of Iron Deficiency Anemia and Reduced Inflammatory Response', ACS Applied Bio Materials, vol. 4, no. 10, pp. 7467-7484. https://doi.org/10.1021/acsabm.1c00720
2020
Singh, V & Kumar, MV 2020, 'Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health: Health benefits of refined dietary fibers need to be redefined!', Gastroenterology Report, vol. 8, no. 2, pp. 85-89. https://doi.org/10.1093/gastro/goz072
Singh, V, Galla, S, Golonka, RM, Patterson, AD, Chassaing, B, Joe, B & Vijay-Kumar, M 2020, 'Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice', Physiological genomics, vol. 52, no. 8, pp. 314-321. https://doi.org/10.1152/physiolgenomics.00118.2019
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96. https://doi.org/10.3389/fnut.2020.00096
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612. https://doi.org/10.1074/jbc.ac120.013646
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes, vol. 11, no. 4, pp. 1077-1091. https://doi.org/10.1080/19490976.2020.1743492