Patrick Chi-Chung Ma, MD, MSc - Penn State Cancer Institute
Researcher Profile
Patrick Chi-Chung Ma, MD, MSc
Professor, Department of Medicine
Interim Chief, Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Interim Chief, Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Scientific Program:Next-Generation Therapies
Clinical Trials
NRG-CC013: A Randomized, Masked, Placebo Controlled, Phase II Trial Of Concurrent Chemoradiation With Bmx-001 In Patients With Head And Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation
Consolidative Use Of Radiotherapy To Block (Curb2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer - A Randomized Phase 3 Trial (BR.38)
A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab With or Without MK-2870 in Participants With Resectable Stage II to IIIB (N2) NSCLC not Achieving pCR After Receiving Neoadjuvant Pembrolizumab With Platinum-based Doublet Chemotherapy Followed by Surgery
EA5221: A Randomized Phase III Trial of Chemo-Immunotherapy vs Immunotherapy Alone for the Vulnerable older adult with Advanced Non-Small Cell Lung Cancer: The ACHIEVE Study
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without Radiation Therapy for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
NRG-LU008: Phase III Prospective Randomized Trial Of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed By Concurrent Mediastinal Chemoradiation For Locally Advanced Non-Small Cell Lung Cancer
A randomized phase II trial of adjuvant Pembrolizumab versus observation following curative resection for stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm: Big Ten Cancer Research Consortium BTCRC-LUN18-153
Recent Publications
2025
Nassar, AH, Kim, C, Adeyelu, T, Bou Farhat, E, Abushukair, H, Rakaee, M, Matteson, K, Lau, SF, Takabe, Y, Ocejo, A, Ardeshir-Larijani, F, Leal, T, Ramalingam, S, Alam, S, Gray, JE, Hicks, J, Kaldas, D, Baena, J, Berjaga, MZ, Nana, FA, Grohe, C, Leuders, H, Citarella, F, Cortellini, A, Mingo, EC, Pancirer, D, Das, M, Ellis-Caleo, TJ, Cheung, JM, Lin, JJ, Watson, AS, Camidge, DR, Sridhar, A, Parikh, K, Crowley, F, Marron, TU, Aggarwal, V, Ahmed, M, Sankar, K, Kawtharany, H, Zhang, J, Owen, DH, Li, M, Nagasaka, M, Pinato, DJ, Awosika, N, Alhamad, K, Puri, S, Zaman, U, Gupta, DM, Lau, C, Khan, H, Liauw, J, Velazquez, AI, Brown, T, Moliner, L, Mosteiro, M, Rocha, P, Evans, M, Vanderwalde, A, Elliott, A, Nieva, J, Lopes, G, Ma, PC, Borghaei, H, Lee, M, Young, L, Aljumaily, R, Mirza, H, Kwiatkowski, DJ, Herbst, RS, Flavell, RA, Naqash, AR & Chiang, AC 2025, 'Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma', Nature communications, vol. 16, no. 1, 7717. https://doi.org/10.1038/s41467-025-63091-0
Florez, N, Patel, SP, Wakelee, H, Bazhenova, L, Massarelli, E, Salgia, R, Stiles, B, Peters, S, Malhotra, J, Gadgeel, SM, Nieva, JJ, Afkhami, M, Hirsch, FR, Gubens, M, Cascone, T, Levy, B, Sabari, J, Husain, H, Ma, PC, Backhus, LM, Iyengar, P, Lee, P, Miller, R, Sands, J & Kim, E 2025, 'Proceedings of the 1st biannual bridging the gaps in lung cancer conference', Oncologist, vol. 30, no. 2, oyae228. https://doi.org/10.1093/oncolo/oyae228
Sen, U, Coleman, C, Gandhi, N, Jethalia, V, Demircioglu, D, Elliott, A, Vanderwalde, AM, Hayatt, O, de Stanchina, E, Halmos, B, Ma, PC, Berisa, M, Hasson, D & Sen, T 2025, 'SCD1 Inhibition Blocks the AKT–NRF2–SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma', Cancer Research, vol. 85, no. 13, pp. 2485-2503. https://doi.org/10.1158/0008-5472.CAN-24-2745
2024
Pecci, F, Nakazawa, S, Ricciuti, B, Harada, G, Lee, JK, Alessi, JV, Barrichello, A, Vaz, VR, Lamberti, G, Di Federico, A, Gandhi, MM, Gazgalis, D, Feng, WW, Jiang, J, Baldacci, S, Locquet, MA, Gottlieb, FH, Chen, MF, Lee, E, Haradon, D, Smokovich, A, Voligny, E, Nguyen, T, Goel, VK, Zimmerman, Z, Atwal, S, Wang, X, Bahcall, M, Heist, RS, Iqbal, S, Gandhi, N, Elliott, A, Vanderwalde, AM, Ma, PC, Halmos, B, Liu, SV, Che, J, Schrock, AB, Drilon, A, Jänne, PA & Awad, MM 2024, 'Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors', Cancer Discovery, vol. 14, no. 8, pp. 1440-1456. https://doi.org/10.1158/2159-8290.CD-23-1217
Luo, J, Florez, N, Donnelly, A, Lou, Y, Lu, K, Ma, PC, Spira, AI, Ryan, D & Husain, H 2024, 'Adagrasib Treatment After Sotorasib-Related Hepatotoxicity in Patients With KRASG12C-Mutated Non–Small Cell Lung Cancer: A Case Series and Literature Review', JCO Precision Oncology, vol. 8, e2300644. https://doi.org/10.1200/PO.23.00644
Bodor, JN, Xiu, J, Ernani, V, Kaur, S, Mamdani, H, Ou, SHI, Ma, PC, Borghaei, H, Clapper, ML, VanderWalde, A & Treat, J 2024, 'Brief Report: The Immune Profiles of the Molecular Subtypes of EGFR-Mutant Lung Adenocarcinomas in a Large Real-World Cohort', Clinical Lung Cancer, vol. 25, no. 7, pp. e312-e315.e1. https://doi.org/10.1016/j.cllc.2024.04.016
Morgenstern-Kaplan, D, Kareff, SA, Trabolsi, A, Rodriguez, E, Krause, H, Ribeiro, JR, Tan, H, Antonarakis, ES, Lou, E, Nagasaka, M, Algaze, S, Lenz, HJ, Liu, SV, Halmos, B, Hoon, DSB, Seeber, A, Ma, PC, El-Deiry, WS, Vanderwalde, AM & Lopes, G 2024, 'Genomic, immunologic, and prognostic associations of TROP2 (TACSTD2) expression in solid tumors', Oncologist, vol. 29, no. 11, pp. e1480-e1491. https://doi.org/10.1093/oncolo/oyae168
Naqash, AR, Floudas, CS, Aber, E, Maoz, A, Nassar, AH, Adib, E, Choucair, K, Xiu, J, Baca, Y, Ricciuti, B, Alessi, JV, Awad, MM, Kim, C, Judd, J, Raez, LE, Lopes, G, Nieva, JJ, Borghaei, H, Takebe, N, Ma, PC, Halmos, B, Kwiatkowski, DJ, Liu, SV & Mamdani, H 2024, 'Influence of TP53 Comutation on the Tumor Immune Microenvironment and Clinical Outcomes With Immune Checkpoint Inhibitors in STK11-Mutant Non–Small-Cell Lung Cancer', JCO Precision Oncology, vol. 8, e2300371. https://doi.org/10.1200/PO.23.00371
Marks, JA, Gandhi, N, Halmos, B, Marmarelis, ME, Yeon Kim, S, Bazhenova, L, Ramalingam, SS, Xiu, J, Walker, P, Oberley, MJ, Ma, PC & Liu, SV 2024, 'Molecular profiling METex14+ non-small cell lung cancer (NSCLC): Impact of histology', Lung Cancer, vol. 196, 107935. https://doi.org/10.1016/j.lungcan.2024.107935
Hsiehchen, D, Elliott, A, Xiu, J, Seeber, A, El-Deiry, W, Antonarakis, ES, Graff, SL, Hall, MJ, Borghaei, H, Hoon, DSB, Liu, SV, Ma, PC, McKay, RR, Wise-Draper, T, Marshall, J, Sledge, GW, Spetzler, D & Zhu, H 2024, 'Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation', Cancer Cell, vol. 42, no. 12, pp. 1985-1987. https://doi.org/10.1016/j.ccell.2024.10.017
Lim, ZF, Wu, X, Zhu, L, Albandar, H, Hafez, M, Zhao, C, Almubarak, M, Smolkin, M, Zheng, H, Wen, S & Ma, PC 2024, 'Quantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes', Translational Lung Cancer Research, vol. 13, no. 12, pp. 3323-3343. https://doi.org/10.21037/tlcr-24-260
Dmukauskas, M, Cioffi, G, Waite, KA, Mammoser, AG, Sloan, AE, Ma, PC & Barnholtz-Sloan, JS 2024, 'Sex Difference in Disease-Related Adverse Events Post-Diagnosis of Lung Cancer Brain Metastases in Medicare Individuals ≥ 66 Years of Age', Cancers, vol. 16, no. 17, 2986. https://doi.org/10.3390/cancers16172986
Muquith, M, Espinoza, M, Elliott, A, Xiu, J, Seeber, A, El-Deiry, W, Antonarakis, ES, Graff, SL, Hall, MJ, Borghaei, H, Hoon, DSB, Liu, SV, Ma, PC, McKay, RR, Wise-Draper, T, Marshall, J, Sledge, GW, Spetzler, D, Zhu, H & Hsiehchen, D 2024, 'Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers', Nature Cancer, vol. 5, no. 7, pp. 1121-1129. https://doi.org/10.1038/s43018-024-00752-x
Watson, AS, Krause, HB, Elliott, A, Farrell, A, Liu, SV, Ma, PC, VanderWalde, A, Sledge, GW, Spetzler, D, Schenk, EL & Camidge, DR 2024, 'Use of Oncogene Overlap by Tissue-Based Next-Generation Sequencing to Explore the Mutational Landscape and Survival Impact of HER2, KRAS and MET Copy-Number Gain in Nonsmall Cell Lung Cancer', Clinical Lung Cancer, vol. 25, no. 8, pp. 712-722.e1. https://doi.org/10.1016/j.cllc.2024.09.001
2023
Guo, T, Zhao, S, Wang, P, Xue, X, Zhang, Y, Yang, M, Li, N, Li, Z, Xu, L, Jiang, L, Zhao, L, Ma, PC, Rosell, R, Li, J & Gu, C 2023, 'Erratum: YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma (Oncotarget (2017) 8 (48110-48125) DOI: 10.18632/oncotarget.18262)', Oncotarget, vol. 14, no. 1, pp. 280. https://doi.org/10.18632/oncotarget.28393
2022
Kim, SY, Yin, J, Bohlman, S, Walker, P, Dacic, S, Kim, C, Khan, H, Liu, SV, Ma, PC, Nagasaka, M, Reckamp, KL, Abraham, J, Uprety, D, Wang, F, Xiu, J, Zhang, J, Cheng, H & Halmos, B 2022, 'Characterization of MET Exon 14 Skipping Alterations (in NSCLC) and Identification of Potential Therapeutic Targets Using Whole Transcriptome Sequencing', JTO Clinical and Research Reports, vol. 3, no. 9, 100381. https://doi.org/10.1016/j.jtocrr.2022.100381
Esposito, R, Polidori, T, Meise, DF, Pulido-Quetglas, C, Chouvardas, P, Forster, S, Schaerer, P, Kobel, A, Schlatter, J, Kerkhof, E, Roemmele, M, Rice, ES, Zhu, L, Lanzós, A, Guillen-Ramirez, HA, Basile, G, Carrozzo, I, Vancura, A, Ullrich, S, Andrades, A, Harvey, D, Medina, PP, Ma, PC, Haefliger, S, Wang, X, Martinez, I, Ochsenbein, AF, Riether, C & Johnson, R 2022, 'Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities', Cell Genomics, vol. 2, no. 9, 100171. https://doi.org/10.1016/j.xgen.2022.100171
Shen, C, Holguin, RAP, Schaefer, E, Zhou, S, Belani, CP, Ma, PC & Reed, MF 2022, 'Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma', BMC health services research, vol. 22, no. 1, 470. https://doi.org/10.1186/s12913-022-07857-y