Kentaro Minagawa, MD, PhD - Penn State Cancer Institute
Researcher Profile
Kentaro Minagawa, MD, PhD
Assistant Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Clinical Trials
Myelomatch, Master Screening And Reassessment Protocol (MSRP) For Tier Advancement In The NCI Myelomatch Clinical Trials
Effective Quadruplet Utilization After Treatment Evaluation (EQUATE): A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma Not Intended for Early Autologous Transplantation
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adult Patients With Relapsed/Refractory Mantle Cell Lymphoma.
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7+3) Vs (Daunorubicin And Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, And (Daunorubicin And Cytarabine) Liposome + Venetoclax In Patients Aged 59 Or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined By Myelomatch; A Myelomatch Clinical Trial
Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene autoleucel (cila-cel) Out-of-Specification (OOS) in patients with Multiple Myeloma
Open-Label, Multicenter, Phase 1 Study to Assess the Safety of P-CD19CD20-ALLO1 in Subjects with Selected Relapsed/Refractory B cell Malignancies
A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Recent Publications
2025
Zhao, C, Jia, B, Jiang, Y, Shike, H, Annageldiyev, C, Cioccio, J, Minagawa, K, Mineishi, S, Ehmann, WC, Schell, TD, Cheng, H & Zheng, H 2025, 'Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity', Cancer Immunology, Immunotherapy, vol. 74, no. 4, 117. https://doi.org/10.1007/s00262-025-03971-y
Inoue, Y, Cioccio, J, Mineishi, S & Minagawa, K 2025, 'Evolution of Allogeneic Stem Cell Transplantation: Main Focus on AML', Cells, vol. 14, no. 8, 572. https://doi.org/10.3390/cells14080572
Velasco, CM, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Ehmann, C, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Mineishi, S, Shike, H & Minagawa, K 2025, 'Prior status of graft-versus-host disease affects donor lymphocyte infusion outcomes in patients with relapsed haematological malignancies after allogeneic stem cell transplantation', British Journal of Haematology, vol. 207, no. 2, pp. 515-524. https://doi.org/10.1111/bjh.20215
Venugopal, N, McGowan, A, Inoue, Y, Zheng, H, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Naik, S, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Shike, H, Mineishi, S & Minagawa, K 2025, 'Safety and feasibility of intermediate-dose post-transplant cyclophosphamide for graft-versus-host disease prophylaxis', Annals of Hematology, vol. 104, no. 12, pp. 6451-6462. https://doi.org/10.1007/s00277-025-06657-8
2024
Naik, S, Rakszawski, K, Zheng, H, Claxton, D, Minagawa, K & Mineishi, S 2024, 'Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia', International journal of molecular sciences, vol. 25, no. 2, 957. https://doi.org/10.3390/ijms25020957
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Khosla, A, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Ehmann, C, Claxton, D, Rybka, W, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Hohl, R, Shike, H, Mineishi, S & Minagawa, K 2024, 'Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia patient with a disease risk allele, HLA-B*40:02', Blood Transfusion, vol. 22, no. 6, pp. 525-528. https://doi.org/10.2450/BloodTransfus.674
Zhang, R, Shang, Y, Cioccio, J, Rakszawski, K, Nickolich, M, Ehmann, C, Inoue, Y, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Liao, J, Greiner, R, Brown, V, Claxton, D, Ning, J, Zhou, S, Mineishi, S, Minagawa, K & Shike, H 2024, 'Sensitivity and Specificity of Chimerism Tests in Predicting Leukemia Relapse Using Increasing Mixed Chimerism', Journal of Molecular Diagnostics, vol. 26, no. 12, pp. 1159-1170. https://doi.org/10.1016/j.jmoldx.2024.09.003
Guare, EG, Hale, CM, Sivik, J, Lehman, E, Inoue, Y, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Claxton, D, Rybka, W, Hohl, R, Mineishi, S, Minagawa, K & Paules, CI 2024, 'The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma', Transplant Infectious Disease, vol. 26, no. 2, e14241. https://doi.org/10.1111/tid.14241
2023
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Zhou, H, Jia, B, Annageldiyev, C, Minagawa, K, Zhao, C, Mineishi, S, Ehmann, WC, Naik, SG, Cioccio, J, Wirk, B, Songdej, N, Rakszawski, KL, Nickolich, MS, Shen, J & Zheng, H 2023, 'CD26lowPD-1+ CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia', Frontiers in immunology, vol. 14, 1169144. https://doi.org/10.3389/fimmu.2023.1169144
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068. https://doi.org/10.1016/j.bej.2023.109068
Minagawa, K, Wakahashi, K, Fukui, C, Kawano, Y, Kawano, H, Suzuki, T, Ishii, S, Sada, A, Nishikawa, S, Asada, N, Katayama, Y & Matsui, T 2023, 'Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice', Frontiers in immunology, vol. 14, 1197112. https://doi.org/10.3389/fimmu.2023.1197112
2022
Falcon, C, Smith, L, Al-Obaidi, M, Abu Zaanona, M, Purvis, K, Minagawa, K, Athar, M, Salzman, D, Bhatia, R, Goldman, F & Di Stasi, A 2022, 'Combinatorial suicide gene strategies for the safety of cell therapies', Frontiers in immunology, vol. 13, 975233. https://doi.org/10.3389/fimmu.2022.975233
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Jamy, O, Arora, S, Meredith, R, Salzman, D, Di Stasi, A, Minagawa, K, Mineishi, S & Saad, A 2022, 'Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy', Bone Marrow Transplantation, vol. 57, no. 10, pp. 1597-1599. https://doi.org/10.1038/s41409-022-01757-9