Edward Harhaj, PhD - Penn State Cancer Institute
Researcher Profile
Edward Harhaj, PhD
Professor, Department of Cell and Biological Systems
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Sunilkumar, S, Subrahmanian, SM, Yerlikaya, EI, Toro, AL, Harhaj, EW, Kimball, SR & Dennis, MD 2025, 'REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy', Cell Death and Disease, vol. 16, no. 1, 79. https://doi.org/10.1038/s41419-025-07396-4
Shaikh, K, Bowman, M, McCormick, SM, Gao, L, Zhang, J, White, J, Tawil, J, Kapoor, A, Arav-Boger, R, Norbury, CC & Harhaj, EW 2025, 'ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling', iScience, vol. 28, no. 1, 111544. https://doi.org/10.1016/j.isci.2024.111544
2024
Kazzaz, SA, Shaikh, KA, White, J, Zhou, Q, Powell, WH & Harhaj, EW 2024, 'Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response', Journal of Biological Chemistry, vol. 300, no. 1, 105525. https://doi.org/10.1016/j.jbc.2023.105525
White, J, Choi, YB, Zhang, J, Vo, MT, He, C, Shaikh, K & Harhaj, EW 2025, 'Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates', Autophagy, vol. 21, no. 1, pp. 160-177. https://doi.org/10.1080/15548627.2024.2394306
Kazzaz, SA, Tawil, J & Harhaj, EW 2024, 'The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor', Journal of Biological Chemistry, vol. 300, no. 4, 107157. https://doi.org/10.1016/j.jbc.2024.107157
Mohanty, S, Suklabaidya, S, Lavorgna, A, Ueno, T, Fujisawa, JI, Ngouth, N, Jacobson, S & Harhaj, EW 2024, 'The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein', Nature communications, vol. 15, no. 1, 5380. https://doi.org/10.1038/s41467-024-49737-5
2023
Mohanty, S & Harhaj, EW 2023, 'Mechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion', Pathogens, vol. 12, no. 5, 735. https://doi.org/10.3390/pathogens12050735
2022
White, J, Suklabaidya, S, Vo, MT, Choi, YB & Harhaj, EW 2023, 'Multifaceted roles of TAX1BP1 in autophagy', Autophagy, vol. 19, no. 1, pp. 44-53. https://doi.org/10.1080/15548627.2022.2070331
Madugula, KK, Joseph, J, DeMarino, C, Ginwala, R, Teixeira, V, Khan, ZK, Sales, D, Wilson, S, Kashanchi, F, Rushing, AW, Lemasson, I, Harhaj, EW, Janakiram, M, Hilda Ye, B & Jain, P 2022, 'Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma', Haematologica, vol. 107, no. 12, pp. 2928-2943. https://doi.org/10.3324/haematol.2021.279542