Scott A. Showalter - Penn State Cancer Institute
Researcher Profile
Scott A. Showalter
Biochemistry & Molecular Biology
Professor, Chemistry
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Proteins
- Intrinsically Disordered Proteins
- RNA
- MicroRNAs
- Magnetic Resonance Spectroscopy
- Molecular Dynamics Simulation
- RNA Polymerase II
- Double-Stranded RNA
- Phosphorylation
- Transcription Factors
- Thermodynamics
- RNA Polymerase III
Recent Publications
2023
Fraser, OA, Dewing, SM, Usher, ET, George, C & Showalter, SA 2023, 'A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins', Frontiers in Molecular Biosciences, vol. 9, 1074743. https://doi.org/10.3389/fmolb.2022.1074743
Fraser, OA, Namitz, KEW & Showalter, SA 2023, 'Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using 13C-enriched cofactors', Methods, vol. 218, pp. 72-83. https://doi.org/10.1016/j.ymeth.2023.07.010
Namitz, KEW, Showalter, SA & Cosgrove, MS 2023, 'Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation', Journal of Biological Chemistry, vol. 299, no. 10, 105204. https://doi.org/10.1016/j.jbc.2023.105204
2022
Usher, ET & Showalter, SA 2022, 'Biophysical insights into glucose-dependent transcriptional regulation by PDX1', Journal of Biological Chemistry, vol. 298, no. 12, 102623. https://doi.org/10.1016/j.jbc.2022.102623
2021
Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693. https://doi.org/10.1016/j.jbc.2021.100693
Usher, ET, Namitz, KEW, Cosgrove, MS & Showalter, SA 2021, 'Probing multiple enzymatic methylation events in real time with NMR spectroscopy', Biophysical journal, vol. 120, no. 21, pp. 4710-4721. https://doi.org/10.1016/j.bpj.2021.09.034
Prieto, VA, Namitz, KEW & Showalter, SA 2021, 'Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity', Journal of Physical Chemistry B, vol. 125, no. 39, pp. 10917-10927. https://doi.org/10.1021/acs.jpcb.1c05131
2020
Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17. https://doi.org/10.7554/eLife.58147
Pabit, SA, Chen, YL, Usher, ET, Cook, EC, Pollack, L & Showalter, SA 2020, 'Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures', Biophysical journal, vol. 119, no. 12, pp. 2524-2536. https://doi.org/10.1016/j.bpj.2020.10.038
Usher, ET & Showalter, SA 2020, 'Mapping invisible epitopes by NMR spectroscopy', Journal of Biological Chemistry, vol. 295, no. 51, pp. 17411-17412. https://doi.org/10.1074/jbc.H120.016607
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335. https://doi.org/10.1016/j.bpj.2020.04.003
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745