Sri-Rajasekhar Kothapalli, PhD - Penn State Cancer Institute
Researcher Profile
Sri-Rajasekhar Kothapalli, PhD
Associate Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Samanta, K, Mirg, S, Abbasi, A, Mansour, Y, Ramiah, KM, Jiang, J, Gomez, EW & Kothapalli, SR 2026, A Novel Optical Elastography Platform Integrating Transparent Ultrasound Transducer and Digital Holography. in KV Larin & G Scarcelli (eds), Optical Elastography and Tissue Biomechanics XIII., 138530D, Proceedings of SPIE - The International Society for Optical Engineering, vol. 13853, SPIE, 13th Optical Elastography and Tissue Biomechanics, San Francisco, United States, 1/17/26. https://doi.org/10.1117/12.3081422
Mitra, M, Agrawal, S, Samanta, K, Urban, MW & Kothapalli, SR 2026, Multiparametric Transrectal Ultrasound and Photoacoustic Imaging System for Prostate Cancer Diagnosis. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2026., 138510S, Proceedings of SPIE - The International Society for Optical Engineering, vol. 13851, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2026, San Francisco, United States, 1/18/26. https://doi.org/10.1117/12.3080814
Mitra, M, Gaddale, P, Lagno, N, Pameijer, CR, Aziz, F & Kothapalli, SR 2026, Portable Laser Diode based Multispectral Photoacoustic and Ultrasound Imaging System for Point-of-Care Screening Applications. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2026., 138511J, Proceedings of SPIE - The International Society for Optical Engineering, vol. 13851, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2026, San Francisco, United States, 1/18/26. https://doi.org/10.1117/12.3081259
2025
Saini, B, Laliwala, A, Singh, R, Exner, AA, Matters, G, Han, X, Nieman, MT & Kothapalli, SR 2025, 'Differentiating Aggressive from Nonaggressive Prostate Cancer Using Unconjugated Contrast Agents', ACS Applied Materials and Interfaces, vol. 17, no. 24, pp. 35056-35065. https://doi.org/10.1021/acsami.5c02984
Xu, H, Tan, X, Gerhard, E, Zhang, H, Ray, R, Wang, Y, Kothapalli, SR, Rizk, EB, Armstrong, AD, Yan, S & Yang, J 2025, 'Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways', Science Advances, vol. 11, no. 30, eady2862. https://doi.org/10.1126/sciadv.ady2862
2024
Huang, C, Khandare, S, Kothapalli, SR & Tadigadapa, SA 2024, IMPROVED PERFORMANCE OF PASSIVE LAYER-FREE CURVED PMUT ARRAY. in Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2024. Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2024, Transducer Research Foundation, pp. 372-375, Hilton Head Workshop 2024: A Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head, United States, 6/2/24. https://doi.org/10.31438/TRF.HH2024.99
Doody, N, Mirg, S, Chen, H, Khandare, S, Mitra, M & Kothapalli, SR 2024, Improved performance of piezoelectric transparent ultrasound transducers using electrical impedance matching circuit. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2024., 128421D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12842, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2024, San Francisco, United States, 1/28/24. https://doi.org/10.1117/12.3003083
Chen, H, Mirg, S, Gaddale, P, Agrawal, S, Li, M, Nguyen, V, Xu, T, Li, Q, Liu, J, Tu, W, Liu, X, Drew, PJ, Zhang, N, Gluckman, BJ & Kothapalli, SR 2024, 'Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System', Advanced Science, vol. 11, no. 31, 2401467. https://doi.org/10.1002/advs.202401467
Mitra, M, Haworth, A, Gaddale, P, Badran, F, Lagno, N, Pameijer, C, Aziz, F & Kothapalli, SR 2024, 'Multiwavelength laser diode based portable photoacoustic and ultrasound imaging system for point of care applications', Journal of Biophotonics, vol. 17, no. 7, e202400058. https://doi.org/10.1002/jbio.202400058
Khandare, SP, Huang, C, Kothapalli, SR & Tadigadapa, S 2024, Performance of Aluminum Nitride Curved PMUT Arrays Fabricated Using Glass Blowing Technique. in IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 198-201, 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024, Austin, United States, 1/21/24. https://doi.org/10.1109/MEMS58180.2024.10439406
Mitra, M, Kumar, A, Khandare, S, Gaddale, P, Anandan, Y, Pedibhotla, S, Roy, K, Chen, H, Pratap, R & Kothapalli, SR 2024, Volumetric Photoacoustic Imaging with Low-Cost and Easily Fabricated Planar Array Ultrasound Transducers. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2024., 128420R, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12842, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2024, San Francisco, United States, 1/28/24. https://doi.org/10.1117/12.3001634
2023
Huang, C, Khandare, SP, Kothapalli, SR & Tadigadapa, S 2023, 'Characterization of Curved Piezoelectric Micromachined Ultrasound Transducers Fabricated by Chip-Scale Glass Blowing Technique', IEEE Sensors Letters, vol. 7, no. 10, 2503304. https://doi.org/10.1109/LSENS.2023.3308112
Mitra, M, Kumar, A, Khandare, S, Gaddale, P, Anandan, Y, Pedibhotla, S, Roy, K, Chen, H, Pratap, R & Kothapalli, SR 2024, 'Low-Cost Scalable PCB-Based 2-D Transducer Arrays for Volumetric Photoacoustic Imaging', IEEE Sensors Journal, vol. 24, no. 4, pp. 4380-4386. https://doi.org/10.1109/JSEN.2023.3344824
Lee, K, Davis, B, Wang, X, Mirg, S, Wen, C, Abune, L, Peterson, BE, Han, L, Chen, H, Wang, H, Szczesny, SE, Lei, Y, Kothapalli, SR & Wang, Y 2023, 'Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation', Angewandte Chemie - International Edition, vol. 62, no. 31, e202306583. https://doi.org/10.1002/anie.202306583
Jo, J, Salfi, E, Folz, J, Udager, AM, Keller, E, Kopelman, R, Kothapalli, SR, Xu, G & Wang, X 2023, 'Photoacoustic Spectral Analysis for Evaluating the Aggressiveness of Prostate Cancer Labeled by Methylene Blue Polyacrylamide Nanoparticles', Biosensors, vol. 13, no. 3, 403. https://doi.org/10.3390/bios13030403
Pashaei, V, Huan, J, Chen, H, Osman, MSEA, Kothapalli, SR, Majerus, SJA & Mandal, S 2023, Wearable Ultrasound Probe for Nerve Localization and Stimulation. in BioCAS 2023 - 2023 IEEE Biomedical Circuits and Systems Conference, Conference Proceedings. BioCAS 2023 - 2023 IEEE Biomedical Circuits and Systems Conference, Conference Proceedings, Institute of Electrical and Electronics Engineers Inc., 2023 IEEE Biomedical Circuits and Systems Conference, BioCAS 2023, Toronto, Canada, 10/19/23. https://doi.org/10.1109/BioCAS58349.2023.10388793
2022
Osman, MS, Chen, H, Creamer, K, Minotto, J, Liu, J, Mirg, S, Christian, J, Bai, X, Agrawal, S & Kothapalli, SR 2022, 'A Novel Matching Layer Design for Improving the Performance of Transparent Ultrasound Transducers', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 69, no. 9, pp. 2672-2680. https://doi.org/10.1109/TUFFC.2022.3195998
Chen, H, Agrawal, S, Osman, M, Minotto, J, Mirg, S, Liu, J, Dangi, A, Tran, Q, Jackson, T & Kothapalli, SR 2022, 'A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging', BME Frontiers, vol. 2022, 9871098. https://doi.org/10.34133/2022/9871098
Osman, M, Creamer, K, Chen, H, Minotto, J, Liu, J, Agrawal, S & Kothapalli, SR 2022, A novel translucent ultrasound transducer approach for dual-modality ultrasound and photoacosutic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119601A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610187
Chen, H, Zhu, N, Biskowitz, R, Liu, J, Deng, C, Wong, PK & Kothapalli, SR 2022, A transparent ultrasound on-chip platform enables high-throughput cell stimulation and simultaneous high-resolution optical imaging. in A Tarnok & JP Houston (eds), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX., 119640C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11964, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610058
Liu, J, Chen, H, Agrawal, S, Zhang, N, Gluckman, B & Kothapalli, SR 2022, An optimized geometry for simultaneous functional ultrasound and photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610443
Mirg, S, Chen, H, Turner, KL, Gheres, KW, Liu, J, Gluckman, BJ, Drew, PJ & Kothapalli, SR 2022, 'Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window', Optics Letters, vol. 47, no. 5, pp. 1121-1124. https://doi.org/10.1364/OL.450648
Cheng, C, Peters, T, Dangi, A, Agrawal, S, Chen, H, Kothapalli, SR & Trolier-McKinstry, S 2022, 'Improving PMUT Receive Sensitivity via DC Bias and Piezoelectric Composition', Sensors, vol. 22, no. 15, 5614. https://doi.org/10.3390/s22155614
Mirg, S, Chen, H, Khandare, S, Osman, M & Kothapalli, SR 2022, Noise considerations in piezoelectric transparent ultrasound transducers for photoacoustic imaging applications. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610342
Mirg, S, Turner, KL, Chen, H, Drew, PJ & Kothapalli, SR 2022, 'Photoacoustic imaging for microcirculation', Microcirculation, vol. 29, no. 6-7, e12776. https://doi.org/10.1111/micc.12776